Avaliação da suplementação com vitamina D na expressão gênica e aptidão física em gêmeos saudáveis

• Ano de defesa: 2020
• Autor(a) principal: Pires, Jeane Franco
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Rio Grande do Norte; Brasil; UFRN; PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDE
• Palavras-chave em Português: Colecalciferol; Receptores de Vitamina D; Composição Corporal; Aptidão cardiorrespiratória; Força muscular; Ensaio clínico
• Link de acesso: https://repositorio.ufrn.br/handle/123456789/32217

The presence of the vitamin D receptor in various human cells and tissues, relating vitamin D to several non-skeletal physiological processes has been generating interest in research that helps to better understand this relationship. In addition, prophylactic supplementation with this nutrient is growing every day, in all age groups. Thus, the aim of this study was to evaluate the effect of cholecalciferol supplementation on VDR, TNFa and PPARa gene expression, body composition, cardiorespiratory fitness and muscle strength in healthy adult twins. It was a study carried out in adult monozygotic twins, of the longitudinal randomized clinical trial type, divided into two groups: control group (without treatment) and supplemented group (with individual daily supplementation of 2000 IU / day of vitamin D3 for 60 days). Biochemical analyzes, body composition analyzes were performed using double beam absorptiometry, analysis of cardiorespiratory fitness in a Cortex Ergospirometer, evaluation of muscle strength by the handgrip and scapular strength test and gene expression by real-time PCR. The statistical analysis was performed using the statistical software IBM SPSS version 20.0 for Windows. Our results showed that there was a significant increase in serum vitamin D levels in the supplemented group compared to those who did not use the supplement. (65% increase), as well as the expression of the VDR gene (p = 0.001). We observed improvements in physical fitness parameters, with reduced body fat and increased VO2max after supplementation. Thus, we conclude that the increase in serum vitamin D levels above 30 ng / mL can bring benefits to the health of the population.