Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental
Ano de defesa: | 2016 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Goiás
|
Programa de Pós-Graduação: |
Programa de Pós-graduação em Biologia das Interações PH (IPTSP)
|
Departamento: |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
|
País: |
Brasil
|
Palavras-chave em Português: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.bc.ufg.br/tede/handle/tede/5990 |
Resumo: | The capacity of the tumor has not present as immunogenic to the immune system is one of its escape mechanisms. The aim of this study was to evaluate the use of nanoparticles formed from poly Lactic-co-glycolic acid (PLGA) associated with aluminum hydroxide may potentiate the effect of these on the resolution of the tumor. Balb/c mice inoculated with Sarcoma 180 tumor cells were distributed into nine groups for the implementation of the various immunotherapeutic treatments involving the use of aluminum hydroxide, PLGA nanoparticles, and activated macrophages. The evaluation of the treatment was performed by analysis of the tumor, considering the weight reduction of the dissected tumor, morphological and histological analysis, and analysis of pro-inflammatory and immunosuppressive cytokines in the serum of mice. The group of mice treated with PLGA nanoparticle associated with aluminum hydroxide caused a significant regression of the tumor (p = 0.039) compared with untreated mice. The treatment involving macrophages and PLGA nanoparticles showed significant tumor regression compared to the group treated only with macrophages (p = 0.021). The groups that had significant tumor regression have high levels of IFN--4 and IL-10, differing from the profile found in the other groups. In the other treatments tested there was a reduction of the tumor mass, but without significant statistical results, and without changes in the levels of cytokines measured in the serum of animals. Therefore, it is believed that PLGA nanoparticle by their ability to release hydroxide in target cells controlled manner, can enhance the action of the adjuvant aluminum hydroxide. Further studies are needed to elucidate the mechanisms involved in this phenomenon, which support the other investigations |
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Amaral, André Corrêahttp://lattes.cnpq.br/8801299423520104Silveira, Lucimeire Antonelli da Silveirahttp://lattes.cnpq.br/1252319967725429Silveira, Lucimeire Antonelli daFonseca, Simone Gonçalves daMachado, Julianea Reishttp://lattes.cnpq.br/9203271176485191Praxedes, Layanny Kelly Silveira2016-08-25T11:35:13Z2016-04-08PRAXEDES, L. K. S. Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental. 2016. 65 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2016.http://repositorio.bc.ufg.br/tede/handle/tede/5990The capacity of the tumor has not present as immunogenic to the immune system is one of its escape mechanisms. The aim of this study was to evaluate the use of nanoparticles formed from poly Lactic-co-glycolic acid (PLGA) associated with aluminum hydroxide may potentiate the effect of these on the resolution of the tumor. Balb/c mice inoculated with Sarcoma 180 tumor cells were distributed into nine groups for the implementation of the various immunotherapeutic treatments involving the use of aluminum hydroxide, PLGA nanoparticles, and activated macrophages. The evaluation of the treatment was performed by analysis of the tumor, considering the weight reduction of the dissected tumor, morphological and histological analysis, and analysis of pro-inflammatory and immunosuppressive cytokines in the serum of mice. The group of mice treated with PLGA nanoparticle associated with aluminum hydroxide caused a significant regression of the tumor (p = 0.039) compared with untreated mice. The treatment involving macrophages and PLGA nanoparticles showed significant tumor regression compared to the group treated only with macrophages (p = 0.021). The groups that had significant tumor regression have high levels of IFN--4 and IL-10, differing from the profile found in the other groups. In the other treatments tested there was a reduction of the tumor mass, but without significant statistical results, and without changes in the levels of cytokines measured in the serum of animals. Therefore, it is believed that PLGA nanoparticle by their ability to release hydroxide in target cells controlled manner, can enhance the action of the adjuvant aluminum hydroxide. Further studies are needed to elucidate the mechanisms involved in this phenomenon, which support the other investigationsA capacidade do tumor de não se apresentar como imunogênico ao sistema imune constitui um dos seus mecanismos de escape. O objetivo do presente trabalho foi avaliar