Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas

Detalhes bibliográficos
Ano de defesa: 2017
Autor(a) principal: MORAES, Giselle Vanessa
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal do Triângulo Mineiro
Instituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da Saúde
Brasil
UFTM
Programa de Pós-Graduação em Ciências da Saúde
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://bdtd.uftm.edu.br/handle/tede/675
Resumo: Introdução: As hepatites B e C são as principais causas de câncer de fígado e cirrose e a principal razão para a indicação de transplante hepático. A avaliação do estado nutricional é importante nesses pacientes. Alguns estudos relataram uma diminuição nos níveis séricos de vitamina C em pacientes com resposta inflamatória associada à infecção. Pouco se sabe sobre o estado nutricional e níveis séricos de vitamina C em pacientes com hepatites crônicas. Nosso objetivo é avaliar o estado nutricional dos pacientes com hepatites infecciosas e dosar as concentrações séricas de vitamina C. Material e Métodos: Foram estudados 79 pacientes com hepatite B (n = 16) e C (n = 63). O estado nutricional foi avaliado por antropometria, impedância bioelétrica e consumo alimentar, além de concentrações séricas de vitamina C e testes de função hepática. Resultados: 54,43% tinham sobrepeso e obesidade. A ingestão de alimentos mostrou consumo de uma dieta com altos níveis de gordura. Os níveis séricos de vitamina C estavam dentro do intervalo normal (0,42 ± 0,08mg / dL), enquanto a alanina aminotransferase (ALT) apresentou concentrações séricas significativamente maiores em pacientes obesos quando comparados com pacientes não obesos (55 ± 42 U / L; 32 ± 22 U / L, respectivamente - p <0,05). As concentrações séricas de proteína C reativa (CRP) foram maiores nos pacientes obesos quando comparados aos não obesos (p = 0,01). Conclusão: Concluímos que pacientes com hepatite infecciosa apresentam concentrações normais de vitamina C,sejam eles obesos , ou não.
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spelling Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosasEstado nutricional.Hepatites infecciosas.Vitamina C.Doença hepática gordurosa não alcoólica.Esteatohepatite não-alcoólica.Nutritional status.Infectious hepatitis.Vitamin C.Nonalcoholic Fatty Liver Disease.Nonalcoholic steatohepatitis.MedicinaNutriçãoDoenças Infecciosas e ParasitáriasIntrodução: As hepatites B e C são as principais causas de câncer de fígado e cirrose e a principal razão para a indicação de transplante hepático. A avaliação do estado nutricional é importante nesses pacientes. Alguns estudos relataram uma diminuição nos níveis séricos de vitamina C em pacientes com resposta inflamatória associada à infecção. Pouco se sabe sobre o estado nutricional e níveis séricos de vitamina C em pacientes com hepatites crônicas. Nosso objetivo é avaliar o estado nutricional dos pacientes com hepatites infecciosas e dosar as concentrações séricas de vitamina C. Material e Métodos: Foram estudados 79 pacientes com hepatite B (n = 16) e C (n = 63). O estado nutricional foi avaliado por antropometria, impedância bioelétrica e consumo alimentar, além de concentrações séricas de vitamina C e testes de função hepática. Resultados: 54,43% tinham sobrepeso e obesidade. A ingestão de alimentos mostrou consumo de uma dieta com altos níveis de gordura. Os níveis séricos de vitamina C estavam dentro do intervalo normal (0,42 ± 0,08mg / dL), enquanto a alanina aminotransferase (ALT) apresentou concentrações séricas significativamente maiores em pacientes obesos quando comparados com pacientes não obesos (55 ± 42 U / L; 32 ± 22 U / L, respectivamente - p <0,05). As concentrações séricas de proteína C reativa (CRP) foram maiores nos pacientes obesos quando comparados aos não obesos (p = 0,01). Conclusão: Concluímos que pacientes com hepatite infecciosa apresentam concentrações normais de vitamina C,sejam eles obesos , ou não.Introduction: hepatitis B and C are major causes of liver cancer and cirrhosis and the main reason for indication of liver transplantation. The assessment of nutritional status is important in these patients. Some studies reported a decrease in vitamin C serum levels in patients with inflammatory response associated with infection. Little is known about the nutritional status and vitamin C serum levels in patients with chronic hepatitis. Our goal was to assess the nutritional status of patients with infectious hepatitis and to determine the of vitamin C serum levels in these patients. Material and Methods: 79 patients with hepatitis B (n = 16) and C (n = 63) were studied. Nutritional status was assess by anthropometrics, bioelectric impedance and food consumption; besides serum vitamin C and liver function tests were evaluated. Results: 54.43% had overweight and obesity. Food intake showed consumption of a diet with fat high levels. Vitamin C serum levels were within the normal range (0.42 ± 0.08mg/dL), while alanine aminotransferase (ALT) showed significantly higher serum levels in obese patients when compared with no obese patients (55±42 U/L; 32±22 U/L, respectively – p<0.05). The C-reactive protein (CRP) serum levels were higher in obese patients when compared to non-obese patients (p=0.01). Conclusion: We conclude that patients with infectious hepatitis have normal concentrations of vitamin C, whether obese or not.Universidade Federal do Triângulo MineiroInstituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da SaúdeBrasilUFTMPrograma de Pós-Graduação em Ciências da SaúdeCUNHA, Daniel Ferreira1813965649http://lattes.cnpq.br/2370047576509407MORAES, Giselle Vanessa2019-06-13T17:20:48Z2017-06-23info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfMORAES, Giselle Vanessa. Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas. 2017. 70f. Dissertação (Mestrado em Ciências da saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2017.http://bdtd.uftm.edu.br/handle/tede/675porABBOOTT-JOHNSON, W.; KERLIN, P.; CLAGUE, A.; JOHNSON, H.; CUNEO, R. Relationship between blood levels of fat soluble vitamins and diseas etiology and severity in adults awaiting liver transplantation. J Gastroenterol Hepatol, v. 26, p. 1402-1410. 2011. ACSM’S GUIDELINES FOR EXERCISE TESTING AND PRESCRIPTON – 8ª ed. Editora Lippincott Williams e Wilkins, 2009. 400 p. ARTEH, J.; NARRA, S.; NAIR, S. Prevalence of vitamin D deficiency in chronic liver disease. Dig Dis Sci, v. 55, p. 2624-2628. 2010. BAE, S. et al. In vivo consequence of vitamin C insufficiency in liver injury: vitamin C ameliorates T-cell-mediated acute liver injury in gulo(-/-) mice. Antioxid Redox Signal, v.19, p.2040-2053. 2013. BANDARA, P. et al. Antioxidant levels in peripheral blood, disease activity and fibrotic stage in chronic hepatitis C. Liver Int, v. 25, p.518-526. 