Aspectos epidemiológicos da febre maculosa no município de Quirinópolis, Goiás, Brasil
Ano de defesa: | 2009 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Goiás
|
Programa de Pós-Graduação: |
Doutorado em Ciência Animal
|
Departamento: |
Ciências Agrárias
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.bc.ufg.br/tede/handle/tde/1205 |
Resumo: | Rocky Mountain spotted fever (FM), a zoonosis transmitted to humans through the bite of ticks infected with Rickettsia spp. Especially R. rickettsii, emerged in the United States in the late 19th century, been taking place in Brazil in the mid 20th century. Since then, in Brazil the disease, initially diagnosed in São Paulo, became identified focally in some cities, getting to the end of the 20th century restricted states in the Southeast. Already at the beginning of the 21st century FM was first identified in Southern states, focusing in Santa Catarina and also, occasionally, been observed in rare cases that occurred in states in other regions of the country: State Federal, Bahia, Rondônia and Amapá. Given the above, and aiming to collaborate with the service of Epidemiology in Goias, this unprecedented study throughout the Midwest Region, proposes and creates conditions for the first milestone for the monitoring of FM in this State, by means of serological screening with indirect immunofluorescence assay (IFA) in sera of animals and humans, in addition to the research of tick vectors. This study took place in the city of Quirinópolis-GO, and despite not having been detected in the chain reaction polymerase (PCR), ticks infected with Rickettsia spp., the principal vector of FM in Brazil, the tick Amblyomma cajennense, was observed. In previous pilot study conducted in February 2007 in Quirinópolis-GO, serology by IFAT reagents detected in 25% (7 / 28) of humans in a group of individuals cohabiting with a suspected case of FM, which was notified to the Ministry of Health (MOH) of Brazil in 2006, and in 0% (0 / 5) of dogs and 28.6% (12/42) of horses from 3 rural property where the suspect case was before the manifestation of signs of illness. There were two horses positive sera in these three farms. Unable to trace the likely source of infection, but the findings here obtained allowed to suspect that the suspected case of FM has been in one of these two farms the likely source of antigenic contact with bacteria or micro-FM group antigenically similar. Already in scale epidemiological study horses, held in March 2007 on 20 farms, found the prevalence of positive sera of 11.6% (39/335) among horses and the frequency of seropositive 36.6% (15/41 ) between the human and 16.7% (2 / 12) among the dogs from these properties to create horses. Humans here tested HIV positive were asymptomatic for FM at the time of sample collection. It was concluded that the FM, or antigenically similar disease, may be occurring in the State of Goiás, in the City of Quirinópolis |
id |
UFG_534c0165c4f6274de82de6ad7237317a |
---|---|
oai_identifier_str |
oai:repositorio.bc.ufg.br:tde/1205 |
network_acronym_str |
UFG |
network_name_str |
Biblioteca Digital de Teses e Dissertações da UFG |
repository_id_str |
|
spelling |
BRITO, Wilia Marta Elsner Diederichsen dehttp://lattes.cnpq.br/7605775995731168BORGES, Lígia Miranda Ferreirahttp://lattes.cnpq.br/2591106734434348LINHARES, Guido Fontgalland Coelhohttp://lattes.cnpq.br/6261928164195145http://lattes.cnpq.br/4251058001242615MARTINS, Márcio Eduardo Pereira2014-07-29T15:13:54Z2010-04-092009-12-21MARTINS, Márcio Eduardo Pereira. Epidemiological characteristics of spotted fever in the municipality of Quirinópolis, Goias, Brazil. 2009. 111 f. Tese (Doutorado em Ciências Agrárias) - Universidade Federal de Goiás, Goiânia, 2009.http://repositorio.bc.ufg.br/tede/handle/tde/1205Rocky Mountain spotted fever (FM), a zoonosis transmitted to humans through the bite of ticks infected with Rickettsia spp. Especially R. rickettsii, emerged in the United States in the late 19th century, been taking place in Brazil in the mid 20th century. Since then, in Brazil the disease, initially diagnosed in São Paulo, became identified focally in some cities, getting to the end of the 20th century restricted states in the Southeast. Already at the beginning of the 21st century FM was first identified in Southern states, focusing in Santa Catarina and