Neuropatia periférica induzida por quimioterapia: uma revisão integrativa da literatura
Ano de defesa: | 2021 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
Centro de Ciências da Saúde |
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências da Saúde
|
Departamento: |
Ciências da Saúde
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/23753 |
Resumo: | Antineoplastic chemotherapy represents the use of isolated or combined chemical substances in the treatment of malignant tumors, being considered one of the most important ways to fight cancer. Peripheral neuropathy (PN) is a clinical condition characterized by impairment of sensitive nerves and / or peripheral motors, which can have multiple causes. The main diseases that cause PN are repetitive strain injury, diabetes, systemic lupus erythematosus, rheumatism, psoriasis, hypothyroidism, leprosy, heavy metal poisoning and it is also the adverse effect of certain medications such as some antimicrobials, statins and especially drugs antineoplastic. Chemotherapy-induced peripheral neuropathy (CIPN) is a neurological syndrome that mainly affects patients undergoing treatment with antineoplastic agents such as taxanes (docetaxel, paclitaxel and cabazitaxel), platinum derivatives (oxaliplatin, cisplatin and carboplatin), bortezomib and vinca alkaloids (vimblastine, vincristine and vinorelbine). CIPN is the most frequent neurological complication, secondary to antineoplastic treatment and affects one third of patients, interfering with functionality and compromising quality of life. This NPIQ has different degrees of toxicity, varying according to the type of medication used, time of administration and cumulative dose. An integrative review was carried out on chemotherapy-induced peripheral neuropathy and its effects on cancer patients using scientific articles published, over the past five years, in the databases SciELO (Scientific Electronic Library on Line), LILACS (Latin American and Caribbean Literature in Health Sciences), Medical Literature Analysis (PubMed / MEDLINE) and Spanish Health Sciences Bibliographic Index (IBECS) according to the following eligibility criteria: studies dealing with NPIQ and its effects on cancer patients and possible prevention-related strategies and interventions, minimization and treatment of CIPNs, which included potentially neurotoxic chemotherapy in the treatment in scientific, national and international articles, published in Portuguese, English and Spanish and indexed in the databases in the last five years, including 2015 to the 2020. The final sample consisted of 10 studies published in the past 05 years. There was a small number of studies dealing with the topic, identifying the need to carry out studies of this type, due to the high incidence of NPIQ, so that prevention, diagnosis, and treatment strategies can be shared, with consequent improvement in quality. assistance. The more clinical practices / results are discussed, the greater the number of strategies to improve the quality of life of these patients. |
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2022-03-09T18:02:53Z2022-03-09T18:02:53Z2021-08-24http://repositorio.ufsm.br/handle/1/23753Antineoplastic chemotherapy represents the use of isolated or combined chemical substances in the treatment of malignant tumors, being considered one of the most important ways to fight cancer. Peripheral neuropathy (PN) is a clinical condition characterized by impairment of sensitive nerves and / or peripheral motors, which can have multiple causes. The main diseases that cause PN are repetitive strain injury, diabetes, systemic lupus erythematosus, rheumatism, psoriasis, hypothyroidism, leprosy, heavy metal poisoning and it is also the adverse effect of certain medications such as some antimicrobials, statins and especially drugs antineoplastic. Chemotherapy-induced peripheral neuropathy (CIPN) is a neurological syndrome that mainly affects patients undergoing treatment with antineoplastic agents such as taxanes (docetaxel, paclitaxel and cabazitaxel), platinum derivatives (oxaliplatin, cisplatin and carboplatin), bortezomib and vinca alkaloids (vimblastine, vincristine and vinorelbine). CIPN is the most frequent neurological complication, secondary to antineoplastic treatment and affects one third of patients, interfering with functionality and compromising quality of life. This NPIQ has different degrees of toxicity, varying according to the type of medication used, time of administration and cumulative dose. An integrative review was carried out on chemotherapy-induced peripheral neuropathy and its effects on cancer patients using scientific articles published, over the past five years, in the databases SciELO (Scientific Electronic Library on