Efeitos da boldenona e do estanazolol associados ou não à gonadotrofina coriônica humana no fígado e testículo de ratos
Ano de defesa: | 2018 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
Centro de Ciências Rurais |
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Medicina Veterinária
|
Departamento: |
Medicina Veterinária
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/15593 |
Resumo: | In the present thesis, under the format of two experiments, the deleterious effects of Boldenone Undecylenate (BOL) and Stanazolol (ST) in rats’ liver and testis were assessed. In the first experiment, the inflammatory, metabolic, and oxidative parameters were measured in rats’ liver when treated with either BOL or ST. In the second experiment, oxidative stress and inflammatory parameters were evaluated in rats’ testis treated with BOL associated or not to human chorionic gonadotrophin (hCG) in two dosages: 50U and 200U. In the first experiment, three protocols were established in order to verify which one would be the more deleterious for the users of this kind of anabolic steroids. Thereby, the protocol I represents the users who wish to accelerate the anabolic effects using higher dosages than those recommended, in a shorten time interval, the protocol II represents groups of users of anabolic steroids who choose a moderate dosage and intermediate time and protocol III represents users that reduce the dosage and prolong the exposure time aiming to reduce the androgenic effects. In the second experiment, eight protocols were made aiming to verify if the BOL exposure can be attenuated when using hCG in two dosages considered low, but in accordance to how they are administered, may have the reversion or prevention effect of the testicular damage. Therefore, the group I received only BOL vehicle; group II received BOL and hCH placebo in the cycle form; group III received BOL and three applications of hCG50 in the cycle form; group IV received BOL and three applications of hCG200 in the cycle form; group V received BOL and three applications of hCG50 in the reversion form; group VI received BOL and three applications of hCG200 in the reversion form; group VII received BOL and three applications of hCG placebo in the reversion form; group VIII received BOL and was kept with no applications of any substance until the whole spermatogenesis have finished (approximately 60 days). For the first experiment, our data indicate that the protocol I showed the most deleterious effects in the redox status, cellular infiltration markers, as well as for the metabolic functioning of the hepatic tissue. Concerning to the second experiment, our data indicate that hCG had beneficial effects either in 50U or 200U dosages considering the MPO marker, however the animals in the protocol VIII were better benefited in TBARS evaluation when compared to the animals that had the preventive treatment with hCG administered in cycle form. The present thesis demonstrates that decreasing the dose of anabolics may be less deleterious to the liver and that hCG is able to prevent inflammatory infiltrates in the testis when in use with anabolic steroids. |
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2019-02-11T13:07:45Z2019-02-11T13:07:45Z2018-08-10http://repositorio.ufsm.br/handle/1/15593In the present thesis, under the format of two experiments, the deleterious effects of Boldenone Undecylenate (BOL) and Stanazolol (ST) in rats’ liver and testis were assessed. In the first experiment, the inflammatory, metabolic, and oxidative parameters were measured in rats’ liver when treated with either BOL or ST. In the second experiment, oxidative stress and inflammatory parameters were evaluated in rats’ testis treated with BOL associated or not to human chorionic gonadotrophin (hCG) in two dosages: 50U and 200U. In the first experiment, three protocols were established in order to verify which one would be the more deleterious for the users of this kind of anabolic steroids. Thereby, the protocol I represents the users who wish to accelerate the anabolic effects using higher dosages than those recommended, in a shorten time interval, the protocol II represents groups of users of anabolic steroids who choose a moderate dosage and intermediate time and protocol III represents users that reduce the dosage and prolong the exposure time aiming to reduce the androgenic effects. In the second experiment, eight protocols were made aiming to verify if the