also, occasionally, been observed in rare cases that occurred in states in other regions of the country: State Federal, Bahia, Rondônia and Amapá. Given the above, and aiming to collaborate with the service of Epidemiology in Goias, this unprecedented study throughout the Midwest Region, proposes and creates conditions for the first milestone for the monitoring of FM in this State, by means of serological screening with indirect immunofluorescence assay (IFA) in sera of animals and humans, in addition to the research of tick vectors. This study took place in the city of Quirinópolis-GO, and despite not having been detected in the chain reaction polymerase (PCR), ticks infected with Rickettsia spp., the principal vector of FM in Brazil, the tick Amblyomma cajennense, was observed. In previous pilot study conducted in February 2007 in Quirinópolis-GO, serology by IFAT reagents detected in 25% (7 / 28) of humans in a group of individuals cohabiting with a suspected case of FM, which was notified to the Ministry of Health (MOH) of Brazil in 2006, and in 0% (0 / 5) of dogs and 28.6% (12/42) of horses from 3 rural property where the suspect case was before the manifestation of signs of illness. There were two horses positive sera in these three farms. Unable to trace the likely source of infection, but the findings here obtained allowed to suspect that the suspected case of FM has been in one of these two farms the likely source of antigenic contact with bacteria or micro-FM group antigenically similar. Already in scale epidemiological study horses, held in March 2007 on 20 farms, found the prevalence of positive sera of 11.6% (39/335) among horses and the frequency of seropositive 36.6% (15/41 ) between the human and 16.7% (2 / 12) among the dogs from these properties to create horses. Humans here tested HIV positive were asymptomatic for FM at the time of sample collection. It was concluded that the FM, or antigenically similar disease, may be occurring in the State of Goiás, in the City of QuirinópolisA febre maculosa (FM), zoonose transmitida ao homem por meio da picada de carrapatos infectados com Rickettsia spp., especialmente R. rickettsii, surgiu nos Estados Unidos no final do século 19, vindo a ocorrer no Brasil em meados do século 20. Desde então, no Brasil a enfermidade, inicialmente diagnosticada no Estado de São Paulo, passou a ser identificada focalmente em vários municípios, ficando até o final do século 20 restrita aos Estados da Região Sudeste. Já no inicio do século 21 a FM começou a ser identificada em Estados da Região Sul, concentrando-se em Santa Catarina e também, pontualmente, sendo observada em raros casos ocorridos em Estados das demais regiões do país: Distrito Federal, Bahia, Amapá e Rondônia. Diante do exposto, e visando colaborar com o serviço de Epidemiologia em Goiás, o presente Estudo inédito em toda a Região do Centro-Oeste, se propõe e cria condições de marco inicial para a vigilância da FM neste Estado, por meio de inquérito sorológico com a reação de imunofluorescência indireta (RIFI) em soros de animais e humanos, além da pesquisa de carrapatos vetores. O presente estudo se deu no Município de Quirinópolis-GO, e apesar de não terem sido detectados, na reação em cadeia pela polimerase (PCR), carrapatos infectados com Rickettsia spp., o principal vetor de FM no Brasil, o carrapato Amblyomma cajennense, foi observado. Em prévio estudo piloto realizado em fevereiro de 2007, em Quirinópolis-GO, a sorologia pela RIFI detectou reagentes em 25% (7/28) dos humanos de um grupo de indivíduos conviventes com um caso suspeito de FM, que foi notificado ao Ministério da Saúde (MS) do Brasil em 2006, e em 0% (0/5) dos cães e 28,6% (12/42) dos eqüinos oriundos de 3 propriedade rurais onde esse caso suspeito esteve antes da manifestação dos sinais de enfermidade. Houve eqüinos sororeagentes em duas dessas três propriedades rurais. Não foi possível rastrear a provável fonte de infecção, mas os achados aqui obtidos permitem suspeitar que o caso suspeito de FM tenha tido em uma dessas duas propriedades rurais a fonte antigênica do provável contato com bactérias do grupo da FM ou microrganismos antigenicamente semelhantes. Já no estudo dimensionado epidemiologicamente para eqüinos, realizado em março de 2007 em 20 propriedades rurais, foi encontrada a prevalência de sororeagentes de 11,6% (39/335) entre os