Consumo e bioproteção de componentes do café à presença de micotoxinas em ratos Wistar

• Ano de defesa: 2011
• Autor(a) principal: Rocha, Juliano Silva
• Orientador(a): Pimenta, Carlos José
• Banca de defesa: Chalfoun, Sara Maria
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: UNIVERSIDADE FEDERAL DE LAVRAS
• Programa de Pós-Graduação: DCA - Programa de Pós-graduação
• País: BRASIL
• Palavras-chave em Português: Ácidos clorogênicos; Cafestol; Café; Aflatoxina; Ocratoxina; Aflatoxin; Ochratoxin; Chlorogenic acids
• Área do conhecimento CNPq: CNPQ_NÃO_INFORMADO
• Link de acesso: https://repositorio.ufla.br/handle/1/3068

Coffee is nothing less than the second most consumed beverage in the world; its taste and attractive aroma justify its acceptance. Several studies have been conducted to determine their effects on human health. Confronted with evidence found in literature, this study sought to confront, by "in vivo" testing, the bioprotective action of two the most important chemical compounds in coffee (chlorogenic acids and cafestol) and two known mycotoxins (ochratoxin A and aflatoxin B1). The experiment was composed of four biological tests. The young Winster male rats were used, kept in a controlled environment with 12 hours photoperiod and ambient temperature of about 25 oC, all in individual metabolic cages with access to controlled food (15g/day) and "ad libtum" water. During the each test last four weeks, each animal received 50ng of toxin/day on 3g of powdered milk, added by 1.5 ml of distilled water and shaped into a sphere. Animals from the negative toxin groups received the same treatment without the addition of mycotoxin. It was possible to see bioprotective action forward to mycotoxins, especially by chlorogenic acids, improving the weight gain and the synthesis of muscle and liver glycogen. It is suggest testing for a longer period of time to confirm all the found evidences, especially because was not find difference on biochemical and histopathological exams. The percentage data were compared by Scott Knott and T of Student tests at 5% of probability.