Avalia??o da seguran?a cl?nica e efic?cia do Coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente

Detalhes bibliográficos
Ano de defesa: 2012
Autor(a) principal: Gaud?ncio, Fabr?cio Nascimento lattes
Orientador(a): Scott, Fabio Barbour lattes
Banca de defesa: Fernandes, J?lio Israel, Borja, Gonzalo Efraim Moya
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Ci?ncias Veterin?rias
Departamento: Instituto de Veterin?ria
País: Brasil
Palavras-chave em Português:
organofosforado
parasiticida
colinesterase
Palavras-chave em Inglês:
organophosphate
parasiticide
cholinesterase
Área do conhecimento CNPq:
Medicina Veterin?ria
Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/3536
Resumo: The objectives of this study were to evaluate the effectiveness against the flea Ctenocephalides felis felis and the tick Rhipicephalus sanguineus, and also verify the clinical safety of organophosphate coumaphos in the commercial formulation in the form of presentation of parasiticide soap for dogs. Were used 16 Beagles dogs, kept in the Laboratory of Experimental Chemotherapy in Veterinary Parasitology (LQEPV), Department of Animal Parasitology, Veterinary Institute, University Federal Rural of Rio de Janeiro. Specimens of C. f. felis and R. sanguineus used in artificial infestations were derived from colonies maintained in LQEPV. Pulicide efficiencies in day +2 to +7, were respectively 100% and 63.11%, while the efficiencies acaricides were respectively 99.62% and 43.25%. The coumaphos presented good efficacy against fleas and ticks within 48 hours of use, however, there was no good residual efficacy after re-infestation. In relation to clinical safety, hematology tests were performed (complete hemogram) and biochemical (ALT, AST, alkaline phosphatase, GGT, urea, creatinine, and serum cholinesterase) for evaluation of possible toxic effects from the use of the product. The animals showed no changes in clinical examination and laboratory tests that could be associated with adverse effects from the use of tested products, thus demonstrating that the coumaphos parasiticide in the formulation of soap is safety for use in dogs.
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spelling Scott, Fabio Barbour001.382.167-97http://lattes.cnpq.br/1217253540572819Fernandes, J?lio IsraelBorja, Gonzalo Efraim Moya113.436.707-48http://lattes.cnpq.br/8138213564144068Gaud?ncio, Fabr?cio Nascimento2020-05-20T00:05:40Z2012-02-24GAUD?NCIO, Fabr?cio Nascimento. Avalia??o da seguran?a cl?nica e efic?cia do coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente. 2012. 65 f. Disserta??o (Mestrado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.https://tede.ufrrj.br/jspui/handle/jspui/3536The objectives of this study were to evaluate the effectiveness against the flea Ctenocephalides felis felis and the tick Rhipicephalus sanguineus, and also verify the clinical safety of organophosphate coumaphos in the commercial formulation in the form of presentation of parasiticide soap for dogs. Were used 16 Beagles dogs, kept in the Laboratory of Experimental Chemotherapy in Veterinary Parasitology (LQEPV), Department of Animal Parasitology, Veterinary Institute, University Federal Rural of Rio de Janeiro. Specimens of C. f. felis and R. sanguineus used in artificial infestations were derived from colonies maintained in LQEPV. Pulicide efficiencies in day +2 to +7, were respectively 100% and 63.11%, while the efficiencies acaricides were respectively 99.62% and 43.25%. The coumaphos presented good efficacy against fleas and ticks within 48 hours of use, however, there was no good residual efficacy after re-infestation. In relation to clinical safety, hematology tests were performed (complete hemogram) and biochemical (ALT, AST, alkaline phosphatase, GGT, urea, creatinine, and serum cholinesterase) for evaluation of possible toxic effects from the use of the product. The animals showed no changes in clinical examination and laboratory tests that could be associated with adverse effects from the use of tested products, thus demonstrating that the coumaphos parasiticide in the formulation of soap is safety for use in dogs.Os objetivos do estudo foram avaliar a efic?cia pulguicida para Ctenocephalides felis felis e carrapaticida para Rhipicephalus sanguineus, bem como verificar a seguran?a cl?nica do organofosforado coumaf?s sob formula??o comercial na forma de apresenta??o de sabonete parasiticida para c?es. Foram utilizados 16 c?es da ra?a Beagle, mantidos no Laborat?rio de Quimioterapia Experimental em Parasitologia Veterin?ria (LQEPV), do Departamento de Parasitologia Animal, Instituto de Veterin?ria, da Universidade Federal Rural do Rio de Janeiro. Os esp?cimes de C. f. felis e R. sanguineus utilizados nas infesta??es artificiais foram provenientes das col?nias mantidas no LQEPV. As efic?cias pulguicidas nos dias +2 e +7, foram respectivamente 100% e 63,11%, enquanto que as efic?cias carrapaticidas, foram respectivamente 99,62% e 43,25%. O coumaf?s apresentou boa efic?cia pulguicida e carrapaticida com 48 horas de uso, por?m, n?o houve boa efic?cia residual ap?s nova infesta??o. Em rela??o ? seguran?a cl?nica, foram realizados exames hematol?gicos (hemograma completo) e bioqu?micos (ALT, AST, fosfatase alcalina, GGT, ur?ia, creatinina e colinesterase s?rica) para avalia??o de poss?veis efeitos t?xicos. Os animais n?o apresentaram altera??es em exame cl?nico e laboratoriais que pudessem ser associados a efeitos adversos provenientes do uso do produto testado, demonstrando assim que o coumaf?s na formula??o de sabonete parasiticida ? seguro para uso em c?es.Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2020-05-20T00:05:40Z No. of bitstreams: 1 2012 - Fabr?cio Nascimento Gaud?ncio.pdf: 1126949 bytes, checksum: 985035854cb046e2dcd066944b417a9b (MD5)Made available in DSpace on 2020-05-20T00:05:40Z (GMT). No. of bitstreams: 1 2012 - Fabr?cio Nascimento Gaud?ncio.pdf: 1126949 bytes, checksum: 985035854cb046e2dcd066944b417a9b (MD5) Previous issue date: 2012-02-24application/pdfhttps://tede.ufrrj.br/retrieve/59504/2012%20-%20Fabr%c3%adcio%20Nascimento%20Gaud%c3%aancio.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Ci?ncias Veterin?riasUFRRJBrasilInstituto de Veterin?riaABDELKADER, S.V.; HAUGE J.G. Serum enzyme determination in the study of liver disease in dogs. Acta Veterinaria Scandinavica Supplementum, v. 27, n. 1, p. 59 - 70, 1986. ABDELSALAM, E.B. Organophosphorus compounds. I. Toxicity in domestic animals. Veterinary Research Communications, v.11, n.3, p. 211-219, 1987. ANGELO, I.C.; FERNANDES, E.K.K. ; BAHIENSE, T.C.; PERINOTTO, W.M.S.; MORAES, A.P.R.; TERRA, A.L.M.; BITTENCOURT, V.R.E.P. Efficiency of Lecanicillium lecanii to control the tick Rhipicephalus microplus. Veterinary Parasitology, v. 172, p. 317-322, 2010. ARROWSMITH, J.E. The neuromuscular junction. Basic Science, v.25, n.3, p. 106-112, 2007. ARTHER, R.G. Mites and Lice: Biology and Control. Veterinary Clinical of Small Animal, v.39, n.6, p.1159?1171, 2009. ASTROFF, A.B.; FRESHWATER, K.J.; EIGENBERG, D.A. Comparative Organophosphate-Induced Effects Observed In Adult And Neonatal Sprague?Dawley Rats During The Conduct Of Multigeneration Toxicity Studies. Reproductive Toxicology, v. 12, n. 6, p. 619?645, 1998. BEUGNET, F. Antiparasitaires externes chez les carnivores domestiques. EMC-V?t?rinaire, v.1, n. 4, p.138?153, 2004. BICALHO, K.A.; FERREIRA, F.; BORGES, L.M.F.; RIBEIRO, M.F.B. In vitro evaluation of the effects of some acaricides on life stages of Rhipicephalus sanguineus (Acari: Ixodidae), Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia, v.53, n.5, p.548-552, 2001. BISSINGER, B.W., ROE, R.M. Tick repellents: Past, present, and future. Pesticide Biochemistry and Physiology, v.96, p.63?79, 2010. BITAM, I.; DITTMAR, K.; PAROLA, P.; WHITING, M.F.; RAOULT, D. Fleas and flea-borne diseases. International Journal of Infectious Diseases, v. 14, n. 8, p.667?676, 2010. BLAGBURN, B.L.; DRYDEN, M.W. Biology, Treatment, and Control of Flea and Tick Infestations. Veterinary Clinics of North America: Small Animal Pratice, v. 39, n. 6, p.1173?1200, 2009. BORGES, L.M.F.; SOARES, S.F.; FONSECA, I.N.; CHAVES, V.V.; LOULY,C.C. B. Resist?ncia acaricida em larvas de Rhipicephalus sanguineus (Acari: Ixodidae) de Goi?nia-GO, Brasil, Instituto de Patologia Tropical e Sa?de P?blica - IPTSP, v. 36, n.1, 2007. <Dispon?vel em: http://www.revistas.ufg.br/index.php/iptsp/ article/view/1820/1737> BREMER, W.G.; SCHAEFER, J.J.; WAGNER, E.R.; EWING, S.A.; RIKIHISA, Y.; NEEDHAM, G.R.; JITTAPALAPONG, S.; MOORE, D.L.; STICH, R.W. Transstadial and 58 intrastadial experimental transmission of Ehrlichia canis by male Rhipicephalus sanguineus. Veterinary Parasitology, v.131, p.95?105, 2005. BUSH, B. M. Interpreta??o de resultados laboratoriais para cl?nicos de pequenos animais. S?o Paulo: ROCA LTDA, 2004. CABRINI, T. M.; NAHUN, A.G.; CERINO, A. C.; BISSOLI, E.D.A.G.; COSTA, J.L.O.; PENA, S.B. Intoxica??o por Organofosforado em c?o - Relato de caso. Revista Cient?fica Eletr?nica de Medicina Veterin?ria, n.9, 2007. CARLOTTI, D.N.; JACOBS, D.E. Therapy, control and prevention of flea allergy dermatitis in dogs and cats. Veterinary Dermatology, v.11, p.83-98, 2000. CAVALIERE, M.J.; CALORE, E.E.; PEREZ, N.M.; PUGA, F.R. Miotoxicidade por organofosforados. Rev. Sa?de P?blica, v.30, n.3, p.267-72, 1996. CHARPENTIER, A.; MENOZZI, P.; MARCEL, V.; VILLATTE, F.; FOURNIER, D. A Method to Estimate Acetylcholinesterase-Active Sites and Turnover in Insects. Analytical Biochemistry, v.285, p. 76?81, 2000. CHEN, H-Y.; WANG, W. W-J.; CHAOU, C-H.; LIN, C-C. Prognostic value of serial serum cholinesterase activities in organophosphate poisoned patients. American Journal of Emergency Medicine, v.27, p. 1034?1039, 2009. CHOMEL, B. Tick-borne infections in dogs - An emerging infectious threat, Veterinary Parasitology, v.179, n. 4, p.294? 301, 2011. COOP, R.L.; TAYLOR, M.A.; JACOBS, D.E.; JACKSON, F. Ectoparasites: recent advances in control, TRENDS in Parasitology, v.18, n.2, p. 55-56, 2002. COUMAPHOS. JMPR, 1972. International Programme on Chemical Safety. Pesticide residues series 2. INCHEM. Chemical Safety Information from Intergovernmental Organizations. Dispon?vel em: <http://www.inchem.org/documents/jmpr/ jmpmono/v072pr11.htm> COUTINHO, M.T.Z.; BUENO, L.L.; STERZIK, A.; FUJIWARA, R.T.; BOTELHO, J.R.; MARIA, M.; GENAR, O.; LINARDI, P.M. Participation of Rhipicephalus sanguineus (Acari: Ixodidae) in the epidemiology of canine visceral leishmaniasis. Veterinary Parasitology, v.128, p.149?155, 2005. CUNNINGHAM, J.G. Tratado de Fisiologia Veterin?ria 3? ed. Rio de Janeiro: Guanabara Koogan. 