2005. BEDOSSA, P, POYNARD, T. An algorithm for the grading of activity in chronic hepatitis C: the METAVIR Cooperative Study Group. Hepatology, v. 24, p. 289- 293.1996. BESSEY, O.A. Ascorbic acid microchemical methods. In: Vitamin methods. New York: Academic Press, v.1, p.303. 1960. BJELAKOVIC, G. et al. Meta-analysis: antioxidant supplements for liver diseases - the Cochrane Hepato-Biliary Group. Aliment Pharmacol Ther, v.32, p.356-367. 2010. BOLETIM EPIDEMIOLÓGICO DE HEPATITES VIRAIS, 2016. Disponível em:<<http://www.aids.gov.br/sites/default/files/anexos/publicacao/2016/59121/boleti m_hepatites_05_08_2016_pdf_96185.pdf>>. Acesso em 02 jan, 2017. BRESNAHAN, K.A; TANUMIHARDJO, S.A. Undernutrition, the acute phase response to infection, and its effectson micronutrient status indicators. Advances in Nutrition, v. 5, p. 702-711. 2014. BUDZIARECK, M.B.; PUREZA, D.R.R.; BARBOSA-SILVA, M.C. Refence values and determinats for handgrip strength in healthy subjects. Clin Nutr, v. 27, p. 357-362. 2008. BURDETTE, S.D.; POLENAKOVIK, H.; SURYAPRASAD, S. An HIV-infected man with odynophagia and rash. Clinical Infectious Diseases, v. 41, p. 686-688. 2005. BUSCH, K.; THIMME, R. Natural history of chronic hepatitis B virus infection. Med Microbiol Immunol, v.204, n.1, p.5-10. 2015. CANDOTTI, D. et al. Occult hepatitis B infection in blood donors from South East Asia: molecular characterisation and potential mechanisms of occurrence. Gut, v. 61, n.12, p. 1744-1753. 2012. CANKURTARAN, M. et al. Serum vitamin-E levels and its relation to clinical features in nonalcoholic fatty liver disease with elevated ALT levels Acta . Gastroenterol Belg, v. 69, p. 5-11. 2006. CARREIRA, C.M.; PEREIRA, P.C.M. Nutritional and dietetic profile of individuals with hepatitis C. Semina: Ciências Biológicas e da Saúde, v. 32, p. 143-154. 201. CARVALHO, L.; PARISE, E.R. Evaluation of nutritional status of nonhospitalized patients with liver cirrhosis. Arq Gastroenterol, v. 43, p.269-274. 2006. CECILIANI, F., GIORDANO, A.; SPAGNOLO, V. The systemic reaction during inflammation: the acute-phase proteins. Protein and Peptide Letters, v.9, p. 211- 223. 2002. CENTERS FOR DISEASE CONTROL AND PREVENTION. Viral Hepatitis. Disponível em: <<https://wwwn.cdc.gov/nndss/>> Acesso em: 12 dez, 2016. CHANG, W.T. et al. Albumin and prealbumin may predict retinol status in patients with liver cirrhosis. Hepatogastroenterology, v. 55, p. 1681-1685. 2008. CHEUNG, K.; LEE, S.S.; RAMAN, M. Prevalence and mechanisms of malnutrition in patients with advanced liver disease, and nutrition nanagement strategies. Clinical gastroenterology and hepatology, v.10, n.2, p.117-125. 2012. CHOI, J. et al. Reactive oxygen species suppress hepatitis C virus RNA replication in human hepato-ma cells. Hepatology, v. 39, p. 81-89. 2004. CINCINATUS, R.; CHAVES, G. V.; AQUINO, L. A.; PERES, W. A. F.; LENTO, D.F.; RAMALHO, A. Dietary consumption of macronutrients and micronutrients and their relationship to the severity of hepatic disease. Rev. Soc.Bras. Alim. Nutr, v. 32, p. 61-77. 2007. CLARK, J.M. ; BRANCATI, F.L.; DIEHL,A.M. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol. v.98, p.960-967. 2003. COPPOLA, N. et al., 2014). Clinical and virological characteristics associated with severe acute hepatitis B. Clinical microbiology and infection, v.20, n.12, p.0991- 0997. 2014. COREY, K.E.; KAPLAN, L.M.Obesity and Liver Disease, The Epidemic of the Twenty-First Century. Clin Liver Dis, v. 18, p.1–18. 2014. CUNHA, D.F.; CUNHA, S.F.; UNAMUNO, M.R; VANNUCCHU, H. Serum levels assessment of vitamin A, E, C,B2 and carotenoids in malnourished and nonmalnourished hospitalized elderly patients. Clinical Nutrition, v.20, p.167-170. 2001. DELWART, E. et al. Genetic diversity of recently acquired and prevalent HIV, hepatitis B virus, and hepatitis C virus infections in US blood donors. The journal of infectious diseases, v.205, n.6, p.875-885. 2012. DUBEY, S.S.; PALODHI, G.R.; JAIN, A.K. Ascorbic acid, dehydroascorbic acid and glutathione in liver disease. Indian J Physiol Pharmacol, v. 31, p. 279-283.1987. DURNIN, J.V.; WORNERSLEY, J. Body Fat Assessed from Total Body Density and its Estimation from Skinfold Thickness: Measureme 481 men and women aged from 16 t 72 year. Br J Nutr, v. 32, p.77-97. 1974. DUTRA, C.N.N.; BASSO, C. Alterações nutricionais em portadores de hepatite C. Disc. Scientia, v. 7, p. 109-120. 2006. FARIAS, M.S. et al. Antioxidant supplementation attenuates oxidative stress in chronic hepatitis C patients. Gastroenterol Hepatol, v.35, p.386-394.2012. FIGUEIREDO, F.A; De MELLO, P.R.; KONDO, M. Effect of liver cirrhosis on body composition: evidence of significant depletion even in mild disease. J Gastroenterol Hepatol, v. 20, p. 209-216. 2005. FILHO, G.B. Bogliolo, Patologia Geral, 8ª ed. Rio de Janeiro: Ed Guanabara Koogan, 2011. 1492 p. FOOD AND NUTRITION BOARD OF THE INSTITUTE OF MEDICINE: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc, v. 102, p. 1621-1630. 2002. FOOD AND NUTRITION BOARD OF THE INSTITUTE OF MEDICINE: Dietary Reference Intakes for Vitamin C, Vitamin E,Selenium, and Carotenoids. Washington (DC):National Academies Press (US); p. 12-13. 2000. FORNER, A.; LLOVET, J. M.; BRUIX, J. Hepatocellular carcinoma. Lancet, v.379, n.9822, p.1245-1244. 2012. FOSSITT, D.D.; KOWALSKI, T.J. Classic skin findings of scurvy. Mayo Clinic Proceedings, v. 89, p.61. 2014. FREEMAN, A.J. et al. Estimating progression to cirrhosis in chronic hepatitis C virus infection. Hepatology, v. 34, n.4 pt 1, p. 809-816. 2001. FRISANCHO, AR. Antropometric Standards: An interactive nutritional Reference of Body Size and Body Composition for Chlidren and Adults. 4ª ed. Local: University of Michigan Press, 2011. FUHRMAN, P.; CHARNEY, P. MUELLER, C.M. Hepatic proteins and /nutrition assessment. J Am Diet Assoc, v.104, p. 1258-1264. 2004. GOMES, A.P et al. Hepatites virais: abordagem clínica com ênfase nos vírus A e E*. Rev Bras Clin Med, v. 10, p. 139-146. 2012. GONZÁLEZ, M.I.M Circunferencia de cintura: una medición importante y útil del riesgo cardiometabólico. Rev Chil Cardiol. v. 29, p.85-87. 2010. GORDON, A.; McLEAN, C.A.; PEDERSEN, J.S.; BAILEY, M.J.; ROBERTS, S.K. Hepatic steatosis in chronic hepatitis B and C: predictors, distribution and effect on fibrosis. J Hepatol, v. 43, p.38-44. 2005; GOTTSCHALL, C.B.A.; ÁLVARES-DA-SILVA, M.R.; CAMARGO, A.C., BURTETT, R.M. SILVEIRA, T.R. Avaliação nutricional de pacientes com cirrose pelo vírus da hepatite C: a aplicação da calorimetria indireta. Arq Gastroenterol, v. 41, p. 220- 224. 2004. GOTTSCHALL, C.B.A.; PEREIRA, T.G.; RABITO, E.I.; LVARES-DA-SILVA, M.R. Nutritional status and dietary intake in non-cirrhotic adult chronic hepatitis c patients. Arq Gastroenterol, v. 52, p. 204.209. 2015. GOWER, E. et al. Global epidemiology and genotype distribution of the hepatitis C virus infection. Journal of Hepatology, v. 61, p.45–57 2014 GRANT, R.W; STEPHENS, J.M. Fat in flames: influence of cytokines and pattern recognition receptors on adipocyte lipolysis. American Journal of Physiology − Endocrinology and Metabolism, v. 309, p. 205-213. 