Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es

d'Avila, Mariana Sequeira

Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es

Detalhes bibliográficos
Ano de defesa:	2015
Autor(a) principal:	d'Avila, Mariana Sequeira
Orientador(a):	Carvalho, Vivian de Assun??o Nogueira
Banca de defesa:	Carvalho, Vivian de Assun??o Nogueira , Peixoto, Tiago da Cunha , Nascimento, Aparecida Alves do
Tipo de documento:	Dissertação
Tipo de acesso:	Acesso aberto
Idioma:	por
Instituição de defesa:	Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação:	Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)
Departamento:	Instituto de Veterin?ria
País:	Brasil
Palavras-chave em Português:	Canino Troponina S?ndrome cardiorrenal
Palavras-chave em Inglês:	Canine Troponin Cardiorenal syndrome
Área do conhecimento CNPq:	Medicina Veterin?ria
Link de acesso:	https://tede.ufrrj.br/jspui/handle/jspui/5404
Resumo:	Acute or chronic abnormalities in cardiac function can lead to lesions in kidneys or heart and cause the Cardiorenal syndrome. This study had the objective to (1) to verify, based on morphology, the correlation between Chronic Kidney Disease (CKD) and cardiovascular injury, as well as to reveal the extent of the lesion in dogs; because initial regressive changes often cannot be discerned with hematoxylin and eosin staining (H&E) alone, and (2) to verify the reliability of immunohistochemistry with anti-cTnC human antibody, to detect heart lesions in dogs with renal failure. Cardiac fragments from 22 dogs were submitted to immunohistochemistry, which revealed reduction of cTnC levels in the cytoplasm of cardiomyocytes. This decrease in immunoreactivity occurred usually on the same myocytes with specifics changes in H&E stain, ranging from mild cell swelling to increased eosinophilia, loss of striation, cell lysis and karyolysis that sometimes was accompanied by a inflammatory infiltrate. In 10 cardiac fragments vascular injury was observed, ranging from mild swelling to necrosis of endothelial cells, with deposition of eosinophilic material (staining positively for collagen in Masson?s trichrome) in the vessel wall and mineralization. Grossly, there were left ventricular hypertrophy and extra-renal lesions of uremia, including glossitis and ulcerative stomatitis, uremic pneumo and gastropathy, and intercostal mineralization. The evaluated kidneys had lesions of differtnmet intensity, irregular surface, fibrosis and altered cortico-medullary relationship, hyalinization and glomerular sclerosis, marked tubular cell necrosis and mineralization, mononuclear infiltration, and interstitial fibrosis. In this study, the cardiac vascular lesions were correlated with changes resulting from long term uremia and/or combination of metabolic and cellular changes of the Cardiorenal syndrome type 4, wherein the chronic kidney impairment can induce chronic lesions in the heart

