Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio)
Ano de defesa: | 2019 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
Centro de Ciências da Saúde |
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Farmacologia
|
Departamento: |
Farmacologia
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/21033 |
Resumo: | The dopaminergic system is the subject of numerous researches due to its complexity and to have numerous pathways and receptors in the central nervous system. The release of catecholamines such as dopamine and norepinephrine, are dependent on the presence of tyrosine hydroxylase, which converts L-tyrosine to L-DOPA / levodopa and later into dopamine by dopa decarboxylase. Finally, dopamine is converted to norepinephrine by dopamine β-hydroxylase. On the other hand, L-tyrosine analogues such as a-methyl-para-tyrosine are potent competitive inhibitors of tyrosine hydroxylase, inhibiting the production of catecholamines. It should be noted that dopamine is responsible for innumerable functions such as locomotion, cognition, emotion and neuroendocrine functions. In this context, our objective was to investigate the participation of the dopaminergic pathway on the neuroendocrine axis of stress in zebrafish. We have shown, based on the results of the two articles described, that there is an intimate relationship between catecholamine’s and glucocorticoids in neuroendocrine stress responses. In the first article, we showed that a-methyl-para-tyrosine was able to block the stress axis in adult zebrafish after a stressor event. And in the second article after blocking the dopaminergic pathway with a-methyl-para-tyrosine and subsequent levodopa supplementation, we strongly suggest that dopamine is related to the balance of stress response and norepinephrine to decrease this response. |
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2021-06-01T21:13:22Z2021-06-01T21:13:22Z2019-06-03http://repositorio.ufsm.br/handle/1/21033The dopaminergic system is the subject of numerous researches due to its complexity and to have numerous pathways and receptors in the central nervous system. The release of catecholamines such as dopamine and norepinephrine, are dependent on the presence of tyrosine hydroxylase, which converts L-tyrosine to L-DOPA / levodopa and later into dopamine by dopa decarboxylase. Finally, dopamine is converted to norepinephrine by dopamine β-hydroxylase. On the other hand, L-tyrosine analogues such as a-methyl-para-tyrosine are potent competitive inhibitors of tyrosine hydroxylase, inhibiting the production of catecholamines. It should be noted that dopamine is responsible for innumerable functions such as locomotion, cognition, emotion and neuroendocrine functions. In this context, our objective was to investigate the participation of the dopaminergic pathway on the neuroendocrine axis of stress in zebrafish. We have shown, based on the results of the two articles described, that there is an intimate relationship between catecholamine’s and glucocorticoids in neuroendocrine stress responses. In the first article, we showed that a-methyl-para-tyrosine was able to block the stress axis in adult zebrafish after a stressor event. And in the second article after blocking the dopaminergic pathway with a-methyl-para-tyrosine and subsequent levodopa supplementation, we strongly suggest that dopamine is related to the balance of stress response and norepinephrine to decrease this response.O sistema dopaminérgico é alvo de inúmeras pesquisas devido sua complexidade e por possuir numerosas vias e receptores no sistema nervoso central. A liberação de catecolaminas como a dopamina e norepinefrina, são dependentes da presença de tirosina hidroxilase, que converte a L-tirosina em L-DOPA/levodopa e posteriormente em dopamina pela dopa descarboxilase. Por fim a dopamina é convertida em norepinefrina pela dopamina β-hidroxilase. Por outro lado, análogos da L-tirosina como a a-metil-para-tirosina, são potentes inibidores competitivos da tirosina hidroxilase, inibindo a produção de catecolaminas. Cabe ressaltar que a dopamina é responsável por inúmeras funções como locomoção, cognição, emoção e funções neuroendócrinas. Neste contexto, nosso objetivo foi investigar a participação da via dopaminérgica sobre o eixo neuroendócrino de estresse em peixe-zebra. Nós mostramos, com base nos resultados dos dois artigos descritos que existe uma íntima relação entre catecolaminas e glicocorticoides nas respostas neuroendócrinas de estresse. No primeiro artigo, mostramos que a a-metil-para-tirosina foi capaz de bloquear o eixo de estresse em peixe-zebra adulto após um evento estressor. E no segundo artigo após bloqueio da via dopaminérgica com a-metil-para-tirosina e posterior suplementação com levodopa, sugerimos fortes indícios de que a dopamina está relacionada ao equilíbrio da resposta ao estresse e a norepinefrina a diminuição desta resposta.porUniversidade Federal de Santa MariaCentro de Ciências da SaúdePrograma de Pós-Graduação em FarmacologiaUFSMBrasilFarmacologiaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessCortisolEixo hipotálamo-hipófise-interrenalControle dopaminérgicoAMPTResposta de estresseLevodopaHypothalamus-pituitary-interrenal axisDopaminergic controlStress responseCNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIAEnvolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio)Dopaminergic involvement in the modulation of the stress response in zebrafish (Danio rerio)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisBarcellos, Leonardo Jose Gilhttp://lattes.cnpq.br/4504482634911546Oliveira, Caio Maximino deSiebel, Anna MariaKreutz, Luiz CarlosCunha, Mauro Alves daRosemberg, Denis Broockhttp://lattes.cnpq.br/6366188448478393Idalencio, Renan20100000000060060060060060060060060017da2b0a-d295-4b64-9a39-85a2eb295349c0871bf6-56aa-4b0c-9632-22c3302318bde8c067d4-7e9e-4cb7-a98e-280494979f163d9c4662-bb72-44bc-8384-bcee9a17c230ec7b524e-f440-42c4-b696-31e2b3354e5e26b2d6ff-dcc0-4540-9026-4501d32d2c38607e382a-3bee-4345-8f96-b68eed3a31d3reponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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dc.title.por.fl_str_mv |
Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio) |
dc.title.alternative.eng.fl_str_mv |
Dopaminergic involvement in the modulation of the stress response in zebrafish (Danio rerio) |
title |
Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio) |
spellingShingle |
Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio) Idalencio, Renan Cortisol Eixo hipotálamo-hipófise-interrenal Controle dopaminérgico AMPT Resposta de estresse Levodopa Hypothalamus-pituitary-interrenal axis Dopaminergic control Stress response CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
title_short |
Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio) |
title_full |
Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio) |
title_fullStr |
Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio) |
title_full_unstemmed |
Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio) |
title_sort |
Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio) |
author |
Idalencio, Renan |
author_facet |
Idalencio, Renan |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Barcellos, Leonardo Jose Gil |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4504482634911546 |
dc.contributor.advisor-co1.fl_str_mv |
Oliveira, Caio Maximino de |
dc.contributor.referee1.fl_str_mv |
Siebel, Anna Maria |
dc.contributor.referee2.fl_str_mv |
Kreutz, Luiz Carlos |
dc.contributor.referee3.fl_str_mv |
Cunha, Mauro Alves da |
dc.contributor.referee4.fl_str_mv |
Rosemberg, Denis Broock |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6366188448478393 |
dc.contributor.author.fl_str_mv |
Idalencio, Renan |
contributor_str_mv |
Barcellos, Leonardo Jose Gil Oliveira, Caio Maximino de Siebel, Anna Maria Kreutz, Luiz Carlos Cunha, Mauro Alves da Rosemberg, Denis Broock |
dc.subject.por.fl_str_mv |
Cortisol Eixo hipotálamo-hipófise-interrenal Controle dopaminérgico AMPT Resposta de estresse Levodopa |
topic |
Cortisol Eixo hipotálamo-hipófise-interrenal Controle dopaminérgico AMPT Resposta de estresse Levodopa Hypothalamus-pituitary-interrenal axis Dopaminergic control Stress response CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
dc.subject.eng.fl_str_mv |
Hypothalamus-pituitary-interrenal axis Dopaminergic control Stress response |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
description |
The dopaminergic system is the subject of numerous researches due to its complexity and to have numerous pathways and receptors in the central nervous system. The release of catecholamines such as dopamine and norepinephrine, are dependent on the presence of tyrosine hydroxylase, which converts L-tyrosine to L-DOPA / levodopa and later into dopamine by dopa decarboxylase. Finally, dopamine is converted to norepinephrine by dopamine β-hydroxylase. On the other hand, L-tyrosine analogues such as a-methyl-para-tyrosine are potent competitive inhibitors of tyrosine hydroxylase, inhibiting the production of catecholamines. It should be noted that dopamine is responsible for innumerable functions such as locomotion, cognition, emotion and neuroendocrine functions. In this context, our objective was to investigate the participation of the dopaminergic pathway on the neuroendocrine axis of stress in zebrafish. We have shown, based on the results of the two articles described, that there is an intimate relationship between catecholamine’s and glucocorticoids in neuroendocrine stress responses. In the first article, we showed that a-methyl-para-tyrosine was able to block the stress axis in adult zebrafish after a stressor event. And in the second article after blocking the dopaminergic pathway with a-methyl-para-tyrosine and subsequent levodopa supplementation, we strongly suggest that dopamine is related to the balance of stress response and norepinephrine to decrease this response. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-06-03 |
dc.date.accessioned.fl_str_mv |
2021-06-01T21:13:22Z |
dc.date.available.fl_str_mv |
2021-06-01T21:13:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
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publishedVersion |
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http://repositorio.ufsm.br/handle/1/21033 |
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http://repositorio.ufsm.br/handle/1/21033 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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201000000000 |
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600 600 600 600 600 600 600 600 |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Farmacologia |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Farmacologia |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
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