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Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus

Detalhes bibliográficos
Ano de defesa: 2020
Autor(a) principal: Daher, Valéria Barcelos lattes
Orientador(a): Guimarães, Valeriana de Castro lattes
Banca de defesa: Guimarães, Valeriana de Castro, Torres, Lisa Valéria Vieira, Silva, Maria Sebastiana
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Goiás
Programa de Pós-Graduação: Programa de Pós-graduação em Ciências da Saúde (FM)
Departamento: Faculdade de Medicina - FM (RG)
País: Brasil
Palavras-chave em Português:
Palavras-chave em Inglês:
Área do conhecimento CNPq:
Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/10862
Resumo: Congenital Zika Syndrome is the result of congenital anomalies caused by Zika virus infection by vertical transmission. It is a clinical spectrum ranging from asymptomatic patients to syndromic manifestations. The aim of the study was to evaluate the risk indicators for hearing impairment in children with Congenital Zika Virus Syndrome treated at the Rehabilitation and Rehabilitation Center Dr. Henrique Santillo, from January 2015 to October 2019. The data of the clinical examination and the results of the audiological examinations were obtained by assisting patients referred to the multidisciplinary rehabilitation service by an otorhinolaryngologist. These data were presented in simple frequency. Fisher's Exact test was used at statistical analysis to assess whether the presence of another risk indicator for hearing loss was determinant in the occurrence of the hearing impairment found. For the conclusion regarding the test, the 95% confidence level was set. The most prevalent risk indicator for hearing loss in this population was neonatal jaundice. The prevalence of hearing disorders in children with ZIKV infection was 17.91% with an estimated 17.9:1000 children. These changes were not better justified by the presence of another risk indicator for hearing loss in addition to Zika virus infection. Longitudinal follow-up studies are suggested to assess the potential effects of the interaction between the virus and the host as a progressive worsening of hearing loss or the appearance of late hearing loss.
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spelling Guimarães, Valeriana de Castrohttp://lattes.cnpq.br/6222102545181441Guimarães, Valeriana de CastroTorres, Lisa Valéria VieiraSilva, Maria Sebastianahttp://lattes.cnpq.br/9754469497103231Daher, Valéria Barcelos2020-10-15T12:07:44Z2020-10-15T12:07:44Z2020-08-28DAHER, V. B. Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus. 2020. 73 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2020.http://repositorio.bc.ufg.br/tede/handle/tede/10862Congenital Zika Syndrome is the result of congenital anomalies caused by Zika virus infection by vertical transmission. It is a clinical spectrum ranging from asymptomatic patients to syndromic manifestations. The aim of the study was to evaluate the risk indicators for hearing impairment in children with Congenital Zika Virus Syndrome treated at the Rehabilitation and Rehabilitation Center Dr. Henrique Santillo, from January 2015 to October 2019. The data of the clinical examination and the results of the audiological examinations were obtained by assisting patients referred to the multidisciplinary rehabilitation service by an otorhinolaryngologist. These data were presented in simple frequency. Fisher's Exact test was used at statistical analysis to assess whether the presence of another risk indicator for hearing loss was determinant in the occurrence of the hearing impairment found. For the conclusion regarding the test, the 95% confidence level was set. The most prevalent risk indicator for hearing loss in this population was neonatal jaundice. The prevalence of hearing disorders in children with ZIKV infection was 17.91% with an estimated 17.9:1000 children. These changes were not better justified by the presence of another risk indicator for hearing loss in addition to Zika virus infection. Longitudinal follow-up studies are suggested to assess the potential effects of the interaction between the virus and the host as a progressive worsening of hearing loss or the appearance of late hearing loss.A Síndrome Congênita do Zika Vírus é o resultado de anomalias congênitas pela infecção por Zika vírus, por transmissão vertical, com espectro clínico que varia de pacientes assintomáticos às manifestações sindrômicas. O objetivo deste estudo foi avaliar os indicadores de risco para deficiência auditiva em crianças com Síndrome Congênita do Zika Vírus atendidas no Centro de Reabilitação e Readaptação Dr. Henrique Santillo, no período de janeiro de 2015 a outubro de 2019. Os dados do exame clínico e os resultados dos exames audiológicos foram obtidos através da assistência aos pacientes encaminhados ao serviço multidisciplinar de reabilitação por médico otorrinolaringologista. Estes dados foram apresentados em frequência simples. O teste Exato de Fisher foi utilizado na análise estatística para avaliação se a presença de outro indicador de risco para deficiência auditiva além da infecção pelo Zika vírus foi determinante na ocorrência da alteração auditiva encontrada. Para a conclusão quanto ao teste, fixou-se o nível de 95% de confiança. O indicador de risco para deficiência auditiva mais prevalente nesta população foi a icterícia neonatal. A prevalência de alterações auditivas em crianças com infecção pelo ZIKV foi de 17,91%. Essas alterações não foram melhores justificados pela presença de outro indicador de risco para deficiência auditiva além da infecção pelo Zika vírus. Sugere-se estudos de seguimento longitudinal para avaliar os potenciais efeitos da interação entre o vírus e o hospedeiro como uma piora