Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás
Ano de defesa: | 2020 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Goiás
|
Programa de Pós-Graduação: |
Programa de Pós-graduação em Ciências Biológicas (ICB)
|
Departamento: |
Instituto de Ciências Biológicas - ICB (RG)
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.bc.ufg.br/tede/handle/tede/10423 |
Resumo: | The arboviruses has been a great concern to human health in the worldwide. In Brazil the most prevalents arboviruses are Dengue (DENV), Zika (ZIKV) and Chikungunya (CHIKV), which presents similar sintomatology, as well as Mayaro fever (MAYV), therefore, it is essential to perform laboratorial diagnosis to confirm these infections. The present study aims to perform serological and molecular evaluation of patients with suspected arboviruses dengue-like, assisted at a public health unity in the city of Goiânia, Goiás. A total of 459 samples were collected from March, 30th, 2017 to June, 20th, 2018. For the serological evaluation, commercial Bahiafarma® rapid diagnosis kits were used to detect IgM and IgG antibodies for ZIKV, DENV and CHIKV. The molecular evaluation was performed by RT-qPCR and conventional PCR technique, to detect the viral genome. Subsenquently, 11 samples were select and submitted to the viral isolation in cell culture. As a serological results, samples IgM reagents were obtained, 0.7% for ZIKV and 8.5% for DENV, however no one for CHIKV. Regarding the molecular evaluation it was obtained a percentage of 12.6% positive samples for ZIKV; 28.3% positive samples for DENV; 2.2% positive samples for CHIKV and 17% positive for MAYV. Were obtained, respectively, sensitivity and specificity of 5% and 84% for Bahiafarma® anti-DENV IgM; specificity of 99% for Bahiafarma® anti-ZIKV IgM, and specificity of 42% for for Bahiafarma® anti-CHIKV IgM. Viral isolation in cell culture had no evident cytopathic effect, however, the 11 samples were positive for ZIKV and two samples were positive for MAYV after RT-PCR performed from the cell supernatant. Although arboviruses are benign in most cases, severe cases may occur with irreversible sequelae. Thus, it is essential that confirmation of arbovirus infection be performed by sensitive laboratory diagnostic methods. |
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Lacerda, Elisângela de Paula Silveirahttp://lattes.cnpq.br/9390789693192751Anunciação, Carlos Eduardo http://lattes.cnpq.br/4354412874919580Lacerda , Elisângela de Paula SilveiraSouza, Guilherme Rocha Lino deHerlinger, Alice Laschukhttp://lattes.cnpq.br/2731021589743116Corrêa, Jordana Farias2020-03-16T13:44:05Z2020-02-18CORRÊA, J. F. Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás. 2020. 51 f. Dissertação (Mestrado em Ciências Biológicas ) - Universidade Federal de Goiás, Goiânia, 2020.http://repositorio.bc.ufg.br/tede/handle/tede/10423The arboviruses has been a great concern to human health in the worldwide. In Brazil the most prevalents arboviruses are Dengue (DENV), Zika (ZIKV) and Chikungunya (CHIKV), which presents similar sintomatology, as well as Mayaro fever (MAYV), therefore, it is essential to perform laboratorial diagnosis to confirm these infections. The present study aims to perform serological and molecular evaluation of patients with suspected arboviruses dengue-like, assisted at a public health unity in the city of Goiânia, Goiás. A total of 459 samples were collected from March, 30th, 2017 to June, 20th, 2018. For the serological evaluation, commercial Bahiafarma® rapid diagnosis kits were used to detect IgM and IgG antibodies for ZIKV, DENV and CHIKV. The molecular evaluation was performed by RT-qPCR and conventional PCR technique, to detect the viral genome. Subsenquently, 11 samples were select and submitted to the viral isolation in cell culture. As a serological results, samples IgM reagents were obtained, 0.7% for ZIKV and 8.5% for DENV, however no one for CHIKV. Regarding the molecular evaluation it was obtained a percentage of 12.6% positive samples for ZIKV; 28.3% positive samples for DENV; 2.2% positive samples for CHIKV and 17% positive for MAYV. Were obtained, respectively, sensitivity and specificity of 5% and 84% for Bahiafarma® anti-DENV IgM; specificity of 99% for Bahiafarma® anti-ZIKV IgM, and specificity of 42% for for Bahiafarma® anti-CHIKV IgM. Viral isolation in cell culture had no evident cytopathic effect, however, the 11 samples were positive for ZIKV and two samples were positive for MAYV after RT-PCR performed from the cell supernatant. Although arboviruses are benign in most cases, severe cases may occur with irreversible sequelae. Thus, it is essential that confirmation of arbovirus infection be performed by