Line), LILACS (Latin American and Caribbean Literature in Health Sciences), Medical Literature Analysis (PubMed / MEDLINE) and Spanish Health Sciences Bibliographic Index (IBECS) according to the following eligibility criteria: studies dealing with NPIQ and its effects on cancer patients and possible prevention-related strategies and interventions, minimization and treatment of CIPNs, which included potentially neurotoxic chemotherapy in the treatment in scientific, national and international articles, published in Portuguese, English and Spanish and indexed in the databases in the last five years, including 2015 to the 2020. The final sample consisted of 10 studies published in the past 05 years. There was a small number of studies dealing with the topic, identifying the need to carry out studies of this type, due to the high incidence of NPIQ, so that prevention, diagnosis, and treatment strategies can be shared, with consequent improvement in quality. assistance. The more clinical practices / results are discussed, the greater the number of strategies to improve the quality of life of these patients.A quimioterapia antineoplásica representa a utilização de substâncias químicas isoladas ou combinadas no tratamento dos tumores malignos, sendo considerada uma das mais importantes formas de combater o câncer. A neuropatia periférica (NP) é uma condição clínica caracterizada pelo comprometimento de nervos sensitivos e/ou motores periféricos, que pode apresentar múltiplas causas. As principais doenças causadoras da NP são a lesão por esforço repetitivo, diabetes, lúpus eritematoso sistêmico, reumatismo, psoríase, hipotireoidismo, hanseníase, envenenamento por metais pesados e ainda, é o efeito adverso de determinados medicamentos como alguns antimicrobianos, estatinas e especialmente as drogas antineoplásicas. A neuropatia periférica induzida por quimioterapia (NPIQ) é uma síndrome neurológica que acomete principalmente pacientes que realizam tratamento com antineoplásicos como taxanos (docetaxel, paclitaxel e cabazitaxel), derivados da platina (oxaliplatina, cisplatina e carboplatina), bortezomibe e alcalóides da vinca (vimblastina, vincristina e vinorelbina). A NPIQ é a complicação neurológica mais frequente, secundária ao tratamento antineoplásico e afeta um terço dos pacientes, interferindo na funcionalidade e comprometendo a qualidade de vida. Essa NPIQ apresenta diferentes graus de toxicidade variando de acordo com o tipo de medicamento utilizado, tempo de administração e dose cumulativa. Foi realizada uma revisão integrativa sobre a neuropatia periférica induzida por quimioterapia utilizando artigos científicos publicados nas bases de dados SciELO (Scientific Electronic Library on Line), LILACS (Literatura Latino Americana e do Caribe em Ciências da Saúde), Medical Literature Analysis (PubMed/MEDLINE) e Índice Bibliográfico Espanhol de Ciências da Saúde (IBECS) de acordo com os seguintes critérios de elegibilidade: estudos que tratavam da NPIQ e seus efeitos nos pacientes oncológicos e possíveis estratégias e intervenções relacionadas à prevenção, minimização e tratamento das NPIQ, e que incluíam no tratamento os quimioterápicos potencialmente neurotóxicos no formato de artigos científicos, nacionais e internacionais, publicados nos idiomas português, inglês e espanhol e indexados nos bancos de dados nos últimos cinco anos, incluindo 2015 à 2020. A amostra final consistiu em 10 estudos publicados. Constatou-se um pequeno número de estudos que tratam sobre o tema, identificando-se a necessidade de realização de estudos desse tipo, devido a alta incidência da NPIQ, para que possam ser compartilhadas estratégias de prevenção, diagnóstico e tratamento, com consequente melhora da qualidade da assistência. Quanto mais práticas clínicas/resultados forem comentados, maior será a quantidade de estratégias para melhorar a qualidade de vida desses pacientes.porUniversidade Federal de Santa MariaCentro de Ciências da SaúdePrograma de Pós-Graduação em Ciências da SaúdeUFSMBrasilCiências da SaúdeAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessNeoplasiasDoenças do sistema nervoso periféricoQuimioterapiaNeoplamsPeripheral nervous system diseasesDrug therapyCNPQ::CIENCIAS DA SAUDENeuropatia periférica induzida por quimioterapia: uma revisão integrativa da literaturaChemotherapy-induced peripheral neuropathies: an integrative reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisHorner, Rosmarihttp://lattes.cnpq.br/5907084134183708Santos, Aline Joana Rolina Wohmuth Alves dosBulowski, Patrícia Bernardes Cavalheirohttp://lattes.cnpq.br/7683420249129397Castro, Carolina