Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina
Ano de defesa: | 2021 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Estadual do Oeste do Paraná
Toledo |
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Centro de Engenharias e Ciências Exatas
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://tede.unioeste.br/handle/tede/5715 |
Resumo: | This work aimed to apply Quality by Analytical Design (AQbD) in the development and validation of an analytical method of residual solvents by gas chromatography with Headspace transferline injection of the raw material of Duloxetine Hydrochloride. Multivariate optimization of the analytical method was performed to control residual solvents methanol, acetone, 2-propanol, dichloromethane, tert-butanol, Ethyl acetate, Chloroform, Triethylamine, Dimethylsulfoxide, Cyclohexane and Toluene with the application of experimental designs aimed at meeting the objectives, characteristics and quality criteria. The execution was carried out in stages that can be summarized as screening, optimization, data evaluation, validation and strategic control. In screening, the Plackett-Burman experimental design was applied in order to define the best conditions for the use of Headspace transferline, allowing signal maximization and recovery close to 100% of the analytes. However, there was a division of the analytes to be controlled, and thus opted to present validation of residual solvents Methanol, Acetone, 2-Propanol, Dichloromethane and Tert-butanol. In the optimization stage, the identification of the Performance Characteristics of the Analytical Method (AMPC), Critical Quality Attributes (CQA) and Risk Analysis (QRM) were carried out and finalized with the application of the central composite design (CCD) for the definition of the method operable design region (MODR). The results were evaluated, in which the data were processed and evaluated, allowing the necessary adjustments to be made to the method. The analytical validation step was performed according to RDC 166/2017, obtaining a precise, linear, selective, robust method and limit of quantification. The MODR was defined after varying the kiln initial temperature and carrier gas flow factors, obtaining design regions ranging from 29.3 to 31.1 oC and 0.9 to 1.03 mL.min-1, respectively. Finally, the results are maximized analytical response and recovery close to 100%, ensuring operationality and regulatory flexibility allowing immediate adjustments to the analytical method. The determination of the sensitivity/Limit of analytical quantification at the 40% level for the analytes Methanol, Acetone, Tert-butanol, 2-propanol and Dichloromethane at a content of 1197.50, 1995.58, 398.16, 1997.84 and 239 .26 μg.g-1, respectively. The application of AQbD enabled the paradigm shift through a multivariable approach with the use of quality tools, which demonstrate important points in the development and validation of an analytical method to identify and mitigate weak points. |
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Módenes, Aparecido Nivaldohttp://lattes.cnpq.br/7294940837327863Pereira, Marcos Donizete Peliçonhttp://lattes.cnpq.br/1543951142562291Pereira, Marcos Donizete Peliçonhttp://lattes.cnpq.br/1543951142562291Dragunski, Douglas Cardosohttp://lattes.cnpq.br/0612112281360342Módenes, Aparecido Nivaldohttp://lattes.cnpq.br/7294940837327863http://lattes.cnpq.br/3830038763865288Oliveira, Leonardo Guimarães de2021-12-08T18:48:30Z2021-09-08OLIVEIRA, Leonardo Guimarães de. Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina. 2021. 114 f. Dissertação (Mestrado em Química) - Universidade Estadual do Oeste do Paraná, Toledo, 2021.http://tede.unioeste.br/handle/tede/5715This work aimed to apply Quality by Analytical Design (AQbD) in the development and validation of an analytical method of residual solvents by gas chromatography with Headspace transferline injection of the raw material of Duloxetine Hydrochloride. Multivariate optimization of the analytical method was performed to control residual solvents methanol, acetone, 2-propanol, dichloromethane, tert-butanol, Ethyl acetate, Chloroform, Triethylamine, Dimethylsulfoxide, Cyclohexane and Toluene with the application of experimental designs aimed at meeting the objectives, characteristics and quality criteria. The execution was carried out in stages that can be summarized as screening, optimization, data evaluation, validation and strategic control. In screening, the Plackett-Burman experimental design was applied in order to define the best conditions for the use of Headspace transferline, allowing signal maximization and recovery close to 100% of the analytes. However, there was a division of the analytes to be controlled, and thus opted to present validation of residual solvents Methanol, Acetone, 2-Propanol, Dichloromethane and Tert-butanol. In the optimization stage, the identification of the Performance Characteristics of the Analytical Method (AMPC), Critical Quality Attributes (CQA) and Risk Analysis (QRM) were carried out and finalized with the application of the central composite design (CCD) for the definition of the method operable design region (MODR). The results were evaluated, in which the data were processed and evaluated, allowing the necessary adjustments to be made to the method. The analytical validation step was performed according to RDC 166/2017, obtaining a precise, linear, selective, robust method and limit of quantification. The MODR was defined after varying the kiln initial temperature