Atividade antimicrobiana do óleo de pequi (Caryocar brasiliense) e do óleo essencial de cravo-da-índia (Syzygium aromaticum) frente a isolados de Pseudomonas aeruginosa de otite canina

• Ano de defesa: 2022
• Autor(a) principal: Costa, Larissa Vieira
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Mato Grosso; Brasil; Faculdade de Medicina Veterinária (FAVET); UFMT CUC - Cuiabá; Programa de Pós-Graduação em Ciências Veterinárias
• Palavras-chave em Português: Multirresistência; Óleo essencial; P. aeruginosa; Suscetibilidade; MDR; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA; Multidrug resistance; Essential oil; Susceptibility
• Link de acesso: http://ri.ufmt.br/handle/1/4641

Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium and its increasing resistance is a global threat to public health. It is commonly identified in difficult-to-treat canine otitis media such as severe nosocomial infections. In this scenario, there is a need to search for therapeutic alternatives to the uses of antimicrobials and, in this context, herbal medicines are known for their various biological activities, including their antimicrobial action. The objective of this research was to evaluate the antibacterial effect of clove essential oil and pequi vegetable oil against P. aeruginosa isolates from canine otitis, as well as their resistance profile. 41 P. aeruginosa isolates were evaluated and 20 antibiotics were tested, highlighting the high resistance to beta-lactams including carbapenems. Of these, 97.56% (40/41) of the isolates were classified as multidrug-resistant. The antimicrobial efficacy of clove oil was evaluated by the microdilution method and compared with gentamicin. The minimal inhibitory (MIC) and minimal bactericidal (MBC) concentrations were similar and ranged between 3.26mg/mL and 6.53mg/mL. It was not possible to perform the MIC of pequi oil. In view of these results, it was concluded that clove essential oil has been shown to have antimicrobial action against multidrug-resistant P. aeruginosa isolates, which provides a natural alternative to the use of antimicrobials.