Fun??o tireoideana em ratos submetidos ao treinamento de for?a isom?trico

• Ano de defesa: 2014
• Autor(a) principal: Concei??o, Rodrigo Rodrigues da
• Orientador(a): Marassi, Michelle Porto
• Banca de defesa: Marassi, Michelle Porto, Fortunato, Rodrigo Soares, Almeida, Norma Aparecida dos Santos
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
• Programa de Pós-Graduação: Programa Multic?ntrico de P?s-Gradua??o em Ci?ncias Fisiol?gicas
• Departamento: Instituto de Ci?ncias Biol?gicas e da Sa?de
• País: Brasil
• Palavras-chave em Português: Horm?nios tireoideanos; Iodotironina Desiodase; Treinamento de For?a Isom?trico; Exerc?cio
• Palavras-chave em Inglês: Thyroid hormone; Iodothyronine Deiodinase; Isometric Strength Training; Exercise
• Área do conhecimento CNPq: Fisiologia
• Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/3046

Strength training is known for being a method which increases the neuromuscular functional capacity (Deschenes & Kramer, 2002). This type of training has become a popular form of physical activity and various health benefits have been shown (STRENGHT NATIONAL ASSOCIATION POSITION STATEMENT AND CONDITION, 2001). Moreover thyroid hormones (triiodothyronine, thyroxine and T3, T4) are essential for normal growth and development. Despite the great importance of thyroid hormones, There are currently no studies that evaluate the effect of strength training on thyroid function, however the purpose of this study was to evaluate the acute and chronic modulation of the hypothalamic-pituitary-thyroid axis as well as the activity of iodothyronine desiodades type 1 (D1) and type 2 (D2) in rats that underwent the isometric strength training. To verify the acute effects, the animals were randomly divided into 5 groups: Baseline, 0, 30, 60 and 120 min following training. To the study of chronic responses, the animals were divided into 2 groups: Control and Training. In the study of the acute effects, there were significant increases in serum TSH levels and activity of the co transporter sodium-iodide symporter 0 min after exercise compared to baseline, however since T3 levels were only higher in control than in the trained, 120 min post training. D2 activity in TAM decreased significantly in group 120 min when compared with the basal group, the same occurring with pituitary D1. Which increase in group 120 min when compared with the basal group. With regard to chronic effects, we found significant increases in serum levels of T4, compared with the control group with trained by 8 weeks of isometric strength training. In serum T3, no significant differences were observed in control and training groups, the opposite occurred with respect to serum levels of corticosterone, which found a significant reduction and concentration when compared with the control with the trained by 8 weeks of isometric training strength. In TAM found significant reduction in D2 activity after 8 weeks of training. However we observe, in the soleus muscle, statistically significant decrease after 8 weeks of training. In liver and kidney we found significant increase in D1activity after 8 weeks of training. Our results demonstrate that strength training modulates the HPT axis and that this modulation is related to changes in the activity of iodothyronine deiodinases.