Estudo qu?mico de esp?cies de Solanum

• Ano de defesa: 2002
• Autor(a) principal: Silva, Tania Maria Sarmento da
• Orientador(a): Carvalho, Mario Geraldo de
• Banca de defesa: Carvalho, M?rio Geraldo de, Braz Filho, Raimundo, Velandia, Javier Rinc?n, Martins, Dirceu, Lima, ?urea Echevarria Aznar Neves
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
• Programa de Pós-Graduação: Programa de P?s-Gradua??o em Qu?mica
• Departamento: Instituto de Ci?ncias Exatas
• País: Brasil
• Palavras-chave em Português: Qu?mica
• Área do conhecimento CNPq: Qu?mica
• Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/4304

The chemical study of the aerial parts of a new and rare species of Solanum jabrense Agra & M. Nee resulted in the isolation of two steroids, ?-sitosterol and stigmasterol, one triterpene ?-amyrin, one sesquiterpene (solavetivone), two alkaloids Nb-methyltetrahydro-?-carboline and solasodine, beside vanillic acid. The leaves of S. jabrense fumished three flavonoids 3,7,3',4'-tetramethyl quercetin ether, 7,4'-dimethyl quercetin ether, and 7-methyl kaempferol ether. The aerial parts of Solanum paludosum Moric. afforded two triterpenes ?-amirine acetate and ?-amyrin and its acetyl derivativa, one alkamide N-coumaroyltyramine, protocatecuic acid, two steroidal saponins, (3-0-?-D-glicopyranosylsitosterol and 3-0-?-D-glicopyranosylstigmaterol and eight flavonoids: 3,4',7,8-tetramethylgossypetin ether, 3,3',4',7,8-pentamethyl gossypetin ether, 3,3',4',7-tetramethyl quercetin ether, 3-methyl quercetin ether, 7-methyl apigenin ether, 3,7-dimethyl kaempferol ether, 7-methyl kaempferol ether, and 3,7,8-trimethyl herbacetin ether. The structures were stablished from IV, Mass spectrum and NMR spectral data, including 20 NMR experiments of the natural substances and the acetyl, methyl and the new iodine derivativa of flavonoids. The methanolic extract of the trichomes of Solanum crinitum Lam. fumished 0-glicosylflavonoids astragaline and tilliroside. The analysis of flavonoids by HPLC was carried out with extracts of trichomes of S. rhytidoandrum Sendtn., S. paludosum Moric., S. paraibanum Agra, S. stramonifo/ium Jacq. and lhe extracts of the aerial parts of S. agrarium Sendtn. and S. jabrense Agra & M. Nee. The flavonoid profiles were compared by HPLC. The studied plants belong to four different sections of Solanum subg. Leptostemonum (Dunal) Bitter. Biological tests were run for the Solanum extracts, for solavetivone and for the natural and derivatized flavonoids, including topoisomerase inhibition, spamolitic and molluscicide activities, and citotoxicity against Erlich cells.