2004, 579p. DANTAS-TORRES, F. The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): From taxonomy to control. Veterinary Parasitology, v. 152, n. 3-4, p.173?185, 2008. DAVEY, R.B.; GEORGE, J.E.; MILLER, R.J. Efficacy of various concentrations of coumaphos to control adult, nymphal, and larval stages of an organophosphate-resistant strain of Boophilus microplus on infested cattle. American Journal of Veterinary Research, v.64, n.6, p.684-689, 2003. 59 DECLEMENTI, C. 2007. Chapter 91 - Prevention and treatment of poisoning, p.1139-1158. In: GUPTA, R.C. (Ed.), Veterinary Toxicology. Elsevier Academic Press, San Diego. DELLINGER, J.; MOSTROM, M. Effects of topical fenthion on blood cholinesterase and vagal tone in dogs. Veterinary and Human Toxicology, v. 30, n. 3, p.229?234, 1988. ENZO, O. Acute Poisoning From Food Contaminated by Coumaphos. Wilderness and Environmental Medicine, v.17, n.1, p.67-72, 2006. FERNANDES, E.K.K. ; ANGELO, I.C. ; RANGEL, D.E.N. ; BAHIENSE, T.C. ; MORAES, A.M.L. ; ROBERTS, D.W.; BITTENCOURT, V.R.E.P . An intensive search for promising fungal biological control agents of ticks, particularly Rhipicephalus microplus. Veterinary Parasitology, v. 182, p. 307-318, 2011. FERNANDES, E.K.K.; BITTENCOURT, V.R.E.P.; ROBERTS, D.W. Perspectives on the potential of entomopathogenic fungi in biological control of ticks. Experimental Parasitology, v. 130, p. 300-305, 2011. FLEMING, W.J. Recovery of Brain and Plasma Cholinesterase Activities in Ducklings Exposed to Organophosphorus Pesticides. Archieves of Environmental Contamination and Toxicology, v.10, p.215-229, 1981. FRITZ, C.L. Emerging Tick-borne Diseases. Veterinary Clinics of North America: Small Animal Pratice, v. 39, n. 2, p. 265?278, 2009. GARCIA, S.J.; ASCHNER, M.; SYVERSEN, T. 2006. Interspecies Variation in Toxicity of Cholinesterase Inhibitors, p. 145-158. In: GUPTA, R.C.; ALVES, W.M.; SKOLNICK, B.E. Toxicology of Organophosphate and Carbamate Compounds. Elsevier Academic Press, San Diego. GUPTA, R.C. 2006. Classification and Uses of Organophosphates and Carbamates, p. 5-24. In: GUPTA, R.C.; ALVES, W.M.; SKOLNICK, B.E. Toxicology of Organophosphate and Carbamate Compounds. Elsevier Academic Press, San Diego. GUYTON, A. C.; HALL, J. E. Tratado de Fisiologia M?dica. 11? Ed. Rio de Janeiro: Ed Elsevier LTDA. 2006, 1115p. HILMAS, C.; ADLER, M.; BASKIN, S.I. 2006. Chapter 28 - Pulmonary Toxicity of Cholinesterase Inhibitors, p. 389-397. In: GUPTA, R.C.; ALVES, W.M.; SKOLNICK, B.E. Toxicology of Organophosphate and Carbamate Compounds. Elsevier Academic Press, San Diego. HOVDA, L.R.; HOOSER, S.B. Toxicology of newer pesticides for use in dogs and cats. Veterinary Clinics of North America: Small Animal Practice, v. 32, n. 2, p. 455?467, 2002. HSIEH, B.H.; DENG, J.F.; GER, J.; TSAI, W.J. Acetylcholinesterase Inhibition and the Extrapyramidal Syndrome: A Review of the Neurotoxicity of Organophosphate. NeuroToxicology, v.22, p.423-427, 2001. 60 ILG, T.; SCHMALZ, S.; WERR, M.; CRAMER, J. Acetylcholinesterases of the cat flea Ctenocephalides felis: identification of two distinct genes and biochemical characterization of recombinant and in vivo enzyme activities. Insect Biochemistry and Molecular Biology, v.40, p. 153-164, 2010. JOKANOVIC, M. Biotransformation of organophosphorus compounds. Toxicology, v.166, p.139?160, 2001. KAUFMAN, W.R. Ticks: Physiological aspects with implications for pathogen transmission. Ticks and Tick-borne Diseases, v.1, p. 11?22, 2010. KENDALL, S.B. The Use of Organophosphorus Compounds in Veterinary Medicine. Proceedings of the Royal Society of Medicine, v.54, n.5, p.406-408, 1961. KERR, M.G. 2003. Exames laboratoriais em medicina veterin?ria: bioqu?mica cl?nica e hematologia. S?o Paulo: ROCA LTDA, 436p. KIRK, R.W.; BONAGURA, J.D. 1992. Currenty Veterinary Therapy XI: Small Animal Pratice. Ed. WB Saunders Company, 349p. KNOLHOFF, L.M.; ONSTAD, D.W. 2007. Chapter 7 - Resistance by Ectoparasites, p. 125-151. In: Ibid. (Ed.), Insect Resistance Management. Academic Press, San Diego. LANCASTER, J.L.; MEISCH, M.V. 1986. Arthropods in livestock and poultry production. Ellis Horwood Limited, England. 402p. LINARDI, P. M.; GUIMAR?ES, L. R. Sifon?pteros do Brasil. S?o Paulo: Editora MZUSP/FAPESP, 2000, 291 p. LITTLE, S.E.; HOSTETLER, J.; KOCAN, K.M. Movement of Rhipicephalus sanguineus adults between co-housed dogs during active feeding. Veterinary Parasitology, v.150, p.139?145, 2007. Manual Merck de Veterin?ria 9? edi??o, Editora Roca, 2009, 2301 p. MARABLE, B.R.; MAURISSEN, J.P.J.; MATTSSON, J.L.; BILLINGTON, R. Diferential sensitivity of blood, peripheral, and central cholinesterases in beagle dogs following dietary exposure to chlorpyrifos. Regulatory Toxicology and Pharmacology, v. 47, n. 3, p.240?248, 2007. MARRS, T.; VALE, J.A. 2006. p.715-733. Management of Organophosphorus Pesticide Poisoning. In: GUPTA, R.C.; ALVES, W.M.; SKOLNICK, B.E. Toxicology of Organophosphate and Carbamate Compounds. Elsevier Academic Press, San Diego. MASSARD, C.L.; FONSECA, A.H. Carrapatos e doen?as transmitidas comuns ao homem e aos animais. A Hora Veterin?ria, v. 135, n. 1, p. 15-23, 2004. MATOLCSY, G. 1988. Anti-insect Agents. v. 32, p.21-239. In: Ibid. (Ed) Studies in Environmental Science. Elsevier Science Publishers, Budapest. 