Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética

Detalhes bibliográficos
Ano de defesa: 2016
Autor(a) principal: Garcia, José Mauricio Botto de Barros lattes
Orientador(a): Ávila, Marcos Pereira lattes
Banca de defesa: Ávila, Marcos Pereira lattes, Abud, Murilo, Diniz, Bruno
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Goiás
Programa de Pós-Graduação: Programa de Pós-graduação em Ciências da Saúde (FM)
Departamento: Faculdade de Medicina - FM (RG)
País: Brasil
Palavras-chave em Português:
Macula
Retina
OCT
Palavras-chave em Inglês:
Macula
Retina
OCT
Área do conhecimento CNPq:
CIENCIAS DA SAUDE::MEDICINA
Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/6601
Resumo: The purpose of this study is to compare fluorescein angiography and optical coherence tomography (OCT) angiography images of foveal avascular zone (FAZ) in patients with diabetic retinopathy (DR) with and without diabetic macular ischemia. Regarding our methods, the Wilcoxon signedrank test was used to compare area measurements and P values of < 0.05 were considered statistically significant. Fluorescein angiography and OCT angiography images were independently graded by 2 observers that reached agreement regarding quantitative diabetic macular ischemia according established protocols. The ischemic area was divided into “moderate” and ‘‘large’’ macular ischemia (with diabetic macular ischemia) and ‘‘small’’ (without diabetic macular ischemia) groups. Quantitative analyses of the FAZ were performed using custom software (ImageJ64; National Institute of Health - NIH; http://rsbweb.nih.gov/ij/; public domain). Considering our results, thirty-four eyes from 34 diabetic patients were enrolled. Subjects with diabetic macular ischemia presented a mean area on fluorescein angiography and OCT angiography of 0.68 + 0.53 mm2 and 0.58 + 0.35 mm2, respectively (p = 0.1374). Patients without diabetic macular ischemia presented a mean area on fluorescein angiography and OCT angiography of 0.19 + 0.67 mm2 and 0.20 + 0.79 mm2, respectively (p = 0.9594). The ICC for the FAZ measurements between the 2 observers on fluorescein angiography and OCT angiography was 0.96 and 0.92, respectively. Thereby, OCT angiography may represent a novel technique for the diagnosis of diabetic macular ischemia and could become an alternative to FA for this purpose.
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spelling Ávila, Marcos Pereirahttp://lattes.cnpq.br/3335187297522447Isaac, David Leonardo Cruvinelhttp://lattes.cnpq.br/5474072354473614Ávila, Marcos Pereirahttp://lattes.cnpq.br/3335187297522447Abud, MuriloDiniz, Brunohttp://lattes.cnpq.br/5589344553278040Garcia, José Mauricio Botto de Barros2016-12-16T12:51:20Z2016-12-13GARCIA, J. M. B. B. Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética. 2016. 62 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2016.http://repositorio.bc.ufg.br/tede/handle/tede/6601The purpose of this study is to compare fluorescein angiography and optical coherence tomography (OCT) angiography images of foveal avascular zone (FAZ) in patients with diabetic retinopathy (DR) with and without diabetic macular ischemia. Regarding our methods, the Wilcoxon signedrank test was used to compare area measurements and P values of < 0.05 were considered statistically significant. Fluorescein angiography and OCT angiography images were independently graded by 2 observers that reached agreement regarding quantitative diabetic macular ischemia according established protocols. The ischemic area was divided into “moderate” and ‘‘large’’ macular ischemia (with diabetic macular ischemia) and ‘‘small’’ (without diabetic macular ischemia) groups. Quantitative analyses of the FAZ were performed using custom software (ImageJ64; National Institute of Health - NIH; http://rsbweb.nih.gov/ij/; public domain). Considering our results, thirty-four eyes from 34 diabetic patients were enrolled. Subjects with diabetic macular ischemia presented a mean area on fluorescein angiography and OCT angiography of 0.68 + 0.53 mm2 and 0.58 + 0.35 mm2, respectively (p = 0.1374). Patients without diabetic macular ischemia presented a mean area on fluorescein angiography and OCT angiography of 0.19 + 0.67 mm2 and 0.20 + 0.79 mm2, respectively (p = 0.9594). The ICC for the FAZ measurements between the 2 observers on fluorescein angiography and OCT angiography was 0.96 and 0.92, respectively. Thereby, OCT angiography may represent a novel technique for the diagnosis of diabetic macular ischemia and could become an alternative to FA for this purpose.O objetivo do presente estudo é comparar as imagens da zona avascular foveal (ZAF) obtidas por meio da angiografia fluorescente e da angiografia por OCT em pacientes com retinopatia diabética (RD), com e sem maculopatia isquêmica diabética. Na metodologia, o Wilcoxon signed-rank test foi usado para comparar as medidas de área e o P valor menor que 0,05 foi considerado estatisticamente significativo. As imagens de angiografia fluorescente e angiografia por OCT foram classificadas de maneira independente por dois observadores. A área de isquemia foi dividida em isquemia macular “moderada” e “grande” (com maculopatia isquêmica diabética) e “pequena” (sem maculopatia isquêmica diabética). Análises quantitativas da ZAF foram realizadas usando software adequado (ImageJ64; (National Institute of Health - NIH; http://rsbweb.nih.gov/ij/ sob domínio público). De acordo com os nossos resultados, trinta e quatro olhos de 34 pacientes com retinopatia diabética foram avaliados. Indivíduos com maculopatia isquêmica diabética apresentaram uma área média na angiografia fluorescente e angiografia por OCT de 0,68 + 0,53 mm2 e 0,58 + 0,35 mm2, respectivamente (p = 0,1374). Pacientes sem maculopatia isquêmica diabética apresentaram uma área media na angiografia fluorescente e angiografia por OCT de 0,19 + 0,67 mm2 e 0,20 + 0,79 mm2 respectivamente (p = 0,9594). O ICC para as medidas de ZAF entre os dois examinadores usando angiografia fluorescente e angiografia por OCT foi de 0,96 e 0,92, respectivamente, demonstrando a concordância entre os examinadores nas medidas da ZAF. Concluiu-se que, a angiografia por OCT pode representar uma nova técnica para o diagnóstico de maculopatia isquêmica diabética, e pode vir a ser uma alternativa à angiografia fluorescente para este propósito.application/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências da Saúde (FM)UFGBrasilFaculdade de Medicina - FM (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessMaculaRetinaOCTMaculaRetinaOCTCIENCIAS DA SAUDE::MEDICINAEstudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabéticaComparison between OCT angiography and fluorescein angiography on diabetic macular ischemia diagnosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-10068643126177453106006006001545772475950486338-969369452308786627reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://repositorio.bc.ufg.br/tede/bitstreams/125bce7d-d5a4-4296-b6bd-6a144a11a5c9/downloadbd3efa91386c1718a7f26a329fdcb468MD51CC-LICENSElicense_urllicense_urltext/plain; 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dc.title.por.fl_str_mv Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética
dc.title.alternative.eng.fl_str_mv Comparison between OCT angiography and fluorescein angiography on diabetic macular ischemia diagnosis
title Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética
spellingShingle Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética
Garcia, José Mauricio Botto de Barros
Macula
Retina
OCT
Macula
Retina
OCT
CIENCIAS DA SAUDE::MEDICINA
title_short Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética
title_full Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética
title_fullStr Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética
title_full_unstemmed Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética
title_sort Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética
author Garcia, José Mauricio Botto de Barros
author_facet Garcia, José Mauricio Botto de Barros
author_role author
dc.contributor.advisor1.fl_str_mv Ávila, Marcos Pereira
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3335187297522447
dc.contributor.advisor-co1.fl_str_mv Isaac, David Leonardo Cruvinel
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/5474072354473614
dc.contributor.referee1.fl_str_mv Ávila, Marcos Pereira
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/3335187297522447
dc.contributor.referee2.fl_str_mv Abud, Murilo
dc.contributor.referee3.fl_str_mv Diniz, Bruno
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/5589344553278040
dc.contributor.author.fl_str_mv Garcia, José Mauricio Botto de Barros
contributor_str_mv Ávila, Marcos Pereira
Isaac, David Leonardo Cruvinel
Ávila, Marcos Pereira
Abud, Murilo
Diniz, Bruno
dc.subject.por.fl_str_mv Macula
Retina
OCT
topic Macula
Retina
OCT
Macula
Retina
OCT
CIENCIAS DA SAUDE::MEDICINA
dc.subject.eng.fl_str_mv Macula
Retina
OCT
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::MEDICINA
description The purpose of this study is to compare fluorescein angiography and optical coherence tomography (OCT) angiography images of foveal avascular zone (FAZ) in patients with diabetic retinopathy (DR) with and without diabetic macular ischemia. Regarding our methods, the Wilcoxon signedrank test was used to compare area measurements and P values of < 0.05 were considered statistically significant. Fluorescein angiography and OCT angiography images were independently graded by 2 observers that reached agreement regarding quantitative diabetic macular ischemia according established protocols. The ischemic area was divided into “moderate” and ‘‘large’’ macular ischemia (with diabetic macular ischemia) and ‘‘small’’ (without diabetic macular ischemia) groups. Quantitative analyses of the FAZ were performed using custom software (ImageJ64; National Institute of Health - NIH; http://rsbweb.nih.gov/ij/; public domain). Considering our results, thirty-four eyes from 34 diabetic patients were enrolled. Subjects with diabetic macular ischemia presented a mean area on fluorescein angiography and OCT angiography of 0.68 + 0.53 mm2 and 0.58 + 0.35 mm2, respectively (p = 0.1374). Patients without diabetic macular ischemia presented a mean area on fluorescein angiography and OCT angiography of 0.19 + 0.67 mm2 and 0.20 + 0.79 mm2, respectively (p = 0.9594). The ICC for the FAZ measurements between the 2 observers on fluorescein angiography and OCT angiography was 0.96 and 0.92, respectively. Thereby, OCT angiography may represent a novel technique for the diagnosis of diabetic macular ischemia and could become an alternative to FA for this purpose.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-16T12:51:20Z
dc.date.issued.fl_str_mv 2016-12-13
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
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dc.identifier.citation.fl_str_mv GARCIA, J. M. B. B. Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética. 2016. 62 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2016.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tede/6601
identifier_str_mv GARCIA, J. M. B. B. Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética. 2016. 62 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2016.
url http://repositorio.bc.ufg.br/tede/handle/tede/6601
dc.language.iso.fl_str_mv por
language por
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600
600
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Goiás
dc.publisher.program.fl_str_mv Programa de Pós-graduação em Ciências da Saúde (FM)
dc.publisher.initials.fl_str_mv UFG
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dc.publisher.department.fl_str_mv Faculdade de Medicina - FM (RG)
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