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spelling	Carvalho, Vivian de Assun??o Nogueira089.375.877-93https://orcid.org/0000-0002-4034-9675http://lattes.cnpq.br/6012855368365110Fran?a, Ticiana do Nascimento027.897.197-05https://orcid.org/0000-0002-7365-2697http://lattes.cnpq.br/3545873525091315Carvalho, Vivian de Assun??o Nogueira089.375.877-93https://orcid.org/0000-0002-4034-9675http://lattes.cnpq.br/6012855368365110Peixoto, Tiago da Cunhahttp://lattes.cnpq.br/2092167505993680Nascimento, Aparecida Alves dohttp://lattes.cnpq.br/9303894913891155139.802.847-94https://orcid.org/0000-0003-0308-0758http://lattes.cnpq.br/1296726599206006d'Avila, Mariana Sequeira2022-02-18T13:17:01Z2015-03-13D'AVILA, Mariana Sequeira. Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es. 2015. 101 f. Disserta??o (Mestrado em Medicina Veterin?ria) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica,2015.https://tede.ufrrj.br/jspui/handle/jspui/5404Acute or chronic abnormalities in cardiac function can lead to lesions in kidneys or heart and cause the Cardiorenal syndrome. This study had the objective to (1) to verify, based on morphology, the correlation between Chronic Kidney Disease (CKD) and cardiovascular injury, as well as to reveal the extent of the lesion in dogs; because initial regressive changes often cannot be discerned with hematoxylin and eosin staining (H&E) alone, and (2) to verify the reliability of immunohistochemistry with anti-cTnC human antibody, to detect heart lesions in dogs with renal failure. Cardiac fragments from 22 dogs were submitted to immunohistochemistry, which revealed reduction of cTnC levels in the cytoplasm of cardiomyocytes. This decrease in immunoreactivity occurred usually on the same myocytes with specifics changes in H&E stain, ranging from mild cell swelling to increased eosinophilia, loss of striation, cell lysis and karyolysis that sometimes was accompanied by a inflammatory infiltrate. In 10 cardiac fragments vascular injury was observed, ranging from mild swelling to necrosis of endothelial cells, with deposition of eosinophilic material (staining positively for collagen in Masson?s trichrome) in the vessel wall and mineralization. Grossly, there were left ventricular hypertrophy and extra-renal lesions of uremia, including glossitis and ulcerative stomatitis, uremic pneumo and gastropathy, and intercostal mineralization. The evaluated kidneys had lesions of differtnmet intensity, irregular surface, fibrosis and altered cortico-medullary relationship, hyalinization and glomerular sclerosis, marked tubular cell necrosis and mineralization, mononuclear infiltration, and interstitial fibrosis. In this study, the cardiac vascular lesions were correlated with changes resulting from long term uremia and/or combination of metabolic and cellular changes of the Cardiorenal syndrome type 4, wherein the chronic kidney impairment can induce chronic lesions in the heartLes?es card?acas agudas ou cr?nicas podem resultar em perturba??es na fun??o renal e vice versa, fen?meno conhecido como S?ndrome Cardiorrenal. Este trabalho teve como objetivos verificar, com base na morfologia, as correla??es entre Doen?a Renal Cr?nica (DRC) e les?es cardiovasculares, avaliar a real extens?o dessas les?es em c?es, visto que altera??es mioc?rdicas regressivas incipientes podem n?o ser percept?veis ou facilmente identificadas atrav?s da colora??o rotineira pela hematoxilina e eosina, bem como verificar a efic?cia do teste imunohistoqu?mico com o uso do anticorpo antitroponina C humano na detec??o de les?es card?acas em c?es com insufici?ncia renal. Pela avalia??o imunohistoqu?mica do cora??o dos 22 caninos, observaram-se diversos grupos de mi?citos com redu??o significativa ou aus?ncia de imunorreatividade para o anticorpo anti-troponina C, essas ?reas, via de regra, correspondiam aos mesmos grupos de mi?citos que, pela colora??o de H.E. apresentavam altera??es que variavam de leve tumefa??o celular a aumento da eosinofilia, perda de estria??o, lise celular e cari?lise, por vezes, acompanhadas de infiltrado inflamat?rio predominantemente mononuclear. Adicionalmente, havia, no cora??o de 10 c?es, les?o vascular, que variou de leve tumefa??o das c?lulas endoteliais a necrose, com deposi??o de material eosinof?lico (marca??o positiva para col?geno pela colora??o Tricr?mico de Masson), na parede vascular e mineraliza??o. Macroscopicamente, observaram-se hipertrofia ventricular esquerda e les?es extra-renais da uremia, incluindo glossite e estomatite ulcerativas, pneumopatia e gastropatia ur?mica, al?m de mineraliza??o do espa?o intercostal. Macroscopicamente os rins avaliados apresentaram atrofia, superf?cie irregular, fibrose e altera??o na rela??o c?rtico-medular e na microscopia hialiniza??o e esclerose glomerular, necrose marcada nas c?lulas tubulares, mineraliza??o de algumas estruturas, inflama??o (predominantemente mononuclear) e fibrose intersticial. Neste estudo, as les?es mioc?rdicas foram estreitamente correlacionadas ?s altera??es vasculares, resultantes da uremia de longa dura??o e/ou da combina??o de altera??es metab?licas e celulares que ocorrem na S?ndrome Cardiorrenal tipo 4, na qual o comprometimento cr?nico do rim pode induzir les?es cr?nicas no cora??o.Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2022-02-18T13:17:01Z No. of bitstreams: 1 2015 - Mariana Sequeira d'Avila.pdf: 11423397 bytes, checksum: 3d616f493b6d265189352ebbb4638b82 (MD5)Made available in DSpace on 2022-02-18T13:17:01Z (GMT). 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dc.title.por.fl_str_mv	Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es
