Diabetes mellitus, equilíbrio e memória: efeito agudo do exercício físico

• Ano de defesa: 2016
• Autor(a) principal: Borges, Mariana Eiras [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• dARK ID: ark:/48912/001300002fcnw
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Diabetes mellitus type I; Body balance testing; Object recognition task; Hippocampus; Cerebellum; Acute exercise; Diabetes mellitus tipo I; Memória de reconhecimento de objetos; Teste de trave de equilíbrio; Hipocampo; Cerebelo; Exercício agudo
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=3699675; https://repositorio.unifesp.br/handle/11600/46637

Diabetes Mellitus (DM) is controlled deficits associated with the central nervous system. Regular exercise training is effective in reducing cognitive impairment, but little is known about the acute effects of exercise on these aspects. Thus, the aim of this study was to investigate the effect of acute aerobic exercise on memory and balance, as well as the IGF-1R protein, GSK- 3? and tau in the hippocampus and cerebellum of diabetic rats induced by alloxan (32 mg / kg). The study was divided into two experiments. In experiment I, 20 male Wistar rats randomly assigned into groups: control evaluated immediately after exercise (C0), rated control 24 hours after exercise (C24), diabetic evaluated immediately after exercise (D0) and diabetic assessed 24 hours after exercise (D24). In the second experiment (n=20), the animals were divided into sedentary control group (CS), exercise control (EC), sedentary diabetic (SD) and diabetic exercise (DE). Molecular analysis of the hippocampus and cerebellum (pIGF-1R, pGSK-3? and ptau) were performed immediately after exercise in C0 and D0 groups, and 24 hours after exercise in C24 and D24 groups. In the experimental II, behavioral analyzis were performed using body balance testing and object recognition task. Data were expressed as mean ± standard deviation error and analyzed using Student's t test and/or two-way ANOVA, with a significance level of p <0.05. The results showed deficit of short term memory to DS group and increase to the DE group. Furthermore, the DS group showed higher number of errors in crossing the balance beam. In the cerebellum there was increase in GSK-3? phosphorylation and IGF-1R inC24 group when compared to D0 and increase phosphorylation of GSK-3? in comparison D24 to D0. In the hippocampus, acute exercise was able to increase phosphorylation of GSK-3? and IGF-1R in C24 and D24 groups when compared to D0 group. Taken together, results show that DM leads to an impairment in short term memory and balance, and acute exercise is able to improve these parameters accompanied by increase in the phosphorylation of proteins signaling pathway in the hippocampus and cerebellum.