Estudo comparativo das diferentes versões de testes laboratoriais de triagem para doenças alérgicas em crianças e adolescentes brasileiros

• Ano de defesa: 2018
• Autor(a) principal: Pierotti, Felipe Faria [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• dARK ID: ark:/48912/001300001z08c
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Hipersensitivity; Child; Immunoglobulin E; Comorbidity; Chronic disease; Allergens; Hipersensibilidade; Criança; Imunoglobulina E; Comorbidade; Doença crônica; Alérgenos
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=6641565; https://repositorio.unifesp.br/handle/11600/52467

Introduction: In the last decades, the prevalence of allergic diseases worldwide has increased. Although the clinical history is considered of great importance in the suspicion of an allergic disease, false-positive results can be observed when only anamnesis data are used. With this, measurable indicators used to examine any aspects of the disease become essential. Total immunoglobulin E dosage (TIgE) as well as panels that contain allergens prevalent in the population studied may serve as screening tests and facilitate a future diagnosis of an allergic disease. The objective of this study was to evaluate the positivity of the different versions of the screening tests for allergic diseases (PhadiatopEurope®, PhEU and PhadiatopInfant, PhInf) and TIgE values in patients with medical diagnosis of allergic disease and in children and adolescents without medical history of allergy. Methods: A cross-sectional study was carried out in 11 Brazilian Pediatric Allergy Centers whose patients were divided into groups according to the main disease. A control group composed of participants without allergic disease also integrated into the research. TIgE measurement and screening tests (Europe and Infant) were performed. Results: Serum total IgE concentration ranged from less than 2.0 kU/L to more than 5000 kU/L, with a median of 302 kU/L, and among allergy patients, values were significantly higher when compared to controls. In addition, the two screening tests performed in the same individuals showed an average agreement, according to the allergic disease evaluated, of 87.7%. Kappa index revealed substantial agreement (0.70). Conclusions:TIgE were significantly higher among "allergic" patients when compared to controls. The Infant test showed better performance in the identification of sensitized individuals, regardless of age. Screening tests do not diagnose allergic diseases. Once positive, referral to the specialist should be done.