Avaliação de pacientes ambulatoriais em uso de anticoagulantes orais
Ano de defesa: | 2006 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências Farmacêuticas
|
Departamento: |
Análises Clínicas e Toxicológicas
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/5871 |
Resumo: | Trombotic diseases are a global health problem of multifactorial and multigenic etiology. They are characterized by the acute formation of trombus in veins and arteries. The oral anticoagulants are applied in order to create a partial deficiency on the active form of vitamin K, a co-factor in the changing of the factors of vitamin K-dependents coagulation, so that the risk of an abnormal coagulation can be reduced. The anti-vitamin K drugs or oral anticoagulants avoid the carboxylation of the II, VII, IX and X coagulation factors leading to the synthesis of the inactive factors. Several substances can change the action of oral anticoagulants, decreasing their action and increasing the thrombotic risk or increasing their activity and enlarging the blooding risk. The laboratory control of the oral anticoagulation is accomplished through the Time of Protrombine (TP) and of the Partial Thromboplastin Time (TTP) which are responsible for the success and safety of this therapeutic procedure. The present work has analyzed the parameters regarding the laboratory accompaniment of patients in use of oral anticoagulants as well as their interference on the medicine effect aiming to reach a better security for this kind of treatment. We can notice that most of the patients have made use of a quite rich diet in vitamin K producing variations in the values of their Normalized International Reasons (INRs) and consequently a larger difficulty in finding the right dose of the medicine for each patient. It also may be concluded that the anticoagulants response is influenced by some factors and those ones must be considered as, for example, the use of other medicines which affects the release or the absorption of the drug, laboratory technical troubles and the individual variability of each patient in relation to the drug. |
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2006-09-142006-09-142006-07-10SANTANA, Ana Paula Bagesteiro. Evaluation of ambulatory patients in use of oral anticoagulants. 2006. 87 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Santa Maria, Santa Maria, 2006.http://repositorio.ufsm.br/handle/1/5871Trombotic diseases are a global health problem of multifactorial and multigenic etiology. They are characterized by the acute formation of trombus in veins and arteries. The oral anticoagulants are applied in order to create a partial deficiency on the active form of vitamin K, a co-factor in the changing of the factors of vitamin K-dependents coagulation, so that the risk of an abnormal coagulation can be reduced. The anti-vitamin K drugs or oral anticoagulants avoid the carboxylation of the II, VII, IX and X coagulation factors leading to the synthesis of the inactive factors. Several substances can change the action of oral anticoagulants, decreasing their action and increasing the thrombotic risk or increasing their activity and enlarging the blooding risk. The laboratory control of the oral anticoagulation is accomplished through the Time of Protrombine (TP) and of the Partial Thromboplastin Time (TTP) which are responsible for the success and safety of this therapeutic procedure. The present work has analyzed the parameters regarding the laboratory accompaniment of patients in use of oral anticoagulants as well as their interference on the medicine effect aiming to reach a better security for this kind of treatment. We can notice that most of the patients have made use of a quite rich diet in vitamin K producing variations in the values of their Normalized International Reasons (INRs) and consequently a larger difficulty in finding the right dose of the medicine for each patient. It also may be concluded that the anticoagulants response is influenced by some factors and those ones must be considered as, for example, the use of other medicines which affects the release or the absorption of the drug, laboratory technical troubles and the individual variability of each patient in relation to the drug.As doenças trombóticas constituem um problema de saúde mundial de etiologia multifatorial e multigênica. São caracterizadas por formação aguda de trombos em veias e artérias. Os anticoagulantes orais são usados para criar uma deficiência parcial da forma ativa da vitamina K, um cofator na modificação dos fatores da coagulação vitamina K-dependentes e, assim, reduzir o risco de uma coagulação anormal. Os fármacos antivitamina K ou anticoagulantes orais impedem a carboxilação dos fatores II, VII, IX e X da coagulação, levando à síntese de fatores inativos. Uma série de substâncias pode alterar a ação dos anticoagulantes orais, reduzindo sua ação e aumentando o risco trombótico ou aumentando sua atividade e elevando o risco de sangramento. O controle laboratorial da anticoagulação oral é feito através do Tempo de Protrombina (TP) e do Tempo de Tromboplastina Parcial (TTP), os quais são responsáveis pelo sucesso e segurança deste procedimento terapêutico. Neste trabalho, foram analisados os parâmetros relativos ao acompanhamento ambulatorial de pacientes em uso de anticoagulantes orais e a interferência destes na atividade do fármaco em questão, buscando, dessa forma, uma melhor segurança para este tipo de tratamento. Observo-se que grande parte dos pacientes fazia uso de uma dieta bastante rica em vitamina K, o que acarretava variações nos valores de suas Razões Normalizadas Internacionais (INRs) e, com isso, uma dificuldade maior em encontrar a dose adequada do medicamento para cada paciente. Também se pode concluir que a resposta dos anticoagulantes é influenciada por alguns fatores e estes devem ser considerados como, por exemplo, o uso de outros medicamentos que afetem a liberação ou absorção do fármaco, problemas técnicos de laboratório e a variabilidade individual de cada paciente frente ao medicamento.application/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciências