Distúrbios do sono e comprometimento da função cardiopulmonar em indivíduos com sintoma de fadiga pós-covid

• Ano de defesa: 2024
• Autor(a) principal: Arruda, Nathalea Spode de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• dARK ID: ark:/26339/00130000193j8
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; Brasil; Fonoaudiologia; UFSM; Programa de Pós-Graduação em Distúrbios da Comunicação Humana; Centro de Ciências da Saúde
• Palavras-chave em Português: Covid longa; Fadiga; Sono; Aptidão cardiorrespiratória; Post-acute COVID-19 syndrome; Fatigue; Sleep; Cardiorespiratory fitness; CNPQ::CIENCIAS DA SAUDE::FONOAUDIOLOGIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/34471

Individuals who have been affected by Covid-19 may experience symptoms of fatigue, sleep disorders and cardiopulmonary function, impacting their quality of life. However, sleep disorders and cardiopulmonary function between groups with and without symptoms of post-Covid fatigue remain uninvestigated. Therefore, the objective of this study is to compare the prevalence of sleep disorders, lung function, inspiratory muscle strength and endurance, functional capacity and quality of life of individuals with and without postCovid fatigue, as well as to examine the predictive factors of fatigue symptoms. A crosssectional study was carried out, with a sample obtained from social media, and collections carried out at the UFSM Physiology and Rehabilitation Laboratory. Individuals aged 18 to 59 were included, who had Covid-19, were clinically stable, had no previous comorbidities and did not perform physical exercise. 34 individuals who had Covid-19 participated in the study, 20 with fatigue (age 32 ± 12, 15% male) and 14 without fatigue (age 31 ± 12, 42.9% male). Study participants were classified using the Chalder Fatigue Scale into individuals with fatigue (score ≥ 4 points) and without fatigue (score < 4 points). To assess sleep, the Insomnia Severity Index (IGI) and Epworth Daytime Sleepiness Scale (ESS) questionnaires were applied, as well as nighttime oximetry. Lung function was assessed by spirometry. Vacuum manometer was used to assess inspiratory muscle strength, through maximum inspiratory pressure (PImax), and to assess inspiratory muscle resistance, using a test with a load adjusted to 60% of PImax coupled to a mouthpiece. Functional capacity was assessed using the six-minute walk test (6MWT) and quality of life was assessed using the Whoqol-BREF questionnaire. Individuals with post-Covid fatigue had a higher prevalence of excessive daytime sleepiness and insomnia, lower PImax, shorter distance covered in the 6MWT, lower FEV1, FEV1/FVC and FEV1/FVC % of predicted, in addition to worse quality of life in the physical domains (p=0.001) and environment (p=0.02). EFC showed a direct correlation with IGI (r=0.436 p=0.01) and ESS (r = 0.593; p = 0.001) and inverse correlation with the distance covered in the 6MWT (r=-0.398 p=0.022) and FEV1 (r=-0.412 p=0.01). The IGI was an independent predictor for EFC, with 62% of the variance in EFC explained by the variance in IGI. In conclusion, individuals with post-Covid fatigue symptoms may experience sleep disturbances, reduced inspiratory muscle strength, functional capacity, lung function and quality of life, with IGI being an independent predictor of fatigue.