Produção de fitas cerâmicas via tape casting para aplicação biomédica

• Ano de defesa: 2023
• Autor(a) principal: Freitas, Anna Karla de Carvalho
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Rio Grande do Norte; Brasil; UFRN; PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIA E ENGENHARIA DE MATERIAIS
• Palavras-chave em Português: Tape casting; Nanomateriais; Liberação de fármaco; quitosana; Paligorskita; CNPQ::ENGENHARIAS::ENGENHARIA DE MATERIAIS E METALURGICA
• Link de acesso: https://repositorio.ufrn.br/handle/123456789/53344

To overcome the shortcomings existing in conventional dosage forms, the targeted drug delivery system was created. The aim was to deliver drugs to site-specific with a reduced dosing frequency and to mitigate the side effects caused by conventional drug delivery systems. Nanoparticles have been used as carriers of these drugs, including mesoporous silica nanoparticles, carbon nanotubes, and polymeric nanoparticles. In addition, the use of different techniques to produce these systems, such as the tape casting method, is responsible for producing thin films, and flexible ceramic tapes with good surface quality and low cost. In this work, studies were carried out regarding the production of ceramic tapes through the tape casting method, obtaining materials to be used in the biomedical area. Tricalcium phosphate ceramic tapes with different percentages of chitosan were produced. Another composition studied was the clay mineral palygorskite, using neomycin to study drug release. The first step was to study the powders, with X-ray diffraction analysis (XRD), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The slips were identified through the rheological test and then the ceramic tape was tape casting. These were characterized through X-ray diffraction analysis (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), elemental analysis (CHN-S), and scanning electron microscopy (SEM). In addition to these, antimicrobial activity tests were carried out, as well as absorption energy calculations. According to the results obtained, the pseudoplastic behavior of the suspension was observed, as suitable for the conformation of ceramic tapes. Reflection peaks referring to the palygorskite phase, with an orthorhombic structure, and the tricalcium phosphate phase, with an orthorhombic structure, were detected. DSC analysis identified exothermic peaks characteristic of neomycin. Therefore, thin films and flexible, biodegradable, biocompatible ceramic tapes were produced, which presented important characteristics for use in the biomedical area.