Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva

Detalhes bibliográficos
Ano de defesa: 2018
Autor(a) principal: Gomes, Viviane Horta lattes
Orientador(a): Silva, Marta Fernanda Albuquerque da lattes
Banca de defesa: Paiva, Jonimar Pereira lattes, Abreu, Mariana Boechat de lattes, Moreno, Juan Carlos Duque lattes, Santos, Paulo Sergio Patto dos lattes
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)
Departamento: Instituto de Veterin?ria
País: Brasil
Palavras-chave em Português:
Analgesia
Agonista-antagonista
C?o
Escala de dor
Opioide
Palavras-chave em Inglês:
Analgesia
Agonist-antagonist
Dog
Opioid
Pain scale
Área do conhecimento CNPq:
Medicina Veterin?ria
Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/5002
Resumo: The management of perioperative pain can be performed by opioids, drugs that form the base of a balanced analgesic plane. The aim of this study was to compare the analgesic efficacy of nalbuphine, butorphanol and morphine in the early postoperative analgesia, in bitches submitted to ovariohysterectomy. Forty-eight healthy bitches of different breeds were randomly assigned to four treatments: nalbuphine 0,5 mg kg-1 (N0.5) and 1,0 mg kg-1(N1.0), butorphanol 0,4 mg kg-1(B0.4) or morphine 0,2 mg kg-1 (M0.2), combined with acepromazine 0,02 mg kg-1intravenously. Anesthesia was induced with propofol and maintained with isoflurane. Dynamic Interactive Visual Analog Scale (DIVAS, 0?100 mm), phases I (DIVAS I), II (DIVAS II) and III (DIVAS III), and the Modified Glasgow Composite Measure Pain Scale (GCMPS, 0?10) were used to used to assess pain prior administration of the drugs (BL), 1, 2, 3, 4, 5 and 6 hours after extubation. The analgesic rescue (0,2 mg kg1IV of morphine combined with 0,2 mg kg-1IV of meloxicam) was given if the dog had DIVAS > 70 mm or GCMPS > 3,5. B0.4 had a higher DIVAS II score compared with N1.0, at 2 (p = 0,038) and 3 hours (p = 0,002), and with N0.5 at 3 hours (p = 0,003). There was no difference in DIVAS I, III and GCMPS scores between treatments. Rescue analgesia was required in thirty-four bitches. The number of analgesic rescues (p = 0,813) and total dose of morphine given as rescue (p = 0,763) were not different between groups. Preemptive administration of nalbuphine, butorphanol and morphine produce similar postoperative analgesia with great possibility of analgesic rescue in the first 6 hours, therefore, over this period, regular and interactive evaluations should be performed to ensure adequate analgesia in bitches submitted to ovariohysterectomy.
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spelling Silva, Marta Fernanda Albuquerque da0544591266946007http://lattes.cnpq.br/0544591266946007Paiva, Jonimar Pereira0555358847663175http://lattes.cnpq.br/0555358847663175Abreu, Mariana Boechat de0171700191037164http://lattes.cnpq.br/0171700191037164Moreno, Juan Carlos Duque8509640024284103http://lattes.cnpq.br/8509640024284103Santos, Paulo Sergio Patto dos5331938962896664http://lattes.cnpq.br/53319389628966648842502819385308http://lattes.cnpq.br/8842502819385308Gomes, Viviane Horta2021-09-01T18:51:55Z2018-08-21GOMES, Viviane Horta. Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva. 2018. 51 f. Tese (Mestrado em Medicina Veterin?ria) - Instituto de Veterin?ria, Departamento de Medicina e Cirurgia Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2018.https://tede.ufrrj.br/jspui/handle/jspui/5002The management of perioperative pain can be performed by opioids, drugs that form the base of a balanced analgesic plane. The aim of this study was to compare the analgesic efficacy of nalbuphine, butorphanol and morphine in the early postoperative analgesia, in bitches submitted to ovariohysterectomy. Forty-eight healthy bitches of different breeds were randomly assigned to four treatments: nalbuphine 0,5 mg kg-1 (N0.5) and 1,0 mg kg-1(N1.0), butorphanol 0,4 mg kg-1(B0.4) or morphine 0,2 mg kg-1 (M0.2), combined with acepromazine 0,02 mg kg-1intravenously. Anesthesia was induced with propofol and maintained with isoflurane. Dynamic Interactive Visual Analog Scale (DIVAS, 0?100 mm), phases I (DIVAS I), II (DIVAS II) and III (DIVAS III), and the Modified Glasgow Composite Measure Pain Scale (GCMPS, 0?10) were used to used to assess pain prior administration of the drugs (BL), 1, 2, 3, 4, 5 and 6 hours after extubation. The analgesic rescue (0,2 mg kg1IV of morphine combined with 0,2 mg kg-1IV of meloxicam) was given if the dog had DIVAS > 70 mm or GCMPS > 3,5. B0.4 had a higher DIVAS II score