eqüinos e a freqüência de soropositivos de 36,6% (15/41) entre os humanos e de 16,7% (2/12) entre os cães oriundos dessas propriedades de criação de eqüinos. Os humanos soropositivos aqui testados eram assintomáticos para FM no momento da coleta de amostras. Concluiu-se que a FM, ou doença antigenicamente semelhante, possa estar ocorrendo no Estado de Goiás, no Município de QuirinópolisMade available in DSpace on 2014-07-29T15:13:54Z (GMT). No. of bitstreams: 1 Tese_Marcio_Pereira_Martins.pdf: 660888 bytes, checksum: 070c9552e0ed53121a6615f34c32ec29 (MD5) Previous issue date: 2009-12-21application/pdfhttp://repositorio.bc.ufg.br/TEDE/retrieve/4036/Tese_Marcio_Pereira_Martins.pdf.jpgporUniversidade Federal de GoiásDoutorado em Ciência AnimalUFGBRCiências Agráriascães, carrapatos, eqüinos, RIFI, PCR, Rickettsia sppdogs, ticks, horse, IFA, PCR, Rickettsia sppCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::MEDICINA VETERINARIA PREVENTIVA::SAUDE ANIMAL (PROGRAMAS SANITARIOS)Aspectos epidemiológicos da febre maculosa no município de Quirinópolis, Goiás, BrasilEpidemiological characteristics of spotted fever in the municipality of Quirinópolis, Goias, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGORIGINALTese_Marcio_Pereira_Martins.pdfapplication/pdf660888http://repositorio.bc.ufg.br/tede/bitstreams/c3e811f1-46ee-4e73-9868-4aadfbb557b0/download070c9552e0ed53121a6615f34c32ec29MD51THUMBNAILTese_Marcio_Pereira_Martins.pdf.jpgTese_Marcio_Pereira_Martins.pdf.jpgGenerated Thumbnailimage/jpeg3491http://repositorio.bc.ufg.br/tede/bitstreams/3a24f757-8dbe-4c6f-92de-56c016d0fb93/downloadc3b72a5a489bde44a6436b064fd58ed0MD52tde/12052014-07-30 03:10:34.141open.accessoai:repositorio.bc.ufg.br:tde/1205http://repositorio.bc.ufg.br/tedeBiblioteca Digital de Teses e Dissertaçõeshttp://repositorio.bc.ufg.br/PUBhttps://repositorio.bc.ufg.br/tede_oai/requesttesesdissertacoes.bc@ufg.br ||tesesdissertacoes.bc@ufg.bropendoar:32082014-07-30T06:10:34Biblioteca Digital de Teses e Dissertações da UFG - Universidade Federal de Goiás (UFG)false |
dc.title.por.fl_str_mv |
Aspectos epidemiológicos da febre maculosa no município de Quirinópolis, Goiás, Brasil |
dc.title.alternative.eng.fl_str_mv |
Epidemiological characteristics of spotted fever in the municipality of Quirinópolis, Goias, Brazil |
title |
Aspectos epidemiológicos da febre maculosa no município de Quirinópolis, Goiás, Brasil |
spellingShingle |
Aspectos epidemiológicos da febre maculosa no município de Quirinópolis, Goiás, Brasil MARTINS, Márcio Eduardo Pereira cães, carrapatos, eqüinos, RIFI, PCR, Rickettsia spp dogs, ticks, horse, IFA, PCR, Rickettsia spp CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::MEDICINA VETERINARIA PREVENTIVA::SAUDE ANIMAL (PROGRAMAS SANITARIOS) |
title_short |
Aspectos epidemiológicos da febre maculosa no município de Quirinópolis, Goiás, Brasil |
title_full |
Aspectos epidemiológicos da febre maculosa no município de Quirinópolis, Goiás, Brasil |
title_fullStr |
Aspectos epidemiológicos da febre maculosa no município de Quirinópolis, Goiás, Brasil |
title_full_unstemmed |
Aspectos epidemiológicos da febre maculosa no município de Quirinópolis, Goiás, Brasil |
title_sort |
Aspectos epidemiológicos da febre maculosa no município de Quirinópolis, Goiás, Brasil |
author |
MARTINS, Márcio Eduardo Pereira |
author_facet |
MARTINS, Márcio Eduardo Pereira |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
BRITO, Wilia Marta Elsner Diederichsen de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7605775995731168 |
dc.contributor.advisor-co1.fl_str_mv |
BORGES, Lígia Miranda Ferreira |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/2591106734434348 |
dc.contributor.advisor-co2.fl_str_mv |
LINHARES, Guido Fontgalland Coelho |
dc.contributor.advisor-co2Lattes.fl_str_mv |
http://lattes.cnpq.br/6261928164195145 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4251058001242615 |
dc.contributor.author.fl_str_mv |
MARTINS, Márcio Eduardo Pereira |
contributor_str_mv |
BRITO, Wilia Marta Elsner Diederichsen de BORGES, Lígia Miranda Ferreira LINHARES, Guido Fontgalland Coelho |
dc.subject.por.fl_str_mv |
cães, carrapatos, eqüinos, RIFI, PCR, Rickettsia spp |
topic |
cães, carrapatos, eqüinos, RIFI, PCR, Rickettsia spp dogs, ticks, horse, IFA, PCR, Rickettsia spp CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::MEDICINA VETERINARIA PREVENTIVA::SAUDE ANIMAL (PROGRAMAS SANITARIOS) |
