S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina

Detalhes bibliográficos
Ano de defesa: 2013
Autor(a) principal: Santos, Sabrina Neves lattes
Orientador(a): K?mmerle, Arthur Eugen
Banca de defesa: K?mmerle, Arthur Eugen, Lima, Marco Edilson Freire de, Lacerda, Renata Barbosa
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Qu?mica
Departamento: Instituto de Ci?ncias Exatas
País: Brasil
Palavras-chave em Português:
Doen?a de Alzheimer
piperina
atividade anticolinester?sica
Palavras-chave em Inglês:
Alzheimer's disease
piperine
anticholinesterase activity
Área do conhecimento CNPq:
Qu?mica
Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/3398
Resumo: The increase in life expectancy is a worldwide occurrence that shows the relative success of public health politics, But the increase in life expectancy has a negative effect: the appearance of degenerative diseases typical of old age, including several forms of dementia, like Alzheimer?s Disease (AD) that is certainly the most important. It is an irreversible and progressive disease characterized by neuronal deterioration. As a result this neuronal deterioration, the activity of cholinergic neurons that use the neurotransmitter acetylcholine (ACh) is reduced. One of the most promising approaches to treat this disease is to increase the level of acetylcholine in the brain using inhibitors of acetylcholinesterase (AChE). Therefore, this work aims to conduct structural modifications on the chemical structure of piperine and evaluate the influence of certain structural parameters, such as conformational flexibility and steric front of acetylcholinesterase activity (AChE and BChE) of these compounds, as well as make a kinetic study in order to discover what the profile of inhibition of AChE and BChE enzymes in order to find new compounds that could be useful in treating the symptoms of AD.
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spelling K?mmerle, Arthur Eugen053.978.487-78Lima, Marco Ed?lson Freire de880.202.667-04K?mmerle, Arthur EugenLima, Marco Edilson Freire deLacerda, Renata Barbosa058.228.127-08http://lattes.cnpq.br/3184287763785869Santos, Sabrina Neves2020-03-13T18:45:50Z2013-07-17SANTOS, Sabrina Neves. S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina. 2013. 135 f. Disserta??o (Mestrado em Qu?mica Org?nica) - Instituto de Ci?ncias Exatas, Departamento de Qu?mica, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2013.https://tede.ufrrj.br/jspui/handle/jspui/3398The increase in life expectancy is a worldwide occurrence that shows the relative success of public health politics, But the increase in life expectancy has a negative effect: the appearance of degenerative diseases typical of old age, including several forms of dementia, like Alzheimer?s Disease (AD) that is certainly the most important. It is an irreversible and progressive disease characterized by neuronal deterioration. As a result this neuronal deterioration, the activity of cholinergic neurons that use the neurotransmitter acetylcholine (ACh) is reduced. One of the most promising approaches to treat this disease is to increase the level of acetylcholine in the brain using inhibitors of acetylcholinesterase (AChE). Therefore, this work aims to conduct structural modifications on the chemical structure of piperine and evaluate the influence of certain structural parameters, such as conformational flexibility and steric front of acetylcholinesterase activity (AChE and BChE) of these compounds, as well as make a kinetic study in order to discover what the profile of inhibition of AChE and BChE enzymes in order to find new compounds that could be useful in treating the symptoms of AD.O aumento da expectativa de vida ? um fen?meno mundial que mostra o relativo sucesso de pol?ticas de sa?de p?blica, no entanto, o aumento da expectativa de vida tem como efeito negativo o aparecimento de doen?as degenerativas, t?picas de idades mais avan?adas, incluindo-se as v?rias formas de dem?ncia e entre estas, a mais importante ? a Doen?a de Alzheimer (DA), patologia irrevers?vel e progressiva caracterizada pela deteriora??o neuronal. Como resultado da neurodegenara??o, a atividade de neur?nios colin?rgicos, que utilizam o neurotransmissor acetilcolina (ACh), ? reduzida. Um dos mais promissores caminhos para tratar esta doen?a ? aumentar o n?vel de acetilcolina no c?rebro usando inibidores da acetilcolinesterase (AChE). Portanto, este trabalho tem como objetivo realizar modifica??es estruturais sobre a estrutura qu?mica da piperina e avaliar a influ?ncia de determinados par?metros estruturais, como a flexibilidade conformacional e o impedimento est?rico frente ? atividade anticolinester?sica (AChE e BChE) destes compostos, bem como fazer um estudo cin?tico a fim de descobrir qual o perfil de inibi??o das enzimas AChE e BChE, a fim de buscar novos compostos que poderiam ser ?teis no tratamento dos sintomas da DA.Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2020-03-13T18:45:50Z No. of bitstreams: 1 2013 - Sabrina Neves Santos.pdf: 4043550 bytes, checksum: 7c23cf3575011941dbe7a2492f6ee3f8 (MD5)Made available in DSpace on 2020-03-13T18:45:50Z (GMT). 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dc.title.por.fl_str_mv S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina
title S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina
spellingShingle S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina
Santos, Sabrina Neves
Doen?a de Alzheimer
piperina
atividade anticolinester?sica
Alzheimer's disease
piperine
anticholinesterase activity
Qu?mica
title_short S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina
title_full S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina
title_fullStr S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina
title_full_unstemmed S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina
title_sort S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina
author Santos, Sabrina Neves
author_facet Santos, Sabrina Neves
author_role author
dc.contributor.advisor1.fl_str_mv K?mmerle, Arthur Eugen
dc.contributor.advisor1ID.fl_str_mv 053.978.487-78
dc.contributor.advisor-co1.fl_str_mv Lima, Marco Ed?lson Freire de
dc.contributor.advisor-co1ID.fl_str_mv 880.202.667-04
dc.contributor.referee1.fl_str_mv K?mmerle, Arthur Eugen
dc.contributor.referee2.fl_str_mv Lima, Marco Edilson Freire de
dc.contributor.referee3.fl_str_mv Lacerda, Renata Barbosa
dc.contributor.authorID.fl_str_mv 058.228.127-08
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3184287763785869
dc.contributor.author.fl_str_mv Santos, Sabrina Neves
contributor_str_mv K?mmerle, Arthur Eugen
Lima, Marco Ed?lson Freire de
K?mmerle, Arthur Eugen
Lima, Marco Edilson Freire de
Lacerda, Renata Barbosa
dc.subject.por.fl_str_mv Doen?a de Alzheimer
piperina
atividade anticolinester?sica
topic Doen?a de Alzheimer
piperina
atividade anticolinester?sica
Alzheimer's disease
piperine
anticholinesterase activity
Qu?mica
dc.subject.eng.fl_str_mv Alzheimer's disease
piperine
anticholinesterase activity
dc.subject.cnpq.fl_str_mv Qu?mica
description The increase in life expectancy is a worldwide occurrence that shows the relative success of public health politics, But the increase in life expectancy has a negative effect: the appearance of degenerative diseases typical of old age, including several forms of dementia, like Alzheimer?s Disease (AD) that is certainly the most important. It is an irreversible and progressive disease characterized by neuronal deterioration. As a result this neuronal deterioration, the activity of cholinergic neurons that use the neurotransmitter acetylcholine (ACh) is reduced. One of the most promising approaches to treat this disease is to increase the level of acetylcholine in the brain using inhibitors of acetylcholinesterase (AChE). Therefore, this work aims to conduct structural modifications on the chemical structure of piperine and evaluate the influence of certain structural parameters, such as conformational flexibility and steric front of acetylcholinesterase activity (AChE and BChE) of these compounds, as well as make a kinetic study in order to discover what the profile of inhibition of AChE and BChE enzymes in order to find new compounds that could be useful in treating the symptoms of AD.
publishDate 2013
dc.date.issued.fl_str_mv 2013-07-17
dc.date.accessioned.fl_str_mv 2020-03-13T18:45:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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dc.identifier.citation.fl_str_mv SANTOS, Sabrina Neves. S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina. 2013. 135 f. Disserta??o (Mestrado em Qu?mica Org?nica) - Instituto de Ci?ncias Exatas, Departamento de Qu?mica, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2013.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/3398
identifier_str_mv SANTOS, Sabrina Neves. S?ntese e avalia??o da atividade anticolinester?sica de novos derivados da piperina. 2013. 135 f. Disserta??o (Mestrado em Qu?mica Org?nica) - Instituto de Ci?ncias Exatas, Departamento de Qu?mica, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2013.
url https://tede.ufrrj.br/jspui/handle/jspui/3398
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dc.publisher.department.fl_str_mv Instituto de Ci?ncias Exatas
publisher.none.fl_str_mv Universidade Federal Rural do Rio de Janeiro
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