2015. GRUYS, E.; TOUSSAINT, M.J.M., NIEWOLD, T.A.; KOOPMANS, S.J. Acute phase reaction and acute phase proteins. Journal of Zhejiang University Science, v.6, p. 1045-1056. 2005. HARRIS, J.A; BENEDICT, F.G. Biometric Study of Basal Metabolism in Man. Carnegie Institution of Washington, 1919. HAYASHI, F. et al., Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis. World J Gastroenterol, v. 18, p.5759-5770. 2012 HISE, M.E.; SULLIVAN, D.K.; JACOBSEN, D.J.; JOHBSON, S.L.; DONNELLY, J.E. Validation of energy intake measurements determined from observer – recorded food records and recall methods compared with the doubly labeled water method in overweight and obese individuals. Am J Clin Nutr, v. 75, p. 263 - 267. 2002. HORNIG, D. Distribution of ascorbic acid, metabolites and analogues in man and animals. Annals of the New York Academy of Sciences, v.258, p.103-118. 1975. IPSEN, D.H.; TVEDEN-NYBORG, P.; LYKKESFELDT, J. Does Vitamin C Deficiency Promote Fatty Liver Disease Development? Nutrients, v.6, p. 5473-5499. 2014. doi:10.3390/nu6125473 ISMAIL, F.W. et al. Nutritional Status in Patients with Hepatitis C. Journal of the College of Physicians and Surgeons Pakistan, v. 22, p. 139-142.2012. JEONG, S.; LEE, H. Hepatites A: clinical manifestations and management. Intervirology, v.53, p.15-19. 2010. JOHANSSON, L.; SOLVOLI, K.; BJORNEBOE, G.A.; DREVON, C.A. Under and overreporting of energy intake related to weight status and lifestyle in a nationwide sample. Am J Clin Nutr, v. 68, p. 266 - 274. 1998. JOHNSON, T.; OVERGARD, E.B.; COHEN, A.E.; DiBAISE, J.K. Nutrition assessment and management in advanced liver disease. Nutrition in Clinical Practice, v.28, p. 15-29. 2013. JUNQUEIRA, L.C; CARNEIRO, J. Histologia Básica. 12ª ed. Rio de Janeiro: Ed. Guanabara Koogan, 2013. 558 p. JUZA, R.M.; PAULI E.M. Clinical and Surgical Anatomy of the Liver: A Review for Clinicians. Clinical Anatomy, v.27, p.764–769. 2014. KALLNER, A.; HARTMANN, D.; HORNING, D. Steady-state turnover and body pool of ascorbic acid in man. American Journal of Clinical Nutrition, v.32, p.530-539. 1979. KAWABE, N.et al. Assessment of nutritional status of patients with hepatites C virusrelated liver cirrhosis. Hepatology Research, v. 38, p. 484-490. 2008. KOHLI, A. et al. Treatment of hepatitis C: a systematic review. The journal of the american medical association, v. 312, n.6, p.631-640. 2014. KOJ, A. Initiation of the acute phase response and synthesis of cytokines. Biochimica et Biophysica Acta, v.1317, p. 84-94.1996. KOTLER, D.P. Cachexia. Annals of Internal Medicine, v.133, p.622-634. 2000. KOWDLEY, K.V; EMOND, M.J.; SADOWSKI, J.A.; KAPLAH, M.M. Plasma vitamin K1 level is decreased in primary biliary cirrhosis. Am J Gastroenterol, v. 92, p. 2059-2061.1997. KRALL, E.A.; DWYER, J.T. Validity of a food frequency questionnaire and a food diary in a short-term recall situation. J Am Diet Assoc, v. 87, p. 1374-1377.1987. KUCZMARSKI, M.F.; KUCZMARSKI R.J.; NAJJAR, M. Descriptive antropometric reference data for older Americans. J Am Diet Assoc, v. 100, p. 59-66. 2000. KWAK, M.; KIM, Y.J. Occult hepatitis B virus infection. World Journal of Hepatology, v.6, n.12, p. 860-869. 2014. LÉGER, D. Scurvy: reemergence of nutritional deficiencies. Canadian Family Physician, v. 54, p. 1403-1406. 2008. LIAW, F.; CHU, C. Hepatitis B vírus infection. Lancet, v.373, n.9663, p.582-592. 2009. LIN, C.L.; KAO, J.H. The clinical implications of hepatitis B vírus genotype: recent advances. J Gastroenterol Hepatol, v.26, p. 123–30. 2011; LIND, J.A. Treatise on the scurvy. Edinburgh: Edinburgh University Press. Ed. C.P. Stewart and D. Guthrie.1953. LINDBLAND, M.; TVEDEN-NYBORG, P.; LYKKESFELDT, J. Regulation of Vitamin C Homeostasis during Deficiency. Nutrients, v. 4, p. 2860 – 2879. 2013. LOUW, J.A. et al. Blood vitamin concentrations during the acute-phase response. Critical Care Medicine, v. 20, p. 934-941.1992. LYKKESFELDT, J.; MICHELS, A.J. FREI, B. Vitamin C. Advances in Nutrition, v.5, p.16-18. 2014. MAHAN, L.K.; ESCOTT-STUMP, S. 10ª ed. Krause, alimentos, nutrição e dietoterapia. São Paulo: Rocca. 2002. 1157 p. MALTOS, A.L.; PORTARI, G.V.; SALDANHA, J.C., BERNARDES JÚNIOR, A.G.; PARDI, G.R., CUNHA, D.F. Scurvy in an alcoholic malnourished cirrhotic man with spontaneous bacterial peritonitis. Clinics v.67, p. 405-407. 2012. MALTOS, A.L.; SILVA, L.L.; BERNARDES JUNIOR, A.G.; PORTARI, G.V.; CUNHA, D.F. Scurvy in a patient with AIDS: case report. Revista da Sociedade Brasileira de Medicina Tropical , v. 44, p. 122-123. 2011. MANDL, J.; SZARKA, A. BANHEGYI, G. Vitamin C: update on physiology and pharmacology. British Journal of Pharmacology, v.157, p. 1097-1110. 2009. MANELA-AZULAY, et al. Vitamina C. An bras Dermatol, v. 78, p. 265-274. 2003. MANJATE, D.A.; NASSER, A.L.M; CÉSAR, T.B. Influência da ingestão do suco de laranja sobre estado nutricional e dietético em pacientes com hepatite C crônica. J. Food Nutr, v. 24, p.15-19. 2013 MARDONES, L. et al.The glucose transporter-2 (GLUT2) is a lo affinity dehydroascorbic acid transporter. Biochem.Biophys, v. 410, p. 7-12. 2011. MAYO MEDICAL LABORATORIES. Ascorbic Acid (Vitamin C), Plasma. Disponível: <<http://www.mayomedicallaboratories.com/testcatalog/Clinical+and+Interpretive/42362>>. Acessado em: 25,mar. 2017. McKENZIE D.C.; JOHNSON, R.K.; HAR, V.B.; GOLD, B.C. Impact of interviewer ́s body mass index on underreporting energy intake in overweight and obese women. Obes Res, v. 10, p. 471-477.2002. McMAHON et al. Antibody levels and protection after hepatitis B vaccine: results of a 22-year follow-up study and response to a booster dose. The journal of infectious diseases, v.200, n.9, p.1390-1396. 2009. McPHERSON, RA. Laboratory diagnosis of human hepatitis viruses. J Clin Lab Anal, v.8, p.369-377. 1994. MELETHIL, S.; MASON, W.D.; CHANG, C.J. Dose-dependen absorption and excretion of vitamin C in humans. International Journal of Pharmaceutics, v. 31, p. 83-89. 1986. MENTA, P.L.R. et al. Nutrition status of patients with chronic hepatitis B or C. Nutrition in clinical practice, v.30, n.2, p.290-296. 2015. MONTEIRO, J.P. et al. Consumo Alimentar, visualizando porções. Nutrição e Metabolismo. Rio de Janeiro: Ed.Guarabara, 2013. 92 p. MOURA, L.P. et al. Hepatic biochemical changes in rats submitted to a high-fat/highenergy diet. Rev. Nutr., Campinas, v. 25, p.685-693. 2012. MURAKAMI, Y. et al. Vitamin E and C supplementation prevents decrease of eicosapentaenoic acid in mononuclear cells in chronic hepatitis C patients during combination therapy of interferon alpha-2b and ribavirin. Nutrition, v. 22, p. 114-122, 2006. NAKAMURA, A.; YASUO, T. Lessons from Mouse Models of High-Fat Diet-Induced NAFLD. Int. J. Mol. Sci, v. 14, p. 21240-21257. 2013. NUNES, F.F. et al. Food consumption of cirrhotic patients, comparison with the nutritional status and disease staging. Arq Gastroenterol, v. 53, p. 250-256. 