and carrier gas flow factors, obtaining design regions ranging from 29.3 to 31.1 oC and 0.9 to 1.03 mL.min-1, respectively. Finally, the results are maximized analytical response and recovery close to 100%, ensuring operationality and regulatory flexibility allowing immediate adjustments to the analytical method. The determination of the sensitivity/Limit of analytical quantification at the 40% level for the analytes Methanol, Acetone, Tert-butanol, 2-propanol and Dichloromethane at a content of 1197.50, 1995.58, 398.16, 1997.84 and 239 .26 μg.g-1, respectively. The application of AQbD enabled the paradigm shift through a multivariable approach with the use of quality tools, which demonstrate important points in the development and validation of an analytical method to identify and mitigate weak points.Este trabalho teve como objetivo aplicar o Qualidade por Design Analítico (AQbD) no desenvolvimento e validação de método analítico de solventes residuais por cromatografia gasosa com injeção Headspace transferline da matéria-prima de Cloridrato de Duloxetina. Foi realizado otimização multivariada do método analítico, para o controle dos solventes residuais metanol, acetona, 2-propanol, diclorometano, terc-butanol, Acetato de etila, Clorofórmio, Trietilamina, Dimetilsulfóxido, Ciclohexano e Tolueno com a aplicação de planejamentos experimentais que visam o atendimento dos objetivos, características e critérios de qualidade. A execução foi conduzida por etapas que podem ser resumidas em triagem, otimização, avaliação dos dados, validação e controle estratégico. Na triagem, o planejamento experimental de Plackett-Burman foi aplicado de maneira a definir as melhores condições de utilização de Headspace transferline, permitindo maximização do sinal e recuperação próximos a 100% dos analitos. Contudo, houve a divisão dos analitos a serem controlados, e assim optados por apresentar validação de solventes residuais Metanol, Acetona, 2-Propanol, Diclorometano e Terc-butanol. Já na etapa de otimização foram realizadas as identificações das Características de Desempenho do Método Analítico (AMPC), Atributos Críticos de Qualidade (CQA) e Análise de Risco (QRM) e finalização com a aplicação do delineamento de composto central (CCD) para a definição da região de design operável do método (MODR). Procedeu-se para a avaliação dos resultados, em que os dados foram processados e avaliados, permitindo a realização de ajustes necessários ao método. A etapa de validação analítica foi realizada conforme RDC 166/2017, obtendo um método preciso, linear, seletivo, robusto e limite de quantificação. A MODR foi definida após a variação dos fatores temperatura inicial do forno e fluxo de gás de arraste, obtendo as regiões de design que vai de 29,3 a 31,1 oC e 0,9 a 1,03 mL.min-1, respectivamente. Por fim, os resultados a maximização da resposta analítica e recuperação próxima a 100%, garantindo a operacionalidade e a flexibilidade regulatória permitindo ajustes imediato do método analítico. A determinação da sensibilidade/Limite de quantificação analítica no nível 40% para os analitos Metanol, Acetona, Terc-butanol, 2-propanol e Diclorometano em um teor de 1197,50, 1995,58, 398,16, 1997,84 e 239,26 μg.g-1, respectivamente. A aplicação do AQbD possibilitou a mudança de paradigma por meio de uma abordagem multivariável com a utilização de ferramentas da qualidade, as quais demonstram pontos importantes no desenvolvimento e validação de um método analítico ao identificar e mitigar os pontos de fragilidade.Submitted by Marilene Donadel (marilene.donadel@unioeste.br) on 2021-12-08T18:48:30Z No. of bitstreams: 1 Leonardo_Oliveira_2021.pdf: 2372060 bytes, checksum: 3f620ca5a4c4cf4f17b114a6e888ae00 (MD5)Made available in DSpace on 2021-12-08T18:48:30Z (GMT). No. of bitstreams: 1 Leonardo_Oliveira_2021.pdf: 2372060 bytes, checksum: 3f620ca5a4c4cf4f17b114a6e888ae00 (MD5) Previous issue date: 2021-09-08application/pdfpor-2624803687637593200500Universidade Estadual do Oeste do ParanáToledoPrograma de Pós-Graduação em QuímicaUNIOESTEBrasilCentro de Engenharias e Ciências ExatasAQbDQualidadeMétodos analíticosCromatografia em fase gasosaCloridrato de duloxetinaQualityAnalytical methodsGas chromatographyDuloxetine hydrochlorideCIENCIAS EXATAS E DA TERRA::QUIMICAQualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de DuloxetinaAnalitycal Quality by Desing (AQbD) applied in the development of gas chromatographic methods on raw material Duloxetine Hydrochlorideinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis1435648362225100898600600600-77344021240821469221571700325303117195info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UNIOESTEinstname:Universidade Estadual do Oeste do Paraná (UNIOESTE)instacron:UNIOESTEORIGINALLeonardo_Oliveira_2021.pdfLeonardo_Oliveira_2021.pdfapplication/pdf2372060http://tede.unioeste.br:8080/tede/bitstream/tede/5715/2/Leonardo_Oliveira_2021.pdf3f620ca5a4c4cf4f17b114a6e888ae00MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://tede.unioeste.br:8080/tede/bitstream/tede/5715/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/57152021-12-08 15:48:30.82oai:tede.unioeste.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede.unioeste.br/PUBhttp://tede.unioeste.br/oai/requestbiblioteca.repositorio@unioeste.bropendoar:2021-12-08T18:48:30Biblioteca Digital de Teses e Dissertações do UNIOESTE - Universidade Estadual do Oeste do Paraná (UNIOESTE)false |
dc.title.por.fl_str_mv |
Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina |
dc.title.alternative.eng.fl_str_mv |
