Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7
Ano de defesa: | 2016 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Goiás
|
Programa de Pós-Graduação: |
Programa de Pós-graduação em Biologia (ICB)
|
Departamento: |
Instituto de Ciências Biológicas - ICB (RG)
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.bc.ufg.br/tede/handle/tede/5695 |
Resumo: | LVV-hemorphin-7 (LVV-h7) and LVV-hemorphin-6 (LVV-h6) are bioactive peptides resulting from degradation of hemoglobin β-globin chain. LVV-h7 is a specific agonist of angiotensin IV receptor. This receptor belongs to the class of insulin-regulated aminopeptidases (IRAP), which also exerts oxytocinase activity. Herein, our aims were: i) to evaluate whether LVVs modify centrally-organized behavior and cardiovascular responses to stress and ii) to assess whether underlying mechanisms involve activation of oxytocin (OT) receptors, as result of reduction of IRAP proteolytic activity upon OT. Adult male Wistar rats (270-370g) received (ip) injections of LVV-h7 and LVV-h6 (153nmol/Kg), or vehicle (0.1ml). Different protocols were used: i) open field (OP) test for locomotor/exploratory activities; ii) elevated plus maze (EPM) for anxiety-like behavior; iii) forced swimming (FS) test for depression-like behavior and iv) air jet for cardiovascular reactivity to acute stress exposure. Diazepam (2mg/Kg) and imipramine (15mg/Kg) were used as positive control for EPM and FS tests, respectively. The antagonist of OT receptors, atosiban (1 e 0,1 mg/Kg), was used to determine the involvement of oxytocinergic paths. Both LVVs: i) increased the number of entries and the time spent in open arms of the maze, an indicative of anxiolysis; ii) reduced the immobility during FS test, an indicative of antidepressant effect; and iii) increased the exploratory activity, but locomotion episodes were significantly increased only by LVV-h7; while the specific OT antagonist, atosiban, did not revert the effect anxiolytic-like evoked by LVVs. It also changed the effects upon exploration evoked by LVV’s and the antidepressant-like effect promoted by LVV-h7. Besides, LVV-h6 and LVV-h7 did not change the cardiovascular reactivity and neuroendocrine responses to acute stress. We conclude that LVVs modulate behavior, display antidepressant and anxiolytic effects and do not change the cardiovascular reactivity to acute stress exposure. LVV-h7 behavioral effects are mediated in part by oxytocin receptors. |
id |
UFG-2_6417473cda79ff623cee7af115d0ea83 |
---|---|
oai_identifier_str |
oai:repositorio.bc.ufg.br:tede/5695 |
network_acronym_str |
UFG-2 |
network_name_str |
Repositório Institucional da UFG |
repository_id_str |
|
spelling |
Custódio, Carlos Henrique Xavierhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4233298D1Ianzer, Danielle Alveshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4760882T6Custódio, Carlos Henrique XavierIanzer, Danielle AlvesGhedini, Paulo CesarCastro, Carlos Henrique dehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4402531D1Cruz, Kellen Rosa da2016-06-28T12:38:55Z2016-03-04CRUZ, K. R. Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7. 2016. 91 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2016.http://repositorio.bc.ufg.br/tede/handle/tede/5695LVV-hemorphin-7 (LVV-h7) and LVV-hemorphin-6 (LVV-h6) are bioactive peptides resulting from degradation of hemoglobin β-globin chain. LVV-h7 is a specific agonist of angiotensin IV receptor. This receptor belongs to the class of insulin-regulated aminopeptidases (IRAP), which also exerts oxytocinase activity. Herein, our aims were: i) to evaluate whether LVVs modify centrally-organized behavior and cardiovascular responses to stress and ii) to assess whether underlying mechanisms involve activation of oxytocin (OT) receptors, as result of reduction of IRAP proteolytic activity upon OT. Adult male Wistar rats (270-370g) received (ip) injections of LVV-h7 and LVV-h6 (153nmol/Kg), or vehicle (0.1ml). Different protocols were used: i) open field (OP) test for locomotor/exploratory