Estudo do impacto da dor e da fadiga na qualidade de vida e na capacidade funcional dos pacientes com narcolepsia com e sem cataplexia

• Ano de defesa: 2017
• Autor(a) principal: Cremaschi, Renata Maria de Carvalho [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• dARK ID: ark:/48912/001300002gd9t
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Sleep; Narcolepsy; Pain; Fatigue; Depression; Quality of life; Sono; Narcolepsia; Dor; Fadiga; Depressão; Qualidade de vida
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5226714; http://repositorio.unifesp.br/handle/11600/50429

Objectives: To compare the prevalence of pain and fatigue in patients with narcolepsy (type 1 and 2) with control subjects. To identify the effect of the interaction between nutritional status (by body mass index categories) and narcolepsy type (through evidence of hypocretin-1 levels in cerebrospinal fluid) on pain, fatigue, depression, anxiety and quality of life. Methods: It was a controlled, cross-sectional study using participant-oriented outcome assessment. A total of 66 patients with narcolepsy were included, according to the International Classification of Sleep Disorders of 2014 (n=33 for type 1), Federal University of São Paulo, matched by age and sex with 33 control subjects. Primary outcomes were pain and fatigue. Secondary outcomes were psychiatric symptoms and quality of life. Results: Patients with type 1 and type 2 narcolepsy had a high prevalence of chronic pain, with indistinct pain characteristics among them, with a higher risk of type 1 narcolepsy. Obese patients with narcolepsy type 1 and type 2 did not present a significant difference in the intensity of pain, and there was only difference in an item of pain quality, compared to the control group. Patients with narcolepsy type 1 and type 2, regardless of nutritional status, had greater symptoms of fatigue, depression and anxiety. Patients with narcolepsy type 1 and type 2 presented worse mean scores compared to control subjects in all domains of physical and mental health quality of life. Conclusions: Patients with narcolepsy, regardless of its type, had high prevalence of chronic pain and fatigue, increased symptoms of comorbid depression and anxiety, with reduced quality of life. Interaction with nutritional status showed that obesity may play a role in pain intensity and quality characteristics in patients with type 1 and type 2 narcolepsy.