Síntese de 2-amino(alcoxi)-5-trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas

Detalhes bibliográficos
Ano de defesa: 2006
Autor(a) principal: Fernandes, Liana da Silva lattes
Orientador(a): Zanatta, Nilo lattes
Banca de defesa: Martins, Marcos Antonio Pinto lattes, Barichello, Rosemario lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Santa Maria
Programa de Pós-Graduação: Programa de Pós-Graduação em Química
Departamento: Química
País: BR
Palavras-chave em Português:
Química
Palavras-chave em Inglês:
Chemistry
Área do conhecimento CNPq:
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
Link de acesso: http://repositorio.ufsm.br/handle/1/10382
Resumo: The present work describes the synthesis of novel 2-alkoxy-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines, 2-amino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines and oxazolo[3,2-a]pyridines from the cyclocondensation reactions between 2-alkoxy-5-trifluoroacetyl-2H-3,4-dihydropyranes and aminomethyl pyridines, aminoalcohols and o-aminophenol, respectively, in good yields (72-96%). The 2-alkoxy-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines were synthesized using stoichiometric amounts of the trifluoroacetyl dihydropyranes and three different aminomethyl pyridines. When the reactions were carried in an one molar excess of the aminomethyl pyridines the 2-amino-5-trifluoromethyl-1,2,3,4-tetrahydropyridines were isolated as single products. Finally, the oxazolo[3,2-a]pyridines were obtained from the cyclocondensation reactions between equal molar quantities of the trifluoroacetyl dihydropyranes and three different aminoalcohols and oaminophenol.
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spelling 2006-12-112006-12-112006-07-03FERNANDES, Liana da Silva. 2-amino synthesis of (alcoxi) - 5-trifluoracetil-1,2,3,4-tetraidropiridinas and oxazolo [3,2 it] piridinas. 2006. 187 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2006.http://repositorio.ufsm.br/handle/1/10382The present work describes the synthesis of novel 2-alkoxy-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines, 2-amino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines and oxazolo[3,2-a]pyridines from the cyclocondensation reactions between 2-alkoxy-5-trifluoroacetyl-2H-3,4-dihydropyranes and aminomethyl pyridines, aminoalcohols and o-aminophenol, respectively, in good yields (72-96%). The 2-alkoxy-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines were synthesized using stoichiometric amounts of the trifluoroacetyl dihydropyranes and three different aminomethyl pyridines. When the reactions were carried in an one molar excess of the aminomethyl pyridines the 2-amino-5-trifluoromethyl-1,2,3,4-tetrahydropyridines were isolated as single products. Finally, the oxazolo[3,2-a]pyridines were obtained from the cyclocondensation reactions between equal molar quantities of the trifluoroacetyl dihydropyranes and three different aminoalcohols and oaminophenol.Este trabalho apresenta a síntese de três séries de compostos inéditos: 2-alcoxi-5-trifluoracetil-1,2,3,4-tetraidropiridinas, 2-amino-5- trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas, obtidos através de reações de ciclização entre os 2-alcoxi-5-trifluoracetil-3,4-diidro- 2H-piranos com aminometil piridinas, aminoálcoois e com o o-amino-fenol, em bons rendimentos (72-96%), através de um único passo reacional. As 2-alcoxi-5-trifluoracetil-1,2,3,4-tetraidropiridinas foram obtidas utilizando-se quantidades estequiométricas dos trifluoracetil diidropiranos com três aminometil piridinas diferentes, enquanto que, as 2-amino-5- trifluoracetil-1,2,3,4-tetraidropiridinas foram obtidas através da reação entre os mesmos precursores, em relação estequiométrica de 1:2, frente às aminometil piridinas e aos aminoálcoois. As oxazolo[3,2-a]piridinas foram obtidas através de reações de ciclização entre os precursores, em quantidades equimolares, frente a três aminoálcoois e ao o-amino-fenol.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em QuímicaUFSMBRQuímicaQuímicaChemistryCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICASíntese de 2-amino(alcoxi)-5-trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas2-amino synthesis of (alcoxi) - 5-trifluoracetil-1,2,3,4-tetraidropiridinas and oxazolo [3,2 it] piridinasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisZanatta, Nilohttp://lattes.cnpq.br/0719465062354576Martins, Marcos Antonio Pintohttp://lattes.cnpq.br/6457412713967642Barichello, Rosemariohttp://lattes.cnpq.br/8251059080103642http://lattes.cnpq.br/0573570242395130Fernandes, Liana da 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dc.title.por.fl_str_mv Síntese de 2-amino(alcoxi)-5-trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas
dc.title.alternative.eng.fl_str_mv 2-amino synthesis of (alcoxi) - 5-trifluoracetil-1,2,3,4-tetraidropiridinas and oxazolo [3,2 it] piridinas
title Síntese de 2-amino(alcoxi)-5-trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas
spellingShingle Síntese de 2-amino(alcoxi)-5-trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas
Fernandes, Liana da Silva
Química
Chemistry
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
title_short Síntese de 2-amino(alcoxi)-5-trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas
title_full Síntese de 2-amino(alcoxi)-5-trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas
title_fullStr Síntese de 2-amino(alcoxi)-5-trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas
title_full_unstemmed Síntese de 2-amino(alcoxi)-5-trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas
title_sort Síntese de 2-amino(alcoxi)-5-trifluoracetil-1,2,3,4-tetraidropiridinas e oxazolo[3,2-a]piridinas
author Fernandes, Liana da Silva
author_facet Fernandes, Liana da Silva
author_role author
dc.contributor.advisor1.fl_str_mv Zanatta, Nilo
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/0719465062354576
dc.contributor.referee1.fl_str_mv Martins, Marcos Antonio Pinto
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/6457412713967642
dc.contributor.referee2.fl_str_mv Barichello, Rosemario
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/8251059080103642
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/0573570242395130
dc.contributor.author.fl_str_mv Fernandes, Liana da Silva
contributor_str_mv Zanatta, Nilo
Martins, Marcos Antonio Pinto
Barichello, Rosemario
dc.subject.por.fl_str_mv Química
topic Química
Chemistry
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
dc.subject.eng.fl_str_mv Chemistry
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
description The present work describes the synthesis of novel 2-alkoxy-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines, 2-amino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines and oxazolo[3,2-a]pyridines from the cyclocondensation reactions between 2-alkoxy-5-trifluoroacetyl-2H-3,4-dihydropyranes and aminomethyl pyridines, aminoalcohols and o-aminophenol, respectively, in good yields (72-96%). The 2-alkoxy-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines were synthesized using stoichiometric amounts of the trifluoroacetyl dihydropyranes and three different aminomethyl pyridines. When the reactions were carried in an one molar excess of the aminomethyl pyridines the 2-amino-5-trifluoromethyl-1,2,3,4-tetrahydropyridines were isolated as single products. Finally, the oxazolo[3,2-a]pyridines were obtained from the cyclocondensation reactions between equal molar quantities of the trifluoroacetyl dihydropyranes and three different aminoalcohols and oaminophenol.
publishDate 2006
dc.date.accessioned.fl_str_mv 2006-12-11
dc.date.available.fl_str_mv 2006-12-11
dc.date.issued.fl_str_mv 2006-07-03
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dc.identifier.citation.fl_str_mv FERNANDES, Liana da Silva. 2-amino synthesis of (alcoxi) - 5-trifluoracetil-1,2,3,4-tetraidropiridinas and oxazolo [3,2 it] piridinas. 2006. 187 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2006.
dc.identifier.uri.fl_str_mv http://repositorio.ufsm.br/handle/1/10382
identifier_str_mv FERNANDES, Liana da Silva. 2-amino synthesis of (alcoxi) - 5-trifluoracetil-1,2,3,4-tetraidropiridinas and oxazolo [3,2 it] piridinas. 2006. 187 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2006.
url http://repositorio.ufsm.br/handle/1/10382
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