Atividade de produtos vegetais contra bactérias patogênicas para peixes

• Ano de defesa: 2008
• Autor(a) principal: Castro, Sandra Bertelli Ribeiro de
• Orientador(a): Figueiredo, Henrique César Pereira
• Banca de defesa: Schwan, Rosane Freitas, Carvalho, Douglas Antonio de, Oliveira, Denilson Ferreira de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: UNIVERSIDADE FEDERAL DE LAVRAS
• Programa de Pós-Graduação: DBI - Programa de Pós-graduação
• País: BRASIL
• Palavras-chave em Português: Extrato vegetal; Antimicrobianos; Bactérias patogênicas; Peixe; Ácido ursólico; Fish pathogenic; Agentes antiinfecciosos
• Área do conhecimento CNPq: CNPQ_NÃO_INFORMADO
• Link de acesso: https://repositorio.ufla.br/handle/1/2845

In Brazil, infectious diseases are common in aquaculture and causes high economic losses. Streptococcus agalactiae Flavobacterium columnare and Aeromonas hydrophila are major pathogens for several fish species. The common treatment used is the oral administration of antibiotics. The aim of this work was to evaluate the antimicrobial activity of plant extracts and the ursolic acid. A screening of 45 methanol plant extracts was performed to identify antibacterial properties against the pathogens Streptococcus agalactiae (SA 16-06) Flavobacterium columnare (FL 02-07L) and Aeromonas hydrophila (AE 255-03). After that the minimum inhibitory concentration (MIC) of the active extracts was determined. The ursolic acid was isolated from Merremia tomentosa (Choisy) Hallier and its antimicrobial effect determined by the minimum inhibitory concentration (MIC) against 48 strains of fish pathogenic bacteria. 31 of the 45 extracts analyzed showed antibacterial activity. The MIC values ranged from 93,75 to 1500 µg/mL to extracts, the strain FL 02-07L was the most sensitive. To ursolic acid the MIC values were 62,5 and 125 µg/mL. The strains of Aeromonas hydrophila were resistant to this triterpenoid. The plant extracts and ursolic acid evaluated in this study showed a good potential for the control of bacterial infections in aquaculture.