Avaliação das alterações genéticas em crianças e adolescentes com leucemia linfoblástica aguda, em um hospital universitário do Sul do Brasil, no período de 2000 a 2018.
Ano de defesa: | 2023 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
Centro de Ciências da Saúde |
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências da Saúde
|
Departamento: |
Ciências da Saúde
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/29572 |
Resumo: | Acute lymphoblastic leukemia (ALL) is diagnosed cytomorphologically by immunophenotyping, cytogenetics and molecular biology. The classifications, together with the clinical data, stratify the groups at risk of relapse, for a more or less invasive therapeutic decision. Carrying out genetic tests in the diagnosis is fundamental to outline a better prognosis and a more appropriate treatment in each case. This was a retrospective and cross-sectional study, which evaluated the profile of patients diagnosed with ALL in childhood and adolescence, their genetic alterations, prognosis, relapse/death outcome and survival, whose treatment was by the GBTLI ALL-1999 and GBTLI ALL- 2009, at the University Hospital of Santa Maria, from July 2000 to November 2018. There were 215 diagnoses of ALL, with a mean age of 7.45 years, 54.9% male. Stratified by relapse risk groups, 35.8% of patients were at High Risk, 41.9% at Low Risk, 15.3% with T Lineage ALL, 4.2% with Ph+ chromosome and 2.8% Infants. All patients had their cytogenetic and molecular biology tests analyzed and stratified by the main markers. When comparing the data from the GBTLI-LLA 1999 and GBTLI-LLA 2009 protocols, similarity was observed in relapse rates of 17.6% and 17.6% and in death rates of 22% and 21%, respectively. In the last three decades, with the treatment by clinical protocol, there has been an advance in the cure, and the survival rates reach 70 to 80%, which was evidenced in this study, with an overall survival of 87.9% in one year , 83.5% in two years and 79.8% in five years of patients treated by the GBTLI LLA-1999 protocol and 85.5% in one year, 83.95 in two years and 81.4% in five years of patients treated by GBTLI LLA-2009, showing similar survival rates. |
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2023-06-28T15:05:07Z2023-06-28T15:05:07Z2023-03-27http://repositorio.ufsm.br/handle/1/29572Acute lymphoblastic leukemia (ALL) is diagnosed cytomorphologically by immunophenotyping, cytogenetics and molecular biology. The classifications, together with the clinical data, stratify the groups at risk of relapse, for a more or less invasive therapeutic decision. Carrying out genetic tests in the diagnosis is fundamental to outline a better prognosis and a more appropriate treatment in each case. This was a retrospective and cross-sectional study, which evaluated the profile of patients diagnosed with ALL in childhood and adolescence, their genetic alterations, prognosis, relapse/death outcome and survival, whose treatment was by the GBTLI ALL-1999 and GBTLI ALL- 2009, at the University Hospital of Santa Maria, from July 2000 to November 2018. There were 215 diagnoses of ALL, with a mean age of 7.45 years, 54.9% male. Stratified by relapse risk groups, 35.8% of patients were at High Risk, 41.9% at Low Risk, 15.3% with T Lineage ALL, 4.2% with Ph+ chromosome and 2.8% Infants. All patients had their cytogenetic and molecular biology tests analyzed and stratified by the main markers. When comparing the data from the GBTLI-LLA 1999 and GBTLI-LLA 2009 protocols, similarity was observed in relapse rates of 17.6% and 17.6% and in death rates of 22% and 21%, respectively. In the last three decades, with the treatment by clinical protocol, there has been an advance in the cure, and the survival rates reach 70 to 80%, which was evidenced in this study, with an overall survival of 87.9% in one year , 83.5% in two years and 79.8% in five years of patients treated by the GBTLI LLA-1999 protocol and 85.5% in one year, 83.95 in two years and 81.4% in five years of patients treated by GBTLI LLA-2009, showing similar survival rates.A leucemia linfoblástica aguda (LLA) é diagnosticada citomorfologicamente