Immunogenicity and effectiveness of vaccines against bovine brucellosis

Detalhes bibliográficos
Ano de defesa: 2025
Autor(a) principal: Gonçalves, Maysa Serpa lattes
Outros Autores: https://orcid.org/0000-0002-1831-2753
Orientador(a): Dorneles, Elaine Maria Seles
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: eng
Instituição de defesa: Universidade Federal de Lavras
Faculdade de Zootecnia e Medicina Veterinária (FZMV)
Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências Veterinárias (PPGCV )
Departamento: Não Informado pela instituição
País: brasil
Palavras-chave em Português:
Brucellosis control
S19
RB51
Systematic review
Brucellosis vaccination
Controle da brucelose
Revisão sistemática
Vacinação contra brucelose
Área do conhecimento CNPq:
Ciências Veterinárias
Link de acesso: https://repositorio.ufla.br/handle/1/60373
Resumo: Vaccination of production animals with Brucella spp. live strains is one of the major measures for brucellosis control worldwide, aiming both human and animal health. However, although vaccine strains have been widely studied, there are still many aspects for being clarified. This thesis contains four chapters: (1) “Efficacy of Brucella vaccine strains: S19, RB51 and Rev-1” and (2) “Does lipopolysaccharide morphology (smooth or rough) of Brucella abortus vaccine strains influence the potency or efficacy of the vaccine?”; (3) “Systematic review on the effectiveness of Brucella abortus S19 and RB51 vaccine strains in field studies”; and (4) “Short communication: Effects of age on the immune response induced by Brucella abortus S19 or RB51 vaccination in calves”. The principal scientific contributions were: (1) clarification of various aspects about dissociation of smooth Brucella strains and its use for bovine vaccination; (2) confirmation of the effectiveness of B. abortus S19 and RB51 vaccines in the field, particularly when combined with other control policies; and (3) observation of similar immunogenicity of the S19 and RB51 strains in calves vaccinated at different ages within the 3 to 8-month range.
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spelling Guimarães, Alessandro de SáHeinemann, Marcos BryanGuimarães, Alessandro de SáPereira, Carine RodriguesMian, Gláucia FrasnelliDorneles, Elaine Maria Seleshttp://lattes.cnpq.br/9007124125263730Gonçalves, Maysa Serpahttps://orcid.org/0000-0002-1831-27532025-10-07T14:03:32Z2025-08-06GONÇALVES, Maysa Serpa. Immunogenicity and effectiveness of vaccines against bovine brucellosis. 2025. 140 p. Tese (Doutorado em Ciências Veterinárias) - Universidade Federal de Lavras, Lavras, 2025.https://repositorio.ufla.br/handle/1/60373Vaccination of production animals with Brucella spp. live strains is one of the major measures for brucellosis control worldwide, aiming both human and animal health. However, although vaccine strains have been widely studied, there are still many aspects for being clarified. This thesis contains four chapters: (1) “Efficacy of Brucella vaccine strains: S19, RB51 and Rev-1” and (2) “Does lipopolysaccharide morphology (smooth or rough) of Brucella abortus vaccine strains influence the potency or efficacy of the vaccine?”; (3) “Systematic review on the effectiveness of Brucella abortus S19 and RB51 vaccine strains in field studies”; and (4) “Short communication: Effects of age on the immune response induced by Brucella abortus S19 or RB51 vaccination in calves”. The principal scientific contributions were: (1) clarification of various aspects about dissociation of smooth Brucella strains and its use for bovine vaccination; (2) confirmation of the effectiveness of B. abortus S19 and RB51 vaccines in the field, particularly when combined with other control policies; and (3) observation of similar immunogenicity of the S19 and RB51 strains in calves vaccinated at different ages within the 3 to 8-month range.A vacinação de animais