sensitive laboratory diagnostic methods.Os arbovírus têm sido motivo de grande preocupação para a saúde humana a nível mundial. No Brasil, as arboviroses de maior incidência, são Dengue (DENV), Zika (ZIKV) e Chikungunya (CHIKV), as quais apresentam sintomatologia semelhantes, assim como ocorre também na febre Mayaro (MAYV), sendo desta forma, imprescindível a realização de diagnóstico diferencial para a confirmação destas infecções. O presente estudo tem como objetivo, realizar avaliação sorológica e molecular de pacientes com suspeita de arboviroses, atendidos em uma unidade pública de saúde do município de Goiânia, Goiás. Foram, então, coletadas 459 amostras no período compreendido entre o dia 30 de março de 2017 e 20 de junho de 2018. Para avaliação sorológica, foram utilizados kits comerciais de diagnóstico rápido Bahiafarma® para detecção dos anticorpos IgM e IgG para ZIKV, DENV e CHIKV. A avaliação molecular foi realizada por meio da técnica de RT-qPCR e PCR convencional, para detecção do genoma viral. Posteriormente, 11 amostras foram selecionadas e submetidas à técnica de isolamento viral em cultivo de celular. Como resultados sorológicos, foram obtidas amostras IgM reagentes, sendo 0,7% para ZIKV e 8,5% para DENV, porém nenhuma para CHIKV. Com relação à avaliação molecular foi obtido um percentual de 12,6% amostras positivas para ZIKV; 28,3% positivas para DENV; 2,2% positivas para CHIKV e 17% positivas para MAYV. Foram obtidas, respectivamente, sensibilidade e especificidade de 5% e 84% para Bahiafarma® anti-DENV IgM; especificidade de 99% ara Bahiafarma® anti-ZIKV IgM, e especificidade de 42% para Bahiafarma® anti-CHIKV IgM. O isolamento viral em cultivo celular não apresentou efeito citopático evidente, no entanto, as 11 amostras foram positivas para ZIKV e duas amostras foram positivas para MAYV, após RT-PCR realizada a partir do sobrenadante celular. Embora as arboviroses cursem de maneira benigna na maioria das vezes, casos graves podem ocorrer com sequelas irreversíveis. Desta forma, é fundamental que a confirmação de infecção por arbovírus seja realizada por métodos diagnósticos laboratoriais sensíveis.Submitted by Liliane Ferreira (ljuvencia30@gmail.com) on 2020-03-13T13:15:06Z No. of bitstreams: 2 Dissertação - Jordana Farias Corrêa - 2020.pdf: 1491721 bytes, checksum: c3e7fd8fe4af4f22ba90da2d0bd9a988 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2020-03-16T13:44:04Z (GMT) No. of bitstreams: 2 Dissertação - Jordana Farias Corrêa - 2020.pdf: 1491721 bytes, checksum: c3e7fd8fe4af4f22ba90da2d0bd9a988 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2020-03-16T13:44:05Z (GMT). No. of bitstreams: 2 Dissertação - Jordana Farias Corrêa - 2020.pdf: 1491721 bytes, checksum: c3e7fd8fe4af4f22ba90da2d0bd9a988 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2020-02-18Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências Biológicas (ICB)UFGBrasilInstituto de Ciências Biológicas - ICB (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessArbovirosesTeste rápidoDiagnóstico molecularIsolamento viralCélulas veroAbovirusesRapid testMolecular diagnosisViral IsolationVero cellsCIENCIAS BIOLOGICAS::GENETICAAvaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-GoiásSerological and molecular evaluation of patients with suspected arboviruses in a municipal health unit of Goiânia-Goiásinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-3362730732320261554600600600600-3872772117827373404-55181442685852520512075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.eng.fl_str_mv |
Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás |
dc.title.alternative.eng.fl_str_mv |
Serological and molecular evaluation of patients with suspected arboviruses in a municipal health unit of Goiânia-Goiás |
title |
Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás |
spellingShingle |
Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás Corrêa, Jordana Farias Arboviroses Teste rápido Diagnóstico molecular Isolamento viral Células vero Aboviruses Rapid test Molecular diagnosis Viral Isolation Vero cells CIENCIAS BIOLOGICAS::GENETICA |
title_short |
Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás |
title_full |
Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás |
title_fullStr |
Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás |
title_full_unstemmed |
Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás |
title_sort |
Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás |
author |
Corrêa, Jordana Farias |
author_facet |
Corrêa, Jordana Farias |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Lacerda, Elisângela de Paula Silveira |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9390789693192751 |