61 MELO, D. R. A??o de Metarhizium anisopliae (Metschnikoff, 1879) Sorokin, 1883 e Beauveria bassiana (Balsamo) Vuilllemin, 1912 sobre C. felis felis (Bo?che, 1806) (Siphonaptera: Pulguicidade). 2006. 38 f. Tese (Doutorado). Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ. 2006. MEYER, D.J.; COLES, E.H.; RICH, L.J. 1995. Medicina de Laborat?rio Veterin?rio: Interpreta??o e diagn?stico. Ed. Roca. 320p. OEHME, F.W.; MANNALA, S. 2001. Chapter 8 - Pesticide Use in Veterinary Medicine. v.1, p.263-274. In: KRIEGER, R.I. (Ed.), Handbook of Pesticide Toxicology (Second Edition). Academic Press, San Diego. PAZ, G.F.; RIBEIRO, M.F.; MICHALSKY, E.M.; DA ROCHA-LIMA, A.C.; FRANC, SILVA, J.C.; BARATA, R.A.; FORTES-DIAS, C.L.; DIAS, E.S. Evaluation of the vectorial capacity of Rhipicephalus sanguineus (Acari: Ixodidae) in the transmission of canine visceral leishmaniasis. Parasitology Research, v.106, p.523?528, 2010. PERINOTTO, W.M.S.; ANGELO, I.C.; GOLO, P.S.; QUINELATO, S.; CAMARGO, M.G.; S?, F.A.; BITTENCOURT, V.R.E.P. Susceptibility of different populations of ticks to entomopathogenic fungi. Experimental Parasitology, v. 130, p. 257-260, 2011. POLLMEIER, M.; PENGO, G.; JEANNIN, P.; SOLL, M. Evaluation of the efficacy of fipronil formulations in the treatment and control of biting lice, Trichodectes canis (De Geer, 1778) on dogs. Veterinary Parasitology, v. 107, p. 127?136, 2002. POPE, C. 2001. Chapter 41 - The Influence of Age on Pesticide Toxicity. v.1, p.873-885. In: KRIEGER, R.I. (Ed.), Handbook of Pesticide Toxicology (Second Edition). Academic Press, San Diego. POPE, C.; KARANTH, S.; LIU, J. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action. Environmental Toxicology and Pharmacology, v. 19, n. 3, p.433?446, 2005. Proceedings of the Royal Society of Medicine, v.54, n.5, p. 406?408, 1961. RAHIMI, R.; ABDOLLAHI, M. A review on the mechanisms involved in hyperglycemia induced by organophosphorus pesticides. Pesticide Biochemistry and Physiology, v. 88, p.115?121, 2007. REY, L. Dicion?rio de termos t?cnicos de medicina e sa?de. 2? ed. Rio de Janeiro: Ed Guanabara Koogan. 2008, 950p. ROCCO, L.C.M. Guia pr?tico para coleta e interpreta??o de exames laboratoriais em c?es e gatos. S?o Caetano do Sul, SP: Interbook, 2009. ROSE, R.L.; HODGSON, E.; ROE, R.M. 1999. Chapter 28 ? Pesticides, p.663-697. In: MARQUARDT, H.; SCH?FER, S.G.; MCCLELLAN, R.O.; WELSCH, F. (Ed.), Toxicology. Academic Press, San Diego. RUST, M.K. Advances in the control of Ctenocephalides felis (cat flea) on cats and dogs. Trends in Parasitology, v. 21, n.5, p. 232-236, 2005. 62 SACCARO, R.O. Atividade da colinesterase s?rica em c?es antes e durante o uso de coleira impregnada com agente anticolinester?sico. Porto Alegre: Faculdade de Veterin?ria. Universidade Federal do Rio Grande do Sul. 2007. Monografia. Especializa??o em An?lises Cl?nicas Veterin?ria. SANTOS, S. A Qu?mica dos Insecticidas (parte I). Qu?mica, v.85, p.43-47, 2002. SCOTT, F. B.; MARTINS, I. V. F.; SOUZA, C. P.; CORREIA, T. R. Aspectos gerais do controle da pulga Ctenocephalides felis felis em c?es. A Hora Veterin?ria, v. 21, n. 125, p. 13-18, 2002. SHARMA, R.P. 2006. Chapter 35 - Organophosphates, Carbamates, and the Immune System, p.495-507. In: GUPTA, R.C.; ALVES, W.M.; SKOLNICK, B.E. Toxicology of Organophosphate and Carbamate Compounds. Elsevier Academic Press, San Diego. SHAW, S.E.; DAY, M.J.; BIRTLES, R.J.; BREITSCHWERDT, E.B. Tick-borne infectious diseases of dogs. Trends in Parasitology, v.17, n.2, p. 74-80, 2001. SHELTON, G.D. Myasthenia Gravis and Disorders of Neuromuscular Transmission. Veterinary Clinics of North America: Small Animal Practice, v.32, n.1, p.189-206, 2002. SILVEIRA, J.A.G.; PASSOS, L.M.F.; RIBEIRO, M.F.B. Population dynamics of Rhipicephalus sanguineus (LATRIELLE, 1806) in Belo Horizonte, Minas Gerais state, Brazil. Veterinary Parasitology, v.161, n. 3-4, p.270?275, 2009. SOBRINHO, R.N.; SILVA, M.C.L.; LINHARES, G.F.C. Avalia??o antiixod?dica de Diazinon, Coumaf?s e Cipermetrina, atrav?s de testes in vitro sobre f?meas ingurgitadas de Boophilus microplus (CANESTRINI, 1887) na bacia leiteira da microrregi?o de Goi?nia-Goi?s, Anais da Escola de Agronomia e Veterin?ria, v.27, n.2, p. 13-19, 1997. SONENSHINE, D.E.; LANE, R.S.; NICHOLSON, W.L. 2002. Chapter 24 - Ticks (lxodida), p. 517-558. In: Medical and Veterinary Entomology, Elsevier Science. STARKS, S.E.; GERR, F.; KAMEL, F.; LYNCH, C.F.; JONES, M.P.; ALAVANJA, M.C.; SANDLER, D.P.; HOPPIN, J.A. Neurobehavioral function and organophosphate insecticide use among pesticide applicators in the Agricultural Health Study. Neurotoxicology and Teratology, (2011). doi: 10.1016/j.ntt.2011.08.014 TAYLOR, M. A. Recent Developments in Ectoparasiticides. The Veterinary Journal, v. 161, n. 3, p. 253?268, 2001. TAYLOR, M.A.; COOP, R.L.; WALL, R.L. Veterinary Parasitology. 3? ed. Iowa: Blackwell Publishing. 2007, 874p. TECLES, F.; CER?N, J.J. Determination of whole blood cholinesterase in different animal species using specific substrates. Research in Veterinary Science, v.70, p.233?238, 2001. TECLES, F.; MART?NEZ SUBIELA, S.; BERNAL, L.J.; CER?N, J.J. Use of Whole Blood for Spectrophotometric Determination of Cholinesterase Activity in Dogs. The Veterinary Journal, v. 160, n. 3, p. 242?249, 2000. 