dc.subject.eng.fl_str_mv |
dogs, ticks, horse, IFA, PCR, Rickettsia spp |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::MEDICINA VETERINARIA PREVENTIVA::SAUDE ANIMAL (PROGRAMAS SANITARIOS) |
description |
Rocky Mountain spotted fever (FM), a zoonosis transmitted to humans through the bite of ticks infected with Rickettsia spp. Especially R. rickettsii, emerged in the United States in the late 19th century, been taking place in Brazil in the mid 20th century. Since then, in Brazil the disease, initially diagnosed in São Paulo, became identified focally in some cities, getting to the end of the 20th century restricted states in the Southeast. Already at the beginning of the 21st century FM was first identified in Southern states, focusing in Santa Catarina and also, occasionally, been observed in rare cases that occurred in states in other regions of the country: State Federal, Bahia, Rondônia and Amapá. Given the above, and aiming to collaborate with the service of Epidemiology in Goias, this unprecedented study throughout the Midwest Region, proposes and creates conditions for the first milestone for the monitoring of FM in this State, by means of serological screening with indirect immunofluorescence assay (IFA) in sera of animals and humans, in addition to the research of tick vectors. This study took place in the city of Quirinópolis-GO, and despite not having been detected in the chain reaction polymerase (PCR), ticks infected with Rickettsia spp., the principal vector of FM in Brazil, the tick Amblyomma cajennense, was observed. In previous pilot study conducted in February 2007 in Quirinópolis-GO, serology by IFAT reagents detected in 25% (7 / 28) of humans in a group of individuals cohabiting with a suspected case of FM, which was notified to the Ministry of Health (MOH) of Brazil in 2006, and in 0% (0 / 5) of dogs and 28.6% (12/42) of horses from 3 rural property where the suspect case was before the manifestation of signs of illness. There were two horses positive sera in these three farms. Unable to trace the likely source of infection, but the findings here obtained allowed to suspect that the suspected case of FM has been in one of these two farms the likely source of antigenic contact with bacteria or micro-FM group antigenically similar. Already in scale epidemiological study horses, held in March 2007 on 20 farms, found the prevalence of positive sera of 11.6% (39/335) among horses and the frequency of seropositive 36.6% (15/41 ) between the human and 16.7% (2 / 12) among the dogs from these properties to create horses. Humans here tested HIV positive were asymptomatic for FM at the time of sample collection. It was concluded that the FM, or antigenically similar disease, may be occurring in the State of Goiás, in the City of Quirinópolis |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-12-21 |
dc.date.available.fl_str_mv |
2010-04-09 |
dc.date.accessioned.fl_str_mv |
2014-07-29T15:13:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MARTINS, Márcio Eduardo Pereira. Epidemiological characteristics of spotted fever in the municipality of Quirinópolis, Goias, Brazil. 2009. 111 f. Tese (Doutorado em Ciências Agrárias) - Universidade Federal de Goiás, Goiânia, 2009. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tde/1205 |
identifier_str_mv |
MARTINS, Márcio Eduardo Pereira. Epidemiological characteristics of spotted fever in the municipality of Quirinópolis, Goias, Brazil. 2009. 111 f. Tese (Doutorado em Ciências Agrárias) - Universidade Federal de Goiás, Goiânia, 2009. |
url |
http://repositorio.bc.ufg.br/tede/handle/tde/1205 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Doutorado em Ciência Animal |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Ciências Agrárias |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UFG |
collection |
Biblioteca Digital de Teses e Dissertações da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/c3e811f1-46ee-4e73-9868-4aadfbb557b0/download http://repositorio.bc.ufg.br/tede/bitstreams/3a24f757-8dbe-4c6f-92de-56c016d0fb93/download |
bitstream.checksum.fl_str_mv |
070c9552e0ed53121a6615f34c32ec29 c3b72a5a489bde44a6436b064fd58ed0 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tesesdissertacoes.bc@ufg.br ||tesesdissertacoes.bc@ufg.br |
_version_ |
1800237197883867136 |