de produção com cepas vivas de Brucella spp. é uma das principais medidas para o controle da brucelose em todo o mundo, visando à saúde humana e animal. No entanto, embora as cepas vacinais tenham sido amplamente estudadas, ainda há muitos aspectos a serem esclarecidos. Esta tese contém quatro capítulos: (1) “Eficácia das cepas vacinais de Brucella: S19, RB51 e Rev-1” e (2) “A morfologia dos lipopolissacarídeos (lisa ou rugosa) das cepas vacinais de Brucella abortus influencia a potência ou eficácia da vacina?”; (3) “Revisão sistemática sobre a eficácia das cepas vacinais de Brucella abortus S19 e RB51 em estudos de campo”; e (4) “Short communication: Efeitos da idade na resposta imune induzida pela vacinação de Brucella abortus S19 ou RB51 em bezerros”. As principais contribuições trazidas por estes capítulos científicas foram: (1) esclarecimento de vários aspectos sobre a dissociação de cepas de Brucella lisa e seu uso para vacinação bovina; (2) confirmação da eficácia das vacinas B. abortus S19 e RB51 no campo, particularmente quando combinadas com outras políticas de controle; e (3) observação de imunogenicidade semelhante das cepas S19 e RB51 em bezerros vacinados em diferentes idades dentro da faixa de 3 a 8 meses.Fundação de Amparo à Pesquisa no Estado de Minas Gerais (Fapemig)SociaisTecnológicoEconômicosMeio ambienteSaúdeTecnologia e produçãoTrabalhoODS 2: Fome zero e agricultura sustentávelODS 3: Saúde e bem-estarODS 8: Trabalho decente e crescimento econômicoODS 12: Consumo e produção responsáveisODS 15: Vida terrestreUniversidade Federal de LavrasFaculdade de Zootecnia e Medicina Veterinária (FZMV)Programa de Pós-Graduação em Ciências Veterinárias (PPGCV )UFLAbrasilAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessCiências VeterináriasBrucellosis controlS19RB51Systematic reviewBrucellosis vaccinationControle da bruceloseRevisão sistemáticaVacinação contra bruceloseImmunogenicity and effectiveness of vaccines against bovine brucellosisImunogenicidade e eficácia a campo de vacinas contra a brucelose bovinainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisengreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAORIGINALTexto completo.pdfTexto completo.pdfapplication/pdf2155130https://repositorio.ufla.br/bitstreams/cd607499-a998-48cd-9de5-b15e9a49c3b7/downloadbbee2aa3a5584c56daee62aaaf08f556MD52trueAnonymousREADImpactos da pesquisa.pdfImpactos da pesquisa.pdfapplication/pdf175487https://repositorio.ufla.br/bitstreams/4683a5f9-07b4-4047-9580-1a6dc9240200/download97522c87118dd7fdba32e22a827361f2MD53falseAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81025https://repositorio.ufla.br/bitstreams/ba5964f4-09ab-412e-8b1d-dcd940fd626e/download5a033ee506f3a0a175bee8fc81f0bd66MD51falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-8955https://repositorio.ufla.br/bitstreams/c623b32e-22ca-4368-ab90-4bc98187a7df/downloaddc1a173fe9489e283d3a1f54f6ab2ab9MD52falseAnonymousREAD1/603732025-10-07 11:03:34.449http://creativecommons.org/licenses/by/3.0/br/Attribution 3.0 Brazilopen.accessoai:repositorio.ufla.br:1/60373https://repositorio.ufla.brRepositório InstitucionalPUBhttps://repositorio.ufla.br/server/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2025-10-07T14:03:34Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)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
dc.title.none.fl_str_mv Immunogenicity and effectiveness of vaccines against bovine brucellosis
dc.title.alternative.none.fl_str_mv Imunogenicidade e eficácia a campo de vacinas contra a brucelose bovina
title Immunogenicity and effectiveness of vaccines against bovine brucellosis
spellingShingle Immunogenicity and effectiveness of vaccines against bovine brucellosis
Gonçalves, Maysa Serpa
Ciências Veterinárias
Brucellosis control
S19
RB51
Systematic review
Brucellosis vaccination
Controle da brucelose
Revisão sistemática
Vacinação contra brucelose
