Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos

Detalhes bibliográficos
Ano de defesa: 2019
Autor(a) principal: Oliveira, Priscila Cardim de lattes
Orientador(a): Scott, Fabio Barbour lattes
Banca de defesa: Scott, Fabio Barbour lattes, Azevedo, Tha?s Ribeiro Correia lattes, Martins, Isabella Vilhena Freire lattes, Campos, Diefrey Ribeiro lattes, Freire, Licius de Sa lattes
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Ci?ncias Veterin?rias
Departamento: Instituto de Veterin?ria
País: Brasil
Palavras-chave em Português:
Isoxazolinas
Ectoparasitas
Mi?ases
Myiasis
Palavras-chave em Inglês:
Isoxazolines
Ectoparasites
Área do conhecimento CNPq:
Medicina Veterin?ria
Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/5829
Resumo: Dog and cat ectoparasites are fleas, ticks, flies, lice and scabies. Infestation from these parasites can lead to serious infections for both animals and humans. The aim of this study was to evaluate the contributions of sarolaner in the clinical treatment of controlled Ctenocephalides felis felis infestations in dogs and cats, Rhipicephalus sanguineus in dogs and in the treatment of naturally occurring myiasis caused by Cochliomyia hominivorax in dogs. Thus, four studies were conducted and separated into chapters. The chapters were titled I ?Efficacy of sarolaner in the control of Rhipicephalus sanguineus ticks in artificially infested dogs?, II ?Efficacy of sarolaner in the control of Ctenocephalides felis felis fleas?, III ?Efficacy of sarolaner in the control of Ctenocephalides felis fleas felis in artificially infested cats ?and IV? Effectiveness of sarolaner in the treatment of myiasis caused by Cochliomyia hominivorax in naturally infested dogs ?. In the tick efficacy study, 20 adult beagles were selected. Infestations were carried out with 25 male and 25 non-fed R. sanguineus adult females weekly for 5 weeks. Counts were performed weekly 48 hours after infestations. The animals received 2.0 to 4.0 mg/kg of sarolaner orally in a single dose. The average efficacy of sarolaner was 97.3% for 35 days. For efficacy in dogs, 20 male and female Beagle animals, aged between 1 and 4 years, who received orally 2.0 to 4.0 mg/kg of sarolaner in a single dose. Infestations occurred weekly with 50 (+ -5) pairs of unfeeded adult C felis. Desinfestations or combing were performed 24 hours after the infestations. The average efficacy was 99.75% over the 35 day period. To evaluate the efficacy of cats, 14 male and female mongrel animals were included in the same proportion, aged between one and six years. The animals received 2.0 to 3.5 mg/kg sarolaner orally in a single dose. Infestations were performed weekly with 50 (+/- 5) C flea couples for 12 weeks. Counts occurred 48 hours after infestations and sarolaner was 100% effective on all experimental days, totaling 84 days. In the treatment of naturally occurring myiasis by Cochliomyia hominivorax, eight adult beagle dogs receiving oral 2.0 to 4.0mg/kg sarolaner and supportive wound care medication were evaluated. Larval expulsion was evaluated every 15 minutes in the first hour and every hour for the next six hours and with 24 hours of treatment. Larvae were evaluated for motility for differentiation between dead and alive. After 24 hours the animals were sedated for wound cleaning and manual removal of all larvae. The average expulsion of the larvae was 50.9% occurring mainly after four hours of treatment. The larvicidal effect was 70.6% at six hours after treatment and 100% at 24 hours. Overall efficacy was 100%. Sarolaner was effective in all proposed treatments and may be a good choice in cases of multiple infestations. No clinical or behavioral changes were observed during studies that could be related to treatment or procedures performed
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spelling Scott, Fabio Barbour001.382.167-97https://orcid.org/0000-0003-1683-8724http://lattes.cnpq.br/1217253540572819Scott, Fabio Barbour001.382.167-97https://orcid.org/0000-0003-1683-8724http://lattes.cnpq.br/1217253540572819Azevedo, Tha?s Ribeiro Correiahttps://orcid.org/0000-0003-3045-8787http://lattes.cnpq.br/6049103053269712Martins, Isabella Vilhena Freirehttps://orcid.org/0000-0002-8700-3065http://lattes.cnpq.br/6446528818006897Campos, Diefrey Ribeirohttps://orcid.org/0000-0002-5434-1463http://lattes.cnpq.br/8547992443497955Freire, Licius de Sahttp://lattes.cnpq.br/8536627339990442721.473.507-53http://lattes.cnpq.br/6069474085821136Oliveira, Priscila Cardim de2022-07-29T14:00:30Z2019-07-12OLIVEIRA, Priscila Cardim de. Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos. 2019.79 f. Tese (Doutorado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2019.https://tede.ufrrj.br/jspui/handle/jspui/5829Dog and cat ectoparasites are fleas, ticks, flies, lice and scabies. Infestation from these parasites can lead to serious infections for both animals and humans. The aim of this study was to evaluate the contributions of sarolaner in the clinical treatment of controlled Ctenocephalides felis felis infestations in dogs and cats, Rhipicephalus sanguineus in dogs and in the treatment of naturally occurring myiasis caused by Cochliomyia hominivorax in dogs. Thus, four studies were conducted and separated into chapters. The chapters were titled I ?Efficacy of sarolaner in the control of Rhipicephalus sanguineus ticks in artificially infested dogs?, II ?Efficacy of sarolaner in the control of Ctenocephalides felis felis fleas?, III ?Efficacy of sarolaner in the control of Ctenocephalides felis fleas felis in artificially infested cats ?and IV? Effectiveness of sarolaner in the treatment of myiasis caused by Cochliomyia hominivorax in naturally infested dogs ?. In the tick efficacy study, 20 adult beagles were selected. Infestations were carried out with 25 male and 25 non-fed R. sanguineus adult females weekly for 5 weeks. Counts were performed weekly 48 hours after infestations. The animals received 2.0 to 4.0 mg/kg of sarolaner orally in a single dose. The average efficacy of sarolaner was 97.3% for 35 days. For efficacy in dogs, 20 male and female Beagle animals, aged between 1 and 4 years, who received orally 2.0 to 4.0 mg/kg of sarolaner in a single dose. Infestations occurred weekly with 50 (+ -5) pairs of unfeeded adult C felis. Desinfestations or combing were performed 24 hours after the infestations. The average efficacy was 99.75% over the 35 day period. To evaluate the efficacy of cats, 14 male and female mongrel animals were included in the same proportion, aged between one and six years. The animals received 2.0 to 3.5 mg/kg sarolaner orally in a single dose. Infestations were performed weekly with 50 (+/- 5) C flea couples for 12 weeks. Counts occurred 48 hours after infestations and sarolaner was 100% effective on all experimental days, totaling 84 days. In the treatment of naturally occurring myiasis by Cochliomyia hominivorax, eight adult beagle dogs receiving oral 2.0 to 4.0mg/kg sarolaner and supportive wound care medication were evaluated. Larval expulsion was evaluated every 15 minutes in the first hour and every hour for the next six hours and with 24 hours of treatment. Larvae were evaluated for motility for differentiation between dead and alive. After 24 hours the animals were sedated for wound cleaning and manual removal of all larvae. The average expulsion of the larvae was 50.9% occurring mainly after four hours of treatment. The larvicidal effect was 70.6% at six hours after treatment and 100% at 24 hours. Overall efficacy was 100%. Sarolaner was effective in all proposed treatments and may be a good choice in cases of multiple infestations. No clinical or behavioral changes were observed during studies that could be related to treatment or procedures performedOs ectoparasitos de c?es e gatos s?o pulgas, carrapatos, moscas, piolhos e sarnas. As infesta??es decorrentes destes parasitos podem levar a infec??es graves tanto para os animais como para seres humanos. O objetivo deste trabalho foi avaliar as contribui??es do sarolaner nos tratamentos cl?nicos de infesta??es controladas de Ctenocephalides felis felis em c?es e gatos, Rhipicephalus sanguineus em c?es e no tratamento de mi?ases de ocorr?ncia natural causadas por Cochliomyia hominivorax em c?es. Sendo assim, quatro estudos foram realizados e separados em cap?tulos. Os cap?tulos foram intitulados I ?Efic?cia do sarolaner no controle de carrapatos Rhipicephalus sanguineus em c?es infestados artificialmente?, II ?Efic?cia do sarolaner no controle de pulgas Ctenocephalides felis felis em c?es infestados artificialmente?, III ?Efic?cia do sarolaner no controle de pulgas Ctenocephalides felis felis em gatos infestados artificialmente? e IV ?Efic?cia do sarolaner no tratamento de mi?ases causadas por Cochliomyia hominivorax em c?es naturalmente infestados?. No estudo de efic?cia carrapaticida foram selecionados 20 c?es beagles adultos. As infesta??es foram realizadas com 25 machos e 25 f?meas adultos n?o