Interleucina-17 em pacientes com doença renal crônica
Ano de defesa: | 2018 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Mato Grosso
Brasil Instituto de Ciências Biológicas e da Saúde (ICBS) – Araguaia UFMT CUA - Araguaia Programa de Pós-Graduação em Imunologia e Parasitologia Básicas e Aplicadas |
Programa de Pós-Graduação: |
Não Informado pela instituição
|
Departamento: |
Não Informado pela instituição
|
País: |
Não Informado pela instituição
|
Palavras-chave em Português: | |
Link de acesso: | http://ri.ufmt.br/handle/1/2790 |
Resumo: | Interleukin-17A (IL-17A) plays an important role in the human immune system with its proinflammatory actions, agonist mediator of defenses in infections, is also associated with several autoimmune diseases and the imbalance of this cytokine is associated with many pathologies such as rheumatoid arthritis, hypertension and chronic kidney disease (DRC). The problem of CKD for public health is the disproportionate increase in cases in the last two decades, both because of its high incidence and prevalence, as well as its considerable morbidity and mortality rate and socioeconomic cost, making it a major challenge for medicine and the whole world. society in general. Thus, the objective of this study was to analyze and correlate conventional renal parameters such as urea, creatinine, albumin and glomerular filtration rate (GFR) with serum levels of interleukin-17A in patients diagnosed with CKD at different stages. The study included 71 patients diagnosed with CKD at stage 3, 4, 5 and 21 control cases. For the serum levels of renal factors, specific kits were used for each test using the semi-automatic spectrophotometer (Bioplus® 2000). The quantification of the cytokine was performed by a cytometer (FACScalibur, BD, USA) and the statistical differences were evaluated by the Statistical Package for the Social Sciences (SPSS), where values of P ≤ 0.05 were considered significant. The results of this study demonstrated that the serum level of IL-17A has a positive correlation with urea and creatinine. On the other hand, IL-17A has an inverse association with GFR and albumin. Interestingly, IL-17A still showed association with various renal parameters, even when variables including age, sex, hypertension and diabetes were removed. In view of the above, we can conclude that IL-17A has a strong correlation with the conventional renal parameters used in the diagnosis and evaluation of the progression of CKD. Therefore, we may suggest that this cytokine is closely associated with the progression of CKD and its related complications, and may be a useful biomarker in the diagnosis and prevention of CKD.. |
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Interleucina-17 em pacientes com doença renal crônicaInterleucina-17ADoença renal crônicaTaxa de filtração glomerularCNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIAInterleukin-17 AChronic kidney diseaseGlomerular filtration rateInterleukin-17A (IL-17A) plays an important role in the human immune system with its proinflammatory actions, agonist mediator of defenses in infections, is also associated with several autoimmune diseases and the imbalance of this cytokine is associated with many pathologies such as rheumatoid arthritis, hypertension and chronic kidney disease (DRC). The problem of CKD for public health is the disproportionate increase in cases in the last two decades, both because of its high incidence and prevalence, as well as its considerable morbidity and mortality rate and socioeconomic cost, making it a major challenge for medicine and the whole world. society in general. Thus, the objective of this study was to analyze and correlate conventional renal parameters such as urea, creatinine, albumin and glomerular filtration rate (GFR) with serum levels of interleukin-17A in patients diagnosed with CKD at different stages. The study included 71 patients diagnosed with CKD at stage 3, 4, 5 and 21 control cases. For the serum levels of renal factors, specific kits were used for each test using the semi-automatic spectrophotometer (Bioplus® 2000). The quantification of the cytokine was performed by a cytometer (FACScalibur, BD, USA) and the statistical differences were evaluated by the Statistical Package for the Social Sciences (SPSS), where values of P ≤ 0.05 were considered significant. The results of this study demonstrated that the serum level of IL-17A has a positive correlation with urea and creatinine. On the other hand, IL-17A has an inverse association with GFR and albumin. Interestingly, IL-17A still showed association with various renal parameters, even when variables including age, sex, hypertension and diabetes were