BOL exposure can be attenuated when using hCG in two dosages considered low, but in accordance to how they are administered, may have the reversion or prevention effect of the testicular damage. Therefore, the group I received only BOL vehicle; group II received BOL and hCH placebo in the cycle form; group III received BOL and three applications of hCG50 in the cycle form; group IV received BOL and three applications of hCG200 in the cycle form; group V received BOL and three applications of hCG50 in the reversion form; group VI received BOL and three applications of hCG200 in the reversion form; group VII received BOL and three applications of hCG placebo in the reversion form; group VIII received BOL and was kept with no applications of any substance until the whole spermatogenesis have finished (approximately 60 days). For the first experiment, our data indicate that the protocol I showed the most deleterious effects in the redox status, cellular infiltration markers, as well as for the metabolic functioning of the hepatic tissue. Concerning to the second experiment, our data indicate that hCG had beneficial effects either in 50U or 200U dosages considering the MPO marker, however the animals in the protocol VIII were better benefited in TBARS evaluation when compared to the animals that had the preventive treatment with hCG administered in cycle form. The present thesis demonstrates that decreasing the dose of anabolics may be less deleterious to the liver and that hCG is able to prevent inflammatory infiltrates in the testis when in use with anabolic steroids.Na presente tese verificamos, sob a forma de dois experimentos, os efeitos deletérios de Undecilenato de Boldenona (BOL) e Estanazolol (ES) no fígado e nos testículos de ratos. No primeiro experimento, os parâmetros inflamatórios, metabólicos e de estresse oxidativo foram mensurados no fígado de ratos tratados com BOL ou ES. No segundo experimento, parâmetros de estresse oxidativo e inflamatórios foram avaliados nos testículos de ratos tratados com BOL associada ou não à gonadotrofina coriônica humana (hCG) em duas doses: 50U e 200U. No primeiro experimento, três protocolos foram estabelecidos a fim de se verificar qual deles seria o mais deletério para usuários desses tipos de anabolizantes. Sendo assim, o protocolo I representa os usuários que desejam acelerar os efeitos anabólicos usando doses superiores às recomendadas, em um intervalo de tempo mais curto, o protocolo II representa grupos de usuários de esteróides anabolizantes, que elegem uma dose moderada e tempo intermediário e protocolo III, que representa usuários que reduzem a dose e prolongam o tempo de exposição com o objetivo de diminuir os efeitos androgênicos. No segundo experimento, oito protocolos foram estabelecidos com o intuito de verificar se a exposição à BOL pode ser atenuada com o uso de hCG em duas doses consideradas baixas, mas que de acordo como são administradas, podem ter efeito de prevenção ou de reversão da lesão testicular. Sendo assim, o grupo I recebeu somente veículo de BOL; grupo II recebeu BOL e placebo de hCG na forma de ciclo; grupo III recebeu BOL e 3 aplicações de hCG50 na forma de ciclo; grupo IV recebeu BOL e 3 aplicações de hCG200 na forma de ciclo; grupo V recebeu BOL e 3 aplicações de hCG50 na forma de reversão; grupo VI recebeu BOL e 3 aplicações de hCG200 na forma de reversão; grupo VII recebeu BOL e 3 aplicações de hCG placebo na forma de reversão; grupo VIII recebeu BOL e foram mantidos sem aplicação de nenhuma substância até o tempo para que a espermatogênese completa ser alcançado (aproximadamente 60 dias). Para o primeiro experimento, os nossos resultados indicam que o protocolo I mostrou os efeitos mais deletérios no estado redox, marcadores de infiltração celular, bem como para o funcionamento metabólico do tecido hepático. Para o segundo experimento, nossos dados indicaram que o hCG teve efeitos benéficos tanto na dose de 50U como na dose de 200U ao se considerar o marcador MPO, contudo animais do protocolo VIII foram melhor beneficiados na avaliação de TBARS quando comparado aos animais que receberam o tratamento preventivo com hCG administrado em ciclos. A presente tese demonstra que diminuição da dose de anabolizantes pode ser menos deletéria ao fígado e que o hCG é capaz de prevenir infiltrado inflamatório nos testículos quando em uso com anabolizantes.Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPqporUniversidade Federal de Santa MariaCentro de Ciências RuraisPrograma de Pós-Graduação em Medicina VeterináriaUFSMBrasilMedicina VeterináriaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessUndecilenato de boldenonaEstanazololFígadoTestículosEstresse oxidativoMarcador inflamatórioGonadotrofina coriônica humanaBoldenone undecylenateStanazololLiverTesticlesOxidative stressInflammatory markerHuman chorionic gonadotrophinCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIAEfeitos da boldenona e do estanazolol associados ou não à gonadotrofina coriônica humana no fígado e testículo de ratosEffects of boldenone and stanazolol associated or not to human chorionic gonadotrophin in liver and testis of ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisAndrade, Cinthia Melazzo dehttp://lattes.cnpq.br/2886709251370905Bueno, Andressahttp://lattes.cnpq.br/4870571413044992Pinto Filho, Saulo Tadeu Lemoshttp://lattes.cnpq.br/1626744106896196Gutierres, Jessié Martinshttp://lattes.cnpq.br/8202862581642039Wolkmer, Patriciahttp://lattes.cnpq.br/5142205719893657http://lattes.cnpq.br/9973271333972597Lhamas, Cibele Lima500500000007600e0391f7d-99bf-47cd-a356-a3994d247daac1a31e21-29b1-4e0f-9b10-edfe002d2f564dbb1c6f-c4e8-4f7f-8060-d29843d58a24ee458f00-9a4f-4deb-b4fc-d17dd351ccac57fd6416-02cf-4091-a0d4-18961560066dfd30bdc0-41f4-47e1-9ebb-bbf0189a164breponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALTES_PPGMV_2018_LHAMAS_CIBELE.pdfTES_PPGMV_2018_LHAMAS_CIBELE.pdfTese de Doutoradoapplication/pdf1644836http://repositorio.ufsm.br/bitstream/1/15593/1/TES_PPGMV_2018_LHAMAS_CIBELE.pdfdfb69988b7af4adf141ca239a8bfcf7eMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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dc.title.por.fl_str_mv |
Efeitos da boldenona e do estanazolol associados ou não à gonadotrofina coriônica humana no fígado e testículo de ratos |
dc.title.alternative.eng.fl_str_mv |
Effects of boldenone and stanazolol associated or not to human chorionic gonadotrophin in liver and testis of rats |
title |
Efeitos da boldenona e do estanazolol associados ou não à gonadotrofina coriônica humana no fígado e testículo de ratos |
spellingShingle |
Efeitos da boldenona e do estanazolol associados ou não à gonadotrofina coriônica humana no fígado e testículo de ratos Lhamas, Cibele Lima Undecilenato de boldenona Estanazolol Fígado Testículos Estresse oxidativo Marcador inflamatório Gonadotrofina coriônica humana Boldenone undecylenate Stanazolol Liver Testicles Oxidative stress Inflammatory marker Human chorionic gonadotrophin CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Efeitos da boldenona e do estanazolol associados ou não à gonadotrofina coriônica humana no fígado e testículo de ratos |
title_full |
Efeitos da boldenona e do estanazolol associados ou não à gonadotrofina coriônica humana no fígado e testículo de ratos |
title_fullStr |
Efeitos da boldenona e do estanazolol associados ou não à gonadotrofina coriônica humana no fígado e testículo de ratos |
title_full_unstemmed |
Efeitos da boldenona e do estanazolol associados ou não à gonadotrofina coriônica humana no fígado e testículo de ratos |
title_sort |
Efeitos da boldenona e do estanazolol associados ou não à gonadotrofina coriônica humana no fígado e testículo de ratos |
author |
Lhamas, Cibele Lima |
author_facet |
Lhamas, Cibele Lima |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Andrade, Cinthia Melazzo de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2886709251370905 |
dc.contributor.referee1.fl_str_mv |
Bueno, Andressa |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/4870571413044992 |
dc.contributor.referee2.fl_str_mv |
Pinto Filho, Saulo Tadeu Lemos |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/1626744106896196 |
dc.contributor.referee3.fl_str_mv |
Gutierres, Jessié Martins |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/8202862581642039 |
dc.contributor.referee4.fl_str_mv |
Wolkmer, Patricia |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/5142205719893657 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9973271333972597 |
dc.contributor.author.fl_str_mv |
Lhamas, Cibele Lima |
contributor_str_mv |
Andrade, Cinthia Melazzo de Bueno, Andressa Pinto Filho, Saulo Tadeu Lemos Gutierres, Jessié Martins Wolkmer, Patricia |
dc.subject.por.fl_str_mv |
Undecilenato de boldenona Estanazolol Fígado Testículos Estresse oxidativo Marcador inflamatório Gonadotrofina coriônica humana |
topic |