compared with N1.0, at 2 (p = 0,038) and 3 hours (p = 0,002), and with N0.5 at 3 hours (p = 0,003). There was no difference in DIVAS I, III and GCMPS scores between treatments. Rescue analgesia was required in thirty-four bitches. The number of analgesic rescues (p = 0,813) and total dose of morphine given as rescue (p = 0,763) were not different between groups. Preemptive administration of nalbuphine, butorphanol and morphine produce similar postoperative analgesia with great possibility of analgesic rescue in the first 6 hours, therefore, over this period, regular and interactive evaluations should be performed to ensure adequate analgesia in bitches submitted to ovariohysterectomy.Os opioides s?o utilizados no manejo da dor perioperat?ria, formando a base do plano analg?sico balanceado. O objetivo deste estudo foi comparar a efic?cia analg?sica da nalbufina, butorfanol e morfina no p?s-operat?rio imediato, em cadelas submetidas a ovariohisterectomia eletiva. Quarenta e oito cadelas h?gidas de diferentes ra?as foram distribu?das de forma aleat?ria em quatro tratamentos: nalbufina 0,5 mg kg-1(N0.5) e 1,0 mg kg-1 (N1.0), butorfanol 0,4 mg kg-1(B0.4) ou morfina 0,2 mg kg-1(M0.2) associados ? acepromazina 0,02 mg kg-1 , por via intravenosa (IV). A anestesia foi induzida com propofol e mantida com isofluorano. A Escala Anal?gica Visual Din?mica e Interativa (DIVAS, 0?100 mm), fases I (DIVAS I), II (DIVAS II) e III (DIVAS III), e a Escala de Dor Composta de Glasgow Modificada (GCMPS, 0?10) foram utilizadas para avaliar a dor antes da administra??o dos f?rmacos (BL), 1, 2, 3, 4, 5 e 6 horas ap?s a extuba??o. O resgateanalg?sico (0,2 mg kg-1 IV de morfina combinada a 0,2 mg kg-1 IV de meloxicam) foi administrado se o c?o apresentasse DIVAS > 70 mm ou GCMPS > 3,5. B0.4 apresentou maior escore em DIVAS II comparado ao N1.0, nas horas 2 (p = 0,038) e 3 (p = 0,002), e ao N0.5, na hora 3 (p = 0,003). N?o houve diferen?a em DIVAS I, III e GCMPS entre os tratamentos. Trinta e quatro cadelas necessitaram de resgate analg?sico. N?o houve diferen?a entre os grupos em rela??o a n?mero de resgates analg?sicos (p = 0,813) e a dose total de morfina administrada como resgate (p = 0,763). A administra??o preemptiva de nalbufina, butorfanol e morfina promove similar analgesia p?s-operat?ria com grande possibilidade de resgate analg?sico nas 6 primeiras horas, dessa forma, nesse per?odo devem ser realizadas avalia??es regulares e interativas para garantir analgesia adequada ?s cadelas submetidas a ovariohisterectomia.Submitted by Leticia Schettini (leticia@ufrrj.br) on 2021-09-01T18:51:54Z No. of bitstreams: 1 2018 - Viviane Horta Gomes (6).pdf: 835054 bytes, checksum: 73187d3b1797750f7f4e5e4321b23dd5 (MD5)Made available in DSpace on 2021-09-01T18:51:55Z (GMT). No. of bitstreams: 1 2018 - Viviane Horta Gomes (6).pdf: 835054 bytes, checksum: 73187d3b1797750f7f4e5e4321b23dd5 (MD5) Previous issue date: 2018-08-21application/pdfhttps://tede.ufrrj.br/retrieve/66581/2018%20-%20Viviane%20Horta%20Gomes%20%286%29.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)UFRRJBrasilInstituto de Veterin?riaAUBRUN, F.; SALVI, N.; CORIAT, P.; RIOU, B. Sex- and age-related differences in morphine requirements for postoperative pain relief. Anesthesiology, v. 103, p. 156?160, 2005. ANIL, S.; ANIL, L.; DEEN, J. Challenges of pain assessment in domestic animals. Journal of the American Veterinary Medical Association, v. 220, p. 313?319, 2002. BERRY, S. H. Analgesia in the Perioperative Period. Veterinary Clinics of North America: Small Animal Practice, v. 45, p. 1013?1027, 2015. BONNET, F.; MARRET, E. Influence of anaesthetic and analgesic techniques on outcome after surgery. 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dc.title.por.fl_str_mv Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva
dc.title.alternative.eng.fl_str_mv Nalbuphine, butorphanol and morphine for the control of early postoperative pain in canine elective ovariohysterectomy
title Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva
spellingShingle Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva
Gomes, Viviane Horta
Analgesia
Agonista-antagonista
C?o
Escala de dor
Opioide
Analgesia
Agonist-antagonist
Dog
Opioid
Pain scale
Medicina Veterin?ria
title_short Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva
title_full Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva
title_fullStr Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva
title_full_unstemmed Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva
title_sort Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva
author Gomes, Viviane Horta
author_facet Gomes, Viviane Horta
author_role author
dc.contributor.advisor1.fl_str_mv Silva, Marta Fernanda Albuquerque da
dc.contributor.advisor1ID.fl_str_mv 0544591266946007
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/0544591266946007
dc.contributor.referee1.fl_str_mv Paiva, Jonimar Pereira
dc.contributor.referee1ID.fl_str_mv 0555358847663175
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/0555358847663175
dc.contributor.referee2.fl_str_mv Abreu, Mariana Boechat de
dc.contributor.referee2ID.fl_str_mv 0171700191037164
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/0171700191037164
dc.contributor.referee3.fl_str_mv Moreno, Juan Carlos Duque
dc.contributor.referee3ID.fl_str_mv 8509640024284103
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/8509640024284103
dc.contributor.referee4.fl_str_mv Santos, Paulo Sergio Patto dos
dc.contributor.referee4ID.fl_str_mv 5331938962896664
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/5331938962896664
dc.contributor.authorID.fl_str_mv 8842502819385308
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/8842502819385308
dc.contributor.author.fl_str_mv Gomes, Viviane Horta
contributor_str_mv Silva, Marta Fernanda Albuquerque da
Paiva, Jonimar Pereira
Abreu, Mariana Boechat de
Moreno, Juan Carlos Duque
Santos, Paulo Sergio Patto dos
dc.subject.por.fl_str_mv Analgesia
Agonista-antagonista
C?o
Escala de dor
Opioide
topic Analgesia
Agonista-antagonista
C?o
Escala de dor
Opioide
Analgesia
Agonist-antagonist
Dog
Opioid
Pain scale
Medicina Veterin?ria
dc.subject.eng.fl_str_mv Analgesia
Agonist-antagonist
Dog
Opioid
Pain scale
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description The management of perioperative pain can be performed by opioids, drugs that form the base of a balanced analgesic plane. The aim of this study was to compare the analgesic efficacy of nalbuphine, butorphanol and morphine in the early postoperative analgesia, in bitches submitted to ovariohysterectomy. Forty-eight healthy bitches of different breeds were randomly assigned to four treatments: nalbuphine 0,5 mg kg-1 (N0.5) and 1,0 mg kg-1(N1.0), butorphanol 0,4 mg kg-1(B0.4) or morphine 0,2 mg kg-1 (M0.2), combined with acepromazine 0,02 mg kg-1intravenously. Anesthesia was induced with propofol and maintained with isoflurane. Dynamic Interactive Visual Analog Scale (DIVAS, 0?100 mm), phases I (DIVAS I), II (DIVAS II) and III (DIVAS III), and the Modified Glasgow Composite Measure Pain Scale (GCMPS, 0?10) were used to used to assess pain prior administration of the drugs (BL), 1, 2, 3, 4, 5 and 6 hours after extubation. The analgesic rescue (0,2 mg kg1IV of morphine combined with 0,2 mg kg-1IV of meloxicam) was given if the dog had DIVAS > 70 mm or GCMPS > 3,5. B0.4 had a higher DIVAS II score compared with N1.0, at 2 (p = 0,038) and 3 hours (p = 0,002), and with N0.5 at 3 hours (p = 0,003). There was no difference in DIVAS I, III and GCMPS scores between treatments. Rescue analgesia was required in thirty-four bitches. The number of analgesic rescues (p = 0,813) and total dose of morphine given as rescue (p = 0,763) were not different between groups. Preemptive administration of nalbuphine, butorphanol and morphine produce similar postoperative analgesia with great possibility of analgesic rescue in the first 6 hours, therefore, over this period, regular and interactive evaluations should be performed to ensure adequate analgesia in bitches submitted to ovariohysterectomy.
publishDate 2018
dc.date.issued.fl_str_mv 2018-08-21
dc.date.accessioned.fl_str_mv 2021-09-01T18:51:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Viviane Horta. Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva. 2018. 51 f. Tese (Mestrado em Medicina Veterin?ria) - Instituto de Veterin?ria, Departamento de Medicina e Cirurgia Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2018.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/5002
identifier_str_mv GOMES, Viviane Horta. Nalbufina, butorfanol e morfina no controle da dor p?s-operat?ria imediata em cadelas submetidas a ovariohisterectomia eletiva. 2018. 51 f. Tese (Mestrado em Medicina Veterin?ria) - Instituto de Veterin?ria, Departamento de Medicina e Cirurgia Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2018.
url https://tede.ufrrj.br/jspui/handle/jspui/5002
dc.language.iso.fl_str_mv por
language por
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