Análise integrada de genes e miRNAs diferencialmente expressos em carcinomas de ovário seroso de alto grau de pacientes com distintas respostas à quimioterapia

• Ano de defesa: 2021
• Autor(a) principal: Melo, Natalia Cruz E [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• dARK ID: ark:/48912/00130000201nv
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Breast Neoplasm; Acupuncture; Chemotherapy; Immunity; Quality Of Life; Integrative And Complementary Practices; Neoplasia Da Mama; Acupuntura; Quimioterapia; Imunidade; Qualidade De Vida; Práticas Integrativas E Complementares
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=11277992; https://repositorio.unifesp.br/handle/11600/68226

OBJECTIVE: This study intended to evaluate the action of acupuncture on myelodepression in women with breast cancer during treatment with anthracyclines and quality of life, before and after chemotherapy. METHODS: The population of this study was composed of women newly diagnosed with breast cancer at the UNIFESP Mastology outpatient clinic and with indication for chemotherapy with anthracyclines. Patients were randomized into two groups: the Acupuncture Group (GA) and the Control Group (CG). All participants, before and at the end of treatment with anthracyclines and at the end of it, answered the quality of life questionnaire (FACT-G) and were monitored for leukocyte and neutrophil levels in peripheral blood as an indicator of the level of spinal depression. The GA underwent intervention with Acupuncture for up to 10 sessions, starting before the first infusion of chemotherapy and continuing throughout the treatment. The points were used: GV14, CV6, ST36, SP6, KI3, GB39. RESULTS: A total of 26 women were randomized into 2 groups: GA (10) and CG (16). Of these, 7 (26.92%) received a dense dose indication (according to the service protocol) and, therefore, received the granulocyte stimulating factor G- CSF from the first cycle. Thus, for the analysis of the protective effect of acupuncture on the myeloprotective medulla, 2 women from GA and 5 from GC were excluded. The Quality of Life (QOL) analysis was performed for the total sample and also in the subgroups that received G-CSF. The need for secondary prophylaxis with G-CSF occurred in 72.7% (08/11) in the control group and in 12% (08/01) in the acupuncture group (p-value = 0.009). Regarding quality of life (QOL), the initial and final FACT-G showed a difference between the groups, where the mean GA at the end rose from 80.68 to 90.12 (p-value = 0.004) and in the CG mean fell from 81.95 to 70.59 (p-value = 0.003) .In the analysis of subgroups that used G-CSF, the QoL of women in GA showed better QoL (p-value = 0.036). CONCLUSION: Based on the results presented, acupuncture showed efficiency in the prophylaxis of myelosuppression induced by chemotherapy with anthracyclines and increased the quality of life of women during treatment, including those who needed G-CSF.