FarmacêuticasUFSMBRAnálises Clínicas e ToxicológicasFarmáciaAnticoagulantesFarmacologiaPharmacyAnticoagulantsPharmacologyCNPQ::CIENCIAS DA SAUDE::FARMACIAAvaliação de pacientes ambulatoriais em uso de anticoagulantes oraisEvaluation of ambulatory patients in use of oral anticoagulantsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisSilva, José Edson Paz dahttp://lattes.cnpq.br/1177504021154172Dalmora, Sergio Luizhttp://lattes.cnpq.br/4505166045049607Becker, Mônicahttp://lattes.cnpq.br/2912332982651131Santana, Ana Paula Bagesteiro201000000000400300300300300e7eceac5-be97-49f0-9619-62a17927bd1a35e38c85-32ee-4540-bd82-09912db07adb65727677-efa6-4ac9-8a1b-4a215c09195541787ea0-82c1-4a57-aec7-267121eff5beinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINAL2006 SANTANA, Ana Paula Bagesteiro.pdfapplication/pdf847808http://repositorio.ufsm.br/bitstream/1/5871/1/2006%20SANTANA%2c%20Ana%20Paula%20Bagesteiro.pdf0d09aed5095e44e37d864af29cc6c83fMD51TEXT2006 SANTANA, Ana Paula Bagesteiro.pdf.txt2006 SANTANA, Ana Paula Bagesteiro.pdf.txtExtracted texttext/plain125301http://repositorio.ufsm.br/bitstream/1/5871/2/2006%20SANTANA%2c%20Ana%20Paula%20Bagesteiro.pdf.txt84f8d577ab833d3f149d88b85c7866c9MD52THUMBNAIL2006 SANTANA, Ana Paula Bagesteiro.pdf.jpg2006 SANTANA, Ana Paula Bagesteiro.pdf.jpgIM Thumbnailimage/jpeg5508http://repositorio.ufsm.br/bitstream/1/5871/3/2006%20SANTANA%2c%20Ana%20Paula%20Bagesteiro.pdf.jpg406f1e4cbf2ee958e533016291523d3cMD531/58712023-02-07 08:09:42.067oai:repositorio.ufsm.br:1/5871Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestopendoar:39132023-02-07T11:09:42Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Avaliação de pacientes ambulatoriais em uso de anticoagulantes orais |
dc.title.alternative.eng.fl_str_mv |
Evaluation of ambulatory patients in use of oral anticoagulants |
title |
Avaliação de pacientes ambulatoriais em uso de anticoagulantes orais |
spellingShingle |
Avaliação de pacientes ambulatoriais em uso de anticoagulantes orais Santana, Ana Paula Bagesteiro Farmácia Anticoagulantes Farmacologia Pharmacy Anticoagulants Pharmacology CNPQ::CIENCIAS DA SAUDE::FARMACIA |
title_short |
Avaliação de pacientes ambulatoriais em uso de anticoagulantes orais |
title_full |
Avaliação de pacientes ambulatoriais em uso de anticoagulantes orais |
title_fullStr |
Avaliação de pacientes ambulatoriais em uso de anticoagulantes orais |
title_full_unstemmed |
Avaliação de pacientes ambulatoriais em uso de anticoagulantes orais |
title_sort |
Avaliação de pacientes ambulatoriais em uso de anticoagulantes orais |
author |
Santana, Ana Paula Bagesteiro |
author_facet |
Santana, Ana Paula Bagesteiro |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Silva, José Edson Paz da |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1177504021154172 |
dc.contributor.referee1.fl_str_mv |
Dalmora, Sergio Luiz |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/4505166045049607 |
dc.contributor.referee2.fl_str_mv |
Becker, Mônica |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/2912332982651131 |
dc.contributor.author.fl_str_mv |
Santana, Ana Paula Bagesteiro |
contributor_str_mv |
Silva, José Edson Paz da Dalmora, Sergio Luiz Becker, Mônica |
dc.subject.por.fl_str_mv |
Farmácia Anticoagulantes Farmacologia |
topic |
Farmácia Anticoagulantes Farmacologia Pharmacy Anticoagulants Pharmacology CNPQ::CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
Pharmacy Anticoagulants Pharmacology |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::FARMACIA |
description |
Trombotic diseases are a global health problem of multifactorial and multigenic etiology. They are characterized by the acute formation of trombus in veins and arteries. The oral anticoagulants are applied in order to create a partial deficiency on the active form of vitamin K, a co-factor in the changing of the factors of vitamin K-dependents coagulation, so that the risk of an abnormal coagulation can be reduced. The anti-vitamin K drugs or oral anticoagulants avoid the carboxylation of the II, VII, IX and X coagulation factors leading to the synthesis of the inactive factors. Several substances can change the action of oral anticoagulants, decreasing their action and increasing the thrombotic risk or increasing their activity and enlarging the blooding risk. The laboratory control of the oral anticoagulation is accomplished through the Time of Protrombine (TP) and of the Partial Thromboplastin Time (TTP) which are responsible for the success and safety of this therapeutic procedure. The present work has analyzed the parameters regarding the laboratory accompaniment of patients in use of oral anticoagulants as well as their interference on the medicine effect aiming to reach a better security for this kind of treatment. We can notice that most of the patients have made use of a quite rich diet in vitamin K producing variations in the values of their Normalized International Reasons (INRs) and consequently a larger difficulty in finding the right dose of the medicine for each patient. It also may be concluded that the anticoagulants response is influenced by some factors and those ones must be considered as, for example, the use of other medicines which affects the release or the absorption of the drug, laboratory technical troubles and the individual variability of each patient in relation to the drug. |
publishDate |
2006 |
dc.date.accessioned.fl_str_mv |
2006-09-14 |
dc.date.available.fl_str_mv |
2006-09-14 |
dc.date.issued.fl_str_mv |
2006-07-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTANA, Ana Paula Bagesteiro. Evaluation of ambulatory patients in use of oral anticoagulants. 2006. 87 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Santa Maria, Santa Maria, 2006. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/5871 |
identifier_str_mv |
SANTANA, Ana Paula Bagesteiro. Evaluation of ambulatory patients in use of oral anticoagulants. 2006. 87 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Santa Maria, Santa Maria, 2006. |
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http://repositorio.ufsm.br/handle/1/5871 |
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