activities; ii) elevated plus maze (EPM) for anxiety-like behavior; iii) forced swimming (FS) test for depression-like behavior and iv) air jet for cardiovascular reactivity to acute stress exposure. Diazepam (2mg/Kg) and imipramine (15mg/Kg) were used as positive control for EPM and FS tests, respectively. The antagonist of OT receptors, atosiban (1 e 0,1 mg/Kg), was used to determine the involvement of oxytocinergic paths. Both LVVs: i) increased the number of entries and the time spent in open arms of the maze, an indicative of anxiolysis; ii) reduced the immobility during FS test, an indicative of antidepressant effect; and iii) increased the exploratory activity, but locomotion episodes were significantly increased only by LVV-h7; while the specific OT antagonist, atosiban, did not revert the effect anxiolytic-like evoked by LVVs. It also changed the effects upon exploration evoked by LVV’s and the antidepressant-like effect promoted by LVV-h7. Besides, LVV-h6 and LVV-h7 did not change the cardiovascular reactivity and neuroendocrine responses to acute stress. We conclude that LVVs modulate behavior, display antidepressant and anxiolytic effects and do not change the cardiovascular reactivity to acute stress exposure. LVV-h7 behavioral effects are mediated in part by oxytocin receptors.LVV-h7 e LVV-h6 são peptídeos bioativos resultantes da degradação da cadeia β-globina da hemoglobina. LVV-h7 é um agonista do receptor de angiotensina IV. Esse receptor pertence a classe de aminopeptidases reguladas por insulina (IRAP), que também exerce atividade ocitocinase. Ao se ligar ao receptor, LVV-h7 inibe a atividade catalítica de IRAP sobre neuropeptídeos, incluindo ocitocina (OT), levando ao aumento nos níveis de ocitocina. Assim, nossos objetivos foram: i) avaliar se as LVVs modificam o comportamento organizado centralmente e as respostas cardiovascular ao estresse agudo emocional e ii) verificar se os mecanismos responsáveis pelos efeitos, envolvem a ativação de receptores de ocitocina, como resultado da redução da atividade proteolítica de IRAP sobre a OT. Ratos Wistar, adultos, (270-370 g) receberam injeções i.p. de LVV-h6 e LVV-h7 (153nmol/Kg), ou veículo (0,1 ml). Diferentes protocolos foram usados: i) labirinto em cruz elevada para comportamento tipo-ansiedade; ii) campo aberto para atividade locomotora/exploratória; iii) nado forçado para comportamento tipo-depressão e iv) estresse por jato de ar para reatividade cardiovascular à exposição ao estresse agudo. Diazepam (2 mg/Kg) e imipramina (15 mg/Kg) foram usados como controle positivo para LCE e NF, respectivamente. O antagonista de receptores de OT, atosibano (1 e 0,1 mg/Kg), foi usado para determinar o envolvimento de vias ocitocinérgicas. Ambas LVVs: i) aumentaram o número de entradas e o tempo despendido nos braços abertos do LCE, um indicativo de ansiólise; ii) reduziram a imobilidade durante o NF, indicando efeito tipo antidepressivo e, iii) aumentaram a atividade exploratória no CA, episódios de locomoção foram significativamente aumentados apenas pela LVV-h7; iv) o antagonista de receptores de OT não alterou o efeito evocado pela LVVs sobre o efeito tipo ansiolítico. Entretanto, reverteu o aumento na exploração evocado pelas LVV’s e também o efeito tipo antidepressivo evocado apenas pela LVV-h7. Além disso, LVV-h6 e LVV-h7 não alteraram a resposta pressora, taquicárdica e neuroendócrina evocada pelo estresse egudo emocional. Nós concluímos que LVVs modulam o comportamento, desempenhando efeito tipo ansiolítico e tipo antidepressivo e não são capazes de alterar a reatividade cardiovascular ao estresse. Os efeitos comportamentais de LVV-h7 são mediados, em parte, por receptores de OT.Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2016-06-15T20:37:56Z No. of bitstreams: 2 Dissertação - Kellen Rosa da Cruz - 2016.pdf: 2861182 bytes, checksum: 0321c4e0cfb84ad753664693273c2e23 (MD5) license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-06-28T12:38:55Z (GMT) No. of bitstreams: 2 Dissertação - Kellen Rosa da Cruz - 2016.pdf: 2861182 bytes, checksum: 0321c4e0cfb84ad753664693273c2e23 (MD5) license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (MD5)Made available in DSpace on 2016-06-28T12:38:55Z (GMT). No. of bitstreams: 2 Dissertação - Kellen Rosa da Cruz - 2016.pdf: 2861182 bytes, checksum: 0321c4e0cfb84ad753664693273c2e23 (MD5) license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (MD5) Previous issue date: 2016-03-04Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Biologia (ICB)UFGBrasilInstituto de Ciências Biológicas - ICB (RG)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessLVV-h7LVV-h6IrapAnsiolíticoAntidepressivoEstresseAanxiolyticAntidepressantStressCIENCIAS BIOLOGICAS::FARMACOLOGIAEfeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7Central effects of hemoglobin-derived peptides, lvv-hemorphin-6 and lvv-hemorfina-7info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis6883982777473437920600600600600-38727721178273734047008146506511543632075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://repositorio.bc.ufg.br/tede/bitstreams/6ec867d1-16a6-4799-8b71-a5c3fd2f0726/downloadbd3efa91386c1718a7f26a329fdcb468MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-843http://repositorio.bc.ufg.br/tede/bitstreams/b3087009-33f3-45b2-9709-350bcf445203/download321f3992dd3875151d8801b773ab32edMD52license_textlicense_texttext/html; charset=utf-821818http://repositorio.bc.ufg.br/tede/bitstreams/742d3f73-2af6-4977-ba8d-77271a4f2325/downloadb19767193fa05eb8852808b812c188a0MD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-819874http://repositorio.bc.ufg.br/tede/bitstreams/e81ba218-db4d-4153-be14-60ced55e5a28/download38cb62ef53e6f513db2fb7e337df6485MD54ORIGINALDissertação - Kellen Rosa da Cruz - 2016.pdfDissertação - Kellen Rosa da Cruz - 2016.pdfapplication/pdf2861182http://repositorio.bc.ufg.br/tede/bitstreams/8c507a15-549a-4a65-b2a9-14b815cd9f47/download0321c4e0cfb84ad753664693273c2e23MD55tede/56952016-06-28 09:38:55.895http://creativecommons.org/licenses/by/4.0/Acesso Abertoopen.accessoai:repositorio.bc.ufg.br:tede/5695http://repositorio.bc.ufg.br/tedeRepositório InstitucionalPUBhttp://repositorio.bc.ufg.br/oai/requesttasesdissertacoes.bc@ufg.bropendoar:2016-06-28T12:38:55Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)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 |
dc.title.por.fl_str_mv |
Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7 |
dc.title.alternative.eng.fl_str_mv |
Central effects of hemoglobin-derived peptides, lvv-hemorphin-6 and lvv-hemorfina-7 |
title |
Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7 |
spellingShingle |
Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7 Cruz, Kellen Rosa da LVV-h7 LVV-h6 Irap Ansiolítico Antidepressivo Estresse Aanxiolytic Antidepressant Stress CIENCIAS BIOLOGICAS::FARMACOLOGIA |
title_short |
Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7 |
title_full |
Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7 |
title_fullStr |
Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7 |
title_full_unstemmed |
Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7 |
title_sort |
Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7 |
author |
Cruz, Kellen Rosa da |
author_facet |
Cruz, Kellen Rosa da |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Custódio, Carlos Henrique Xavier |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4233298D1 |
dc.contributor.advisor-co1.fl_str_mv |
Ianzer, Danielle Alves |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4760882T6 |
dc.contributor.referee1.fl_str_mv |
Custódio, Carlos Henrique Xavier |
dc.contributor.referee2.fl_str_mv |
Ianzer, Danielle Alves |
dc.contributor.referee3.fl_str_mv |
Ghedini, Paulo Cesar |
dc.contributor.referee4.fl_str_mv |
Castro, Carlos Henrique de |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4402531D1 |
dc.contributor.author.fl_str_mv |
Cruz, Kellen Rosa da |
contributor_str_mv |
Custódio, Carlos Henrique Xavier Ianzer, Danielle Alves Custódio, Carlos Henrique Xavier Ianzer, Danielle Alves Ghedini, Paulo Cesar Castro, Carlos Henrique de |
