Terapia celular na pseudo-artrose

• Ano de defesa: 2010
• Autor(a) principal: Bastos Filho, Ricardo Pinheiro dos Santos
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Programa de Pós-graduação em Ciências Médicas; Ciências Médicas
• Palavras-chave em Português: Pseudo-artrose; Células da Medula Óssea; Células Progenitoras; Tíbia; Fêmur; Consolidação da Fratura; MEDICINA; CIÊNCIAS MÉDICAS; Células-tronco; Nonunion; Bone Marrow Cells; Progenitor Cells; Femur; Fracture Healing; CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA
• Link de acesso: https://app.uff.br/riuff/handle/1/19052

This study was done to assess the safety and efficiency of cell therapy for pseudoarthrosis. Implant of the bone marrow aspirate was compared to mononuclear cells purified extemnporaneously using the Sepax® equipment. Seven patients with nonunion of the tibia or femur were treated. Five received a percutaneous infusion of autologous bone marrow aspirated from the iliac crest, and two received autologous bone marrow mononuclear cells separated from the aspirate by Sepax®. The primary fixation method was unchanged, and the nonunion focus was not exposed. Physical examination and radiographies were done 2, 4 and 6 months after the treatment by the same physician. After the consolidation of the fracture the satisfaction of the patients was estimated using a 0 to 10 scale. No complications occurred as a result of the referred procedures. Bone consolidation was obtained in all cases within 3 to 24 weeks. The degree of patient satisfaction before and after bone consolidation was assessed, with the average value increasing from two to nine (p=0.0156). The proposed method is effective and safe for the treatment of nonunion of long bones regardless the stabilization method used.