Anestesia de animais de laboratório com associação tiletamina-zolazepam em combinação ou não com a levomepromazina

• Ano de defesa: 2005
• Autor(a) principal: Alonso, Douglas do Carmo
• Orientador(a): Pompermayer, Luiz Gonzaga
• Banca de defesa: Borges, Andrea Pacheco Batista , Carlo, Ricardo Junqueira Del , Pinto, Aloísio da Silva , Ribeiro Filho, José Dantas
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Viçosa
• Programa de Pós-Graduação: Mestrado em Medicina Veterinária
• Departamento: Biotecnologia, diagnóstico e controle de doenças; Epidemiologia e controle de qualidade de prod. de
• País: BR
• Palavras-chave em Português: Anestesia; Animais de laboratório; Tiletamina-zolazepam; Fenotiazina; Benzodiazepinas
• Palavras-chave em Inglês: Anesthesia; Laboratory animals; Tiletamine; Zolazepam
• Área do conhecimento CNPq: CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL::CLINICA CIRURGICA ANIMAL
• Link de acesso: http://locus.ufv.br/handle/123456789/5017

Four species of laboratory animals, mouse (Mus musculus), gerbil (Meriones unguiculatus), hamster (Mesocricetus auratus) and rat (Rattus norvegicus), were submitted to anesthesia with combination of tiletamine and zolazepam (TZ) intramuscularly, with or without levomepromazine (LV), in the same syringe. Sixty animals of each specie were divided into six groups with five males and five females. Mice received the following treatments: group1, group2 e group3, with the doses of 40, 60 e 80mg/kg of TZ, respectively, and the groups 1L, 2L e 3L, TZ with the doses of 30, 40 e 50mg/kg respectively, added with 3mg/kg of LV. Gerbils received the following treatments: group1, group2 e group3, with the doses of 50, 60 e 70mg/kg of TZ, respectively, and the groups 1L, 2L e 3L, TZ with the doses of 20, 30 e 40mg/kg respectively, added with 2mg/kg of LV. Hamsters received the following treatments: group1, group2 e group3, with the doses of 180, 300 e 400mg/kg of TZ, respectively, and the groups 1L, 2L e 3L, TZ with the doses of 120, 140 e 160mg/kg respectively, added with 4mg/kg of LV. Rats received the following treatments: group1, group2 e group3, with the doses of 30, 40 e 50mg/kg of TZ, respectively, and the groups 1L, 2L e 3L, TZ with the doses of 20, 30 e 0mg/kg respectively, added with 2mg/kg of LV. Onset of anesthesia, duration of anesthesia, recovery time, posture and other physiological and clinical changing manifested by the animals were evaluated. The analgesia was confirmed when the execution of laparotomy and visceral manipulation was possible. The results in mice showed that even in the higher dose (80mg/kg), TZ was incapable to promote appropriate analgesia and muscular relaxation while the dose of 40mg/kg added of 3mg/kg of LV resulted in adequate anesthesia for the execution of laparotomy. In gerbils, the results demonstrated that even in the higher dose (70mg/kg), the TZ was incapable to promote appropriate analgesia and muscular relaxation, and should be avoided as an anesthetic for painful procedures in gerbils. However when 2mg/kg of LV was added, the dose of 30mg/kg resulted in adequate anesthesia for the execution of laparotomy. In hamsters the TZ promoted surgery anesthesia only in the higher dose (400mg/kg). However, all animals presented respiratory distress and 50% died in the anesthetic period and other 50% in the recovery period, thus the TZ should be avoided as anesthetic in this specie. However when 4mg/kg of LV was added, the 120mg/kg dose resulted in adequate anesthesia for laparotomy. The results with rats showed that even in the higher dose (50mg/kg), the TZ was incapable to promote adequate analgesia and muscular relaxation for abdominal surgery, but when associated the dose of 40mg/kg with LV, an adequate anesthesia for laparotomy occurred. The TZ was incapable to promote appropriate anesthesia for abdominal surgery in any specie, however the LV added to TZ promoted adequate muscular relaxation and analgesia for painful procedures in all the studied species. Any problems or unsuitable effects was observed for the administration of TZ and LV mixed in the same syringe.