dc.contributor.advisor-co1.fl_str_mv |
Anunciação, Carlos Eduardo |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/4354412874919580 |
dc.contributor.referee1.fl_str_mv |
Lacerda , Elisângela de Paula Silveira |
dc.contributor.referee2.fl_str_mv |
Souza, Guilherme Rocha Lino de |
dc.contributor.referee3.fl_str_mv |
Herlinger, Alice Laschuk |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2731021589743116 |
dc.contributor.author.fl_str_mv |
Corrêa, Jordana Farias |
contributor_str_mv |
Lacerda, Elisângela de Paula Silveira Anunciação, Carlos Eduardo Lacerda , Elisângela de Paula Silveira Souza, Guilherme Rocha Lino de Herlinger, Alice Laschuk |
dc.subject.por.fl_str_mv |
Arboviroses Teste rápido Diagnóstico molecular Isolamento viral Células vero |
topic |
Arboviroses Teste rápido Diagnóstico molecular Isolamento viral Células vero Aboviruses Rapid test Molecular diagnosis Viral Isolation Vero cells CIENCIAS BIOLOGICAS::GENETICA |
dc.subject.eng.fl_str_mv |
Aboviruses Rapid test Molecular diagnosis Viral Isolation Vero cells |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::GENETICA |
description |
The arboviruses has been a great concern to human health in the worldwide. In Brazil the most prevalents arboviruses are Dengue (DENV), Zika (ZIKV) and Chikungunya (CHIKV), which presents similar sintomatology, as well as Mayaro fever (MAYV), therefore, it is essential to perform laboratorial diagnosis to confirm these infections. The present study aims to perform serological and molecular evaluation of patients with suspected arboviruses dengue-like, assisted at a public health unity in the city of Goiânia, Goiás. A total of 459 samples were collected from March, 30th, 2017 to June, 20th, 2018. For the serological evaluation, commercial Bahiafarma® rapid diagnosis kits were used to detect IgM and IgG antibodies for ZIKV, DENV and CHIKV. The molecular evaluation was performed by RT-qPCR and conventional PCR technique, to detect the viral genome. Subsenquently, 11 samples were select and submitted to the viral isolation in cell culture. As a serological results, samples IgM reagents were obtained, 0.7% for ZIKV and 8.5% for DENV, however no one for CHIKV. Regarding the molecular evaluation it was obtained a percentage of 12.6% positive samples for ZIKV; 28.3% positive samples for DENV; 2.2% positive samples for CHIKV and 17% positive for MAYV. Were obtained, respectively, sensitivity and specificity of 5% and 84% for Bahiafarma® anti-DENV IgM; specificity of 99% for Bahiafarma® anti-ZIKV IgM, and specificity of 42% for for Bahiafarma® anti-CHIKV IgM. Viral isolation in cell culture had no evident cytopathic effect, however, the 11 samples were positive for ZIKV and two samples were positive for MAYV after RT-PCR performed from the cell supernatant. Although arboviruses are benign in most cases, severe cases may occur with irreversible sequelae. Thus, it is essential that confirmation of arbovirus infection be performed by sensitive laboratory diagnostic methods. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-03-16T13:44:05Z |
dc.date.issued.fl_str_mv |
2020-02-18 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CORRÊA, J. F. Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás. 2020. 51 f. Dissertação (Mestrado em Ciências Biológicas ) - Universidade Federal de Goiás, Goiânia, 2020. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/10423 |
identifier_str_mv |
CORRÊA, J. F. Avaliação sorológica e molecular de pacientes com suspeita de arboviroses em uma unidade municipal de saúde de Goiânia-Goiás. 2020. 51 f. Dissertação (Mestrado em Ciências Biológicas ) - Universidade Federal de Goiás, Goiânia, 2020. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/10423 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
-3362730732320261554 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-3872772117827373404 |
dc.relation.cnpq.fl_str_mv |
-5518144268585252051 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Ciências Biológicas (ICB) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Ciências Biológicas - ICB (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/cf82f9aa-f79e-4d64-b10b-5afc3fb4daf0/download http://repositorio.bc.ufg.br/tede/bitstreams/e5194ced-d9b0-4445-badb-09d6795d4700/download http://repositorio.bc.ufg.br/tede/bitstreams/10316eb3-a1b0-4e85-9c44-db993083c4e8/download http://repositorio.bc.ufg.br/tede/bitstreams/08d926dc-23e9-4876-b15e-ab3b28ae10aa/download http://repositorio.bc.ufg.br/tede/bitstreams/5c5c817d-ce6a-49e4-86f6-f01bd900b246/download |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e c3e7fd8fe4af4f22ba90da2d0bd9a988 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798045004583665664 |