dc.title.alternative.eng.fl_str_mv	Morphological and immunohistochemical studies (Troponin C) to detect cardiac lesions secondary to chronic kidney disease in dogs
title	Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es
spellingShingle	Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es d'Avila, Mariana Sequeira Canino Troponina S?ndrome cardiorrenal Canine Troponin Cardiorenal syndrome Medicina Veterin?ria
title_short	Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es
title_full	Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es
title_fullStr	Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es
title_full_unstemmed	Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es
title_sort	Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es
author	d'Avila, Mariana Sequeira
author_facet	d'Avila, Mariana Sequeira
author_role	author
dc.contributor.advisor1.fl_str_mv	Carvalho, Vivian de Assun??o Nogueira
dc.contributor.advisor1ID.fl_str_mv	089.375.877-93 https://orcid.org/0000-0002-4034-9675
dc.contributor.advisor1Lattes.fl_str_mv	http://lattes.cnpq.br/6012855368365110
dc.contributor.advisor-co1.fl_str_mv	Fran?a, Ticiana do Nascimento
dc.contributor.advisor-co1ID.fl_str_mv	027.897.197-05 https://orcid.org/0000-0002-7365-2697
dc.contributor.advisor-co1Lattes.fl_str_mv	http://lattes.cnpq.br/3545873525091315
dc.contributor.referee1.fl_str_mv	Carvalho, Vivian de Assun??o Nogueira
dc.contributor.referee1ID.fl_str_mv	089.375.877-93 https://orcid.org/0000-0002-4034-9675
dc.contributor.referee1Lattes.fl_str_mv	http://lattes.cnpq.br/6012855368365110
dc.contributor.referee2.fl_str_mv	Peixoto, Tiago da Cunha
dc.contributor.referee2Lattes.fl_str_mv	http://lattes.cnpq.br/2092167505993680
dc.contributor.referee3.fl_str_mv	Nascimento, Aparecida Alves do
dc.contributor.referee3Lattes.fl_str_mv	http://lattes.cnpq.br/9303894913891155
dc.contributor.authorID.fl_str_mv	139.802.847-94 https://orcid.org/0000-0003-0308-0758
dc.contributor.authorLattes.fl_str_mv	http://lattes.cnpq.br/1296726599206006
dc.contributor.author.fl_str_mv	d'Avila, Mariana Sequeira
contributor_str_mv	Carvalho, Vivian de Assun??o Nogueira Fran?a, Ticiana do Nascimento Carvalho, Vivian de Assun??o Nogueira Peixoto, Tiago da Cunha Nascimento, Aparecida Alves do
dc.subject.por.fl_str_mv	Canino Troponina S?ndrome cardiorrenal
topic	Canino Troponina S?ndrome cardiorrenal Canine Troponin Cardiorenal syndrome Medicina Veterin?ria
dc.subject.eng.fl_str_mv	Canine Troponin Cardiorenal syndrome
dc.subject.cnpq.fl_str_mv	Medicina Veterin?ria
description	Acute or chronic abnormalities in cardiac function can lead to lesions in kidneys or heart and cause the Cardiorenal syndrome. This study had the objective to (1) to verify, based on morphology, the correlation between Chronic Kidney Disease (CKD) and cardiovascular injury, as well as to reveal the extent of the lesion in dogs; because initial regressive changes often cannot be discerned with hematoxylin and eosin staining (H&E) alone, and (2) to verify the reliability of immunohistochemistry with anti-cTnC human antibody, to detect heart lesions in dogs with renal failure. Cardiac fragments from 22 dogs were submitted to immunohistochemistry, which revealed reduction of cTnC levels in the cytoplasm of cardiomyocytes. This decrease in immunoreactivity occurred usually on the same myocytes with specifics changes in H&E stain, ranging from mild cell swelling to increased eosinophilia, loss of striation, cell lysis and karyolysis that sometimes was accompanied by a inflammatory infiltrate. In 10 cardiac fragments vascular injury was observed, ranging from mild swelling to necrosis of endothelial cells, with deposition of eosinophilic material (staining positively for collagen in Masson?s trichrome) in the vessel wall and mineralization. Grossly, there were left ventricular hypertrophy and extra-renal lesions of uremia, including glossitis and ulcerative stomatitis, uremic pneumo and gastropathy, and intercostal mineralization. The evaluated kidneys had lesions of differtnmet intensity, irregular surface, fibrosis and altered cortico-medullary relationship, hyalinization and glomerular sclerosis, marked tubular cell necrosis and mineralization, mononuclear infiltration, and interstitial fibrosis. In this study, the cardiac vascular lesions were correlated with changes resulting from long term uremia and/or combination of metabolic and cellular changes of the Cardiorenal syndrome type 4, wherein the chronic kidney impairment can induce chronic lesions in the heart
publishDate	2015
dc.date.issued.fl_str_mv	2015-03-13
dc.date.accessioned.fl_str_mv	2022-02-18T13:17:01Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/masterThesis
format	masterThesis
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	D'AVILA, Mariana Sequeira. Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es. 2015. 101 f. Disserta??o (Mestrado em Medicina Veterin?ria) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica,2015.
dc.identifier.uri.fl_str_mv	https://tede.ufrrj.br/jspui/handle/jspui/5404
identifier_str_mv	D'AVILA, Mariana Sequeira. Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es. 2015. 101 f. Disserta??o (Mestrado em Medicina Veterin?ria) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica,2015.
url	https://tede.ufrrj.br/jspui/handle/jspui/5404
dc.language.iso.fl_str_mv	por
language	por
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A comparative study on the immunohistochemical detection of early myocardial damage. International Journal of Legal Medicine, v. 113, p. 215?220
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Estudo morfol?gico e imunohistoqu?mico (Troponina C) na detec??o de les?es card?acas secund?rias ? doen?a renal cr?nica em c?es

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