Ação in vivo de Lactococcus lactis subsp. lactis (R7) com potencial probiótico na estabilização de células cancerígenas no epitélio colorretal

• Ano de defesa: 2018
• Autor(a) principal: Jaskulski, Itiane Barcellos
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Pelotas; Faculdade de Agronomia Eliseu Maciel; Programa de Pós-Graduação em Ciência e Tecnologia de Alimentos; UFPel; Brasil
• Palavras-chave em Português: Bactérias ácido lácticas; Câncer colorretal; Estresse oxidativo; Resposta imune; Lactic acid bacteria; Colorectal cancer; Oxidative stress; Immune response; CNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS
• Link de acesso: http://guaiaca.ufpel.edu.br/handle/prefix/4100

In the last decade, science has contributed significantly to numerous advances and advances in treating and preventing colorectal cancer (CRC), but the overall prevalence and mortality rate remain high. There are reports on the beneficial effects of Bifidobacterium and Lactobacillus species with probiotic potential in the prevention of CRC, however, the probiotic bacterium Lactococcus lactis subps. lactis is commonly used for industrial purposes, and there is no in vivo evidence for its anticarcinogenic potential. Given the emerging interest in the beneficial effects of probiotics in preventing or treating CRC, the present study aimed to explore the protective effects of Lactococcus lactis subsp. lactis in the CRC. Wistar rats received subcutaneous doses of 1,2-dimethylhydrazine (DMH), suspension of Lactococcus lactis subsp. lactis orally and a hypercaloric diet. After 20 weeks, intestinal tissues were analyzed histologically, in addition to weight control and food consumption, hematological and biochemical parameters, oxidative stress and redox status of the hepatic tissue. According to the results, the isolate demonstrated anticarcinogenic potential against CRC, stabilized the weight gain, reduced abdominal adiposity, showed a slight improvement in the immune response, exerted antioxidant activity against oxidative stress and demonstrated protection of lipid peroxidation. These results are promising for science regarding the treatment and prevention of CRC.