Síntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxal
Ano de defesa: | 2017 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
Centro de Ciências Naturais e Exatas |
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Química
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/12160 |
Resumo: | This work treat with the synthesis and characterization of new cobalt complexes with ligands derived from pyridoxal and their application as mimetics of the enzyme peroxidase. The complexes were structurally characterized by monocrystal X-ray diffraction and their redox behavior was studied by cyclic voltammetry. In the synthesis of the complexes, a reactivity pattern was observed with respect to the cobalt salts used, by selecting appropriately between Co(CH3COO)2 and CoCl2(PPh3)2, it was possible to obtain two sets of analogous mononuclear complexes. In one, the C-S bonds are cleaved from the organic ligands and in other hand, the cleavage of the C-S bond is not observed. Was also evidenced, it was evidenced the formation of dinuclear zwitterionic and tetranuclear complexes, due to the different coordination modes of the ligands used and the methodological differences. The complexes obtained were tested as mimetics of the enzyme peroxidase, presenting promising results. |
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Biblioteca Digital de Teses e Dissertações do UFSM |
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2017-12-15T12:37:20Z2017-12-15T12:37:20Z2017-02-16http://repositorio.ufsm.br/handle/1/12160This work treat with the synthesis and characterization of new cobalt complexes with ligands derived from pyridoxal and their application as mimetics of the enzyme peroxidase. The complexes were structurally characterized by monocrystal X-ray diffraction and their redox behavior was studied by cyclic voltammetry. In the synthesis of the complexes, a reactivity pattern was observed with respect to the cobalt salts used, by selecting appropriately between Co(CH3COO)2 and CoCl2(PPh3)2, it was possible to obtain two sets of analogous mononuclear complexes. In one, the C-S bonds are cleaved from the organic ligands and in other hand, the cleavage of the C-S bond is not observed. Was also evidenced, it was evidenced the formation of dinuclear zwitterionic and tetranuclear complexes, due to the different coordination modes of the ligands used and the methodological differences. The complexes obtained were tested as mimetics of the enzyme peroxidase, presenting promising results.Este trabalho trata da síntese e caracterização de novos complexos de cobalto com ligantes derivados do piridoxal, e de sua aplicação como miméticos da enzima peroxidase. Os complexos foram caracterizados estruturalmente por difração de raios X de monocristal e seu comportamento redox foi estudado por voltametria cíclica. Na síntese dos complexos, foi observado um padrão de reatividade com relação aos sais de cobalto utilizados, de modo que, selecionando-se adequadamente entre o Co(CH3COO)2 e o CoCl2(PPh3)2 foi possível obter duas séries de complexos mononucleares. Em uma delas, ocorre a cisão de ligações C-S dos ligantes orgânicos, enquanto na outra série, isto não é observado. Também foi evidenciada a formação de complexos dinucleares zwitteriônicos e tetranucleares, em decorrência dos diversos modos de coordenação dos ligantes utilizados e das diferenças metodológicas. Os complexos obtidos foram testados como miméticos da enzima peroxidase, apresentando resultados promissores.porUniversidade Federal de Santa MariaCentro de Ciências Naturais e ExatasPrograma de Pós-Graduação em QuímicaUFSMBrasilQuímicaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessPiridoxalCobaltoDifração de raios XPeroxidasePyridoxalCobaltX-ray diffractionCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICASíntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxalSynthesis, characterization and evaluation of the peroxidase activity of new cobalt complexes with ligands derived from pyridoxalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisBack, Davi Fernandohttp://lattes.cnpq.br/3778138554788107Tirloni, Barbarahttp://lattes.cnpq.br/2866324870100182Vargas, Jaqueline Pintohttp://lattes.cnpq.br/2927700876012801http://lattes.cnpq.br/1644537701848242Fontana, Liniquer André1006000000006006028c486-84b0-44fc-aa73-1e49cc9c8fbb7a747ca4-21fe-4816-9581-7b12f0fd4328c0fdbcac-0be4-42a7-87f7-7d98df7c1dfb0bde100a-e8ed-45e0-8c25-fa6924a52dbbreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGQUIMICA_2017_FONTANA_LINIQUER.pdfDIS_PPGQUIMICA_2017_FONTANA_LINIQUER.pdfDissertação de Mestradoapplication/pdf6751624http://repositorio.ufsm.br/bitstream/1/12160/1/DIS_PPGQUIMICA_2017_FONTANA_LINIQUER.pdfbdd8f6898269fd27fd11dfab94b899f0MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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dc.title.por.fl_str_mv |
Síntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxal |
dc.title.alternative.eng.fl_str_mv |
Synthesis, characterization and evaluation of the peroxidase activity of new cobalt complexes with ligands derived from pyridoxal |
title |
Síntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxal |
spellingShingle |
Síntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxal Fontana, Liniquer André Piridoxal Cobalto Difração de raios X Peroxidase Pyridoxal Cobalt X-ray diffraction CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Síntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxal |
title_full |
Síntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxal |
title_fullStr |
Síntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxal |
title_full_unstemmed |
Síntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxal |
title_sort |
Síntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxal |
author |
Fontana, Liniquer André |
author_facet |
Fontana, Liniquer André |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Back, Davi Fernando |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3778138554788107 |
dc.contributor.referee1.fl_str_mv |
Tirloni, Barbara |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2866324870100182 |
dc.contributor.referee2.fl_str_mv |
Vargas, Jaqueline Pinto |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/2927700876012801 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1644537701848242 |
dc.contributor.author.fl_str_mv |
Fontana, Liniquer André |
contributor_str_mv |
Back, Davi Fernando Tirloni, Barbara Vargas, Jaqueline Pinto |
dc.subject.por.fl_str_mv |
Piridoxal Cobalto Difração de raios X Peroxidase |
topic |
Piridoxal Cobalto Difração de raios X Peroxidase Pyridoxal Cobalt X-ray diffraction CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Pyridoxal Cobalt X-ray diffraction |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
This work treat with the synthesis and characterization of new cobalt complexes with ligands derived from pyridoxal and their application as mimetics of the enzyme peroxidase. The complexes were structurally characterized by monocrystal X-ray diffraction and their redox behavior was studied by cyclic voltammetry. In the synthesis of the complexes, a reactivity pattern was observed with respect to the cobalt salts used, by selecting appropriately between Co(CH3COO)2 and CoCl2(PPh3)2, it was possible to obtain two sets of analogous mononuclear complexes. In one, the C-S bonds are cleaved from the organic ligands and in other hand, the cleavage of the C-S bond is not observed. Was also evidenced, it was evidenced the formation of dinuclear zwitterionic and tetranuclear complexes, due to the different coordination modes of the ligands used and the methodological differences. The complexes obtained were tested as mimetics of the enzyme peroxidase, presenting promising results. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-12-15T12:37:20Z |
dc.date.available.fl_str_mv |
2017-12-15T12:37:20Z |
dc.date.issued.fl_str_mv |
2017-02-16 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/12160 |
url |
http://repositorio.ufsm.br/handle/1/12160 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
100600000000 |
dc.relation.confidence.fl_str_mv |
600 |
dc.relation.authority.fl_str_mv |
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dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Química |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Química |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações do UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
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Universidade Federal de Santa Maria (UFSM) |
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UFSM |
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UFSM |
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Biblioteca Digital de Teses e Dissertações do UFSM |
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Biblioteca Digital de Teses e Dissertações do UFSM |
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