2016. OLIVEIRA, G.S. et al. Severe hepatitis and jaundice during the evolution of dengue virus infection: case report. Revista da sociedade brasileira de medicina tropical, v.43, p.339-341. 2010. PAULING, L. Evolution and the need for ascorbic acid. Proc Natl Acad Sci USA, v.67, p.1643-1648. 1970. PENG, S. et al. Body composition, muscle function, and energy expenditure in patients with liver cirrhosis: a comprehensive study. Am J Clin Nutr, v. 85, p. 1257- 1266. 2007. POOVORAWAN, K. et al.The important role of early diagnosis and preventive management during a large-scale outbreak of hepatitis A in Thailand. Pathogens and Global Health, v.107, p. 367-372. 2013. PRADAT, P. et al. Predictive value of ALT levels for histologic findings in chronic hepatitis C: a European collaborative study. Hepatology, v.36, p. 973-977. 2002. PURNAK, T.; YILMAZ, Y. Liver disease and malnutrition. Best practice e research clinical gastroenterology, v. 27, n.4, p.619-629. 2013. REED, R.M.Captain Ignose to the rescue. American Journal of Medicine, v.123, p. 704-706. 2010. RIZZETTO ,M. Hepatitis D Virus: Introduction and Epidemiology. Cold Spring Harb Perspect Med, v.5, p.1-9. 2015. RUMSEY, S.C. et al. Dehydroascorbic acid transport by GLUT4 in Xenopus Oocytes and isolated rat adipocytes. J. Biol.Chem, v.275, p. 28246–28253. 2000. RUMSEY, S.C. et al. Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J. Biol. Chem., v. 272, p. 18982–18989,.1997. SAJA, M.F., et al. The coagulopathy of liver disease: does vitamin K help? Blood Coagul Fibrinolysis, v. 24, p. 10-17. 2013. SALUDES, V. et al. Tools for the diagnosis of hepatitis C virus infection and hepatic fibrosis staging. World Journal of Hepatology, v.20, n.13, p.3431- 3442. 2014. SANTIS E SILVA, V, A. et al. Association of the nutritional Profile with histological findings Of patients with genotype 1 chronic Hepatitis c infection. Arq Gastroenterol, v. 52, p. 315-320.2015. SAVINI, et al. SVCT1 and SVCT2: key proteins for vitaminC uptake. Amino Acids, v. 34, p. 347-355. 2008. SCHLEICHER, R.L.; CARROLL, M.D.; FORD, E.S. LACHER, D.A. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES). American Journal of Clinical Nutrition, v.90, p. 1252-1263. 2009. SCHUPPAN, D.; AFDHAL, N. H. Liver cirrhosis. Lancet, v.371, n.9615, p.838-851. 2008. SEO, D.; NIU, J. Evaluation of Internet-Based Interventions on Waist Circumference Reduction: A Meta-Analysis. J Med Internet Res. v. 17, p. (7) 2015. SEREJO, F. Accuracy of transient elastography (Fibroscan©) for the evaluation of liver fibrosis. Factors of discordances. GE J Port Gastrenterol, v. 21, p.91-93. 2014. SHEEDFAR, F.; BIASE, S.D.; KOONEN, D.; VINCIGUERRA, V. Liver diseases and aging: friends or foes? Agin Cell, v.12, p.950-954. 2013. SI-TAYEB, K.; LEMAIGRE, F.P.; DUNCAN, S.A.. Organogenesis and development of the liver. Dev Cell, v.18, p.175–189. 2010. SMITH, A.; DI PRIMO, G.; HUMPHREY-MURTO, S.. Scurvy in the developed world. Canadian Medical Association Journal, v.183, p. E752-755. 2011. SOMI, M.; RAHIMI, A.; MOSHREFI, B.; RAZAEIFAR, P.; MAGHAMI, J. Nutritional status and blood trace elements in cirrhotic patients. Hep Mon, v. 7, p. 27-32. 2007. SOUZA DOS SANTOS, R.M. et al. Plasmatic vitamin C in nontreated hepatitis C patients is negatively associated with aspartate aminotransferase. Liver Int. v.28, p. 54-60. 2008. SRIDHAR, S.; LAU, S.K.P.; WOO, P.C.Y. Hepatitis E: A disease of reemerging importance. Journal of the Formosan Medical Association, v. 114, p. 681-690. 2015. TAKAHASHI, T. et al.,Histopathological characteristics of glutamine synthetasepositive hepatic tumor lesions in a mouse model of spontaneous metabolic syndrome (TSOD mouse). Molecular and Clinical Oncology, v. 5, p. 267-270. 2016. TIRAPEGUI, J.; RIBEIRO, S. M. L. Avaliação nutricional: teoria e prática. Rio de Janeiro: Ed. Guanabara Koogan, 2009. 326 p. TRÉPO, C.; CHAN, H.; LOK, A. Hepatitis B virus infection. Lancet, v.384, n.9959, p.2053-2073. 2014. TSOCHATZIS, E. A.; BOSCH, J.; BURROUGHS, A.K. Liver cirrhosis. Lancet, v.383, n.9930, p.1749-1761. 2014. VANNUCCHI, H.; MARCHINI, J.S. Nutrição e Metabolismo- Nutrição Clínica. Rio de Janeiro: Ed. Guanabara Koogan, 2012. 482 p. VIEIRA, P.M.; DE-SOUZA, D.A.; OLIVEIRA, L.C.M. Nutritional assessment in hepatic cirrhosis; clinical, anthropometric, biochemical and hematological parameters. Nutr Hosp, v. 28, p. 1615-1621. 2013. VIDIMLISKI, P. D. et al. Review: occult hepatitis C virus infection: still remains a controversy. Journal of Medical Virology, v.86, n.9, p.1491-1498. 2014. WATSON, R.R.; MAHADEVA, D. Handbook of nutrition and diet in leukemia and blood disease therapy. Wageningen: Ed. Wageningen Academic Publishers 2016. 378 p. WELCH, R.W. et al. Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms. J Biol Chem, v. 270, p. 12584-12592.1995. WORD HEALTH ORGANIZATION. BMI classification. Disponível em: <<http://apps.who.int/bmi/index.jsp?introPage=intro_3.html. >> Acesso em: 05 mar, 2017. WORD HEALTH ORGANIZATION. Hepatitis B. Fact sheet N°204 Updated March 2015. Disponível em:<<http://www.who.int/mediacentre/factsheets/fs204/en/>> Acesso em: 25 abr, 2015. WORD HEALTH ORGANIZATION. Hepatitis C. Fact sheet N°164 Updated April 2014. Disponível em: <<http://www.who.int/mediacentre/factsheets/fs164/en/ />> Acesso em: 25 abr, 2015. WORD HEALTH ORGANIZATION. Nutrition disorders. Disponível em: << http://www.who.int/topics/nutrition_disorders/en/>> Acesso em: 15 jun, 2015. WORD HEALTH ORGANIZATION. Obesity. Preventing and managing the global epidemic. Report of a WHO Consultation (TRS 894). Geneva. 2000. YAPALI, S.; TALAAT, N.; LOK, A. S. Management of hepatitis B: our practice and how It relates to the guidelines. Clinical Gastroenterology and Hepatology, v. 12, n.1, p.16-26. 2014. YASUTAKE, K.et al K. Assessing current nutritional status of patients with HCVrelated liver cirrhosis in the compensated stage. Asia Pac J Clin Nutr, v.21, p.400- 405.2012. YURDAYDIN, C; IDILMAN,R. Therapy of Delta Hepatitis. Cold Spring Harb Perspect Med, v. 5, p.10. 2015. ZHOU, W.; ZHANG, Q.; QIAO, L. Pathogenesis of liver cirrhosis. World Journal of Hepatology, v.20, n.23, p.7312- 7324. 2014.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFTMinstname:Universidade Federal do Triangulo Mineiro (UFTM)instacron:UFTM2019-06-14T04:00:20Zoai:bdtd.uftm.edu.br:tede/675Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.uftm.edu.br/PUBhttp://bdtd.uftm.edu.br/oai/requestbdtd@uftm.edu.br||bdtd@uftm.edu.bropendoar:2019-06-14T04:00:20Biblioteca Digital de Teses e Dissertações da UFTM - Universidade Federal do Triangulo Mineiro (UFTM)false
dc.title.none.fl_str_mv Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas
title Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas
spellingShingle Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas
MORAES, Giselle Vanessa
Estado nutricional.