alimentados de R. sanguineus semanalmente por 5 semanas. As contagens foram realizadas semanalmente 48 horas ap?s as infesta??es. Os animais receberam 2,0 a 4,0mg/kg do sarolaner por via oral em dose ?nica. A efic?cia m?dia do sarolaner foi 97,3%, por 35 dias. Para efic?cia pulguicida em c?es foram inclu?dos 20 animais da ra?a Beagle, machos e f?meas, com idade entre 1 e 4 anos que receberam por via oral 2,0 a 4,0mg/kg do sarolaner em dose ?nica. As infesta??es ocorreram semanalmente com 50 (+-5) casais de pulgas C felis adultas n?o alimentadas. As desinfesta??es ou pentea??es foram realizadas 24 horas ap?s as infesta??es. A m?dia de efic?cia foi de 99,75% no per?odo de 35 dias. Para avalia??o da efic?cia pulguicida em gatos, foram inclu?dos 14 animais sem ra?a definida machos e f?meas em igual propor??o, idade entre um e seis anos. Os animais receberam 2,0-3,5mg/kg de sarolaner por via oral em dose ?nica. As infesta??es foram realizadas semanalmente com 50(+-5) casais de pulgas C felis por 12 semanas. As contagens ocorreram 48 horas ap?s as infesta??es e a efic?cia do sarolaner foi de 100% em todos os dias experimentais, totalizando 84 dias. No tratamento de mi?ases de ocorr?ncia natural por Cochliomyia hominivorax foram avaliados oito c?es beagles adultos que receberam a dose de 2,0 ? 4,0mg/kg de sarolaner por via oral e a medica??o de suporte para tratamento da ferida. A expuls?o das larvas foi avaliada a cada 15 minutos na primeira hora e a cada hora nas seis horas subsequentes e com 24 horas de tratamento. As larvas foram avaliadas quanto ? motilidade para diferencia??o entre mortas e vivas. Ap?s 24 horas os animais foram sedados para a limpeza da ferida e a retirada manual de todas as larvas. A m?dia de expuls?o das larvas foi de 50,9% ocorrendo principalmente ap?s quatro horas do tratamento. O efeito larvicida foi de 70,6% nas seis horas ap?s o tratamento e de 100% em 24 horas. A efic?cia global foi de 100%. O sarolaner se mostrou eficaz em todos os tratamentos propostos podendo ser uma boa escolha em casos de infesta??es m?ltiplas. N?o foram observadas altera??es clinicas ou comportamentais durante os estudos que pudessem estar relacionadas ao tratamento ou aos procedimentos realizadosSubmitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2022-07-29T14:00:30Z No. of bitstreams: 1 2019 - Priscila Cardim de Oliveira.pdf: 1526514 bytes, checksum: 0f07598d6c8817084c689ef69fb152c9 (MD5)Made available in DSpace on 2022-07-29T14:00:30Z (GMT). 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dc.title.por.fl_str_mv Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos
dc.title.alternative.eng.fl_str_mv Clinical contributions of sarolaner in ectoparasitosis of dog and cat
title Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos
spellingShingle Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos
Oliveira, Priscila Cardim de
Isoxazolinas
Ectoparasitas
Mi?ases
Myiasis
Isoxazolines
Ectoparasites
Medicina Veterin?ria
title_short Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos
title_full Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos
title_fullStr Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos
title_full_unstemmed Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos
title_sort Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos
author Oliveira, Priscila Cardim de
author_facet Oliveira, Priscila Cardim de
author_role author
dc.contributor.advisor1.fl_str_mv Scott, Fabio Barbour
dc.contributor.advisor1ID.fl_str_mv 001.382.167-97
https://orcid.org/0000-0003-1683-8724
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1217253540572819
dc.contributor.referee1.fl_str_mv Scott, Fabio Barbour
dc.contributor.referee1ID.fl_str_mv 001.382.167-97
https://orcid.org/0000-0003-1683-8724
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/1217253540572819
dc.contributor.referee2.fl_str_mv Azevedo, Tha?s Ribeiro Correia
dc.contributor.referee2ID.fl_str_mv https://orcid.org/0000-0003-3045-8787
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/6049103053269712
dc.contributor.referee3.fl_str_mv Martins, Isabella Vilhena Freire
dc.contributor.referee3ID.fl_str_mv https://orcid.org/0000-0002-8700-3065
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/6446528818006897
dc.contributor.referee4.fl_str_mv Campos, Diefrey Ribeiro
dc.contributor.referee4ID.fl_str_mv https://orcid.org/0000-0002-5434-1463
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/8547992443497955
dc.contributor.referee5.fl_str_mv Freire, Licius de Sa