Undecilenato de boldenona Estanazolol Fígado Testículos Estresse oxidativo Marcador inflamatório Gonadotrofina coriônica humana Boldenone undecylenate Stanazolol Liver Testicles Oxidative stress Inflammatory marker Human chorionic gonadotrophin CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.eng.fl_str_mv |
Boldenone undecylenate Stanazolol Liver Testicles Oxidative stress Inflammatory marker Human chorionic gonadotrophin |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
In the present thesis, under the format of two experiments, the deleterious effects of Boldenone Undecylenate (BOL) and Stanazolol (ST) in rats’ liver and testis were assessed. In the first experiment, the inflammatory, metabolic, and oxidative parameters were measured in rats’ liver when treated with either BOL or ST. In the second experiment, oxidative stress and inflammatory parameters were evaluated in rats’ testis treated with BOL associated or not to human chorionic gonadotrophin (hCG) in two dosages: 50U and 200U. In the first experiment, three protocols were established in order to verify which one would be the more deleterious for the users of this kind of anabolic steroids. Thereby, the protocol I represents the users who wish to accelerate the anabolic effects using higher dosages than those recommended, in a shorten time interval, the protocol II represents groups of users of anabolic steroids who choose a moderate dosage and intermediate time and protocol III represents users that reduce the dosage and prolong the exposure time aiming to reduce the androgenic effects. In the second experiment, eight protocols were made aiming to verify if the BOL exposure can be attenuated when using hCG in two dosages considered low, but in accordance to how they are administered, may have the reversion or prevention effect of the testicular damage. Therefore, the group I received only BOL vehicle; group II received BOL and hCH placebo in the cycle form; group III received BOL and three applications of hCG50 in the cycle form; group IV received BOL and three applications of hCG200 in the cycle form; group V received BOL and three applications of hCG50 in the reversion form; group VI received BOL and three applications of hCG200 in the reversion form; group VII received BOL and three applications of hCG placebo in the reversion form; group VIII received BOL and was kept with no applications of any substance until the whole spermatogenesis have finished (approximately 60 days). For the first experiment, our data indicate that the protocol I showed the most deleterious effects in the redox status, cellular infiltration markers, as well as for the metabolic functioning of the hepatic tissue. Concerning to the second experiment, our data indicate that hCG had beneficial effects either in 50U or 200U dosages considering the MPO marker, however the animals in the protocol VIII were better benefited in TBARS evaluation when compared to the animals that had the preventive treatment with hCG administered in cycle form. The present thesis demonstrates that decreasing the dose of anabolics may be less deleterious to the liver and that hCG is able to prevent inflammatory infiltrates in the testis when in use with anabolic steroids. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-08-10 |
dc.date.accessioned.fl_str_mv |
2019-02-11T13:07:45Z |
dc.date.available.fl_str_mv |
2019-02-11T13:07:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/15593 |
url |
http://repositorio.ufsm.br/handle/1/15593 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
500500000007 |
dc.relation.confidence.fl_str_mv |
600 |
dc.relation.authority.fl_str_mv |
e0391f7d-99bf-47cd-a356-a3994d247daa c1a31e21-29b1-4e0f-9b10-edfe002d2f56 4dbb1c6f-c4e8-4f7f-8060-d29843d58a24 ee458f00-9a4f-4deb-b4fc-d17dd351ccac 57fd6416-02cf-4091-a0d4-18961560066d fd30bdc0-41f4-47e1-9ebb-bbf0189a164b |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Rurais |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Medicina Veterinária |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Medicina Veterinária |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Rurais |
dc.source.none.fl_str_mv |
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Universidade Federal de Santa Maria (UFSM) |
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Manancial - Repositório Digital da UFSM |
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Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
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