removed. In view of the above, we can conclude that IL-17A has a strong correlation with the conventional renal parameters used in the diagnosis and evaluation of the progression of CKD. Therefore, we may suggest that this cytokine is closely associated with the progression of CKD and its related complications, and may be a useful biomarker in the diagnosis and prevention of CKD..CAPESA interleucina-17A (IL-17A) desempenha um papel importante no sistema imunológico humano com suas ações pro-inflamatórias, mediador agonista de defensas em infeções, também esta associada a varias doenças autoimunes e o desequilíbrio desta citocina está associada a muitas doenças, tais como: artrite reumatóide, hipertensão arterial e a doença renal crônica (DRC). A problemática da DRC para a saúde pública, é o aumento desproporcionado de casos nas últimas duas décadas, tanto por sua elevada incidência e prevalência como sua considerável taxa de morbimortalidade e custo socioeconômico, tornando-se assim, um grande desafio para a medicina e toda a sociedade científica em geral. Assim, o objetivo deste trabalho foi analisar e correlacionar os parâmetros renais convencionais tais como ureia, creatinina, albumina e a taxa de filtração glomerular (TFG) com o nível sérico de IL-17A em pacientes diagnosticados com DRC em diferentes estágios. O estudo incluiu 71 pacientes diagnosticados com a DRC nos estágio 3, 4, 5 e 21 casos controle. Para dosagem sérica dos fatores renais foram utilizados kits específicos para cada exame, através do espectrofotômetro semiautomático (Bioplus® 2000). A quantificação da citocina foi realizada por citômetro de fluxo (FACScalibur,BD,USA) e as diferenças estatísticas foram avaliadas pelo programa Statistical Package for the Social Sciences (SPSS) onde foram considerados significativos valores de P ≤ 0,05. Os resultados deste estudo demostraram que o nível sérico de IL-17A possui uma correlação positiva com ureia e creatinina. Por outro lado, a IL-17A apresenta uma associação inversa com a TFG e albúmina. Interessantemente, IL-17A ainda apresentou associação com vários parâmetros renais, mesmo quando variáveis incluindo idade, sexo, hipertensão e diabetes foram removidas. Frente ao exposto, podemos concluir que a IL-17A apresenta uma forte correlação com os parâmetros renais convencionais utilizados no diagnóstico e na avaliação da progressão da DRC. Portanto, podemos sugerir que esta citocina esta intimamente associada à progressão da DRC e suas complicações relacionadas, podendo vir a ser um biomarcador útil no diagnóstico e na prevenção da DRCUniversidade Federal de Mato GrossoBrasilInstituto de Ciências Biológicas e da Saúde (ICBS) – AraguaiaUFMT CUA - AraguaiaPrograma de Pós-Graduação em Imunologia e Parasitologia Básicas e AplicadasLima, Victor VitorinoVitorino, Fernanda Regina Casagrande Giachinihttp://lattes.cnpq.br/3100345884689140http://lattes.cnpq.br/7503102443670435Lima, Victor Vitorino005.356.961-08http://lattes.cnpq.br/7503102443670435Triches, Danny Laura Gomes Fagundes002.166.281-99http://lattes.cnpq.br/6871314744513521005.356.961-08712.962.121-49Lopes, Rheure Alves Moreira022.246.041-57http://lattes.cnpq.br/1574139597014927Paula, Florange Licelot Campusano2021-08-23T16:57:31Z2018-03-122021-08-23T16:57:31Z2018-02-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisPAULA, Florange Licelot Campusano. Interleucina-17 em pacientes com doença renal crônica. 2018. 59 f. Dissertação (Mestrado em Imunologia e Parasitologia Básicas e Aplicadas) - Universidade Federal de Mato Grosso, Instituto de Ciências Biológicas e da Saúde, Barra do Garças, 2018.http://ri.ufmt.br/handle/1/2790porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMTinstname:Universidade Federal de Mato Grosso (UFMT)instacron:UFMT2021-08-26T07:02:59Zoai:localhost:1/2790Repositório InstitucionalPUBhttp://ri.ufmt.br/oai/requestjordanbiblio@gmail.comopendoar:2021-08-26T07:02:59Repositório Institucional da UFMT - Universidade Federal de Mato Grosso (UFMT)false |
dc.title.none.fl_str_mv |
Interleucina-17 em pacientes com doença renal crônica |
title |
Interleucina-17 em pacientes com doença renal crônica |
spellingShingle |
Interleucina-17 em pacientes com doença renal crônica Paula, Florange Licelot Campusano Interleucina-17A Doença renal crônica Taxa de filtração glomerular CNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA Interleukin-17 A Chronic kidney disease Glomerular filtration rate |
title_short |
Interleucina-17 em pacientes com doença renal crônica |
title_full |
Interleucina-17 em pacientes com doença renal crônica |
title_fullStr |
Interleucina-17 em pacientes com doença renal crônica |
title_full_unstemmed |
