S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania

Detalhes bibliográficos
Ano de defesa: 2000
Autor(a) principal: Gomes, Denise de Castro Ferreira
Orientador(a): Alegrio, Leila Vilela
Banca de defesa: Alegrio, Leila Vilela, Lima, Marco Edilson Freire de, Carvalho, M?rio Geraldo de, Grynberg, Noema Faiga, Freitas, Antonio Carlos Carreira de
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Qu?mica
Departamento: Instituto de Ci?ncias Exatas
País: Brasil
Palavras-chave em Português:
Qu?mica
Área do conhecimento CNPq:
Qu?mica
Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/4298
Resumo: Curcumin [1,7-bis- (4-hydroxy-3-methoxyphenyl) -1,6-heptadiene-3,5-dione] is extracted from different species of turmeric, and its use is widespread in folk medicine in Asia , India and Africa. From the knowledge of its pharmacological activities, as well as the reaction possibilities offered by its structure, structural changes were made to curcumin, using various types of reactions. Syntheses of differently substituted curcuminoid derivatives were also made in the aromatic ring. The substances obtained were identified by IR spectra (1600 FT), NMR1H (200 MHz), NMR 13C (50.3 MHz) and mass spectrometry (70 ev). In this study, in addition to the reactions carried out, analyzes were carried out through in vitro tests of the potential of antiparasitic activity against the promastigote forms of Leishmania amazonensis. The obtained LD50 values ??allowed us to hypothesize the relationship between the structure and biological activity exhibited by these products.
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spelling Alegrio, Leila VilelaLima, Marco Edilson Freire dehttp://lattes.cnpq.br/8392420706762318Alegrio, Leila VilelaLima, Marco Edilson Freire deCarvalho, M?rio Geraldo deGrynberg, Noema FaigaFreitas, Antonio Carlos Carreira deGomes, Denise de Castro Ferreira2020-12-24T13:24:26Z2000-05-05GOMES, Denise de Castro Ferreira. S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania. 2000. 188 f. Tese (Doutorado em Qu?mica) - Instituto de Ci?ncias Exatas, Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ, 2000.https://tede.ufrrj.br/jspui/handle/jspui/4298Curcumin [1,7-bis- (4-hydroxy-3-methoxyphenyl) -1,6-heptadiene-3,5-dione] is extracted from different species of turmeric, and its use is widespread in folk medicine in Asia , India and Africa. From the knowledge of its pharmacological activities, as well as the reaction possibilities offered by its structure, structural changes were made to curcumin, using various types of reactions. Syntheses of differently substituted curcuminoid derivatives were also made in the aromatic ring. The substances obtained were identified by IR spectra (1600 FT), NMR1H (200 MHz), NMR 13C (50.3 MHz) and mass spectrometry (70 ev). In this study, in addition to the reactions carried out, analyzes were carried out through in vitro tests of the potential of antiparasitic activity against the promastigote forms of Leishmania amazonensis. The obtained LD50 values ??allowed us to hypothesize the relationship between the structure and biological activity exhibited by these products.A curcumina [1,7-bis-(4-hidr?xi-3-met?xifenil)-1,6-heptadieno-3,5-diona] ? extra?da de diferentes esp?cies de Curcuma, e seu uso ? bastante difundido em medicina popular na ?sia, ?ndia e ?frica. A partir do conhecimento das suas atividades farmacol?gicas, e tamb?m das possibilidades reacionais oferecidas pela sua estrutura, foram realizadas modifica??es estruturais na curcumina, utilizando v?rios tipos de rea??es. Tamb?m foram feitas s?nteses de derivados curcumin?ides diferentemente substitu?dos no anel arom?tico. As subst?ncias obtidas foram identificadas por espectros de IV (1600 FT), RMN1H (200 MHz), RMN 13C (50.3 MHz) e espectrometria de massas (70 ev). Neste estudo, al?m das rea??es realizadas, foram feitas an?lises atrav?s de testes in vitro do potencial da atividade antiparasit?ria contra as formas promastigotas de Leishmania amazonensis. Os valores de DL50 obtidos permitiram lan?ar hip?teses sobre a rela??o entre a estrutura e atividade biol?gica exibida por estes produtos.Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2020-12-24T13:24:26Z No. of bitstreams: 1 2000 - Denise de Castro Ferreira Gomes.pdf: 4919801 bytes, checksum: e7344214bc7a6ae11a86642b78a4ac96 (MD5)Made available in DSpace on 2020-12-24T13:24:26Z (GMT). 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dc.title.por.fl_str_mv S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania
title S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania
spellingShingle S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania
Gomes, Denise de Castro Ferreira
Qu?mica
Qu?mica
title_short S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania
title_full S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania
title_fullStr S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania
title_full_unstemmed S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania
title_sort S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania
author Gomes, Denise de Castro Ferreira
author_facet Gomes, Denise de Castro Ferreira
author_role author
dc.contributor.advisor1.fl_str_mv Alegrio, Leila Vilela
dc.contributor.advisor-co1.fl_str_mv Lima, Marco Edilson Freire de
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/8392420706762318
dc.contributor.referee1.fl_str_mv Alegrio, Leila Vilela
dc.contributor.referee2.fl_str_mv Lima, Marco Edilson Freire de
dc.contributor.referee3.fl_str_mv Carvalho, M?rio Geraldo de
dc.contributor.referee4.fl_str_mv Grynberg, Noema Faiga
dc.contributor.referee5.fl_str_mv Freitas, Antonio Carlos Carreira de
dc.contributor.author.fl_str_mv Gomes, Denise de Castro Ferreira
contributor_str_mv Alegrio, Leila Vilela
Lima, Marco Edilson Freire de
Alegrio, Leila Vilela
Lima, Marco Edilson Freire de
Carvalho, M?rio Geraldo de
Grynberg, Noema Faiga
Freitas, Antonio Carlos Carreira de
dc.subject.por.fl_str_mv Qu?mica
topic Qu?mica
Qu?mica
dc.subject.cnpq.fl_str_mv Qu?mica
description Curcumin [1,7-bis- (4-hydroxy-3-methoxyphenyl) -1,6-heptadiene-3,5-dione] is extracted from different species of turmeric, and its use is widespread in folk medicine in Asia , India and Africa. From the knowledge of its pharmacological activities, as well as the reaction possibilities offered by its structure, structural changes were made to curcumin, using various types of reactions. Syntheses of differently substituted curcuminoid derivatives were also made in the aromatic ring. The substances obtained were identified by IR spectra (1600 FT), NMR1H (200 MHz), NMR 13C (50.3 MHz) and mass spectrometry (70 ev). In this study, in addition to the reactions carried out, analyzes were carried out through in vitro tests of the potential of antiparasitic activity against the promastigote forms of Leishmania amazonensis. The obtained LD50 values ??allowed us to hypothesize the relationship between the structure and biological activity exhibited by these products.
publishDate 2000
dc.date.issued.fl_str_mv 2000-05-05
dc.date.accessioned.fl_str_mv 2020-12-24T13:24:26Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
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dc.identifier.citation.fl_str_mv GOMES, Denise de Castro Ferreira. S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania. 2000. 188 f. Tese (Doutorado em Qu?mica) - Instituto de Ci?ncias Exatas, Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ, 2000.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/4298
identifier_str_mv GOMES, Denise de Castro Ferreira. S?ntese e modifica??es estruturais de derivados curcumin?ides e avalia??o de suas atividades anti-leishmania. 2000. 188 f. Tese (Doutorado em Qu?mica) - Instituto de Ci?ncias Exatas, Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ, 2000.
url https://tede.ufrrj.br/jspui/handle/jspui/4298
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