Efeitos, percepção de fármacos e comunicação química em peixes
Ano de defesa: | 2017 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
Centro de Ciências da Saúde |
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Farmacologia
|
Departamento: |
Farmacologia
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/13311 |
Resumo: | The presence of drugs in aquatic environments has been studied for decades and their actions have as consequence changes of several physiological mechanisms. It is known that there is a complex chemical communication between the species that inhabit this environment, but the perception of intra and interspecific communication substances is unknown. The studies developed aim to evaluate if the fish are able to identify different stress situations and drugs, analyzing the neuroendocrine, behavioral and osmoregulatory effects. Seven studies were elaborated: 1) acute stress test and osmoregulatory evaluation with fluoxetine; 2) test of the action of fluoxetine in different responses of stressors (physical or chemical); 3) individual perception test to different conspecific situations; 4) testing preference at different concentrations of drugs and detection by olfaction; 5) experimental anosmia test in type-anxiety behavior; 6) experimental anosmia test, by ZnSO4, in behavioral and physiological responses; 7) test of the effects of acute stress on social behavior and "anxiety" in jundias (Rhamdia quelen). Based on the results it was verified that the acute exposure to fluoxetine is able to inhibit osmoregulatory changes caused by stress. Fluoxetine attenuates the cortisol response to physical stressor stimulus, but not to chemical stressor stimulus. Zebrafish can perceive and trigger aversive behaviors when in contact with conditioned waters of physical, chemical, and food stress (acute fasting). Zebrafish is attracted to psychotropic drugs such as diazepam, fluoxetine, risperidone and buspirone, which are probably detected by olfaction. Temporary experimental anosmia (by lidocaine and ZnSO4) modulates anxiety behaviors in adult zebrafish. Jundia can be used for behavioral studies of "anxiety" and social interaction. In general, these results contribute to a better understanding of the effects and perceptions of pharmacological action and chemical communication in fish. |
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2018-06-06T17:25:35Z2018-06-06T17:25:35Z2017-06-08http://repositorio.ufsm.br/handle/1/13311The presence of drugs in aquatic environments has been studied for decades and their actions have as consequence changes of several physiological mechanisms. It is known that there is a complex chemical communication between the species that inhabit this environment, but the perception of intra and interspecific communication substances is unknown. The studies developed aim to evaluate if the fish are able to identify different stress situations and drugs, analyzing the neuroendocrine, behavioral and osmoregulatory effects. Seven studies were elaborated: 1) acute stress test and osmoregulatory evaluation with fluoxetine; 2) test of the action of fluoxetine in different responses of stressors (physical or chemical); 3) individual perception test to different conspecific situations; 4) testing preference at different concentrations of drugs and detection by olfaction; 5) experimental anosmia test in type-anxiety behavior; 6) experimental anosmia test, by ZnSO4, in behavioral and physiological responses; 7) test of the effects of acute stress on social behavior and "anxiety" in jundias (Rhamdia quelen). Based on the results it was verified that the acute exposure to fluoxetine is able to inhibit osmoregulatory changes caused by stress. Fluoxetine attenuates the cortisol response to physical stressor stimulus, but not to chemical stressor stimulus. Zebrafish can perceive and trigger aversive behaviors when in contact with conditioned waters of physical, chemical, and food stress (acute fasting). Zebrafish is attracted to psychotropic drugs such as diazepam, fluoxetine, risperidone and buspirone, which are probably detected by olfaction. Temporary experimental anosmia (by lidocaine and ZnSO4) modulates anxiety behaviors in adult zebrafish. Jundia can be used for behavioral studies of "anxiety" and social interaction. In general, these results contribute to a better understanding of the effects and perceptions of pharmacological action and chemical communication in fish.A presença de fármacos em ambientes aquáticos tem sido estudada há décadas e suas ações têm como consequências alterações de diversos mecanismos fisiológicos. Sabe-se que existe uma complexa comunicação química entre as espécies que habitam esse ambiente, mas a percepção de substâncias das comunicações intra e interespecíficas é desconhecida. Os estudos desenvolvidos objetivam avaliar se os peixes são capazes de identificar diferentes situações estressoras e fármacos, analisando os efeitos neuroendócrinos, comportamentais e osmorregulatórios. Foram elaborados sete estudos: 1) teste de estresse agudo e avaliação osmorregulatória com fluoxetina; 2) teste da ação da fluoxetina em diferentes respostas de estressores (físicos ou químicos); 3) teste de percepção individual a diferentes situações de coespecíficos; 4) teste de preferência a diferentes concentrações de fármacos e detecção pela via olfatória; 5) teste de anosmia experimental em comportamento tipo-ansiedade; 6) teste de anosmia experimental, por ZnSO4, em respostas comportamentais e fisiológicas; 7) teste dos efeitos do estresse agudo sobre comportamento social e "ansiedade" em jundiás (Rhamdia quelen). Com base nos resultados, verificou se que a exposição aguda de fluoxetina é capaz de inibir as alterações osmorregulatórias causadas pelo estresse. A fluoxetina atenua a resposta de cortisol a estímulo estressor físico, mas não a estímulo estressor químico. O zebrafish pode perceber e desencadear comportamentos aversivos quando em contato com águas condicionadas de estresse físico, químico e alimentar (jejum agudo). O zebrafish apresenta atração por psicofármacos como diazepam, fluoxetina, risperidona e buspirona, os quais provavelmente são detectados pela via olfatória. A anosmia experimental temporária (por lidocaína e ZnSO4) modula comportamentos de ansiedade em zebrafish adulto. O jundiá pode ser utilizado para estudos comportamentais de "ansiedade" e interação social. De modo geral, esses resultados contribuem para um melhor entendimento dos efeitos e percepções da ação farmacológica e de comunicação química em peixes.