por imunofenotipagem, citogenética e biologia molecular. As classificações, juntamente com os dados clínicos, estratificam os grupos de risco de recidiva, para decisão terapêutica mais ou menos invasiva. Realizar os exames genéticos no diagnóstico é fundamental para traçar um melhor prognóstico e um tratamento mais adequado em cada caso. Este foi um estudo retrospectivo e transversal, o qual avaliou o perfil dos pacientes diagnosticados com LLA da Infância e Adolescência, suas alterações genéticas, prognóstico, desfecho recidiva/óbito e a sobrevida, cujo tratamento foi pelo protocolo GBTLI LLA-1999 e GBTLI LLA-2009, no Hospital Universitário de Santa Maria, pelo período de julho de 2000 a novembro de 2018. Foram 215 diagnósticos de LLA, com média de idade de 7,45 anos, 54,9% do sexo masculino. Estratificados por grupos de risco de recidiva, 35,8% dos pacientes em Alto Risco, 41,9% em Baixo Risco, 15,3% com LLA Linhagem T, 4,2% com cromossomo Ph+ e 2,8% Lactentes. Todos os pacientes tiveram seus exames de citogenética e biologia molecular analisados e estratificados pelos principais marcadores. Quando comparados os dados dos protocolos GBTLI-LLA 1999 e GBTLI-LLA 2009, foi evidenciado a semelhança nas taxas de recidivas de 17,6% e 17,6% e nas taxas de óbitos de 22% e 21%, respectivamente. Nas últimas três décadas, com o tratamento por protocolo clínico, obteve-se um avanço na cura, e as taxas de sobrevida alcançam 70 a 80%, o que foi evidenciado neste estudo, com uma sobrevida global de 87,9% em um ano, 83,5% em dois anos e 79,8% em cinco anos dos pacientes tratados pelo protocolo GBTLI LLA-1999 e de 85,5% em um ano, 83,95 em dois anos e 81,4% em cinco anos dos pacientes tratados pelo GBTLI LLA-2009, mostrando taxas de sobrevivência semelhantes.porUniversidade Federal de Santa MariaCentro de Ciências da SaúdePrograma de Pós-Graduação em Ciências da SaúdeUFSMBrasilCiências da SaúdeAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessGenéticaPediatriaRecidivaSobrevidaOncologiaGeneticsOncologyPediatricsRecurrenceSurvivalCNPQ::CIENCIAS DA SAUDEAvaliação das alterações genéticas em crianças e adolescentes com leucemia linfoblástica aguda, em um hospital universitário do Sul do Brasil, no período de 2000 a 2018.Evaluation of genetic changes in children and adolescents with acute lymphoblastic leukemia, at a university hospital in southern Brazil, from 2000 to 2018.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisCóser, Virgínia Mariahttp://lattes.cnpq.br/4601008307298787Nunes, Simone dos SantosWeinmann, Angela Regina Macielhttp://lattes.cnpq.br/6621150732424991Marcon, Mariana Nóbrega400000000001600600600600600e3c3ddb3-78b7-4b46-8a31-5614a42f1faa2d31e00e-0e07-4fdf-ba14-ffe1be3bdc58d1e96e09-a932-4dbb-9a29-e5085eb925eb06002688-2a8e-4975-b042-996c51973b0freponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGCS_2023_MARCON_MARIANA.pdfDIS_PPGCS_2023_MARCON_MARIANA.pdfDissertação de Mestradoapplication/pdf2306790http://repositorio.ufsm.br/bitstream/1/29572/1/DIS_PPGCS_2023_MARCON_MARIANA.pdfbb790e607e2981d0c83acfafc5e1cdddMD51LICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Avaliação das alterações genéticas em crianças e adolescentes com leucemia linfoblástica aguda, em um hospital universitário do Sul do Brasil, no período de 2000 a 2018. |
dc.title.alternative.eng.fl_str_mv |
Evaluation of genetic changes in children and adolescents with acute lymphoblastic leukemia, at a university hospital in southern Brazil, from 2000 to 2018. |
title |
Avaliação das alterações genéticas em crianças e adolescentes com leucemia linfoblástica aguda, em um hospital universitário do Sul do Brasil, no período de 2000 a 2018. |
spellingShingle |
Avaliação das alterações genéticas em crianças e adolescentes com leucemia linfoblástica aguda, em um hospital universitário do Sul do Brasil, no período de 2000 a 2018. Marcon, Mariana Nóbrega Genética Pediatria Recidiva Sobrevida Oncologia Genetics Oncology Pediatrics Recurrence Survival CNPQ::CIENCIAS DA SAUDE |
title_short |
Avaliação das alterações genéticas em crianças e adolescentes com leucemia linfoblástica aguda, em um hospital universitário do Sul do Brasil, no período de 2000 a 2018. |
