Avaliação dos níveis de albumina modificada pela isquemia, um novo biomarcador de estresse oxidativo, em pacientes com artrite reumatoide

• Ano de defesa: 2013
• Autor(a) principal: Leitemperguer, Michele Rodrigues
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• dARK ID: ark:/26339/0013000004gv1
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; BR; Análises Clínicas e Toxicológicas; UFSM; Programa de Pós-Graduação em Ciências Farmacêuticas
• Palavras-chave em Português: Artrite reumatóide; Espécies reativas de oxigênio; Albumina modificada pela isquemia; Proteína C-reativa; Produtos proteicos de oxidação avançada; Rheumatoid arthritis; Reactive oxygen species; Ischemia-modified albumin; C-reactive protein; Advanced oxidation protein products; CNPQ::CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/5990

Rheumatoid arthritis (RA) is a chronic inflammatory, autoimmune disease, characterized by peripheral and symmetrical polyarthritis that leads to joint destruction and deformity due to erosion of cartilage and bone. This is a common disease that affects approximately 1% of the world population and is more common in women than men, however, its peak incidence occurs between the fourth and sixth decades of life. Large amounts of reactive oxygen species (ROS) have been identified in the synovial fluid of RA patients, and such large amounts may lead to oxidative damage of hyaluronic acid, lipid, cartilage matrix and DNA. The accumulation of ROS in the cells, also serves as major intracellular signaling molecules that amplify the inflammatory response synovium proliferative. The objective of this study was to evaluate the levels of ischemia-modified albumin (IMA) and also other markers of oxidative stress and inflammation in 16 patients with RA and 20 healthy controls. IMA levels were significantly higher in RA patients than healthy controls (0.495 ± 0.01 vs 0.433 ± 0.02 ABSU, P=0.038). No significant differences were observed for the other markers studied. Thus it was concluded that besides RA being related to inflammation, elevated levels of IMA in RA patients suggest that this pathology promotes increased oxidative stress.