Efeito gastropotetor do extrato etanólico da entrecasca da Caesalpina pyramidalis Tul. em ratos

• Ano de defesa: 2013
• Autor(a) principal: Ribeiro, Ana Roseli Silva
• Orientador(a): Thomazzi, Sara Maria
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Programa de Pós-Graduação: Pós-Graduação em Ciências Fisiológicas
• Palavras-chave em Português: Leguminosa; Plantas da caatinga; Caesalpina pyramidalis; Helicobacter pylori; Ulcera gastrica
• Palavras-chave em Inglês: Caatinga plants; Legumes
• Área do conhecimento CNPq: CNPQ::CIENCIAS BIOLOGICAS::FISIOLOGIA
• Link de acesso: https://ri.ufs.br/handle/riufs/3998

Caesalpinia pyramidalis Tul. (Fabaceae), known as catingueira , have been used in folk medicine for the treatment of various disorders such as gastritis, heartburn, indigestion, and stomach ache. However, the gastroprotective properties of this species have not yet been studied. The ethanol extract of C. pyramidalis inner bark was used in rats via oral, at the doses of 30, 100, and 300 mg/kg. The antiulcer assays were performed using the ethanol- and nonsteroidal anti-inflammatory drug-induced ulcer protocols. Gastric secretion parameters (volume, pH, and total acidity) were also evaluated by the pylorus ligated model, and the mucus in the gastric content was determined. The anti-Helicobacter pylori activity of the ethanol extract of Caesalpinia pyramidalis was performed using the agar-well diffusion and broth microdilution methods to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values. The ethanol extract (30, 100, and 300 mg/kg) produced dose dependent inhibition (p < 0.01) on the ulcer lesion index in the ethanol-induced ulcer model. The ethanol extract (30, 100, and 300 mg/kg) also reduced (p < 0.001) the ulcer index in the indomethacin-induced ulcer model. In the model ligature pylorus, the treatment with C. pyramidalis ethanol extract failed to significantly change the gastric secretion parameters. However, after treatment with the ethanol extract of C. pyramidalis (30, 100, and 300 mg/kg), there was a significant increase (p < 0.05) in mucus production. The ethanol extract of Caesalpinia pyramidalis had an anti-Helicobacter pylori activity with a MIC of 625 ìg/mL and a MBC of 10.000 ìg/mL. Collectively, the present results suggest that the ethanol extract of C. pyramidalis display gastroprotective actions, supporting the folkloric usage of the plant to treat various gastrointestinal disturbances.