title_full |
Avaliação das alterações genéticas em crianças e adolescentes com leucemia linfoblástica aguda, em um hospital universitário do Sul do Brasil, no período de 2000 a 2018. |
title_fullStr |
Avaliação das alterações genéticas em crianças e adolescentes com leucemia linfoblástica aguda, em um hospital universitário do Sul do Brasil, no período de 2000 a 2018. |
title_full_unstemmed |
Avaliação das alterações genéticas em crianças e adolescentes com leucemia linfoblástica aguda, em um hospital universitário do Sul do Brasil, no período de 2000 a 2018. |
title_sort |
Avaliação das alterações genéticas em crianças e adolescentes com leucemia linfoblástica aguda, em um hospital universitário do Sul do Brasil, no período de 2000 a 2018. |
author |
Marcon, Mariana Nóbrega |
author_facet |
Marcon, Mariana Nóbrega |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Cóser, Virgínia Maria |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4601008307298787 |
dc.contributor.referee1.fl_str_mv |
Nunes, Simone dos Santos |
dc.contributor.referee2.fl_str_mv |
Weinmann, Angela Regina Maciel |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6621150732424991 |
dc.contributor.author.fl_str_mv |
Marcon, Mariana Nóbrega |
contributor_str_mv |
Cóser, Virgínia Maria Nunes, Simone dos Santos Weinmann, Angela Regina Maciel |
dc.subject.por.fl_str_mv |
Genética Pediatria Recidiva Sobrevida |
topic |
Genética Pediatria Recidiva Sobrevida Oncologia Genetics Oncology Pediatrics Recurrence Survival CNPQ::CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Oncologia Genetics Oncology Pediatrics Recurrence Survival |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE |
description |
Acute lymphoblastic leukemia (ALL) is diagnosed cytomorphologically by immunophenotyping, cytogenetics and molecular biology. The classifications, together with the clinical data, stratify the groups at risk of relapse, for a more or less invasive therapeutic decision. Carrying out genetic tests in the diagnosis is fundamental to outline a better prognosis and a more appropriate treatment in each case. This was a retrospective and cross-sectional study, which evaluated the profile of patients diagnosed with ALL in childhood and adolescence, their genetic alterations, prognosis, relapse/death outcome and survival, whose treatment was by the GBTLI ALL-1999 and GBTLI ALL- 2009, at the University Hospital of Santa Maria, from July 2000 to November 2018. There were 215 diagnoses of ALL, with a mean age of 7.45 years, 54.9% male. Stratified by relapse risk groups, 35.8% of patients were at High Risk, 41.9% at Low Risk, 15.3% with T Lineage ALL, 4.2% with Ph+ chromosome and 2.8% Infants. All patients had their cytogenetic and molecular biology tests analyzed and stratified by the main markers. When comparing the data from the GBTLI-LLA 1999 and GBTLI-LLA 2009 protocols, similarity was observed in relapse rates of 17.6% and 17.6% and in death rates of 22% and 21%, respectively. In the last three decades, with the treatment by clinical protocol, there has been an advance in the cure, and the survival rates reach 70 to 80%, which was evidenced in this study, with an overall survival of 87.9% in one year , 83.5% in two years and 79.8% in five years of patients treated by the GBTLI LLA-1999 protocol and 85.5% in one year, 83.95 in two years and 81.4% in five years of patients treated by GBTLI LLA-2009, showing similar survival rates. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-06-28T15:05:07Z |
dc.date.available.fl_str_mv |
2023-06-28T15:05:07Z |
dc.date.issued.fl_str_mv |
2023-03-27 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/29572 |
url |
http://repositorio.ufsm.br/handle/1/29572 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
400000000001 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 600 |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências da Saúde |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Ciências da Saúde |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.source.none.fl_str_mv |
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