Ingestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratos
Ano de defesa: | 2009 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica
|
Departamento: |
Bioquímica
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/11101 |
Resumo: | Considering the hypothesis that GABA and oxidative stress are involved in the development of oral movements associated with important neuropathologies, the present study investigated the possible ability of V. officinalis in the prevention of vacuous chewing movements (VCMs) induced by reserpine in rats. Adult male rats were treated with reserpine (1 mg/kg, s.c.) and/or with V. officinalis (in the drinking water). VCMs, locomotor activity and oxidative stress measurements were evaluated. The neuroprotective effect of V. officinalis against iron-induced cell toxicity was investigated in brain cortical slices. Furthermore, we carried out the identification of valeric acid and gallic acid by HPLC in the V. officinalis tincture. Our findings demonstrate that reserpine caused a marked increase on VCMs and the co-treatment with V. officinalis was able to reduce the intensity of VCM. Reserpine did not induce oxidative stress in cerebral structures (cortex, hippocampus, striatum and substantia nigra). However, a significant positive correlation between DCF-oxidation (an estimation of oxidative stress) in the cortex and VCMs (p<0.05) was observed. Moreover, a tendency for a negative correlation between Na+K+- ATPase activity in substantia nigra and the number of VCMs was observed (p= 0.06). In vitro, V. officinalis protected brain cortical slices viability against Fe(II)-induced neurotoxicity. In conclusion, V. officinalis had in vitro and in vivo neuroprotective effects in rats, i.e., reduced Fe(II) neurotoxicity and reserpine-induced VCMs, probably via modulation of oxidative stress in specific brain nucleus and its GABA-mimetic action. However, the mechanisms involved in this protective activity needs to further investigated to better understand the action of V. officinalis. |
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2017-04-262017-04-262009-04-15PEREIRA, Romaiana Picada. Intake of the valeriana officinalis tincture protects against orofacial dyskinesia induced by reserpine in rats. 2009. 100 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2009.http://repositorio.ufsm.br/handle/1/11101Considering the hypothesis that GABA and oxidative stress are involved in the development of oral movements associated with important neuropathologies, the present study investigated the possible ability of V. officinalis in the prevention of vacuous chewing movements (VCMs) induced by reserpine in rats. Adult male rats were treated with reserpine (1 mg/kg, s.c.) and/or with V. officinalis (in the drinking water). VCMs, locomotor activity and oxidative stress measurements were evaluated. The neuroprotective effect of V. officinalis against iron-induced cell toxicity was investigated in brain cortical slices. Furthermore, we carried out the identification of valeric acid and gallic acid by HPLC in the V. officinalis tincture. Our findings demonstrate that reserpine caused a marked increase on VCMs and the co-treatment with V. officinalis was able to reduce the intensity of VCM. Reserpine did not induce oxidative stress in cerebral structures (cortex, hippocampus, striatum and substantia nigra). However, a significant positive correlation between DCF-oxidation (an estimation of oxidative stress) in the cortex and VCMs (p<0.05) was observed. Moreover, a tendency for a negative correlation between Na+K+- ATPase activity in substantia nigra and the number of VCMs was observed (p= 0.06). In vitro, V. officinalis protected brain cortical slices viability against Fe(II)-induced neurotoxicity. In conclusion, V. officinalis had in vitro and in vivo neuroprotective effects in rats, i.e., reduced Fe(II) neurotoxicity and reserpine-induced VCMs, probably via modulation of oxidative stress in specific brain nucleus and its GABA-mimetic action. However, the mechanisms involved in this protective activity needs to further investigated to better understand the action of V. officinalis.Considerando as hipóteses do papel da neurotransmissão gabaérgica e do estresse oxidativo no desenvolvimento de movimentos orais associados a neuropatologias importantes, o presente estudo investigou a possível habilidade da tintura de V. officinalis na prevenção dos movimentos de mascar no vazio (MMV) induzidos por reserpina em ratos. Os animais foram tratados com reserpina (1 mg/Kg, s.c.) e/ou com V. officinalis (na água de beber). MMV, atividade