Hepatites infecciosas.
Vitamina C.
Doença hepática gordurosa não alcoólica.
Esteatohepatite não-alcoólica.
Nutritional status.
Infectious hepatitis.
Vitamin C.
Nonalcoholic Fatty Liver Disease.
Nonalcoholic steatohepatitis.
Medicina
Nutrição
Doenças Infecciosas e Parasitárias
title_short Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas
title_full Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas
title_fullStr Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas
title_full_unstemmed Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas
title_sort Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas
author MORAES, Giselle Vanessa
author_facet MORAES, Giselle Vanessa
author_role author
dc.contributor.none.fl_str_mv CUNHA, Daniel Ferreira
1813965649
http://lattes.cnpq.br/2370047576509407
dc.contributor.author.fl_str_mv MORAES, Giselle Vanessa
dc.subject.por.fl_str_mv Estado nutricional.
Hepatites infecciosas.
Vitamina C.
Doença hepática gordurosa não alcoólica.
Esteatohepatite não-alcoólica.
Nutritional status.
Infectious hepatitis.
Vitamin C.
Nonalcoholic Fatty Liver Disease.
Nonalcoholic steatohepatitis.
Medicina
Nutrição
Doenças Infecciosas e Parasitárias
topic Estado nutricional.
Hepatites infecciosas.
Vitamina C.
Doença hepática gordurosa não alcoólica.
Esteatohepatite não-alcoólica.
Nutritional status.
Infectious hepatitis.
Vitamin C.
Nonalcoholic Fatty Liver Disease.
Nonalcoholic steatohepatitis.
Medicina
Nutrição
Doenças Infecciosas e Parasitárias
description Introdução: As hepatites B e C são as principais causas de câncer de fígado e cirrose e a principal razão para a indicação de transplante hepático. A avaliação do estado nutricional é importante nesses pacientes. Alguns estudos relataram uma diminuição nos níveis séricos de vitamina C em pacientes com resposta inflamatória associada à infecção. Pouco se sabe sobre o estado nutricional e níveis séricos de vitamina C em pacientes com hepatites crônicas. Nosso objetivo é avaliar o estado nutricional dos pacientes com hepatites infecciosas e dosar as concentrações séricas de vitamina C. Material e Métodos: Foram estudados 79 pacientes com hepatite B (n = 16) e C (n = 63). O estado nutricional foi avaliado por antropometria, impedância bioelétrica e consumo alimentar, além de concentrações séricas de vitamina C e testes de função hepática. Resultados: 54,43% tinham sobrepeso e obesidade. A ingestão de alimentos mostrou consumo de uma dieta com altos níveis de gordura. Os níveis séricos de vitamina C estavam dentro do intervalo normal (0,42 ± 0,08mg / dL), enquanto a alanina aminotransferase (ALT) apresentou concentrações séricas significativamente maiores em pacientes obesos quando comparados com pacientes não obesos (55 ± 42 U / L; 32 ± 22 U / L, respectivamente - p <0,05). As concentrações séricas de proteína C reativa (CRP) foram maiores nos pacientes obesos quando comparados aos não obesos (p = 0,01). Conclusão: Concluímos que pacientes com hepatite infecciosa apresentam concentrações normais de vitamina C,sejam eles obesos , ou não.
publishDate 2017
dc.date.none.fl_str_mv 2017-06-23
2019-06-13T17:20:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv MORAES, Giselle Vanessa. Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas. 2017. 70f. Dissertação (Mestrado em Ciências da saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2017.
http://bdtd.uftm.edu.br/handle/tede/675
identifier_str_mv MORAES, Giselle Vanessa. Avaliação do estado nutricional e concentrações séricas de vitamina C em pacientes com hepatites infecciosas. 2017. 70f. Dissertação (Mestrado em Ciências da saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2017.
url http://bdtd.uftm.edu.br/handle/tede/675
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv ABBOOTT-JOHNSON, W.; KERLIN, P.; CLAGUE, A.; JOHNSON, H.; CUNEO, R. Relationship between blood levels of fat soluble vitamins and diseas etiology and severity in adults awaiting liver transplantation. J Gastroenterol Hepatol, v. 26, p. 1402-1410. 2011. ACSM’S GUIDELINES FOR EXERCISE TESTING AND PRESCRIPTON – 8ª ed. Editora Lippincott Williams e Wilkins, 2009. 400 p. ARTEH, J.; NARRA, S.; NAIR, S. Prevalence of vitamin D deficiency in chronic liver disease. Dig Dis Sci, v. 55, p. 2624-2628. 2010. BAE, S. et al. In vivo consequence of vitamin C insufficiency in liver injury: vitamin C ameliorates T-cell-mediated acute liver injury in gulo(-/-) mice. Antioxid Redox Signal, v.19, p.2040-2053. 2013. BANDARA, P. et al. Antioxidant levels in peripheral blood, disease activity and fibrotic stage in chronic hepatitis C. Liver Int, v. 25, p.518-526. 2005. BEDOSSA, P, POYNARD, T. An algorithm for the grading of activity in chronic hepatitis C: the METAVIR Cooperative Study Group. Hepatology, v. 24, p. 289- 293.1996. BESSEY, O.A. Ascorbic acid microchemical methods. In: Vitamin methods. New York: Academic Press, v.1, p.303. 1960. BJELAKOVIC, G. et al. Meta-analysis: antioxidant supplements for liver diseases - the Cochrane Hepato-Biliary Group. Aliment Pharmacol Ther, v.32, p.356-367. 2010. BOLETIM EPIDEMIOLÓGICO DE HEPATITES VIRAIS, 2016. Disponível em:<<http://www.aids.gov.br/sites/default/files/anexos/publicacao/2016/59121/boleti m_hepatites_05_08_2016_pdf_96185.pdf>>. Acesso em 02 jan, 2017. BRESNAHAN, K.A; TANUMIHARDJO, S.A. Undernutrition, the acute phase response to infection, and its effectson micronutrient status indicators. Advances in Nutrition, v. 5, p. 702-711. 2014. BUDZIARECK, M.B.; PUREZA, D.R.R.; BARBOSA-SILVA, M.C. Refence values and determinats for handgrip strength in healthy subjects. Clin Nutr, v. 27, p. 357-362. 2008. BURDETTE, S.D.; POLENAKOVIK, H.; SURYAPRASAD, S. An HIV-infected man with odynophagia and rash. Clinical Infectious Diseases, v. 41, p. 686-688. 2005. BUSCH, K.; THIMME, R. Natural history of chronic hepatitis B virus infection. Med Microbiol Immunol, v.204, n.1, p.5-10. 2015. CANDOTTI, D. et al. Occult hepatitis B infection in blood donors from South East Asia: molecular characterisation and potential mechanisms of occurrence. Gut, v. 61, n.12, p. 1744-1753. 2012. CANKURTARAN, M. et al. Serum vitamin-E levels and its relation to clinical features in nonalcoholic fatty liver disease with elevated ALT levels Acta . Gastroenterol Belg, v. 69, p. 5-11. 