Quintana4000000000016006006005fdaffc5-abc5-4607-8952-fc5c4760b0040f8784fc-780c-4162-9a76-60528eee04a9af623a06-b5b6-41a6-ac87-d9c776c8501c6f97be8e-431c-463d-a8a3-b08f1b551f4areponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGCS_2021_CASTRO_CAROLINA.pdfDIS_PPGCS_2021_CASTRO_CAROLINA.pdfDissertação de mestradoapplication/pdf826676http://repositorio.ufsm.br/bitstream/1/23753/1/DIS_PPGCS_2021_CASTRO_CAROLINA.pdf6e321e953c0299e29cf46bda728d9d7bMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.ufsm.br/bitstream/1/23753/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81956http://repositorio.ufsm.br/bitstream/1/23753/3/license.txt2f0571ecee68693bd5cd3f17c1e075dfMD531/237532022-03-09 15:04:48.618oai:repositorio.ufsm.br:1/23753TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkNvbSBhIGFwcmVzZW50YcOnw6NvIGRlc3RhIGxpY2Vuw6dhLCB2b2PDqiAobyBhdXRvciAoZXMpIG91IG8gdGl0dWxhciBkb3MgZGlyZWl0b3MgZGUgYXV0b3IpIGNvbmNlZGUgw6AgVW5pdmVyc2lkYWRlCkZlZGVyYWwgZGUgU2FudGEgTWFyaWEgKFVGU00pIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSByZXByb2R1emlyLCAgdHJhZHV6aXIgKGNvbmZvcm1lIGRlZmluaWRvIGFiYWl4byksIGUvb3UKZGlzdHJpYnVpciBhIHN1YSB0ZXNlIG91IGRpc3NlcnRhw6fDo28gKGluY2x1aW5kbyBvIHJlc3VtbykgcG9yIHRvZG8gbyBtdW5kbyBubyBmb3JtYXRvIGltcHJlc3NvIGUgZWxldHLDtG5pY28gZQplbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mgw6F1ZGlvIG91IHbDrWRlby4KClZvY8OqIGNvbmNvcmRhIHF1ZSBhIFVGU00gcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250ZcO6ZG8sIHRyYW5zcG9yIGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbwpwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHDp8Ojby4KClZvY8OqIHRhbWLDqW0gY29uY29yZGEgcXVlIGEgVUZTTSBwb2RlIG1hbnRlciBtYWlzIGRlIHVtYSBjw7NwaWEgYSBzdWEgdGVzZSBvdQpkaXNzZXJ0YcOnw6NvIHBhcmEgZmlucyBkZSBzZWd1cmFuw6dhLCBiYWNrLXVwIGUgcHJlc2VydmHDp8Ojby4KClZvY8OqIGRlY2xhcmEgcXVlIGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyDDqSBvcmlnaW5hbCBlIHF1ZSB2b2PDqiB0ZW0gbyBwb2RlciBkZSBjb25jZWRlciBvcyBkaXJlaXRvcyBjb250aWRvcwpuZXN0YSBsaWNlbsOnYS4gVm9jw6ogdGFtYsOpbSBkZWNsYXJhIHF1ZSBvIGRlcMOzc2l0byBkYSBzdWEgdGVzZSBvdSBkaXNzZXJ0YcOnw6NvIG7Do28sIHF1ZSBzZWphIGRlIHNldQpjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd1w6ltLgoKQ2FzbyBhIHN1YSB0ZXNlIG91IGRpc3NlcnRhw6fDo28gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY8OqIG7Do28gcG9zc3VpIGEgdGl0dWxhcmlkYWRlIGRvcyBkaXJlaXRvcyBhdXRvcmFpcywgdm9jw6oKZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc8OjbyBpcnJlc3RyaXRhIGRvIGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBwYXJhIGNvbmNlZGVyIMOgIFVGU00Kb3MgZGlyZWl0b3MgYXByZXNlbnRhZG9zIG5lc3RhIGxpY2Vuw6dhLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlCmlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIG5vIHRleHRvIG91IG5vIGNvbnRlw7pkbyBkYSB0ZXNlIG91IGRpc3NlcnRhw6fDo28gb3JhIGRlcG9zaXRhZGEuCgpDQVNPIEEgVEVTRSBPVSBESVNTRVJUQcOHw4NPIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ8ONTklPIE9VCkFQT0lPIERFIFVNQSBBR8OKTkNJQSBERSBGT01FTlRPIE9VIE9VVFJPIE9SR0FOSVNNTyBRVUUgTsODTyBTRUpBIEEgVUZTTQosIFZPQ8OKIERFQ0xBUkEgUVVFIFJFU1BFSVRPVSBUT0RPUyBFIFFVQUlTUVVFUiBESVJFSVRPUyBERSBSRVZJU8ODTyBDT01PClRBTULDiU0gQVMgREVNQUlTIE9CUklHQcOHw5VFUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKQSBVRlNNIHNlIGNvbXByb21ldGUgYSBpZGVudGlmaWNhciBjbGFyYW1lbnRlIG8gc2V1IG5vbWUgKHMpIG91IG8ocykgbm9tZShzKSBkbyhzKQpkZXRlbnRvcihlcykgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIGRhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbywgZSBuw6NvIGZhcsOhIHF1YWxxdWVyIGFsdGVyYcOnw6NvLCBhbMOpbSBkYXF1ZWxhcwpjb25jZWRpZGFzIHBvciBlc3RhIGxpY2Vuw6dhLgoKRepositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestopendoar:39132022-03-09T18:04:48Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Neuropatia periférica induzida por quimioterapia: uma revisão integrativa da literatura |
dc.title.alternative.eng.fl_str_mv |
Chemotherapy-induced peripheral neuropathies: an integrative review |
title |
Neuropatia periférica induzida por quimioterapia: uma revisão integrativa da literatura |
spellingShingle |
Neuropatia periférica induzida por quimioterapia: uma revisão integrativa da literatura Castro, Carolina Quintana Neoplasias Doenças do sistema nervoso periférico Quimioterapia Neoplams Peripheral nervous system diseases Drug therapy CNPQ::CIENCIAS DA SAUDE |
title_short |
Neuropatia periférica induzida por quimioterapia: uma revisão integrativa da literatura |
title_full |
Neuropatia periférica induzida por quimioterapia: uma revisão integrativa da literatura |
title_fullStr |
Neuropatia periférica induzida por quimioterapia: uma revisão integrativa da literatura |
title_full_unstemmed |
Neuropatia periférica induzida por quimioterapia: uma revisão integrativa da literatura |
title_sort |
Neuropatia periférica induzida por quimioterapia: uma revisão integrativa da literatura |
author |
Castro, Carolina Quintana |
author_facet |
Castro, Carolina Quintana |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Horner, Rosmari |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/5907084134183708 |