progressiva da perda auditiva ou o surgimento de perda auditiva tardia.porUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências da Saúde (FM)UFGBrasilFaculdade de Medicina - FM (RG)Attribution-NonCommercial-NoDerivatives 4.0 Internationalinfo:eu-repo/semantics/openAccessZika vírusSurdezMicrocefaliaCriançaMicrocephalyDeafnessChildZika vírusCIENCIAS DA SAUDEIndicadores de alterações auditivas em crianças com síndrome congênita do Zika vírusHearing impairment indicators in children with congenital Zika virus syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis2450050050019182reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.bc.ufg.br/tede/bitstreams/5a7bed40-f66a-4f63-810a-3eb94412805a/download8a4605be74aa9ea9d79846c1fba20a33MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.bc.ufg.br/tede/bitstreams/36604bbc-ea08-46fc-be66-8b09e640bfcd/download4460e5956bc1d1639be9ae6146a50347MD52ORIGINALDissertação - Valéria Barcelos Daher - 2020.pdfDissertação - Valéria Barcelos Daher - 2020.pdfapplication/pdf7369520http://repositorio.bc.ufg.br/tede/bitstreams/7f625ca3-c502-470a-9f71-06bb988d7f6d/downloadacdd68129d7b4c0927418d418fc04198MD53tede/108622020-10-15 09:07:44.615http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accessoai:repositorio.bc.ufg.br:tede/10862http://repositorio.bc.ufg.br/tedeRepositório InstitucionalPUBhttps://repositorio.bc.ufg.br/tedeserver/oai/requestgrt.bc@ufg.bropendoar:oai:repositorio.bc.ufg.br:tede/12342020-10-15T12:07:44Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)falseTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=
dc.title.pt_BR.fl_str_mv Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus
dc.title.alternative.eng.fl_str_mv Hearing impairment indicators in children with congenital Zika virus syndrome
title Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus
spellingShingle Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus
Daher, Valéria Barcelos
Zika vírus
Surdez
Microcefalia
Criança
Microcephaly
Deafness
Child
Zika vírus
CIENCIAS DA SAUDE
title_short Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus
title_full Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus
title_fullStr Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus
title_full_unstemmed Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus
title_sort Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus
author Daher, Valéria Barcelos
author_facet Daher, Valéria Barcelos
author_role author
dc.contributor.advisor1.fl_str_mv Guimarães, Valeriana de Castro
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/6222102545181441
dc.contributor.referee1.fl_str_mv Guimarães, Valeriana de Castro
dc.contributor.referee2.fl_str_mv Torres, Lisa Valéria Vieira
dc.contributor.referee3.fl_str_mv Silva, Maria Sebastiana
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/9754469497103231
dc.contributor.author.fl_str_mv Daher, Valéria Barcelos
contributor_str_mv Guimarães, Valeriana de Castro
Guimarães, Valeriana de Castro
Torres, Lisa Valéria Vieira
Silva, Maria Sebastiana
dc.subject.por.fl_str_mv Zika vírus
Surdez
Microcefalia
Criança
topic Zika vírus
Surdez
Microcefalia
Criança
Microcephaly
Deafness
Child
Zika vírus
CIENCIAS DA SAUDE
dc.subject.eng.fl_str_mv Microcephaly
Deafness
Child
Zika vírus
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE
description Congenital Zika Syndrome is the result of congenital anomalies caused by Zika virus infection by vertical transmission. It is a clinical spectrum ranging from asymptomatic patients to syndromic manifestations. The aim of the study was to evaluate the risk indicators for hearing impairment in children with Congenital Zika Virus Syndrome treated at the Rehabilitation and Rehabilitation Center Dr. Henrique Santillo, from January 2015 to October 2019. The data of the clinical examination and the results of the audiological examinations were obtained by assisting patients referred to the multidisciplinary rehabilitation service by an otorhinolaryngologist. These data were presented in simple frequency. Fisher's Exact test was used at statistical analysis to assess whether the presence of another risk indicator for hearing loss was determinant in the occurrence of the hearing impairment found. For the conclusion regarding the test, the 95% confidence level was set. The most prevalent risk indicator for hearing loss in this population was neonatal jaundice. The prevalence of hearing disorders in children with ZIKV infection was 17.91% with an estimated 17.9:1000 children. These changes were not better justified by the presence of another risk indicator for hearing loss in addition to Zika virus infection. Longitudinal follow-up studies are suggested to assess the potential effects of the interaction between the virus and the host as a progressive worsening of hearing loss or the appearance of late hearing loss.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-10-15T12:07:44Z
dc.date.available.fl_str_mv 2020-10-15T12:07:44Z
dc.date.issued.fl_str_mv 2020-08-28
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dc.identifier.citation.fl_str_mv DAHER, V. B. Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus. 2020. 73 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2020.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tede/10862
identifier_str_mv DAHER, V. B. Indicadores de alterações auditivas em crianças com síndrome congênita do Zika vírus. 2020. 73 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2020.
url http://repositorio.bc.ufg.br/tede/handle/tede/10862
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dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Faculdade de Medicina - FM (RG)
publisher.none.fl_str_mv Universidade Federal de Goiás
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