locomotora e medidas de estresse oxidativo foram avaliadas. O efeito neuroprotetor da V. officinalis contra a toxicidade celular induzida por ferro foi investigada em fatias de córtex cerebral. Além disso, fez-se a identificação do ácido valérico e do ácido gálico por HPLC na tintura de V. officinalis. Os resultados demonstram que a reserpina causou um aumento nos MMV quando comparado com o seu veículo e o co-tratamento com V. officinalis foi capaz de reduzir a intensidade dos MMV. A reserpina não alterou de forma significativa alguns parâmetros de estresse oxidativo analisados nas estruturas do cérebro (córtex, hipocampo, estriado e substantia nigra). Porém, uma correlação positiva entre os níveis de oxidação da DCF (uma estimativa do estresse oxidativo) no cortex e o número de MMV (p<0.05) foi observada. Além disso, foi observada uma tendência a haver uma correlação negativa entre a atividade da Na+/K+- ATPase na substantia nigra e o número de MMV (p= 0.055). In vitro, V. officinalis protegeu as fatias de córtex cerebral contra a neurotoxicidade induzida por ferro. Desta forma, pode-se concluir que a V. officinalis apresentou efeitos neuroprotetores em ratos tanto in vitro quanto in vivo, ou seja, reduziu a neurotoxicidade induzida por ferro e os MMV induzidos por reserpina, provavelmente via modulação do estresse oxidativo em núcleos específicos do cérebro e sua ação gabamimética. Porém, os mecanismos envolvidos nesta atividade protetora necessitam de mais investigações para melhor entender a ação da V. officinalis.Conselho Nacional de Desenvolvimento Científico e Tecnológicoapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaUFSMBRBioquímicaValeriana officinalisReserpinaDiscinesia tardiaDoença de ParkinsonEstresse oxidativoMovimentos de mascar no vazioDiscinesia orofacialÁcido gálicoÁcido valericoValeriana officinalisReserpineTardive dyskinesiaParkinson's diseaseOxidative stressVacuous chewing movementsOral dyskinesiaGallic acidValeric acidCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICAIngestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratosIntake of the valeriana officinalis tincture protects against orofacial dyskinesia induced by reserpine in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisMorsch, Vera Maria Melchiorshttp://lattes.cnpq.br/1519648219507868Rocha, Joao Batista Teixeira dahttp://lattes.cnpq.br/3935055744673018Ghisleni, Gabriele Cordenonzihttp://lattes.cnpq.br/3918025526443507Burger, Marilise Escobarhttp://lattes.cnpq.br/9128090974948413http://lattes.cnpq.br/3277439471060779Pereira, Romaiana Picada20080000000240050050050030050005cf99a1-4e49-4daa-bb3b-26eee86569c1b31ec08e-9391-48ac-aa6b-cebc34aa55e64a2aa8a7-cae4-4911-ab61-026ad02d652040a51b66-2a70-4e7a-b733-162b17f1cbcaa609a359-a0e0-4c67-b9c2-5c029e49529cinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALPEREIRA, ROMAIANA PICADA.pdfapplication/pdf573964http://repositorio.ufsm.br/bitstream/1/11101/1/PEREIRA%2c%20ROMAIANA%20PICADA.pdfd4feeb7b953638dfd83b1e6012b627afMD51TEXTPEREIRA, ROMAIANA PICADA.pdf.txtPEREIRA, ROMAIANA PICADA.pdf.txtExtracted texttext/plain146498http://repositorio.ufsm.br/bitstream/1/11101/2/PEREIRA%2c%20ROMAIANA%20PICADA.pdf.txt0e47b1b847349a054f1276ea88b78664MD52THUMBNAILPEREIRA, ROMAIANA PICADA.pdf.jpgPEREIRA, ROMAIANA PICADA.pdf.jpgIM Thumbnailimage/jpeg4977http://repositorio.ufsm.br/bitstream/1/11101/3/PEREIRA%2c%20ROMAIANA%20PICADA.pdf.jpg72bfddc27eeab347b68e2c58dd3b86cbMD531/111012022-08-17 11:09:13.954oai:repositorio.ufsm.br:1/11101Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestopendoar:39132022-08-17T14:09:13Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Ingestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratos |
dc.title.alternative.eng.fl_str_mv |
Intake of the valeriana officinalis tincture protects against orofacial dyskinesia induced by reserpine in rats |
title |
Ingestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratos |
spellingShingle |
Ingestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratos Pereira, Romaiana Picada Valeriana officinalis Reserpina Discinesia tardia Doença de Parkinson Estresse oxidativo Movimentos de mascar no vazio Discinesia orofacial Ácido gálico Ácido valerico Valeriana officinalis Reserpine Tardive dyskinesia Parkinson's disease Oxidative stress Vacuous chewing movements Oral dyskinesia Gallic acid Valeric acid CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Ingestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratos |
title_full |
Ingestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratos |
title_fullStr |
Ingestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratos |
title_full_unstemmed |
Ingestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratos |
title_sort |
Ingestão da tintura de valeriana officinalis protege da discinesia orofacial induzida por reserpina em ratos |
author |
Pereira, Romaiana Picada |
author_facet |
Pereira, Romaiana Picada |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Morsch, Vera Maria Melchiors |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1519648219507868 |
dc.contributor.advisor-co1.fl_str_mv |
Rocha, Joao Batista Teixeira da |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/3935055744673018 |
dc.contributor.referee1.fl_str_mv |
Ghisleni, Gabriele Cordenonzi |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/3918025526443507 |
dc.contributor.referee2.fl_str_mv |
Burger, Marilise Escobar |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/9128090974948413 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3277439471060779 |
dc.contributor.author.fl_str_mv |
Pereira, Romaiana Picada |
contributor_str_mv |
Morsch, Vera Maria Melchiors Rocha, Joao Batista Teixeira da Ghisleni, Gabriele Cordenonzi Burger, Marilise Escobar |
dc.subject.por.fl_str_mv |
Valeriana officinalis Reserpina Discinesia tardia Doença de Parkinson Estresse oxidativo Movimentos de mascar no vazio Discinesia orofacial Ácido gálico Ácido valerico |
topic |
Valeriana officinalis Reserpina Discinesia tardia Doença de Parkinson Estresse oxidativo Movimentos de mascar no vazio Discinesia orofacial Ácido gálico Ácido valerico Valeriana officinalis Reserpine Tardive dyskinesia Parkinson's disease Oxidative stress Vacuous chewing movements Oral dyskinesia Gallic acid Valeric acid CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
dc.subject.eng.fl_str_mv |
Valeriana officinalis Reserpine Tardive dyskinesia Parkinson's disease Oxidative stress Vacuous chewing movements Oral dyskinesia Gallic acid Valeric acid |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
Considering the hypothesis that GABA and oxidative stress are involved in the development of oral movements associated with important neuropathologies, the present study investigated the possible ability of V. officinalis in the prevention of vacuous chewing movements (VCMs) induced by reserpine in rats. Adult male rats were treated with reserpine (1 mg/kg, s.c.) and/or with V. officinalis (in the drinking water). VCMs, locomotor activity and oxidative stress measurements were evaluated. The neuroprotective effect of V. officinalis against iron-induced cell toxicity was investigated in brain cortical slices. Furthermore, we carried out the identification of valeric acid and gallic acid by HPLC in the V. officinalis tincture. Our findings demonstrate that reserpine caused a marked increase on VCMs and the co-treatment with V. officinalis was able to reduce the intensity of VCM. Reserpine did not induce oxidative stress in cerebral structures (cortex, hippocampus, striatum and substantia nigra). However, a significant positive correlation between DCF-oxidation (an estimation of oxidative stress) in the cortex and VCMs (p<0.05) was observed. Moreover, a tendency for a negative correlation between Na+K+- ATPase activity in substantia nigra and the number of VCMs was observed (p= 0.06). In vitro, V. officinalis protected brain cortical slices viability against Fe(II)-induced neurotoxicity. In conclusion, V. officinalis had in vitro and in vivo neuroprotective effects in rats, i.e., reduced Fe(II) neurotoxicity and reserpine-induced VCMs, probably via modulation of oxidative stress in specific brain nucleus and its GABA-mimetic action. However, the mechanisms involved in this protective activity needs to further investigated to better understand the action of V. officinalis. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-04-15 |
dc.date.accessioned.fl_str_mv |
2017-04-26 |
dc.date.available.fl_str_mv |
2017-04-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PEREIRA, Romaiana Picada. Intake of the valeriana officinalis tincture protects against orofacial dyskinesia induced by reserpine in rats. 2009. 100 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2009. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/11101 |
identifier_str_mv |
PEREIRA, Romaiana Picada. Intake of the valeriana officinalis tincture protects against orofacial dyskinesia induced by reserpine in rats. 2009. 100 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2009. |
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http://repositorio.ufsm.br/handle/1/11101 |
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