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESporUniversidade Federal de Santa MariaCentro de Ciências da SaúdePrograma de Pós-Graduação em FarmacologiaUFSMBrasilFarmacologiaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessEstresseAnsiedadeFluoxetinaAnosmiaStressAnxietyFluoxetineAnosmiaZebrafishCNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIAEfeitos, percepção de fármacos e comunicação química em peixesEffects, perception of drugs and chemical communication in fishinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisBarcellos, Leonardo Jose Gilhttp://lattes.cnpq.br/4504482634911546Siebel, Anna Mariahttp://lattes.cnpq.br/1971570388738681Baldisserotto, Bernardohttp://lattes.cnpq.br/1036046601275319Bonan, Carla Denisehttp://lattes.cnpq.br/8058052532279136http://lattes.cnpq.br/4365414009598956Abreu, Murilo Sander de201000000000600c9e84488-1380-43c4-aa1d-dc61b89a1f1867ddfa81-009e-43a6-bddf-692ef3db8e633d9c4662-bb72-44bc-8384-bcee9a17c230a64e0440-e917-4c31-ad62-51b4ea8f37fde1e58ef1-e7a8-49ab-9fba-508c06db76dbreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALTES_PPGFARMACOLOGIA_2017_ABREU_ MURILOTES_PPGFARMACOLOGIA_2017_ABREU_ MURILOTese de Doutoradoapplication/pdf18216421http://repositorio.ufsm.br/bitstream/1/13311/1/TES_PPGFARMACOLOGIA_2017_ABREU_%20MURILO2eaa47ca70d0c31b353da71963558c43MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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dc.title.por.fl_str_mv |
Efeitos, percepção de fármacos e comunicação química em peixes |
dc.title.alternative.eng.fl_str_mv |
Effects, perception of drugs and chemical communication in fish |
title |
Efeitos, percepção de fármacos e comunicação química em peixes |
spellingShingle |
Efeitos, percepção de fármacos e comunicação química em peixes Abreu, Murilo Sander de Estresse Ansiedade Fluoxetina Anosmia Stress Anxiety Fluoxetine Anosmia Zebrafish CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
title_short |
Efeitos, percepção de fármacos e comunicação química em peixes |
title_full |
Efeitos, percepção de fármacos e comunicação química em peixes |
title_fullStr |
Efeitos, percepção de fármacos e comunicação química em peixes |
title_full_unstemmed |
Efeitos, percepção de fármacos e comunicação química em peixes |
title_sort |
Efeitos, percepção de fármacos e comunicação química em peixes |
author |
Abreu, Murilo Sander de |
author_facet |
Abreu, Murilo Sander de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Barcellos, Leonardo Jose Gil |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4504482634911546 |
dc.contributor.referee1.fl_str_mv |
Siebel, Anna Maria |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/1971570388738681 |
dc.contributor.referee2.fl_str_mv |
Baldisserotto, Bernardo |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/1036046601275319 |
dc.contributor.referee3.fl_str_mv |
Bonan, Carla Denise |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/8058052532279136 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4365414009598956 |
dc.contributor.author.fl_str_mv |
Abreu, Murilo Sander de |
contributor_str_mv |
Barcellos, Leonardo Jose Gil Siebel, Anna Maria Baldisserotto, Bernardo Bonan, Carla Denise |
dc.subject.por.fl_str_mv |
Estresse Ansiedade Fluoxetina Anosmia |
topic |
Estresse Ansiedade Fluoxetina Anosmia Stress Anxiety Fluoxetine Anosmia Zebrafish CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
dc.subject.eng.fl_str_mv |
Stress Anxiety Fluoxetine Anosmia Zebrafish |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
description |
The presence of drugs in aquatic environments has been studied for decades and their actions have as consequence changes of several physiological mechanisms. It is known that there is a complex chemical communication between the species that inhabit this environment, but the perception of intra and interspecific communication substances is unknown. The studies developed aim to evaluate if the fish are able to identify different stress situations and drugs, analyzing the neuroendocrine, behavioral and osmoregulatory effects. Seven studies were elaborated: 1) acute stress test and osmoregulatory evaluation with fluoxetine; 2) test of the action of fluoxetine in different responses of stressors (physical or chemical); 3) individual perception test to different conspecific situations; 4) testing preference at different concentrations of drugs and detection by olfaction; 5) experimental anosmia test in type-anxiety behavior; 6) experimental anosmia test, by ZnSO4, in behavioral and physiological responses; 7) test of the effects of acute stress on social behavior and "anxiety" in jundias (Rhamdia quelen). Based on the results it was verified that the acute exposure to fluoxetine is able to inhibit osmoregulatory changes caused by stress. Fluoxetine attenuates the cortisol response to physical stressor stimulus, but not to chemical stressor stimulus. Zebrafish can perceive and trigger aversive behaviors when in contact with conditioned waters of physical, chemical, and food stress (acute fasting). Zebrafish is attracted to psychotropic drugs such as diazepam, fluoxetine, risperidone and buspirone, which are probably detected by olfaction. Temporary experimental anosmia (by lidocaine and ZnSO4) modulates anxiety behaviors in adult zebrafish. Jundia can be used for behavioral studies of "anxiety" and social interaction. In general, these results contribute to a better understanding of the effects and perceptions of pharmacological action and chemical communication in fish. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-06-08 |
dc.date.accessioned.fl_str_mv |
2018-06-06T17:25:35Z |
dc.date.available.fl_str_mv |
2018-06-06T17:25:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/13311 |
url |
http://repositorio.ufsm.br/handle/1/13311 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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201000000000 |
dc.relation.confidence.fl_str_mv |
600 |
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dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Farmacologia |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Farmacologia |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.source.none.fl_str_mv |
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