Concentrações eritrocitárias, plasmáticas e urinárias de tiamina em adultos com traumatismo cranioencefálico

• Ano de defesa: 2019
• Autor(a) principal: CRUZ, Sarah Almenara Rodrigues
• Orientador(a): PORTARI, Guilherme Vannucchi
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Triângulo Mineiro
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências da Saúde
• Departamento: Instituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da Saúde
• País: Brasil
• Palavras-chave em Português: Vitamina B1.; Traumatismo cranioencefálico.; HPLC.
• Palavras-chave em Inglês: Vitamin B1.; Trauma brain injury.; HPLC.
• Área do conhecimento CNPq: Medicina
• Link de acesso: http://bdtd.uftm.edu.br/handle/tede/881

INTRODUCTION: Trauma brain injury (TBI) can be defined as a set of changes in brain function by an external agent and the classification of the most accepted level of consciousness in clinical practice is the Glasgow Coma scale. The TBI triggers a hypermetabolic state with severe impairment of homeostasis and in this context, thiamine has a central role in carbohydrate catabolism, neurotransmitter formation and serotonin uptake, which controls the activity of the cerebellum, Hypothalamus and hippocampus. Therefore, thiamine deficiency can cause brain tissue injury. OBJECTIVES: To evaluate possible variations in thiamine levels and the relationship with acute phase responses in patients hospitalized with TBI during the first week after the injury. METHODS: This was a prospective cohort-type longitudinal study. The study was conducted with adult, male and female patients admitted to the Hospital de Clínicas of the Federal University of Triângulo Mineiro with a diagnosis of TBI. A clinical examination was performed to identify the severity of the patient through the ECG by the neurosurgeon, and then the blood and urine samples were collected by an employee. In addition to biochemical analysis of PCR and albumin. RESULTS: One week was not enough time for patients to present thiamine deficiency, even with high concentrations of this vitamin in excretion. CRP and albumin were not correlated with thiamine. CONCLUSION: The patients studied did not have thiamine deficiency in one week of study. It was not possible to know if these patients would be deficient after the hospitalization days, since the study showed a high concentration of thiamine excretion and there was no relationship between thiamine and inflammation, because the CRP and albumin values did not present correlation with thiamine.