dc.contributor.referee5Lattes.fl_str_mv http://lattes.cnpq.br/8536627339990442
dc.contributor.authorID.fl_str_mv 721.473.507-53
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/6069474085821136
dc.contributor.author.fl_str_mv Oliveira, Priscila Cardim de
contributor_str_mv Scott, Fabio Barbour
Scott, Fabio Barbour
Azevedo, Tha?s Ribeiro Correia
Martins, Isabella Vilhena Freire
Campos, Diefrey Ribeiro
Freire, Licius de Sa
dc.subject.por.fl_str_mv Isoxazolinas
Ectoparasitas
Mi?ases
Myiasis
topic Isoxazolinas
Ectoparasitas
Mi?ases
Myiasis
Isoxazolines
Ectoparasites
Medicina Veterin?ria
dc.subject.eng.fl_str_mv Isoxazolines
Ectoparasites
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description Dog and cat ectoparasites are fleas, ticks, flies, lice and scabies. Infestation from these parasites can lead to serious infections for both animals and humans. The aim of this study was to evaluate the contributions of sarolaner in the clinical treatment of controlled Ctenocephalides felis felis infestations in dogs and cats, Rhipicephalus sanguineus in dogs and in the treatment of naturally occurring myiasis caused by Cochliomyia hominivorax in dogs. Thus, four studies were conducted and separated into chapters. The chapters were titled I ?Efficacy of sarolaner in the control of Rhipicephalus sanguineus ticks in artificially infested dogs?, II ?Efficacy of sarolaner in the control of Ctenocephalides felis felis fleas?, III ?Efficacy of sarolaner in the control of Ctenocephalides felis fleas felis in artificially infested cats ?and IV? Effectiveness of sarolaner in the treatment of myiasis caused by Cochliomyia hominivorax in naturally infested dogs ?. In the tick efficacy study, 20 adult beagles were selected. Infestations were carried out with 25 male and 25 non-fed R. sanguineus adult females weekly for 5 weeks. Counts were performed weekly 48 hours after infestations. The animals received 2.0 to 4.0 mg/kg of sarolaner orally in a single dose. The average efficacy of sarolaner was 97.3% for 35 days. For efficacy in dogs, 20 male and female Beagle animals, aged between 1 and 4 years, who received orally 2.0 to 4.0 mg/kg of sarolaner in a single dose. Infestations occurred weekly with 50 (+ -5) pairs of unfeeded adult C felis. Desinfestations or combing were performed 24 hours after the infestations. The average efficacy was 99.75% over the 35 day period. To evaluate the efficacy of cats, 14 male and female mongrel animals were included in the same proportion, aged between one and six years. The animals received 2.0 to 3.5 mg/kg sarolaner orally in a single dose. Infestations were performed weekly with 50 (+/- 5) C flea couples for 12 weeks. Counts occurred 48 hours after infestations and sarolaner was 100% effective on all experimental days, totaling 84 days. In the treatment of naturally occurring myiasis by Cochliomyia hominivorax, eight adult beagle dogs receiving oral 2.0 to 4.0mg/kg sarolaner and supportive wound care medication were evaluated. Larval expulsion was evaluated every 15 minutes in the first hour and every hour for the next six hours and with 24 hours of treatment. Larvae were evaluated for motility for differentiation between dead and alive. After 24 hours the animals were sedated for wound cleaning and manual removal of all larvae. The average expulsion of the larvae was 50.9% occurring mainly after four hours of treatment. The larvicidal effect was 70.6% at six hours after treatment and 100% at 24 hours. Overall efficacy was 100%. Sarolaner was effective in all proposed treatments and may be a good choice in cases of multiple infestations. No clinical or behavioral changes were observed during studies that could be related to treatment or procedures performed
publishDate 2019
dc.date.issued.fl_str_mv 2019-07-12
dc.date.accessioned.fl_str_mv 2022-07-29T14:00:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Priscila Cardim de. Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos. 2019.79 f. Tese (Doutorado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2019.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/5829
identifier_str_mv OLIVEIRA, Priscila Cardim de. Contribui??es cl?nicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de c?es e gatos. 2019.79 f. Tese (Doutorado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2019.
url https://tede.ufrrj.br/jspui/handle/jspui/5829
dc.language.iso.fl_str_mv por
language por
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