se o uso de nanopartículas formadas a partir de co-polímeros de ácido láctico-co-glicólico (PLGA), associada ao hidróxido de alumínio poderia potencializar o efeito destes na resolução do tumor. Camundongos Balb/c inoculados com células tumorais de Sarcoma 180 e distribuídos em nove grupos para a realização dos diferentes tratamentos imunoterápicos, envolvendo a utilização de hidróxido de alumínio, nanopartículas de PLGA e macrófagos ativados. A avaliação dos tratamentos foi realizada pela análise do tumor, considerando a redução do peso do tumor dissecado, análise morfológica e histopatológica e análise de citocinas pró-inflamatórias e imunossupressoras no soro dos camundongos. O grupo de camundongos tratados com nanopartículas de PLGA associadas ao hidróxido de alumínio promoveu uma regressão significativa do tamanho da massa tumoral (p = 0,039) comparado com camundongos não tratados. O tratamento envolvendo macrófagos e nanopartículas de PLGA apresentou uma regressão tumoral significativa comparada com o grupo tratado apenas com macrófagos (p = 0,021). Os grupos que tiveram regressão tumoral significativa apresentaram níveis elevados das citocinas IFN-, IL-4 e IL-10, diferenciando-se do perfil encontrado nos demais grupos. Nos outros tratamentos testados houve a redução da massa tumoral, porém sem resultados estatísticos significativos e sem grandes alterações nos níveis de citocinas dosados no soro dos animais. Logo, acredita-se que a nanopartícula de PLGA, por meio de sua capacidade de transporte e liberação do hidróxido nas células alvo de forma controlada, possa potencializar a ação do adjuvante hidróxido de alumínio. Outros estudos são necessários para a elucidação dos mecanismos envolvidos nesse fenômeno.Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2016-08-24T17:06:37Z No. of bitstreams: 2 Dissertação - Layanny Kelly Silveira Praxedes - 2016.pdf: 3738908 bytes, checksum: 6340f77aec0ca6687fb5d273509f20b4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-25T11:35:13Z (GMT) No. of bitstreams: 2 Dissertação - Layanny Kelly Silveira Praxedes - 2016.pdf: 3738908 bytes, checksum: 6340f77aec0ca6687fb5d273509f20b4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2016-08-25T11:35:13Z (GMT). No. of bitstreams: 2 Dissertação - Layanny Kelly Silveira Praxedes - 2016.pdf: 3738908 bytes, checksum: 6340f77aec0ca6687fb5d273509f20b4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-04-08Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEGapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Biologia das Interações PH (IPTSP)UFGBrasilInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessTumorNanopartículaHidróxido de alumínioPLGANanoparticleAluminum hydroxideCIENCIAS BIOLOGICAS::PARASITOLOGIADesenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimentalDevelopment of alternative therapy using nanostructured adjuvants for the treatment of experimental tumorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis6367159433410056917600600600600-7769011444564556288-4544576747271574306-961409807440757778reponame:Biblioteca Digital de Teses e Dissertações da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://repositorio.bc.ufg.br/tede/bitstreams/e0b45fdf-1b03-4c33-ad2a-2739944e3df1/downloadbd3efa91386c1718a7f26a329fdcb468MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-843http://repositorio.bc.ufg.br/tede/bitstreams/91ed88da-d5ca-4843-9e93-d38bed070519/download321f3992dd3875151d8801b773ab32edMD52license_textlicense_texttext/html; charset=utf-80http://repositorio.bc.ufg.br/tede/bitstreams/31135499-f2e5-444a-a082-cd933852e5c4/downloadd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://repositorio.bc.ufg.br/tede/bitstreams/37901c0c-8441-4e2d-b886-84e5fa9d1821/downloadd41d8cd98f00b204e9800998ecf8427eMD54ORIGINALDissertação - Layanny Kelly Silveira Praxedes - 2016.pdfDissertação - Layanny Kelly Silveira Praxedes - 2016.pdfapplication/pdf3738908http://repositorio.bc.ufg.br/tede/bitstreams/6f5d2b2f-151c-4081-8ad2-ebb5c3a6f053/download6340f77aec0ca6687fb5d273509f20b4MD55tede/59902016-08-25 08:35:13.49http://creativecommons.org/licenses/by/4.0/Acesso Abertoopen.accessoai:repositorio.bc.ufg.br:tede/5990http://repositorio.bc.ufg.br/tedeBiblioteca Digital de Teses e Dissertaçõeshttp://repositorio.bc.ufg.br/PUBhttps://repositorio.bc.ufg.br/tede_oai/requesttesesdissertacoes.bc@ufg.br ||tesesdissertacoes.bc@ufg.bropendoar:32082016-08-25T11:35:13Biblioteca Digital de Teses e Dissertações da UFG - Universidade Federal de Goiás (UFG)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 |
dc.title.por.fl_str_mv |
Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental |
dc.title.alternative.eng.fl_str_mv |
Development of alternative therapy using nanostructured adjuvants for the treatment of experimental tumors |