2006. CARREIRA, C.M.; PEREIRA, P.C.M. Nutritional and dietetic profile of individuals with hepatitis C. Semina: Ciências Biológicas e da Saúde, v. 32, p. 143-154. 201. CARVALHO, L.; PARISE, E.R. Evaluation of nutritional status of nonhospitalized patients with liver cirrhosis. Arq Gastroenterol, v. 43, p.269-274. 2006. CECILIANI, F., GIORDANO, A.; SPAGNOLO, V. The systemic reaction during inflammation: the acute-phase proteins. Protein and Peptide Letters, v.9, p. 211- 223. 2002. CENTERS FOR DISEASE CONTROL AND PREVENTION. Viral Hepatitis. Disponível em: <<https://wwwn.cdc.gov/nndss/>> Acesso em: 12 dez, 2016. CHANG, W.T. et al. Albumin and prealbumin may predict retinol status in patients with liver cirrhosis. Hepatogastroenterology, v. 55, p. 1681-1685. 2008. CHEUNG, K.; LEE, S.S.; RAMAN, M. Prevalence and mechanisms of malnutrition in patients with advanced liver disease, and nutrition nanagement strategies. Clinical gastroenterology and hepatology, v.10, n.2, p.117-125. 2012. CHOI, J. et al. Reactive oxygen species suppress hepatitis C virus RNA replication in human hepato-ma cells. Hepatology, v. 39, p. 81-89. 2004. CINCINATUS, R.; CHAVES, G. V.; AQUINO, L. A.; PERES, W. A. F.; LENTO, D.F.; RAMALHO, A. Dietary consumption of macronutrients and micronutrients and their relationship to the severity of hepatic disease. Rev. Soc.Bras. Alim. Nutr, v. 32, p. 61-77. 2007. CLARK, J.M. ; BRANCATI, F.L.; DIEHL,A.M. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol. v.98, p.960-967. 2003. COPPOLA, N. et al., 2014). Clinical and virological characteristics associated with severe acute hepatitis B. Clinical microbiology and infection, v.20, n.12, p.0991- 0997. 2014. COREY, K.E.; KAPLAN, L.M.Obesity and Liver Disease, The Epidemic of the Twenty-First Century. Clin Liver Dis, v. 18, p.1–18. 2014. CUNHA, D.F.; CUNHA, S.F.; UNAMUNO, M.R; VANNUCCHU, H. Serum levels assessment of vitamin A, E, C,B2 and carotenoids in malnourished and nonmalnourished hospitalized elderly patients. Clinical Nutrition, v.20, p.167-170. 2001. DELWART, E. et al. Genetic diversity of recently acquired and prevalent HIV, hepatitis B virus, and hepatitis C virus infections in US blood donors. The journal of infectious diseases, v.205, n.6, p.875-885. 2012. DUBEY, S.S.; PALODHI, G.R.; JAIN, A.K. Ascorbic acid, dehydroascorbic acid and glutathione in liver disease. Indian J Physiol Pharmacol, v. 31, p. 279-283.1987. DURNIN, J.V.; WORNERSLEY, J. Body Fat Assessed from Total Body Density and its Estimation from Skinfold Thickness: Measureme 481 men and women aged from 16 t 72 year. Br J Nutr, v. 32, p.77-97. 1974. DUTRA, C.N.N.; BASSO, C. Alterações nutricionais em portadores de hepatite C. Disc. Scientia, v. 7, p. 109-120. 2006. FARIAS, M.S. et al. Antioxidant supplementation attenuates oxidative stress in chronic hepatitis C patients. Gastroenterol Hepatol, v.35, p.386-394.2012. FIGUEIREDO, F.A; De MELLO, P.R.; KONDO, M. Effect of liver cirrhosis on body composition: evidence of significant depletion even in mild disease. J Gastroenterol Hepatol, v. 20, p. 209-216. 2005. FILHO, G.B. Bogliolo, Patologia Geral, 8ª ed. Rio de Janeiro: Ed Guanabara Koogan, 2011. 1492 p. FOOD AND NUTRITION BOARD OF THE INSTITUTE OF MEDICINE: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc, v. 102, p. 1621-1630. 2002. FOOD AND NUTRITION BOARD OF THE INSTITUTE OF MEDICINE: Dietary Reference Intakes for Vitamin C, Vitamin E,Selenium, and Carotenoids. Washington (DC):National Academies Press (US); p. 12-13. 2000. FORNER, A.; LLOVET, J. M.; BRUIX, J. Hepatocellular carcinoma. Lancet, v.379, n.9822, p.1245-1244. 2012. FOSSITT, D.D.; KOWALSKI, T.J. Classic skin findings of scurvy. Mayo Clinic Proceedings, v. 89, p.61. 2014. FREEMAN, A.J. et al. Estimating progression to cirrhosis in chronic hepatitis C virus infection. Hepatology, v. 34, n.4 pt 1, p. 809-816. 2001. FRISANCHO, AR. Antropometric Standards: An interactive nutritional Reference of Body Size and Body Composition for Chlidren and Adults. 4ª ed. Local: University of Michigan Press, 2011. FUHRMAN, P.; CHARNEY, P. MUELLER, C.M. Hepatic proteins and /nutrition assessment. J Am Diet Assoc, v.104, p. 1258-1264. 2004. GOMES, A.P et al. Hepatites virais: abordagem clínica com ênfase nos vírus A e E*. Rev Bras Clin Med, v. 10, p. 139-146. 2012. GONZÁLEZ, M.I.M Circunferencia de cintura: una medición importante y útil del riesgo cardiometabólico. Rev Chil Cardiol. v. 29, p.85-87. 2010. GORDON, A.; McLEAN, C.A.; PEDERSEN, J.S.; BAILEY, M.J.; ROBERTS, S.K. Hepatic steatosis in chronic hepatitis B and C: predictors, distribution and effect on fibrosis. J Hepatol, v. 43, p.38-44. 2005; GOTTSCHALL, C.B.A.; ÁLVARES-DA-SILVA, M.R.; CAMARGO, A.C., BURTETT, R.M. SILVEIRA, T.R. Avaliação nutricional de pacientes com cirrose pelo vírus da hepatite C: a aplicação da calorimetria indireta. Arq Gastroenterol, v. 41, p. 220- 224. 2004. GOTTSCHALL, C.B.A.; PEREIRA, T.G.; RABITO, E.I.; LVARES-DA-SILVA, M.R. Nutritional status and dietary intake in non-cirrhotic adult chronic hepatitis c patients. Arq Gastroenterol, v. 52, p. 204.209. 2015. GOWER, E. et al. Global epidemiology and genotype distribution of the hepatitis C virus infection. Journal of Hepatology, v. 61, p.45–57 2014 GRANT, R.W; STEPHENS, J.M. Fat in flames: influence of cytokines and pattern recognition receptors on adipocyte lipolysis. American Journal of Physiology − Endocrinology and Metabolism, v. 309, p. 205-213. 2015. GRUYS, E.; TOUSSAINT, M.J.M., NIEWOLD, T.A.; KOOPMANS, S.J. Acute phase reaction and acute phase proteins. Journal of Zhejiang University Science, v.6, p. 1045-1056. 2005. HARRIS, J.A; BENEDICT, F.G. Biometric Study of Basal Metabolism in Man. Carnegie Institution of Washington, 1919. HAYASHI, F. et al., Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis. World J Gastroenterol, v. 18, p.5759-5770. 2012 HISE, M.E.; SULLIVAN, D.K.; JACOBSEN, D.J.; JOHBSON, S.L.; DONNELLY, J.E. Validation of energy intake measurements determined from observer – recorded food records and recall methods compared with the doubly labeled water method in overweight and obese individuals. Am J Clin Nutr, v. 75, p. 263 - 267. 2002. HORNIG, D. Distribution of ascorbic acid, metabolites and analogues in man and animals. Annals of the New York Academy of Sciences, v.258, p.103-118. 