dc.subject.por.fl_str_mv |
LVV-h7 LVV-h6 Irap Ansiolítico Antidepressivo Estresse |
topic |
LVV-h7 LVV-h6 Irap Ansiolítico Antidepressivo Estresse Aanxiolytic Antidepressant Stress CIENCIAS BIOLOGICAS::FARMACOLOGIA |
dc.subject.eng.fl_str_mv |
Aanxiolytic Antidepressant Stress |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::FARMACOLOGIA |
description |
LVV-hemorphin-7 (LVV-h7) and LVV-hemorphin-6 (LVV-h6) are bioactive peptides resulting from degradation of hemoglobin β-globin chain. LVV-h7 is a specific agonist of angiotensin IV receptor. This receptor belongs to the class of insulin-regulated aminopeptidases (IRAP), which also exerts oxytocinase activity. Herein, our aims were: i) to evaluate whether LVVs modify centrally-organized behavior and cardiovascular responses to stress and ii) to assess whether underlying mechanisms involve activation of oxytocin (OT) receptors, as result of reduction of IRAP proteolytic activity upon OT. Adult male Wistar rats (270-370g) received (ip) injections of LVV-h7 and LVV-h6 (153nmol/Kg), or vehicle (0.1ml). Different protocols were used: i) open field (OP) test for locomotor/exploratory activities; ii) elevated plus maze (EPM) for anxiety-like behavior; iii) forced swimming (FS) test for depression-like behavior and iv) air jet for cardiovascular reactivity to acute stress exposure. Diazepam (2mg/Kg) and imipramine (15mg/Kg) were used as positive control for EPM and FS tests, respectively. The antagonist of OT receptors, atosiban (1 e 0,1 mg/Kg), was used to determine the involvement of oxytocinergic paths. Both LVVs: i) increased the number of entries and the time spent in open arms of the maze, an indicative of anxiolysis; ii) reduced the immobility during FS test, an indicative of antidepressant effect; and iii) increased the exploratory activity, but locomotion episodes were significantly increased only by LVV-h7; while the specific OT antagonist, atosiban, did not revert the effect anxiolytic-like evoked by LVVs. It also changed the effects upon exploration evoked by LVV’s and the antidepressant-like effect promoted by LVV-h7. Besides, LVV-h6 and LVV-h7 did not change the cardiovascular reactivity and neuroendocrine responses to acute stress. We conclude that LVVs modulate behavior, display antidepressant and anxiolytic effects and do not change the cardiovascular reactivity to acute stress exposure. LVV-h7 behavioral effects are mediated in part by oxytocin receptors. |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-06-28T12:38:55Z |
dc.date.issued.fl_str_mv |
2016-03-04 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CRUZ, K. R. Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7. 2016. 91 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/5695 |
identifier_str_mv |
CRUZ, K. R. Efeitos centrais de peptídeos derivados da hemoglobina: lvv-hemorfina-6 e lvv-hemorfina-7. 2016. 91 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2016. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/5695 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6883982777473437920 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-3872772117827373404 |
dc.relation.cnpq.fl_str_mv |
700814650651154363 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Biologia (ICB) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Ciências Biológicas - ICB (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/6ec867d1-16a6-4799-8b71-a5c3fd2f0726/download http://repositorio.bc.ufg.br/tede/bitstreams/b3087009-33f3-45b2-9709-350bcf445203/download http://repositorio.bc.ufg.br/tede/bitstreams/742d3f73-2af6-4977-ba8d-77271a4f2325/download http://repositorio.bc.ufg.br/tede/bitstreams/e81ba218-db4d-4153-be14-60ced55e5a28/download http://repositorio.bc.ufg.br/tede/bitstreams/8c507a15-549a-4a65-b2a9-14b815cd9f47/download |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 321f3992dd3875151d8801b773ab32ed b19767193fa05eb8852808b812c188a0 38cb62ef53e6f513db2fb7e337df6485 0321c4e0cfb84ad753664693273c2e23 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044997237342208 |