title |
Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental |
spellingShingle |
Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental Praxedes, Layanny Kelly Silveira Tumor Nanopartícula Hidróxido de alumínio PLGA Nanoparticle Aluminum hydroxide CIENCIAS BIOLOGICAS::PARASITOLOGIA |
title_short |
Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental |
title_full |
Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental |
title_fullStr |
Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental |
title_full_unstemmed |
Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental |
title_sort |
Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental |
author |
Praxedes, Layanny Kelly Silveira |
author_facet |
Praxedes, Layanny Kelly Silveira |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Amaral, André Corrêa |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/8801299423520104 |
dc.contributor.advisor-co1.fl_str_mv |
Silveira, Lucimeire Antonelli da Silveira |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/1252319967725429 |
dc.contributor.referee1.fl_str_mv |
Silveira, Lucimeire Antonelli da |
dc.contributor.referee2.fl_str_mv |
Fonseca, Simone Gonçalves da |
dc.contributor.referee3.fl_str_mv |
Machado, Julianea Reis |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9203271176485191 |
dc.contributor.author.fl_str_mv |
Praxedes, Layanny Kelly Silveira |
contributor_str_mv |
Amaral, André Corrêa Silveira, Lucimeire Antonelli da Silveira Silveira, Lucimeire Antonelli da Fonseca, Simone Gonçalves da Machado, Julianea Reis |
dc.subject.por.fl_str_mv |
Tumor Nanopartícula Hidróxido de alumínio PLGA Nanoparticle Aluminum hydroxide |
topic |
Tumor Nanopartícula Hidróxido de alumínio PLGA Nanoparticle Aluminum hydroxide CIENCIAS BIOLOGICAS::PARASITOLOGIA |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::PARASITOLOGIA |
description |
The capacity of the tumor has not present as immunogenic to the immune system is one of its escape mechanisms. The aim of this study was to evaluate the use of nanoparticles formed from poly Lactic-co-glycolic acid (PLGA) associated with aluminum hydroxide may potentiate the effect of these on the resolution of the tumor. Balb/c mice inoculated with Sarcoma 180 tumor cells were distributed into nine groups for the implementation of the various immunotherapeutic treatments involving the use of aluminum hydroxide, PLGA nanoparticles, and activated macrophages. The evaluation of the treatment was performed by analysis of the tumor, considering the weight reduction of the dissected tumor, morphological and histological analysis, and analysis of pro-inflammatory and immunosuppressive cytokines in the serum of mice. The group of mice treated with PLGA nanoparticle associated with aluminum hydroxide caused a significant regression of the tumor (p = 0.039) compared with untreated mice. The treatment involving macrophages and PLGA nanoparticles showed significant tumor regression compared to the group treated only with macrophages (p = 0.021). The groups that had significant tumor regression have high levels of IFN--4 and IL-10, differing from the profile found in the other groups. In the other treatments tested there was a reduction of the tumor mass, but without significant statistical results, and without changes in the levels of cytokines measured in the serum of animals. Therefore, it is believed that PLGA nanoparticle by their ability to release hydroxide in target cells controlled manner, can enhance the action of the adjuvant aluminum hydroxide. Further studies are needed to elucidate the mechanisms involved in this phenomenon, which support the other investigations |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-08-25T11:35:13Z |
dc.date.issued.fl_str_mv |
2016-04-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PRAXEDES, L. K. S. Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental. 2016. 65 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/5990 |
identifier_str_mv |
PRAXEDES, L. K. S. Desenvolvimento de terapia alternativa usando adjuvantes nanoestruturados para o tratamento de tumor experimental. 2016. 65 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2016. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/5990 |
dc.language.iso.fl_str_mv |
por |
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por |
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dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
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Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Biologia das Interações PH (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
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