1975. IPSEN, D.H.; TVEDEN-NYBORG, P.; LYKKESFELDT, J. Does Vitamin C Deficiency Promote Fatty Liver Disease Development? Nutrients, v.6, p. 5473-5499. 2014. doi:10.3390/nu6125473 ISMAIL, F.W. et al. Nutritional Status in Patients with Hepatitis C. Journal of the College of Physicians and Surgeons Pakistan, v. 22, p. 139-142.2012. JEONG, S.; LEE, H. Hepatites A: clinical manifestations and management. Intervirology, v.53, p.15-19. 2010. JOHANSSON, L.; SOLVOLI, K.; BJORNEBOE, G.A.; DREVON, C.A. Under and overreporting of energy intake related to weight status and lifestyle in a nationwide sample. Am J Clin Nutr, v. 68, p. 266 - 274. 1998. JOHNSON, T.; OVERGARD, E.B.; COHEN, A.E.; DiBAISE, J.K. Nutrition assessment and management in advanced liver disease. Nutrition in Clinical Practice, v.28, p. 15-29. 2013. JUNQUEIRA, L.C; CARNEIRO, J. Histologia Básica. 12ª ed. Rio de Janeiro: Ed. Guanabara Koogan, 2013. 558 p. JUZA, R.M.; PAULI E.M. Clinical and Surgical Anatomy of the Liver: A Review for Clinicians. Clinical Anatomy, v.27, p.764–769. 2014. KALLNER, A.; HARTMANN, D.; HORNING, D. Steady-state turnover and body pool of ascorbic acid in man. American Journal of Clinical Nutrition, v.32, p.530-539. 1979. KAWABE, N.et al. Assessment of nutritional status of patients with hepatites C virusrelated liver cirrhosis. Hepatology Research, v. 38, p. 484-490. 2008. KOHLI, A. et al. Treatment of hepatitis C: a systematic review. The journal of the american medical association, v. 312, n.6, p.631-640. 2014. KOJ, A. Initiation of the acute phase response and synthesis of cytokines. Biochimica et Biophysica Acta, v.1317, p. 84-94.1996. KOTLER, D.P. Cachexia. Annals of Internal Medicine, v.133, p.622-634. 2000. KOWDLEY, K.V; EMOND, M.J.; SADOWSKI, J.A.; KAPLAH, M.M. Plasma vitamin K1 level is decreased in primary biliary cirrhosis. Am J Gastroenterol, v. 92, p. 2059-2061.1997. KRALL, E.A.; DWYER, J.T. Validity of a food frequency questionnaire and a food diary in a short-term recall situation. J Am Diet Assoc, v. 87, p. 1374-1377.1987. KUCZMARSKI, M.F.; KUCZMARSKI R.J.; NAJJAR, M. Descriptive antropometric reference data for older Americans. J Am Diet Assoc, v. 100, p. 59-66. 2000. KWAK, M.; KIM, Y.J. Occult hepatitis B virus infection. World Journal of Hepatology, v.6, n.12, p. 860-869. 2014. LÉGER, D. Scurvy: reemergence of nutritional deficiencies. Canadian Family Physician, v. 54, p. 1403-1406. 2008. LIAW, F.; CHU, C. Hepatitis B vírus infection. Lancet, v.373, n.9663, p.582-592. 2009. LIN, C.L.; KAO, J.H. The clinical implications of hepatitis B vírus genotype: recent advances. J Gastroenterol Hepatol, v.26, p. 123–30. 2011; LIND, J.A. Treatise on the scurvy. Edinburgh: Edinburgh University Press. Ed. C.P. Stewart and D. Guthrie.1953. LINDBLAND, M.; TVEDEN-NYBORG, P.; LYKKESFELDT, J. Regulation of Vitamin C Homeostasis during Deficiency. Nutrients, v. 4, p. 2860 – 2879. 2013. LOUW, J.A. et al. Blood vitamin concentrations during the acute-phase response. Critical Care Medicine, v. 20, p. 934-941.1992. LYKKESFELDT, J.; MICHELS, A.J. FREI, B. Vitamin C. Advances in Nutrition, v.5, p.16-18. 2014. MAHAN, L.K.; ESCOTT-STUMP, S. 10ª ed. Krause, alimentos, nutrição e dietoterapia. São Paulo: Rocca. 2002. 1157 p. MALTOS, A.L.; PORTARI, G.V.; SALDANHA, J.C., BERNARDES JÚNIOR, A.G.; PARDI, G.R., CUNHA, D.F. Scurvy in an alcoholic malnourished cirrhotic man with spontaneous bacterial peritonitis. Clinics v.67, p. 405-407. 2012. MALTOS, A.L.; SILVA, L.L.; BERNARDES JUNIOR, A.G.; PORTARI, G.V.; CUNHA, D.F. Scurvy in a patient with AIDS: case report. Revista da Sociedade Brasileira de Medicina Tropical , v. 44, p. 122-123. 2011. MANDL, J.; SZARKA, A. BANHEGYI, G. Vitamin C: update on physiology and pharmacology. British Journal of Pharmacology, v.157, p. 1097-1110. 2009. MANELA-AZULAY, et al. Vitamina C. An bras Dermatol, v. 78, p. 265-274. 2003. MANJATE, D.A.; NASSER, A.L.M; CÉSAR, T.B. Influência da ingestão do suco de laranja sobre estado nutricional e dietético em pacientes com hepatite C crônica. J. Food Nutr, v. 24, p.15-19. 2013 MARDONES, L. et al.The glucose transporter-2 (GLUT2) is a lo affinity dehydroascorbic acid transporter. Biochem.Biophys, v. 410, p. 7-12. 2011. MAYO MEDICAL LABORATORIES. Ascorbic Acid (Vitamin C), Plasma. Disponível: <<http://www.mayomedicallaboratories.com/testcatalog/Clinical+and+Interpretive/42362>>. Acessado em: 25,mar. 2017. McKENZIE D.C.; JOHNSON, R.K.; HAR, V.B.; GOLD, B.C. Impact of interviewer ́s body mass index on underreporting energy intake in overweight and obese women. Obes Res, v. 10, p. 471-477.2002. McMAHON et al. Antibody levels and protection after hepatitis B vaccine: results of a 22-year follow-up study and response to a booster dose. The journal of infectious diseases, v.200, n.9, p.1390-1396. 2009. McPHERSON, RA. Laboratory diagnosis of human hepatitis viruses. J Clin Lab Anal, v.8, p.369-377. 1994. MELETHIL, S.; MASON, W.D.; CHANG, C.J. Dose-dependen absorption and excretion of vitamin C in humans. International Journal of Pharmaceutics, v. 31, p. 83-89. 1986. MENTA, P.L.R. et al. Nutrition status of patients with chronic hepatitis B or C. Nutrition in clinical practice, v.30, n.2, p.290-296. 2015. MONTEIRO, J.P. et al. Consumo Alimentar, visualizando porções. Nutrição e Metabolismo. Rio de Janeiro: Ed.Guarabara, 2013. 92 p. MOURA, L.P. et al. Hepatic biochemical changes in rats submitted to a high-fat/highenergy diet. Rev. Nutr., Campinas, v. 25, p.685-693. 2012. MURAKAMI, Y. et al. Vitamin E and C supplementation prevents decrease of eicosapentaenoic acid in mononuclear cells in chronic hepatitis C patients during combination therapy of interferon alpha-2b and ribavirin. Nutrition, v. 22, p. 114-122, 2006. NAKAMURA, A.; YASUO, T. Lessons from Mouse Models of High-Fat Diet-Induced NAFLD. Int. J. Mol. Sci, v. 14, p. 21240-21257. 2013. NUNES, F.F. et al. Food consumption of cirrhotic patients, comparison with the nutritional status and disease staging. Arq Gastroenterol, v. 53, p. 250-256. 2016. OLIVEIRA, G.S. et al. Severe hepatitis and jaundice during the evolution of dengue virus infection: case report. Revista da sociedade brasileira de medicina tropical, v.43, p.339-341. 