Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment

Detalhes bibliográficos
Ano de defesa: 2022
Autor(a) principal: Oliveira, Ana Luiza Cabral de Sá Leitão
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal do Rio Grande do Norte
Brasil
UFRN
PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDE
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Drug delivery system
Nanomedicine
Nanoparticles
Cancer
Biological barriers
Neoplasias colorretais
Câncer colorretal
Nanocarreadores
CNPQ::CIENCIAS DA SAUDE
Link de acesso: https://repositorio.ufrn.br/handle/123456789/49871
Resumo: Nanotechnology is a promising tool for the treatment of cancer. In the past decades, major steps have been made to bring nanotechnology into the clinic in the form of nanoparticle-based drug delivery systems. The great hope of drug delivery systems is to reduce the side effects of chemotherapeutics while simultaneously increasing the efficiency of the therapy. An increased treatment efficiency would greatly benefit the quality of life as well as the life expectancy of cancer patients. However, besides its many advantages, nanomedicines have to face several challenges and hurdles before they can be used for the effective treatment of tumors. Here, we give an overview of the hallmarks of cancer, especially colorectal cancer, and discuss biological barriers as well as how drug delivery systems can be utilized for the effective treatment of tumors and metastases.
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spelling Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatmentDrug delivery systemNanomedicineNanoparticlesCancerBiological barriersNeoplasias colorretaisCâncer colorretalNanocarreadoresCNPQ::CIENCIAS DA SAUDENanotechnology is a promising tool for the treatment of cancer. In the past decades, major steps have been made to bring nanotechnology into the clinic in the form of nanoparticle-based drug delivery systems. The great hope of drug delivery systems is to reduce the side effects of chemotherapeutics while simultaneously increasing the efficiency of the therapy. An increased treatment efficiency would greatly benefit the quality of life as well as the life expectancy of cancer patients. However, besides its many advantages, nanomedicines have to face several challenges and hurdles before they can be used for the effective treatment of tumors. Here, we give an overview of the hallmarks of cancer, especially colorectal cancer, and discuss biological barriers as well as how drug delivery systems can be utilized for the effective treatment of tumors and metastases.Um dos desafios da nanotecnologia é melhorar a eficácia dos tratamentos de doenças, a fim de reduzir as taxas de morbimortalidade. Seguindo essa linha de estudo, fizemos uma formulação de nanopartículas com tamanho pequeno, superfícies uniformes e coeficiente de encapsulamento satisfatório como alvo para células de câncer colorretal. Os resultados de ligação e absorção provam que o uso do sistema alvo com ácido fólico funciona: Usando este sistema, a citotoxicidade e a morte celular são aumentadas quando comparadas ao uso de oxaliplatina livre. Os dados mostram que o sistema maximizou a eficiência da oxaliplatina na modulação da progressão tumoral, aumentando a apoptose e diminuindo a resistência à droga. Assim, pela primeira vez, nossos achados sugerem que o PLGA-PEG-FA aumenta a eficácia antitumoral da oxaliplatina ao funcionar como um facilitador da liberação de drogas no câncer colorretal.Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDEAraújo Júnior, Raimundo Fernandes dehttp://lattes.cnpq.br/6353685475398176http://lattes.cnpq.br/1903940945895093Gasparotto, Luiz Henrique da Silvahttps://orcid.org/0000-0002-4711-393Xhttp://lattes.cnpq.br/2649423643904707Cruz, Luis J.Geus-oei, Lioe-fee deLeitão, Renata Ferreira de CarvalhoOliveira, Ana Luiza Cabral de Sá Leitão2022-11-24T20:34:12Z2022-11-24T20:34:12Z2022-03-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfOLIVEIRA, Ana Luiza Cabral de Sá Leitão. Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment. Orientador: Raimundo Fernandes de Araújo Júnior. 2022. 174f. Tese (Doutorado em Ciências da Saúde) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2022.https://repositorio.ufrn.br/handle/123456789/49871info:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRN2022-11-24T20:34:43Zoai:repositorio.ufrn.br:123456789/49871Repositório InstitucionalPUBhttp://repositorio.ufrn.br/oai/repositorio@bczm.ufrn.bropendoar:2022-11-24T20:34:43Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.none.fl_str_mv Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment
title Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment
spellingShingle Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment
Oliveira, Ana Luiza Cabral de Sá Leitão
Drug delivery system
Nanomedicine
Nanoparticles
Cancer
Biological barriers
Neoplasias colorretais
Câncer colorretal
Nanocarreadores
CNPQ::CIENCIAS DA SAUDE
title_short Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment
title_full Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment
title_fullStr Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment
title_full_unstemmed Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment
title_sort Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment
author Oliveira, Ana Luiza Cabral de Sá Leitão
author_facet Oliveira, Ana Luiza Cabral de Sá Leitão
author_role author
dc.contributor.none.fl_str_mv Araújo Júnior, Raimundo Fernandes de
http://lattes.cnpq.br/6353685475398176
http://lattes.cnpq.br/1903940945895093
Gasparotto, Luiz Henrique da Silva
https://orcid.org/0000-0002-4711-393X
http://lattes.cnpq.br/2649423643904707
Cruz, Luis J.
Geus-oei, Lioe-fee de
Leitão, Renata Ferreira de Carvalho
dc.contributor.author.fl_str_mv Oliveira, Ana Luiza Cabral de Sá Leitão
dc.subject.por.fl_str_mv Drug delivery system
Nanomedicine
Nanoparticles
Cancer
Biological barriers
Neoplasias colorretais
Câncer colorretal
Nanocarreadores
CNPQ::CIENCIAS DA SAUDE
topic Drug delivery system
Nanomedicine
Nanoparticles
Cancer
Biological barriers
Neoplasias colorretais
Câncer colorretal
Nanocarreadores
CNPQ::CIENCIAS DA SAUDE
description Nanotechnology is a promising tool for the treatment of cancer. In the past decades, major steps have been made to bring nanotechnology into the clinic in the form of nanoparticle-based drug delivery systems. The great hope of drug delivery systems is to reduce the side effects of chemotherapeutics while simultaneously increasing the efficiency of the therapy. An increased treatment efficiency would greatly benefit the quality of life as well as the life expectancy of cancer patients. However, besides its many advantages, nanomedicines have to face several challenges and hurdles before they can be used for the effective treatment of tumors. Here, we give an overview of the hallmarks of cancer, especially colorectal cancer, and discuss biological barriers as well as how drug delivery systems can be utilized for the effective treatment of tumors and metastases.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-24T20:34:12Z
2022-11-24T20:34:12Z
2022-03-24
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv OLIVEIRA, Ana Luiza Cabral de Sá Leitão. Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment. Orientador: Raimundo Fernandes de Araújo Júnior. 2022. 174f. Tese (Doutorado em Ciências da Saúde) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2022.
https://repositorio.ufrn.br/handle/123456789/49871
identifier_str_mv OLIVEIRA, Ana Luiza Cabral de Sá Leitão. Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment. Orientador: Raimundo Fernandes de Araújo Júnior. 2022. 174f. Tese (Doutorado em Ciências da Saúde) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2022.
url https://repositorio.ufrn.br/handle/123456789/49871
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
Brasil
UFRN
PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDE
publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
Brasil
UFRN
PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDE
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
repository.name.fl_str_mv Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)
repository.mail.fl_str_mv repositorio@bczm.ufrn.br
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