Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2
Ano de defesa: | 2013 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal Rural do Rio de Janeiro
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Programa de Pós-Graduação: |
Programa de P?s-Gradua??o em Qu?mica
|
Departamento: |
Instituto de Ci?ncias Exatas
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País: |
Brasil
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Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | https://tede.ufrrj.br/jspui/handle/jspui/3173 |
Resumo: | This work describes the isolation and structural determination of special metabolites isolated from of the wood of Simira grazielae species (Rubiaceae). This is the first phytochemical study of a specimen of S. grazielae. The material for study was collected in the Reserva Florestal do Vale do Rio Doce, Linhares- ES. The compounds described in this phytochemistry investigation were isolated by solvents partition with n-hexane (C6H14), dichloromethane (CH2Cl2) and ethyl acetate (EtAcO) and classical chromatographyc techniques of the extracts obtained by maceration at room temperature with methanol. Chromatographic fractionation and analysis of the fractions led to the isolation and identification of 18 substances and 1 derivative. Among the special metabolites are isolated: a mixture of hydrocarbons; a mixture of unsaturated hydrocarbons, a mixture of B-stosterol and stigmasterol, 3-O-B-D-glucopyranosyl sitosterol; the phenolic compound 3,4,5-trimetoxifenol and -6'-O-vaniloiltachioside; the aldeide syringaldehyde; the lignan syringaresinol; the coumarins isofraxidine (7-hydroxy-6,8-dimethoxycoumarin), escopoletina (7-hydroxy-6-B-methoxycoumarin), umbelliferone (7-hydroxycoumarin), trimethoxycoumarin and dimethoxycoumarin and the alkaloids B?carboline harman (1-methyl-9H-pyrido[3,4-B]indole, chemotaxonomic character of the genus), ofiorine alkaloids and N-acetyl serotonin . The structural determination was based on the 1H and 13C NMR (1D and 2C) and ESI-HRMS and GC-MS analysis. The MeOH extract and fractions obtained by partition with organic solvents were submitted to evaluation of antioxidant activity with DPPH and potential antinociceptive, revealing expressive activities. |
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Braz Filho, Raimundo070.100.018-04Carvalho, M?rio Geraldo de257.152.327-91Braz Filho, RaimundoCarvalho, M?rio Geraldo deLeit?o, Gilda Guimar?esOliveira, M?rcia Cristina Campos deMathias, Leda124.157.347-64http://lattes.cnpq.br/9237258375836358Sanches, Mirza Nalesso Gomes2019-12-16T18:06:38Z2013-10-04SANCHES, Mirza Nalesso Gomes. Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2. 2013. 67 f e 95 f. Disserta??o (Mestrado em Qu?mica) - Instituto de Ci?ncias Exatas, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2013.https://tede.ufrrj.br/jspui/handle/jspui/3173This work describes the isolation and structural determination of special metabolites isolated from of the wood of Simira grazielae species (Rubiaceae). This is the first phytochemical study of a specimen of S. grazielae. The material for study was collected in the Reserva Florestal do Vale do Rio Doce, Linhares- ES. The compounds described in this phytochemistry investigation were isolated by solvents partition with n-hexane (C6H14), dichloromethane (CH2Cl2) and ethyl acetate (EtAcO) and classical chromatographyc techniques of the extracts obtained by maceration at room temperature with methanol. Chromatographic fractionation and analysis of the fractions led to the isolation and identification of 18 substances and 1 derivative. Among the special metabolites are isolated: a mixture of hydrocarbons; a mixture of unsaturated hydrocarbons, a mixture of B-stosterol and stigmasterol, 3-O-B-D-glucopyranosyl sitosterol; the phenolic compound 3,4,5-trimetoxifenol and -6'-O-vaniloiltachioside; the aldeide syringaldehyde; the lignan syringaresinol; the coumarins isofraxidine (7-hydroxy-6,8-dimethoxycoumarin), escopoletina (7-hydroxy-6-B-methoxycoumarin), umbelliferone (7-hydroxycoumarin), trimethoxycoumarin