63 THRALL, M. Hematologia e Bioqu?mica Cl?nica Veterin?ria 1? ed. S?o Paulo: Ed. ROCA LTDA. 2007, 582p. THIERMANN, H.; STEINRITZ, D.; WOREKA, F.; RADTKE, M.; EYER, P.; EYER, F.; FELGENHAUER, N.; ZILKER, T. Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning. Toxicology Letters, v.206, p.77? 83, 2011. UNGER, T.A. 1996. Pesticide Synthesis Handbook. New Jersey: Noyes Publications, 1080p. WALL, R. Ectoparasites: Future challenges in a changing world, Veterinary Parasitology, v.148, n. 1, p.62?74, 2007. WILSON, B.W. 2001. Chapter 48 ? Cholinesterases. v.2, p.967-985. In: KRIEGER, R.I. (Ed.), Handbook of Pesticide Toxicology (Second Edition). 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dc.title.por.fl_str_mv Avalia??o da seguran?a cl?nica e efic?cia do Coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente
dc.title.alternative.eng.fl_str_mv Evaluation of safety clinical and effectiveness of Coumaphos in treatment to Ctenocephalides felis felis (BOUCH?, 1835) and Rhipicephalus sanguineus (LATREILLE, 1806) on dogs infested artificially
title Avalia??o da seguran?a cl?nica e efic?cia do Coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente
spellingShingle Avalia??o da seguran?a cl?nica e efic?cia do Coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente
Gaud?ncio, Fabr?cio Nascimento
organofosforado
parasiticida
colinesterase
organophosphate
parasiticide
cholinesterase
Medicina Veterin?ria
title_short Avalia??o da seguran?a cl?nica e efic?cia do Coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente
title_full Avalia??o da seguran?a cl?nica e efic?cia do Coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente
title_fullStr Avalia??o da seguran?a cl?nica e efic?cia do Coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente
title_full_unstemmed Avalia??o da seguran?a cl?nica e efic?cia do Coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente
title_sort Avalia??o da seguran?a cl?nica e efic?cia do Coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente
author Gaud?ncio, Fabr?cio Nascimento
author_facet Gaud?ncio, Fabr?cio Nascimento
author_role author
dc.contributor.advisor1.fl_str_mv Scott, Fabio Barbour
dc.contributor.advisor1ID.fl_str_mv 001.382.167-97
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1217253540572819
dc.contributor.referee1.fl_str_mv Fernandes, J?lio Israel
dc.contributor.referee2.fl_str_mv Borja, Gonzalo Efraim Moya
dc.contributor.authorID.fl_str_mv 113.436.707-48
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/8138213564144068
dc.contributor.author.fl_str_mv Gaud?ncio, Fabr?cio Nascimento
contributor_str_mv Scott, Fabio Barbour
Fernandes, J?lio Israel
Borja, Gonzalo Efraim Moya
dc.subject.por.fl_str_mv organofosforado
parasiticida
colinesterase
topic organofosforado
parasiticida
colinesterase
organophosphate
parasiticide
cholinesterase
Medicina Veterin?ria
dc.subject.eng.fl_str_mv organophosphate
parasiticide
cholinesterase
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description The objectives of this study were to evaluate the effectiveness against the flea Ctenocephalides felis felis and the tick Rhipicephalus sanguineus, and also verify the clinical safety of organophosphate coumaphos in the commercial formulation in the form of presentation of parasiticide soap for dogs. Were used 16 Beagles dogs, kept in the Laboratory of Experimental Chemotherapy in Veterinary Parasitology (LQEPV), Department of Animal Parasitology, Veterinary Institute, University Federal Rural of Rio de Janeiro. Specimens of C. f. felis and R. sanguineus used in artificial infestations were derived from colonies maintained in LQEPV. Pulicide efficiencies in day +2 to +7, were respectively 100% and 63.11%, while the efficiencies acaricides were respectively 99.62% and 43.25%. The coumaphos presented good efficacy against fleas and ticks within 48 hours of use, however, there was no good residual efficacy after re-infestation. In relation to clinical safety, hematology tests were performed (complete hemogram) and biochemical (ALT, AST, alkaline phosphatase, GGT, urea, creatinine, and serum cholinesterase) for evaluation of possible toxic effects from the use of the product. The animals showed no changes in clinical examination and laboratory tests that could be associated with adverse effects from the use of tested products, thus demonstrating that the coumaphos parasiticide in the formulation of soap is safety for use in dogs.
publishDate 2012
dc.date.issued.fl_str_mv 2012-02-24
dc.date.accessioned.fl_str_mv 2020-05-20T00:05:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv GAUD?NCIO, Fabr?cio Nascimento. Avalia??o da seguran?a cl?nica e efic?cia do coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente. 2012. 65 f. Disserta??o (Mestrado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/3536
identifier_str_mv GAUD?NCIO, Fabr?cio Nascimento. Avalia??o da seguran?a cl?nica e efic?cia do coumaf?s no tratamento de Ctenocephalides felis felis (BOUCH?, 1835) e Rhipicephalus sanguineus (LATREILLE, 1806) em c?es infestados artificialmente. 2012. 65 f. Disserta??o (Mestrado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.