dc.contributor.referee1.fl_str_mv |
Santos, Aline Joana Rolina Wohmuth Alves dos |
dc.contributor.referee2.fl_str_mv |
Bulowski, Patrícia Bernardes Cavalheiro |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7683420249129397 |
dc.contributor.author.fl_str_mv |
Castro, Carolina Quintana |
contributor_str_mv |
Horner, Rosmari Santos, Aline Joana Rolina Wohmuth Alves dos Bulowski, Patrícia Bernardes Cavalheiro |
dc.subject.por.fl_str_mv |
Neoplasias Doenças do sistema nervoso periférico Quimioterapia |
topic |
Neoplasias Doenças do sistema nervoso periférico Quimioterapia Neoplams Peripheral nervous system diseases Drug therapy CNPQ::CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Neoplams Peripheral nervous system diseases Drug therapy |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE |
description |
Antineoplastic chemotherapy represents the use of isolated or combined chemical substances in the treatment of malignant tumors, being considered one of the most important ways to fight cancer. Peripheral neuropathy (PN) is a clinical condition characterized by impairment of sensitive nerves and / or peripheral motors, which can have multiple causes. The main diseases that cause PN are repetitive strain injury, diabetes, systemic lupus erythematosus, rheumatism, psoriasis, hypothyroidism, leprosy, heavy metal poisoning and it is also the adverse effect of certain medications such as some antimicrobials, statins and especially drugs antineoplastic. Chemotherapy-induced peripheral neuropathy (CIPN) is a neurological syndrome that mainly affects patients undergoing treatment with antineoplastic agents such as taxanes (docetaxel, paclitaxel and cabazitaxel), platinum derivatives (oxaliplatin, cisplatin and carboplatin), bortezomib and vinca alkaloids (vimblastine, vincristine and vinorelbine). CIPN is the most frequent neurological complication, secondary to antineoplastic treatment and affects one third of patients, interfering with functionality and compromising quality of life. This NPIQ has different degrees of toxicity, varying according to the type of medication used, time of administration and cumulative dose. An integrative review was carried out on chemotherapy-induced peripheral neuropathy and its effects on cancer patients using scientific articles published, over the past five years, in the databases SciELO (Scientific Electronic Library on Line), LILACS (Latin American and Caribbean Literature in Health Sciences), Medical Literature Analysis (PubMed / MEDLINE) and Spanish Health Sciences Bibliographic Index (IBECS) according to the following eligibility criteria: studies dealing with NPIQ and its effects on cancer patients and possible prevention-related strategies and interventions, minimization and treatment of CIPNs, which included potentially neurotoxic chemotherapy in the treatment in scientific, national and international articles, published in Portuguese, English and Spanish and indexed in the databases in the last five years, including 2015 to the 2020. The final sample consisted of 10 studies published in the past 05 years. There was a small number of studies dealing with the topic, identifying the need to carry out studies of this type, due to the high incidence of NPIQ, so that prevention, diagnosis, and treatment strategies can be shared, with consequent improvement in quality. assistance. The more clinical practices / results are discussed, the greater the number of strategies to improve the quality of life of these patients. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-08-24 |
dc.date.accessioned.fl_str_mv |
2022-03-09T18:02:53Z |
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2022-03-09T18:02:53Z |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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http://repositorio.ufsm.br/handle/1/23753 |
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http://repositorio.ufsm.br/handle/1/23753 |
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por |
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por |
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400000000001 |
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600 600 600 |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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Universidade Federal de Santa Maria Centro de Ciências da Saúde |
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Programa de Pós-Graduação em Ciências da Saúde |
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UFSM |
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Brasil |
dc.publisher.department.fl_str_mv |
Ciências da Saúde |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
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