and dimethoxycoumarin and the alkaloids B?carboline harman (1-methyl-9H-pyrido[3,4-B]indole, chemotaxonomic character of the genus), ofiorine alkaloids and N-acetyl serotonin . The structural determination was based on the 1H and 13C NMR (1D and 2C) and ESI-HRMS and GC-MS analysis. The MeOH extract and fractions obtained by partition with organic solvents were submitted to evaluation of antioxidant activity with DPPH and potential antinociceptive, revealing expressive activities.Este trabalho descreve o isolamento e a determina??o estrutural de metab?litos especiais de Simira grazielae, fam?lia Rubiaceae. Este ? o primeiro estudo fitoqu?mico dessa esp?cie. O material para o estudo foi coletado na Reserva Florestal do Vale do Rio Doce, Linhares- ES. As subst?ncias descritas nesta investiga??o fitoqu?mica foram isoladas atrav?s de parti??o com solventes org?nicos n-hexano (C6H14), diclorometano (CH2Cl2) e acetato de etila (AcOEt) e t?cnicas cromatogr?ficas cl?ssicas do extrato metanol (MeOH) obtido atrav?s de macera??o a frio. O fracionamento cromatogr?fico e an?lise das fra??es conduziram ao isolamento e identifica??o de 18 subst?ncias e 1 derivado. Dentre os metab?litos especiais foram isoladas uma mistura de hidrocarbonetos, mistura de hidrocarboneto insaturado, mistura dos esteroides B-sitosterol e estigmasterol, 3-O-B-D-glicopiranosilsitosterol; o alde?do siringalde?do; o composto fen?lico 3,4,5-trimetoxifenol e 6?-O-vaniloiltachioside; a lignana siringaresinol; as cumarinas isofraxidina (7-hidroxi-6,8-dimetoxicumarina), escopoletina (7-hidroxi-6-metoxicumarina), 7-hidroxi-8-metoxicumarina, umbeliferona (7-hidroxicumarina), trimetoxcumarina, 5,7-dimetoxcumarina; o alcaloide B-carbol?nico harmana (1-metil-9H-pirido[3,4-B-]indol), marcador quimiotaxon?mico do g?nero, os alcaloides ofiorina e N-acetil-serotonina. Na determina??o estrutural foram utilizadas t?cnicas de RMN1H e RMN13C (1D e 2D), ESI-HRMS e CG-EM. O extrato MeOH e as fra??es obtidas por parti??es com solventes org?nicos foram submetidas ? avalia??o de atividade antioxidante com DPPH e potencial antinociceptiva, verificando-se elevadas atividades.Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2019-12-16T18:06:37Z No. of bitstreams: 2 2013 - Mirza Nalesso Gomes Sanches - Vol 1.pdf: 1961484 bytes, checksum: 86365b0d8288d86991f997bc5c40c0a8 (MD5) 2013 - Mirza Nalesso Gomes Sanches - Vol 2.pdf: 4616228 bytes, checksum: d45186be41c295224632a28ddc49cd4a (MD5)Made available in DSpace on 2019-12-16T18:06:38Z (GMT). No. of bitstreams: 2 2013 - Mirza Nalesso Gomes Sanches - Vol 1.pdf: 1961484 bytes, checksum: 86365b0d8288d86991f997bc5c40c0a8 (MD5) 2013 - Mirza Nalesso Gomes Sanches - Vol 2.pdf: 4616228 bytes, checksum: d45186be41c295224632a28ddc49cd4a (MD5) Previous issue date: 2013-10-04CAPES - Coordena??o de Aperfei?oamento de Pessoal de N?vel SuperiorCNPq - Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gicoFAPERJ - Funda??o Carlos Chagas Filho de Amparo ? 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dc.title.por.fl_str_mv |
Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2 |
dc.title.alternative.eng.fl_str_mv |
Study of Simira grazielae (Rubiaceae), and biological activities.- Volumes 1 and 2 |
title |
Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2 |
spellingShingle |
Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2 Sanches, Mirza Nalesso Gomes Simira grazielae Rubiaceae alcaloides lignana cumarinas dados espectrais alkaloids lignan coumarin spectral data Qu?mica |
title_short |
Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2 |
title_full |
Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2 |
title_fullStr |
Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2 |
title_full_unstemmed |
Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2 |
title_sort |
Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2 |
author |
Sanches, Mirza Nalesso Gomes |
author_facet |
Sanches, Mirza Nalesso Gomes |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Braz Filho, Raimundo |
dc.contributor.advisor1ID.fl_str_mv |