url https://tede.ufrrj.br/jspui/handle/jspui/3536
dc.language.iso.fl_str_mv por
language por
dc.relation.references.por.fl_str_mv ABDELKADER, S.V.; HAUGE J.G. Serum enzyme determination in the study of liver disease in dogs. Acta Veterinaria Scandinavica Supplementum, v. 27, n. 1, p. 59 - 70, 1986. ABDELSALAM, E.B. Organophosphorus compounds. I. Toxicity in domestic animals. Veterinary Research Communications, v.11, n.3, p. 211-219, 1987. ANGELO, I.C.; FERNANDES, E.K.K. ; BAHIENSE, T.C.; PERINOTTO, W.M.S.; MORAES, A.P.R.; TERRA, A.L.M.; BITTENCOURT, V.R.E.P. Efficiency of Lecanicillium lecanii to control the tick Rhipicephalus microplus. Veterinary Parasitology, v. 172, p. 317-322, 2010. ARROWSMITH, J.E. The neuromuscular junction. Basic Science, v.25, n.3, p. 106-112, 2007. ARTHER, R.G. Mites and Lice: Biology and Control. Veterinary Clinical of Small Animal, v.39, n.6, p.1159?1171, 2009. ASTROFF, A.B.; FRESHWATER, K.J.; EIGENBERG, D.A. Comparative Organophosphate-Induced Effects Observed In Adult And Neonatal Sprague?Dawley Rats During The Conduct Of Multigeneration Toxicity Studies. Reproductive Toxicology, v. 12, n. 6, p. 619?645, 1998. BEUGNET, F. Antiparasitaires externes chez les carnivores domestiques. EMC-V?t?rinaire, v.1, n. 4, p.138?153, 2004. BICALHO, K.A.; FERREIRA, F.; BORGES, L.M.F.; RIBEIRO, M.F.B. In vitro evaluation of the effects of some acaricides on life stages of Rhipicephalus sanguineus (Acari: Ixodidae), Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia, v.53, n.5, p.548-552, 2001. BISSINGER, B.W., ROE, R.M. Tick repellents: Past, present, and future. Pesticide Biochemistry and Physiology, v.96, p.63?79, 2010. BITAM, I.; DITTMAR, K.; PAROLA, P.; WHITING, M.F.; RAOULT, D. Fleas and flea-borne diseases. International Journal of Infectious Diseases, v. 14, n. 8, p.667?676, 2010. BLAGBURN, B.L.; DRYDEN, M.W. Biology, Treatment, and Control of Flea and Tick Infestations. Veterinary Clinics of North America: Small Animal Pratice, v. 39, n. 6, p.1173?1200, 2009. BORGES, L.M.F.; SOARES, S.F.; FONSECA, I.N.; CHAVES, V.V.; LOULY,C.C. B. Resist?ncia acaricida em larvas de Rhipicephalus sanguineus (Acari: Ixodidae) de Goi?nia-GO, Brasil, Instituto de Patologia Tropical e Sa?de P?blica - IPTSP, v. 36, n.1, 2007. <Dispon?vel em: http://www.revistas.ufg.br/index.php/iptsp/ article/view/1820/1737> BREMER, W.G.; SCHAEFER, J.J.; WAGNER, E.R.; EWING, S.A.; RIKIHISA, Y.; NEEDHAM, G.R.; JITTAPALAPONG, S.; MOORE, D.L.; STICH, R.W. Transstadial and 58 intrastadial experimental transmission of Ehrlichia canis by male Rhipicephalus sanguineus. Veterinary Parasitology, v.131, p.95?105, 2005. BUSH, B. M. Interpreta??o de resultados laboratoriais para cl?nicos de pequenos animais. S?o Paulo: ROCA LTDA, 2004. CABRINI, T. M.; NAHUN, A.G.; CERINO, A. C.; BISSOLI, E.D.A.G.; COSTA, J.L.O.; PENA, S.B. Intoxica??o por Organofosforado em c?o - Relato de caso. Revista Cient?fica Eletr?nica de Medicina Veterin?ria, n.9, 2007. CARLOTTI, D.N.; JACOBS, D.E. Therapy, control and prevention of flea allergy dermatitis in dogs and cats. Veterinary Dermatology, v.11, p.83-98, 2000. CAVALIERE, M.J.; CALORE, E.E.; PEREZ, N.M.; PUGA, F.R. Miotoxicidade por organofosforados. Rev. Sa?de P?blica, v.30, n.3, p.267-72, 1996. CHARPENTIER, A.; MENOZZI, P.; MARCEL, V.; VILLATTE, F.; FOURNIER, D. A Method to Estimate Acetylcholinesterase-Active Sites and Turnover in Insects. Analytical Biochemistry, v.285, p. 76?81, 2000. CHEN, H-Y.; WANG, W. W-J.; CHAOU, C-H.; LIN, C-C. Prognostic value of serial serum cholinesterase activities in organophosphate poisoned patients. American Journal of Emergency Medicine, v.27, p. 1034?1039, 2009. CHOMEL, B. Tick-borne infections in dogs - An emerging infectious threat, Veterinary Parasitology, v.179, n. 4, p.294? 301, 2011. COOP, R.L.; TAYLOR, M.A.; JACOBS, D.E.; JACKSON, F. Ectoparasites: recent advances in control, TRENDS in Parasitology, v.18, n.2, p. 55-56, 2002. COUMAPHOS. JMPR, 1972. International Programme on Chemical Safety. Pesticide residues series 2. INCHEM. Chemical Safety Information from Intergovernmental Organizations. Dispon?vel em: <http://www.inchem.org/documents/jmpr/ jmpmono/v072pr11.htm> COUTINHO, M.T.Z.; BUENO, L.L.; STERZIK, A.; FUJIWARA, R.T.; BOTELHO, J.R.; MARIA, M.; GENAR, O.; LINARDI, P.M. Participation of Rhipicephalus sanguineus (Acari: Ixodidae) in the epidemiology of canine visceral leishmaniasis. Veterinary Parasitology, v.128, p.149?155, 2005. CUNNINGHAM, J.G. Tratado de Fisiologia Veterin?ria 3? ed. Rio de Janeiro: Guanabara Koogan. 2004, 579p. DANTAS-TORRES, F. The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): From taxonomy to control. Veterinary Parasitology, v. 152, n. 3-4, p.173?185, 2008. DAVEY, R.B.; GEORGE, J.E.; MILLER, R.J. Efficacy of various concentrations of coumaphos to control adult, nymphal, and larval stages of an organophosphate-resistant strain of Boophilus microplus on infested cattle. American Journal of Veterinary Research, v.64, n.6, p.684-689, 2003. 