Interleucina-17 em pacientes com doença renal crônica |
title_sort |
Interleucina-17 em pacientes com doença renal crônica |
author |
Paula, Florange Licelot Campusano |
author_facet |
Paula, Florange Licelot Campusano |
author_role |
author |
dc.contributor.none.fl_str_mv |
Lima, Victor Vitorino Vitorino, Fernanda Regina Casagrande Giachini http://lattes.cnpq.br/3100345884689140 http://lattes.cnpq.br/7503102443670435 Lima, Victor Vitorino 005.356.961-08 http://lattes.cnpq.br/7503102443670435 Triches, Danny Laura Gomes Fagundes 002.166.281-99 http://lattes.cnpq.br/6871314744513521 005.356.961-08 712.962.121-49 Lopes, Rheure Alves Moreira 022.246.041-57 http://lattes.cnpq.br/1574139597014927 |
dc.contributor.author.fl_str_mv |
Paula, Florange Licelot Campusano |
dc.subject.por.fl_str_mv |
Interleucina-17A Doença renal crônica Taxa de filtração glomerular CNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA Interleukin-17 A Chronic kidney disease Glomerular filtration rate |
topic |
Interleucina-17A Doença renal crônica Taxa de filtração glomerular CNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA Interleukin-17 A Chronic kidney disease Glomerular filtration rate |
description |
Interleukin-17A (IL-17A) plays an important role in the human immune system with its proinflammatory actions, agonist mediator of defenses in infections, is also associated with several autoimmune diseases and the imbalance of this cytokine is associated with many pathologies such as rheumatoid arthritis, hypertension and chronic kidney disease (DRC). The problem of CKD for public health is the disproportionate increase in cases in the last two decades, both because of its high incidence and prevalence, as well as its considerable morbidity and mortality rate and socioeconomic cost, making it a major challenge for medicine and the whole world. society in general. Thus, the objective of this study was to analyze and correlate conventional renal parameters such as urea, creatinine, albumin and glomerular filtration rate (GFR) with serum levels of interleukin-17A in patients diagnosed with CKD at different stages. The study included 71 patients diagnosed with CKD at stage 3, 4, 5 and 21 control cases. For the serum levels of renal factors, specific kits were used for each test using the semi-automatic spectrophotometer (Bioplus® 2000). The quantification of the cytokine was performed by a cytometer (FACScalibur, BD, USA) and the statistical differences were evaluated by the Statistical Package for the Social Sciences (SPSS), where values of P ≤ 0.05 were considered significant. The results of this study demonstrated that the serum level of IL-17A has a positive correlation with urea and creatinine. On the other hand, IL-17A has an inverse association with GFR and albumin. Interestingly, IL-17A still showed association with various renal parameters, even when variables including age, sex, hypertension and diabetes were removed. In view of the above, we can conclude that IL-17A has a strong correlation with the conventional renal parameters used in the diagnosis and evaluation of the progression of CKD. Therefore, we may suggest that this cytokine is closely associated with the progression of CKD and its related complications, and may be a useful biomarker in the diagnosis and prevention of CKD.. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-03-12 2018-02-21 2021-08-23T16:57:31Z 2021-08-23T16:57:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
PAULA, Florange Licelot Campusano. Interleucina-17 em pacientes com doença renal crônica. 2018. 59 f. Dissertação (Mestrado em Imunologia e Parasitologia Básicas e Aplicadas) - Universidade Federal de Mato Grosso, Instituto de Ciências Biológicas e da Saúde, Barra do Garças, 2018. http://ri.ufmt.br/handle/1/2790 |
identifier_str_mv |
PAULA, Florange Licelot Campusano. Interleucina-17 em pacientes com doença renal crônica. 2018. 59 f. Dissertação (Mestrado em Imunologia e Parasitologia Básicas e Aplicadas) - Universidade Federal de Mato Grosso, Instituto de Ciências Biológicas e da Saúde, Barra do Garças, 2018. |
url |
http://ri.ufmt.br/handle/1/2790 |
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por |
language |
por |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Mato Grosso Brasil Instituto de Ciências Biológicas e da Saúde (ICBS) – Araguaia UFMT CUA - Araguaia Programa de Pós-Graduação em Imunologia e Parasitologia Básicas e Aplicadas |
publisher.none.fl_str_mv |
Universidade Federal de Mato Grosso Brasil Instituto de Ciências Biológicas e da Saúde (ICBS) – Araguaia UFMT CUA - Araguaia Programa de Pós-Graduação em Imunologia e Parasitologia Básicas e Aplicadas |
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