070.100.018-04 |
dc.contributor.advisor-co1.fl_str_mv |
Carvalho, M?rio Geraldo de |
dc.contributor.advisor-co1ID.fl_str_mv |
257.152.327-91 |
dc.contributor.referee1.fl_str_mv |
Braz Filho, Raimundo |
dc.contributor.referee2.fl_str_mv |
Carvalho, M?rio Geraldo de |
dc.contributor.referee3.fl_str_mv |
Leit?o, Gilda Guimar?es |
dc.contributor.referee4.fl_str_mv |
Oliveira, M?rcia Cristina Campos de |
dc.contributor.referee5.fl_str_mv |
Mathias, Leda |
dc.contributor.authorID.fl_str_mv |
124.157.347-64 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9237258375836358 |
dc.contributor.author.fl_str_mv |
Sanches, Mirza Nalesso Gomes |
contributor_str_mv |
Braz Filho, Raimundo Carvalho, M?rio Geraldo de Braz Filho, Raimundo Carvalho, M?rio Geraldo de Leit?o, Gilda Guimar?es Oliveira, M?rcia Cristina Campos de Mathias, Leda |
dc.subject.por.fl_str_mv |
Simira grazielae Rubiaceae alcaloides lignana cumarinas dados espectrais |
topic |
Simira grazielae Rubiaceae alcaloides lignana cumarinas dados espectrais alkaloids lignan coumarin spectral data Qu?mica |
dc.subject.eng.fl_str_mv |
alkaloids lignan coumarin spectral data |
dc.subject.cnpq.fl_str_mv |
Qu?mica |
description |
This work describes the isolation and structural determination of special metabolites isolated from of the wood of Simira grazielae species (Rubiaceae). This is the first phytochemical study of a specimen of S. grazielae. The material for study was collected in the Reserva Florestal do Vale do Rio Doce, Linhares- ES. The compounds described in this phytochemistry investigation were isolated by solvents partition with n-hexane (C6H14), dichloromethane (CH2Cl2) and ethyl acetate (EtAcO) and classical chromatographyc techniques of the extracts obtained by maceration at room temperature with methanol. Chromatographic fractionation and analysis of the fractions led to the isolation and identification of 18 substances and 1 derivative. Among the special metabolites are isolated: a mixture of hydrocarbons; a mixture of unsaturated hydrocarbons, a mixture of B-stosterol and stigmasterol, 3-O-B-D-glucopyranosyl sitosterol; the phenolic compound 3,4,5-trimetoxifenol and -6'-O-vaniloiltachioside; the aldeide syringaldehyde; the lignan syringaresinol; the coumarins isofraxidine (7-hydroxy-6,8-dimethoxycoumarin), escopoletina (7-hydroxy-6-B-methoxycoumarin), umbelliferone (7-hydroxycoumarin), trimethoxycoumarin and dimethoxycoumarin and the alkaloids B?carboline harman (1-methyl-9H-pyrido[3,4-B]indole, chemotaxonomic character of the genus), ofiorine alkaloids and N-acetyl serotonin . The structural determination was based on the 1H and 13C NMR (1D and 2C) and ESI-HRMS and GC-MS analysis. The MeOH extract and fractions obtained by partition with organic solvents were submitted to evaluation of antioxidant activity with DPPH and potential antinociceptive, revealing expressive activities. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-10-04 |
dc.date.accessioned.fl_str_mv |
2019-12-16T18:06:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANCHES, Mirza Nalesso Gomes. Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2. 2013. 67 f e 95 f. Disserta??o (Mestrado em Qu?mica) - Instituto de Ci?ncias Exatas, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2013. |
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https://tede.ufrrj.br/jspui/handle/jspui/3173 |
identifier_str_mv |
SANCHES, Mirza Nalesso Gomes. Metab?litos especiais Isolados da madeira de Simira grazielae (Rubiaceae) e atividades biol?gicas - Volumes 1 e 2. 2013. 67 f e 95 f. Disserta??o (Mestrado em Qu?mica) - Instituto de Ci?ncias Exatas, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2013. |
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Universidade Federal Rural do Rio de Janeiro |
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UFRRJ |
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Instituto de Ci?ncias Exatas |
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Universidade Federal Rural do Rio de Janeiro |
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