2010. PAULING, L. Evolution and the need for ascorbic acid. Proc Natl Acad Sci USA, v.67, p.1643-1648. 1970. PENG, S. et al. Body composition, muscle function, and energy expenditure in patients with liver cirrhosis: a comprehensive study. Am J Clin Nutr, v. 85, p. 1257- 1266. 2007. POOVORAWAN, K. et al.The important role of early diagnosis and preventive management during a large-scale outbreak of hepatitis A in Thailand. Pathogens and Global Health, v.107, p. 367-372. 2013. PRADAT, P. et al. Predictive value of ALT levels for histologic findings in chronic hepatitis C: a European collaborative study. Hepatology, v.36, p. 973-977. 2002. PURNAK, T.; YILMAZ, Y. Liver disease and malnutrition. Best practice e research clinical gastroenterology, v. 27, n.4, p.619-629. 2013. REED, R.M.Captain Ignose to the rescue. American Journal of Medicine, v.123, p. 704-706. 2010. RIZZETTO ,M. Hepatitis D Virus: Introduction and Epidemiology. Cold Spring Harb Perspect Med, v.5, p.1-9. 2015. RUMSEY, S.C. et al. Dehydroascorbic acid transport by GLUT4 in Xenopus Oocytes and isolated rat adipocytes. J. Biol.Chem, v.275, p. 28246–28253. 2000. RUMSEY, S.C. et al. Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J. Biol. Chem., v. 272, p. 18982–18989,.1997. SAJA, M.F., et al. The coagulopathy of liver disease: does vitamin K help? Blood Coagul Fibrinolysis, v. 24, p. 10-17. 2013. SALUDES, V. et al. Tools for the diagnosis of hepatitis C virus infection and hepatic fibrosis staging. World Journal of Hepatology, v.20, n.13, p.3431- 3442. 2014. SANTIS E SILVA, V, A. et al. Association of the nutritional Profile with histological findings Of patients with genotype 1 chronic Hepatitis c infection. Arq Gastroenterol, v. 52, p. 315-320.2015. SAVINI, et al. SVCT1 and SVCT2: key proteins for vitaminC uptake. Amino Acids, v. 34, p. 347-355. 2008. SCHLEICHER, R.L.; CARROLL, M.D.; FORD, E.S. LACHER, D.A. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES). American Journal of Clinical Nutrition, v.90, p. 1252-1263. 2009. SCHUPPAN, D.; AFDHAL, N. H. Liver cirrhosis. Lancet, v.371, n.9615, p.838-851. 2008. SEO, D.; NIU, J. Evaluation of Internet-Based Interventions on Waist Circumference Reduction: A Meta-Analysis. J Med Internet Res. v. 17, p. (7) 2015. SEREJO, F. Accuracy of transient elastography (Fibroscan©) for the evaluation of liver fibrosis. Factors of discordances. GE J Port Gastrenterol, v. 21, p.91-93. 2014. SHEEDFAR, F.; BIASE, S.D.; KOONEN, D.; VINCIGUERRA, V. Liver diseases and aging: friends or foes? Agin Cell, v.12, p.950-954. 2013. SI-TAYEB, K.; LEMAIGRE, F.P.; DUNCAN, S.A.. Organogenesis and development of the liver. Dev Cell, v.18, p.175–189. 2010. SMITH, A.; DI PRIMO, G.; HUMPHREY-MURTO, S.. Scurvy in the developed world. Canadian Medical Association Journal, v.183, p. E752-755. 2011. SOMI, M.; RAHIMI, A.; MOSHREFI, B.; RAZAEIFAR, P.; MAGHAMI, J. Nutritional status and blood trace elements in cirrhotic patients. Hep Mon, v. 7, p. 27-32. 2007. SOUZA DOS SANTOS, R.M. et al. Plasmatic vitamin C in nontreated hepatitis C patients is negatively associated with aspartate aminotransferase. Liver Int. v.28, p. 54-60. 2008. SRIDHAR, S.; LAU, S.K.P.; WOO, P.C.Y. Hepatitis E: A disease of reemerging importance. Journal of the Formosan Medical Association, v. 114, p. 681-690. 2015. TAKAHASHI, T. et al.,Histopathological characteristics of glutamine synthetasepositive hepatic tumor lesions in a mouse model of spontaneous metabolic syndrome (TSOD mouse). Molecular and Clinical Oncology, v. 5, p. 267-270. 2016. TIRAPEGUI, J.; RIBEIRO, S. M. L. Avaliação nutricional: teoria e prática. Rio de Janeiro: Ed. Guanabara Koogan, 2009. 326 p. TRÉPO, C.; CHAN, H.; LOK, A. Hepatitis B virus infection. Lancet, v.384, n.9959, p.2053-2073. 2014. TSOCHATZIS, E. A.; BOSCH, J.; BURROUGHS, A.K. Liver cirrhosis. Lancet, v.383, n.9930, p.1749-1761. 2014. VANNUCCHI, H.; MARCHINI, J.S. Nutrição e Metabolismo- Nutrição Clínica. Rio de Janeiro: Ed. Guanabara Koogan, 2012. 482 p. VIEIRA, P.M.; DE-SOUZA, D.A.; OLIVEIRA, L.C.M. Nutritional assessment in hepatic cirrhosis; clinical, anthropometric, biochemical and hematological parameters. Nutr Hosp, v. 28, p. 1615-1621. 2013. VIDIMLISKI, P. D. et al. Review: occult hepatitis C virus infection: still remains a controversy. Journal of Medical Virology, v.86, n.9, p.1491-1498. 2014. WATSON, R.R.; MAHADEVA, D. Handbook of nutrition and diet in leukemia and blood disease therapy. Wageningen: Ed. Wageningen Academic Publishers 2016. 378 p. WELCH, R.W. et al. Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms. J Biol Chem, v. 270, p. 12584-12592.1995. WORD HEALTH ORGANIZATION. BMI classification. Disponível em: <<http://apps.who.int/bmi/index.jsp?introPage=intro_3.html. >> Acesso em: 05 mar, 2017. WORD HEALTH ORGANIZATION. Hepatitis B. Fact sheet N°204 Updated March 2015. Disponível em:<<http://www.who.int/mediacentre/factsheets/fs204/en/>> Acesso em: 25 abr, 2015. WORD HEALTH ORGANIZATION. Hepatitis C. Fact sheet N°164 Updated April 2014. Disponível em: <<http://www.who.int/mediacentre/factsheets/fs164/en/ />> Acesso em: 25 abr, 2015. WORD HEALTH ORGANIZATION. Nutrition disorders. Disponível em: << http://www.who.int/topics/nutrition_disorders/en/>> Acesso em: 15 jun, 2015. WORD HEALTH ORGANIZATION. Obesity. Preventing and managing the global epidemic. Report of a WHO Consultation (TRS 894). Geneva. 2000. YAPALI, S.; TALAAT, N.; LOK, A. S. Management of hepatitis B: our practice and how It relates to the guidelines. Clinical Gastroenterology and Hepatology, v. 12, n.1, p.16-26. 2014. YASUTAKE, K.et al K. Assessing current nutritional status of patients with HCVrelated liver cirrhosis in the compensated stage. Asia Pac J Clin Nutr, v.21, p.400- 405.2012. YURDAYDIN, C; IDILMAN,R. Therapy of Delta Hepatitis. Cold Spring Harb Perspect Med, v. 5, p.10. 2015. ZHOU, W.; ZHANG, Q.; QIAO, L. Pathogenesis of liver cirrhosis. World Journal of Hepatology, v.20, n.23, p.7312- 7324. 2014.
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Brasil
UFTM
Programa de Pós-Graduação em Ciências da Saúde
publisher.none.fl_str_mv Universidade Federal do Triângulo Mineiro
Instituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da Saúde
Brasil
UFTM
Programa de Pós-Graduação em Ciências da Saúde
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