59 DECLEMENTI, C. 2007. Chapter 91 - Prevention and treatment of poisoning, p.1139-1158. In: GUPTA, R.C. (Ed.), Veterinary Toxicology. Elsevier Academic Press, San Diego. DELLINGER, J.; MOSTROM, M. Effects of topical fenthion on blood cholinesterase and vagal tone in dogs. Veterinary and Human Toxicology, v. 30, n. 3, p.229?234, 1988. ENZO, O. Acute Poisoning From Food Contaminated by Coumaphos. Wilderness and Environmental Medicine, v.17, n.1, p.67-72, 2006. FERNANDES, E.K.K. ; ANGELO, I.C. ; RANGEL, D.E.N. ; BAHIENSE, T.C. ; MORAES, A.M.L. ; ROBERTS, D.W.; BITTENCOURT, V.R.E.P . An intensive search for promising fungal biological control agents of ticks, particularly Rhipicephalus microplus. Veterinary Parasitology, v. 182, p. 307-318, 2011. FERNANDES, E.K.K.; BITTENCOURT, V.R.E.P.; ROBERTS, D.W. Perspectives on the potential of entomopathogenic fungi in biological control of ticks. Experimental Parasitology, v. 130, p. 300-305, 2011. FLEMING, W.J. Recovery of Brain and Plasma Cholinesterase Activities in Ducklings Exposed to Organophosphorus Pesticides. Archieves of Environmental Contamination and Toxicology, v.10, p.215-229, 1981. FRITZ, C.L. Emerging Tick-borne Diseases. Veterinary Clinics of North America: Small Animal Pratice, v. 39, n. 2, p. 265?278, 2009. GARCIA, S.J.; ASCHNER, M.; SYVERSEN, T. 2006. Interspecies Variation in Toxicity of Cholinesterase Inhibitors, p. 145-158. In: GUPTA, R.C.; ALVES, W.M.; SKOLNICK, B.E. Toxicology of Organophosphate and Carbamate Compounds. Elsevier Academic Press, San Diego. GUPTA, R.C. 2006. Classification and Uses of Organophosphates and Carbamates, p. 5-24. In: GUPTA, R.C.; ALVES, W.M.; SKOLNICK, B.E. Toxicology of Organophosphate and Carbamate Compounds. Elsevier Academic Press, San Diego. GUYTON, A. C.; HALL, J. E. Tratado de Fisiologia M?dica. 11? Ed. Rio de Janeiro: Ed Elsevier LTDA. 2006, 1115p. HILMAS, C.; ADLER, M.; BASKIN, S.I. 2006. Chapter 28 - Pulmonary Toxicity of Cholinesterase Inhibitors, p. 389-397. In: GUPTA, R.C.; ALVES, W.M.; SKOLNICK, B.E. Toxicology of Organophosphate and Carbamate Compounds. Elsevier Academic Press, San Diego. HOVDA, L.R.; HOOSER, S.B. Toxicology of newer pesticides for use in dogs and cats. Veterinary Clinics of North America: Small Animal Practice, v. 32, n. 2, p. 455?467, 2002. HSIEH, B.H.; DENG, J.F.; GER, J.; TSAI, W.J. Acetylcholinesterase Inhibition and the Extrapyramidal Syndrome: A Review of the Neurotoxicity of Organophosphate. NeuroToxicology, v.22, p.423-427, 2001. 60 ILG, T.; SCHMALZ, S.; WERR, M.; CRAMER, J. Acetylcholinesterases of the cat flea Ctenocephalides felis: identification of two distinct genes and biochemical characterization of recombinant and in vivo enzyme activities. Insect Biochemistry and Molecular Biology, v.40, p. 153-164, 2010. JOKANOVIC, M. Biotransformation of organophosphorus compounds. Toxicology, v.166, p.139?160, 2001. KAUFMAN, W.R. Ticks: Physiological aspects with implications for pathogen transmission. Ticks and Tick-borne Diseases, v.1, p. 11?22, 2010. KENDALL, S.B. The Use of Organophosphorus Compounds in Veterinary Medicine. Proceedings of the Royal Society of Medicine, v.54, n.5, p.406-408, 1961. KERR, M.G. 2003. Exames laboratoriais em medicina veterin?ria: bioqu?mica cl?nica e hematologia. S?o Paulo: ROCA LTDA, 436p. KIRK, R.W.; BONAGURA, J.D. 1992. Currenty Veterinary Therapy XI: Small Animal Pratice. Ed. WB Saunders Company, 349p. KNOLHOFF, L.M.; ONSTAD, D.W. 2007. Chapter 7 - Resistance by Ectoparasites, p. 125-151. In: Ibid. (Ed.), Insect Resistance Management. Academic Press, San Diego. LANCASTER, J.L.; MEISCH, M.V. 1986. Arthropods in livestock and poultry production. Ellis Horwood Limited, England. 402p. LINARDI, P. M.; GUIMAR?ES, L. R. Sifon?pteros do Brasil. S?o Paulo: Editora MZUSP/FAPESP, 2000, 291 p. LITTLE, S.E.; HOSTETLER, J.; KOCAN, K.M. Movement of Rhipicephalus sanguineus adults between co-housed dogs during active feeding. Veterinary Parasitology, v.150, p.139?145, 2007. Manual Merck de Veterin?ria 9? edi??o, Editora Roca, 2009, 2301 p. MARABLE, B.R.; MAURISSEN, J.P.J.; MATTSSON, J.L.; BILLINGTON, R. Diferential sensitivity of blood, peripheral, and central cholinesterases in beagle dogs following dietary exposure to chlorpyrifos. Regulatory Toxicology and Pharmacology, v. 47, n. 3, p.240?248, 2007. MARRS, T.; VALE, J.A. 2006. p.715-733. Management of Organophosphorus Pesticide Poisoning. In: GUPTA, R.C.; ALVES, W.M.; SKOLNICK, B.E. Toxicology of Organophosphate and Carbamate Compounds. Elsevier Academic Press, San Diego. MASSARD, C.L.; FONSECA, A.H. Carrapatos e doen?as transmitidas comuns ao homem e aos animais. A Hora Veterin?ria, v. 135, n. 1, p. 15-23, 2004. MATOLCSY, G. 1988. Anti-insect Agents. v. 32, p.21-239. In: Ibid. (Ed) Studies in Environmental Science. Elsevier Science Publishers, Budapest. 61 MELO, D. R. A??o de Metarhizium anisopliae (Metschnikoff, 1879) Sorokin, 1883 e Beauveria bassiana (Balsamo) Vuilllemin, 1912 sobre C. felis felis (Bo?che, 1806) (Siphonaptera: Pulguicidade). 2006. 38 f. Tese (Doutorado). Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ. 