Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio

Detalhes bibliográficos
Ano de defesa: 2017
Autor(a) principal: RODRIGUES, Isabela Fernandes lattes
Orientador(a): OLIVEIRA JUNIOR, Robson Tadeu Soares de lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal do Triângulo Mineiro
Programa de Pós-Graduação: Programa de Pós-Graduação Multicêntrico em Química de Minas Gerais
Departamento: Instituto de Ciências Exatas, Naturais e Educação - ICENE
País: Brasil
Palavras-chave em Português:
Nanopartículas de prata.
Lipossomos.
Candida albicans.
Palavras-chave em Inglês:
Silver Nanoparticles.
Liposomes.
Candida albicans.
Área do conhecimento CNPq:
Física Química
Link de acesso: http://bdtd.uftm.edu.br/handle/tede/799
Resumo: Silver nanoparticles have a high area/volume ratio, therefore their antimocrobial property is greatly increased. They exhibit action against a wide range of pathogenic microorganisms such as gram negative and gram positive bacteria, algae and fungi. Silver ions can be reduced by a wide range of organic substances such as alcohols, carbohydrates, tartaric acid, ascorbic acid, etc. Synthesis of the nanoparticles was carried out using sodium citrate as reducing agent in the presence of the sodium dodecylsulfate. Characterization of silver nanoparticles was performed by UV-Vis spectroscopy, where it was obtained nanoparticles with diameter of 10-50 nm. A factorial design of 2³ was done using as variables the reagent concentrations and the surface plasmon absorption spectra of silver nanoparticles. Through response surfaces a relationship was obtained between the reagents concentrations and the nanoparticles sizes. The size of the nanoparticles directly influence their biocidal properties, therefore, nanoparticles in the range of 10-14 nm were used on Candida albicans. In this way, the toxicity of silver suspensions and silver encapsulated by liposomes as carriers in plankton and biofilm medium was evaluated. It was concluded that the silver nanoparticles in their different microforms (suspension and liposome) presented activity on C. albicans in both planktonic and biofilm environments.
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spelling OLIVEIRA JUNIOR, Robson Tadeu Soares dehttp://lattes.cnpq.br/7783176519114288PAULINO, Tony de Paivahttp://lattes.cnpq.br/3179978364259887http://lattes.cnpq.br/3026408289407890RODRIGUES, Isabela Fernandes2019-08-01T11:56:35Z2017-06-23RODRIGUES, Isabela Fernandes. Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio. 2017. 80f . Dissertação (Mestrado em Química) - Programa de Pós-Graduação Multicêntrico em Química de Minas Gerais, Universidade Federal do Triângulo Mineiro, Uberaba, 2017 .http://bdtd.uftm.edu.br/handle/tede/799Silver nanoparticles have a high area/volume ratio, therefore their antimocrobial property is greatly increased. They exhibit action against a wide range of pathogenic microorganisms such as gram negative and gram positive bacteria, algae and fungi. Silver ions can be reduced by a wide range of organic substances such as alcohols, carbohydrates, tartaric acid, ascorbic acid, etc. Synthesis of the nanoparticles was carried out using sodium citrate as reducing agent in the presence of the sodium dodecylsulfate. Characterization of silver nanoparticles was performed by UV-Vis spectroscopy, where it was obtained nanoparticles with diameter of 10-50 nm. A factorial design of 2³ was done using as variables the reagent concentrations and the surface plasmon absorption spectra of silver nanoparticles. Through response surfaces a relationship was obtained between the reagents concentrations and the nanoparticles sizes. The size of the nanoparticles directly influence their biocidal properties, therefore, nanoparticles in the range of 10-14 nm were used on Candida albicans. In this way, the toxicity of silver suspensions and silver encapsulated by liposomes as carriers in plankton and biofilm medium was evaluated. It was concluded that the silver nanoparticles in their different microforms (suspension and liposome) presented activity on C. albicans in both planktonic and biofilm environments.A prata na forma de nanopartículas possui elevada razão área volume, o que eleva grandemente suas propriedades antimicróbiais. Apresenta ação contra uma ampla faixa de microrganismos patogênicos como bactérias Gram Negativas e Gram Positivas, algas e fungos. Nanopartículas de prata podem ser obtidas empregando-se agentes redutores como álcoois, carboidratos, ácido tartárico, ácido ascórbico, etc. O presente trabalho teve como objetivo preparar nanopartículas de prata para investigação biocida. Para isso, realizou-se a síntese das nanopartículas através da redução por citrato de sódio na presença do surfactante dodecilsulfato de sódio. A caracterização das nanopartículas de prata foi feita através de espectroscopia UV-Vis. Obteve-se nanopartículas com diâmetro entre 10 e 50 nm. Foi feito um planejamento fatorial 2³ utilizando como variáveis as concentrações dos reagentes e os comprimentos de onda característicos das bandas de plasmons de superfície das nanopartículas de prata. Através de superfícies de resposta obteve-se uma relação entre as concentrações dos reagentes utilizados na síntese e os tamanhos das nanopartículas formadas. Como o tamanho das nanopartículas influencia diretamente nas propriedades biocidas, foram empregadas nanopartículas na faixa de 10-14 nm sobre Candida Albicans. Buscou-se avaliar também a toxicidade da prata em suspensão e veiculada a lipossomos como carreadores em meio planctônico e biofilme. 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dc.title.por.fl_str_mv Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio
title Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio
spellingShingle Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio
RODRIGUES, Isabela Fernandes
Nanopartículas de prata.
