Estudo de polimorfismos genéticos em pacientes portadores de insuficiência cardíaca

• Ano de defesa: 2012
• Autor(a) principal: Silva, Silene Jacinto da
• Orientador(a): Rassi, Salvador
• Banca de defesa: Rassi, Salvador, Barroso, Weimar Kunz Sebba, Afiune Neto, Abrahão
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Ciências da Saúde (FM)
• Departamento: Faculdade de Medicina - FM (RG)
• País: Brasil
• Palavras-chave em Português: Angiotensina; ECA; Insuficiência cardíaca; Polimorfismo genético
• Palavras-chave em Inglês: Angiotensin; ACE; Heart failure; Genetic polymorphism
• Área do conhecimento CNPq: CIENCIAS DA SAUDE
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/4191

The Deletion/Insertion polymorphisms of the angiotensin converting enzyme genes and the A1166C of the angiotensin II receptor AT1R were analyzed in a cohort of 90 patients, among 30 carriers of chronic heart failure, aging from 30 to 86, in which 66, 6% were males. The control group was based on 60 cardiopathic patients without heart failure matched by age and gender. The heart failure was attributed to the etiologies: chagas cardiomyopathy (46,7%), idiopathic dilated cardiomyopathy and others (23,3%), hypertensive cardiomyopathy (20%) and ischemic cardiomyopathy (10%). In order to determine the genotypes the PCR - RFLP (Polymerase Chain Reaction - Restriction Fragment Length Polymorphism) technique was applied. The genotypes distribution was analyzed, as well as the allele’s frequency and the possible polymorphisms associations with different clinical variations and heart failure carrier’s evolution during 12 months. For the analysis of descriptive and inferential statistical were used the t test, chi-square (χ2) test, Kaplan - Meier and ANOVA. The distribution of the genotypes D/I of the genes ACE and the polymorphisms A1166C of the angiotensin II was similar between the two groups (p = 0,23 e p= 0,12). The evaluation of the polymorphisms studies presented a lack of association with the clinical variations analyzed and the evolution of the heart failure carriers during 12 months.