Cognição social e funções executivas em adolescentes com síndrome de Turner

• Ano de defesa: 2017
• Autor(a) principal: Di Benedetto, Luciana Mello [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• dARK ID: ark:/48912/001300001jxcf
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Turner syndrome; Social cognition; Executive functions; Executive function; Síndrome de Turner; Cognição social; Funções executivas; Função executiva
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5380370; http://repositorio.unifesp.br/handle/11600/50407

Objective: Turner syndrome (ST) characterized by total or partial deletion of the second sex chromosome (45, X) affects 1: 2,500 female newborns (Stochholm et al, 2006) and involves a wide genetic and clinical heterogeneity. The present study investigated aspects of social cognition and executive functioning in adolescents diagnosed with Turner Syndrome (TS), in order to contribute to a better understanding of the neurocognitive phenotype. Additionally, it investigated associations between these cognitive functions. Method: Sixty pubertal adolescents, aged 13 to 18 years old, were enrolled in the study, of whom 20 were diagnosed with TS and 40 controls matched by age, verbal intellectual performance, and type of school. All were submitted to a battery of neuropsychological tests with emphasis on executive functions and social cognitive skills. Parents responded to behavioral scales. Descriptive, factorial, logistic regression and correlation analyzes were adopted in the data treatment. Results: Adolescents with TS presented worse performance than controls in most of the tasks, confirming the neuropsychological profile frequently described in the literature. Measures of executive functions and social cognition were dissociated in the analyzes. Conclusions: Results indicate that social cognition is a primary condition in ST and not a consequence of executive dysfunctions. No indicators were obtained for a compensatory mechanism of executive functioning in face of social cognition difficulties.