Lipossomos.
Candida albicans.
Silver Nanoparticles.
Liposomes.
Candida albicans.
Física Química
title_short Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio
title_full Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio
title_fullStr Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio
title_full_unstemmed Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio
title_sort Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio
author RODRIGUES, Isabela Fernandes
author_facet RODRIGUES, Isabela Fernandes
author_role author
dc.contributor.advisor1.fl_str_mv OLIVEIRA JUNIOR, Robson Tadeu Soares de
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/7783176519114288
dc.contributor.advisor-co1.fl_str_mv PAULINO, Tony de Paiva
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/3179978364259887
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3026408289407890
dc.contributor.author.fl_str_mv RODRIGUES, Isabela Fernandes
contributor_str_mv OLIVEIRA JUNIOR, Robson Tadeu Soares de
PAULINO, Tony de Paiva
dc.subject.por.fl_str_mv Nanopartículas de prata.
Lipossomos.
Candida albicans.
topic Nanopartículas de prata.
Lipossomos.
Candida albicans.
Silver Nanoparticles.
Liposomes.
Candida albicans.
Física Química
dc.subject.eng.fl_str_mv Silver Nanoparticles.
Liposomes.
Candida albicans.
dc.subject.cnpq.fl_str_mv Física Química
description Silver nanoparticles have a high area/volume ratio, therefore their antimocrobial property is greatly increased. They exhibit action against a wide range of pathogenic microorganisms such as gram negative and gram positive bacteria, algae and fungi. Silver ions can be reduced by a wide range of organic substances such as alcohols, carbohydrates, tartaric acid, ascorbic acid, etc. Synthesis of the nanoparticles was carried out using sodium citrate as reducing agent in the presence of the sodium dodecylsulfate. Characterization of silver nanoparticles was performed by UV-Vis spectroscopy, where it was obtained nanoparticles with diameter of 10-50 nm. A factorial design of 2³ was done using as variables the reagent concentrations and the surface plasmon absorption spectra of silver nanoparticles. Through response surfaces a relationship was obtained between the reagents concentrations and the nanoparticles sizes. The size of the nanoparticles directly influence their biocidal properties, therefore, nanoparticles in the range of 10-14 nm were used on Candida albicans. In this way, the toxicity of silver suspensions and silver encapsulated by liposomes as carriers in plankton and biofilm medium was evaluated. It was concluded that the silver nanoparticles in their different microforms (suspension and liposome) presented activity on C. albicans in both planktonic and biofilm environments.
publishDate 2017
dc.date.issued.fl_str_mv 2017-06-23
dc.date.accessioned.fl_str_mv 2019-08-01T11:56:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Isabela Fernandes. Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio. 2017. 80f . Dissertação (Mestrado em Química) - Programa de Pós-Graduação Multicêntrico em Química de Minas Gerais, Universidade Federal do Triângulo Mineiro, Uberaba, 2017 .
dc.identifier.uri.fl_str_mv http://bdtd.uftm.edu.br/handle/tede/799
identifier_str_mv RODRIGUES, Isabela Fernandes. Investigação das propriedades biocidas de nanopartículas de prata preparadas em meio de citrato de sódio. 2017. 80f . Dissertação (Mestrado em Química) - Programa de Pós-Graduação Multicêntrico em Química de Minas Gerais, Universidade Federal do Triângulo Mineiro, Uberaba, 2017 .
url http://bdtd.uftm.edu.br/handle/tede/799
dc.language.iso.fl_str_mv por
language por
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