2006. MEYER, D.J.; COLES, E.H.; RICH, L.J. 1995. Medicina de Laborat?rio Veterin?rio: Interpreta??o e diagn?stico. Ed. Roca. 320p. OEHME, F.W.; MANNALA, S. 2001. Chapter 8 - Pesticide Use in Veterinary Medicine. v.1, p.263-274. In: KRIEGER, R.I. (Ed.), Handbook of Pesticide Toxicology (Second Edition). Academic Press, San Diego. PAZ, G.F.; RIBEIRO, M.F.; MICHALSKY, E.M.; DA ROCHA-LIMA, A.C.; FRANC, SILVA, J.C.; BARATA, R.A.; FORTES-DIAS, C.L.; DIAS, E.S. Evaluation of the vectorial capacity of Rhipicephalus sanguineus (Acari: Ixodidae) in the transmission of canine visceral leishmaniasis. Parasitology Research, v.106, p.523?528, 2010. PERINOTTO, W.M.S.; ANGELO, I.C.; GOLO, P.S.; QUINELATO, S.; CAMARGO, M.G.; S?, F.A.; BITTENCOURT, V.R.E.P. Susceptibility of different populations of ticks to entomopathogenic fungi. Experimental Parasitology, v. 130, p. 257-260, 2011. POLLMEIER, M.; PENGO, G.; JEANNIN, P.; SOLL, M. Evaluation of the efficacy of fipronil formulations in the treatment and control of biting lice, Trichodectes canis (De Geer, 1778) on dogs. Veterinary Parasitology, v. 107, p. 127?136, 2002. POPE, C. 2001. Chapter 41 - The Influence of Age on Pesticide Toxicity. v.1, p.873-885. In: KRIEGER, R.I. (Ed.), Handbook of Pesticide Toxicology (Second Edition). Academic Press, San Diego. POPE, C.; KARANTH, S.; LIU, J. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action. Environmental Toxicology and Pharmacology, v. 19, n. 3, p.433?446, 2005. Proceedings of the Royal Society of Medicine, v.54, n.5, p. 406?408, 1961. RAHIMI, R.; ABDOLLAHI, M. A review on the mechanisms involved in hyperglycemia induced by organophosphorus pesticides. Pesticide Biochemistry and Physiology, v. 88, p.115?121, 2007. REY, L. Dicion?rio de termos t?cnicos de medicina e sa?de. 2? ed. Rio de Janeiro: Ed Guanabara Koogan. 2008, 950p. ROCCO, L.C.M. Guia pr?tico para coleta e interpreta??o de exames laboratoriais em c?es e gatos. S?o Caetano do Sul, SP: Interbook, 2009. ROSE, R.L.; HODGSON, E.; ROE, R.M. 1999. Chapter 28 ? Pesticides, p.663-697. In: MARQUARDT, H.; SCH?FER, S.G.; MCCLELLAN, R.O.; WELSCH, F. (Ed.), Toxicology. Academic Press, San Diego. RUST, M.K. Advances in the control of Ctenocephalides felis (cat flea) on cats and dogs. Trends in Parasitology, v. 21, n.5, p. 232-236, 2005. 62 SACCARO, R.O. Atividade da colinesterase s?rica em c?es antes e durante o uso de coleira impregnada com agente anticolinester?sico. Porto Alegre: Faculdade de Veterin?ria. Universidade Federal do Rio Grande do Sul. 2007. Monografia. Especializa??o em An?lises Cl?nicas Veterin?ria. SANTOS, S. A Qu?mica dos Insecticidas (parte I). Qu?mica, v.85, p.43-47, 2002. SCOTT, F. B.; MARTINS, I. V. F.; SOUZA, C. P.; CORREIA, T. R. Aspectos gerais do controle da pulga Ctenocephalides felis felis em c?es. A Hora Veterin?ria, v. 21, n. 125, p. 13-18, 2002. SHARMA, R.P. 2006. Chapter 35 - Organophosphates, Carbamates, and the Immune System, p.495-507. In: GUPTA, R.C.; ALVES, W.M.; SKOLNICK, B.E. Toxicology of Organophosphate and Carbamate Compounds. Elsevier Academic Press, San Diego. SHAW, S.E.; DAY, M.J.; BIRTLES, R.J.; BREITSCHWERDT, E.B. Tick-borne infectious diseases of dogs. Trends in Parasitology, v.17, n.2, p. 74-80, 2001. SHELTON, G.D. Myasthenia Gravis and Disorders of Neuromuscular Transmission. Veterinary Clinics of North America: Small Animal Practice, v.32, n.1, p.189-206, 2002. SILVEIRA, J.A.G.; PASSOS, L.M.F.; RIBEIRO, M.F.B. Population dynamics of Rhipicephalus sanguineus (LATRIELLE, 1806) in Belo Horizonte, Minas Gerais state, Brazil. Veterinary Parasitology, v.161, n. 3-4, p.270?275, 2009. SOBRINHO, R.N.; SILVA, M.C.L.; LINHARES, G.F.C. Avalia??o antiixod?dica de Diazinon, Coumaf?s e Cipermetrina, atrav?s de testes in vitro sobre f?meas ingurgitadas de Boophilus microplus (CANESTRINI, 1887) na bacia leiteira da microrregi?o de Goi?nia-Goi?s, Anais da Escola de Agronomia e Veterin?ria, v.27, n.2, p. 13-19, 1997. SONENSHINE, D.E.; LANE, R.S.; NICHOLSON, W.L. 2002. Chapter 24 - Ticks (lxodida), p. 517-558. In: Medical and Veterinary Entomology, Elsevier Science. STARKS, S.E.; GERR, F.; KAMEL, F.; LYNCH, C.F.; JONES, M.P.; ALAVANJA, M.C.; SANDLER, D.P.; HOPPIN, J.A. Neurobehavioral function and organophosphate insecticide use among pesticide applicators in the Agricultural Health Study. Neurotoxicology and Teratology, (2011). doi: 10.1016/j.ntt.2011.08.014 TAYLOR, M. A. Recent Developments in Ectoparasiticides. The Veterinary Journal, v. 161, n. 3, p. 253?268, 2001. TAYLOR, M.A.; COOP, R.L.; WALL, R.L. Veterinary Parasitology. 3? ed. Iowa: Blackwell Publishing. 2007, 874p. TECLES, F.; CER?N, J.J. Determination of whole blood cholinesterase in different animal species using specific substrates. Research in Veterinary Science, v.70, p.233?238, 2001. TECLES, F.; MART?NEZ SUBIELA, S.; BERNAL, L.J.; CER?N, J.J. Use of Whole Blood for Spectrophotometric Determination of Cholinesterase Activity in Dogs. The Veterinary Journal, v. 160, n. 3, p. 242?249, 2000. 63 THRALL, M. Hematologia e Bioqu?mica Cl?nica Veterin?ria 1? ed. S?o Paulo: Ed. ROCA LTDA. 2007, 582p. THIERMANN, H.; STEINRITZ, D.; WOREKA, F.; RADTKE, M.; EYER, P.; EYER, F.; FELGENHAUER, N.; ZILKER, T. Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning. Toxicology Letters, v.206, p.77? 83, 2011. UNGER, T.A. 1996. Pesticide Synthesis Handbook. New Jersey: Noyes Publications, 1080p. WALL, R. Ectoparasites: Future challenges in a changing world, Veterinary Parasitology, v.148, n. 1, p.62?74, 2007. WILSON, B.W. 2001. Chapter 48 ? Cholinesterases. v.2, p.967-985. In: KRIEGER, R.I. (Ed.), Handbook of Pesticide Toxicology (Second Edition). Academic Press, San Diego.
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