title_short Immunogenicity and effectiveness of vaccines against bovine brucellosis
title_full Immunogenicity and effectiveness of vaccines against bovine brucellosis
title_fullStr Immunogenicity and effectiveness of vaccines against bovine brucellosis
title_full_unstemmed Immunogenicity and effectiveness of vaccines against bovine brucellosis
title_sort Immunogenicity and effectiveness of vaccines against bovine brucellosis
author Gonçalves, Maysa Serpa
author_facet Gonçalves, Maysa Serpa
https://orcid.org/0000-0002-1831-2753
author_role author
author2 https://orcid.org/0000-0002-1831-2753
author2_role author
dc.contributor.co-advisor.none.fl_str_mv Guimarães, Alessandro de Sá
dc.contributor.referee.none.fl_str_mv Heinemann, Marcos Bryan
Guimarães, Alessandro de Sá
Pereira, Carine Rodrigues
Mian, Gláucia Frasnelli
dc.contributor.advisor1.fl_str_mv Dorneles, Elaine Maria Seles
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/9007124125263730
dc.contributor.author.fl_str_mv Gonçalves, Maysa Serpa
https://orcid.org/0000-0002-1831-2753
contributor_str_mv Dorneles, Elaine Maria Seles
dc.subject.cnpq.fl_str_mv Ciências Veterinárias
topic Ciências Veterinárias
Brucellosis control
S19
RB51
Systematic review
Brucellosis vaccination
Controle da brucelose
Revisão sistemática
Vacinação contra brucelose
dc.subject.por.fl_str_mv Brucellosis control
S19
RB51
Systematic review
Brucellosis vaccination
Controle da brucelose
Revisão sistemática
Vacinação contra brucelose
description Vaccination of production animals with Brucella spp. live strains is one of the major measures for brucellosis control worldwide, aiming both human and animal health. However, although vaccine strains have been widely studied, there are still many aspects for being clarified. This thesis contains four chapters: (1) “Efficacy of Brucella vaccine strains: S19, RB51 and Rev-1” and (2) “Does lipopolysaccharide morphology (smooth or rough) of Brucella abortus vaccine strains influence the potency or efficacy of the vaccine?”; (3) “Systematic review on the effectiveness of Brucella abortus S19 and RB51 vaccine strains in field studies”; and (4) “Short communication: Effects of age on the immune response induced by Brucella abortus S19 or RB51 vaccination in calves”. The principal scientific contributions were: (1) clarification of various aspects about dissociation of smooth Brucella strains and its use for bovine vaccination; (2) confirmation of the effectiveness of B. abortus S19 and RB51 vaccines in the field, particularly when combined with other control policies; and (3) observation of similar immunogenicity of the S19 and RB51 strains in calves vaccinated at different ages within the 3 to 8-month range.
publishDate 2025
dc.date.accessioned.fl_str_mv 2025-10-07T14:03:32Z
dc.date.issued.fl_str_mv 2025-08-06
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv GONÇALVES, Maysa Serpa. Immunogenicity and effectiveness of vaccines against bovine brucellosis. 2025. 140 p. Tese (Doutorado em Ciências Veterinárias) - Universidade Federal de Lavras, Lavras, 2025.
dc.identifier.uri.fl_str_mv https://repositorio.ufla.br/handle/1/60373
identifier_str_mv GONÇALVES, Maysa Serpa. Immunogenicity and effectiveness of vaccines against bovine brucellosis. 2025. 140 p. Tese (Doutorado em Ciências Veterinárias) - Universidade Federal de Lavras, Lavras, 2025.
url https://repositorio.ufla.br/handle/1/60373
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Lavras
Faculdade de Zootecnia e Medicina Veterinária (FZMV)
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Ciências Veterinárias (PPGCV )
dc.publisher.initials.fl_str_mv UFLA
dc.publisher.country.fl_str_mv brasil
publisher.none.fl_str_mv Universidade Federal de Lavras
Faculdade de Zootecnia e Medicina Veterinária (FZMV)
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFLA
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