Analitycal Quality by Desing (AQbD) applied in the development of gas chromatographic methods on raw material Duloxetine Hydrochloride |
title |
Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina |
spellingShingle |
Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina Oliveira, Leonardo Guimarães de AQbD Qualidade Métodos analíticos Cromatografia em fase gasosa Cloridrato de duloxetina Quality Analytical methods Gas chromatography Duloxetine hydrochloride CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina |
title_full |
Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina |
title_fullStr |
Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina |
title_full_unstemmed |
Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina |
title_sort |
Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina |
author |
Oliveira, Leonardo Guimarães de |
author_facet |
Oliveira, Leonardo Guimarães de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Módenes, Aparecido Nivaldo |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7294940837327863 |
dc.contributor.advisor-co1.fl_str_mv |
Pereira, Marcos Donizete Peliçon |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/1543951142562291 |
dc.contributor.referee1.fl_str_mv |
Pereira, Marcos Donizete Peliçon |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/1543951142562291 |
dc.contributor.referee2.fl_str_mv |
Dragunski, Douglas Cardoso |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/0612112281360342 |
dc.contributor.referee3.fl_str_mv |
Módenes, Aparecido Nivaldo |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/7294940837327863 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3830038763865288 |
dc.contributor.author.fl_str_mv |
Oliveira, Leonardo Guimarães de |
contributor_str_mv |
Módenes, Aparecido Nivaldo Pereira, Marcos Donizete Peliçon Pereira, Marcos Donizete Peliçon Dragunski, Douglas Cardoso Módenes, Aparecido Nivaldo |
dc.subject.por.fl_str_mv |
AQbD Qualidade Métodos analíticos Cromatografia em fase gasosa Cloridrato de duloxetina |
topic |
AQbD Qualidade Métodos analíticos Cromatografia em fase gasosa Cloridrato de duloxetina Quality Analytical methods Gas chromatography Duloxetine hydrochloride CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Quality Analytical methods Gas chromatography Duloxetine hydrochloride |
dc.subject.cnpq.fl_str_mv |
CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
This work aimed to apply Quality by Analytical Design (AQbD) in the development and validation of an analytical method of residual solvents by gas chromatography with Headspace transferline injection of the raw material of Duloxetine Hydrochloride. Multivariate optimization of the analytical method was performed to control residual solvents methanol, acetone, 2-propanol, dichloromethane, tert-butanol, Ethyl acetate, Chloroform, Triethylamine, Dimethylsulfoxide, Cyclohexane and Toluene with the application of experimental designs aimed at meeting the objectives, characteristics and quality criteria. The execution was carried out in stages that can be summarized as screening, optimization, data evaluation, validation and strategic control. In screening, the Plackett-Burman experimental design was applied in order to define the best conditions for the use of Headspace transferline, allowing signal maximization and recovery close to 100% of the analytes. However, there was a division of the analytes to be controlled, and thus opted to present validation of residual solvents Methanol, Acetone, 2-Propanol, Dichloromethane and Tert-butanol. In the optimization stage, the identification of the Performance Characteristics of the Analytical Method (AMPC), Critical Quality Attributes (CQA) and Risk Analysis (QRM) were carried out and finalized with the application of the central composite design (CCD) for the definition of the method operable design region (MODR). The results were evaluated, in which the data were processed and evaluated, allowing the necessary adjustments to be made to the method. The analytical validation step was performed according to RDC 166/2017, obtaining a precise, linear, selective, robust method and limit of quantification. The MODR was defined after varying the kiln initial temperature and carrier gas flow factors, obtaining design regions ranging from 29.3 to 31.1 oC and 0.9 to 1.03 mL.min-1, respectively. Finally, the results are maximized analytical response and recovery close to 100%, ensuring operationality and regulatory flexibility allowing immediate adjustments to the analytical method. The determination of the sensitivity/Limit of analytical quantification at the 40% level for the analytes Methanol, Acetone, Tert-butanol, 2-propanol and Dichloromethane at a content of 1197.50, 1995.58, 398.16, 1997.84 and 239 .26 μg.g-1, respectively. The application of AQbD enabled the paradigm shift through a multivariable approach with the use of quality tools, which demonstrate important points in the development and validation of an analytical method to identify and mitigate weak points. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-12-08T18:48:30Z |
dc.date.issued.fl_str_mv |
2021-09-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Leonardo Guimarães de. Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina. 2021. 114 f. Dissertação (Mestrado em Química) - Universidade Estadual do Oeste do Paraná, Toledo, 2021. |
dc.identifier.uri.fl_str_mv |
http://tede.unioeste.br/handle/tede/5715 |
identifier_str_mv |
OLIVEIRA, Leonardo Guimarães de. Qualidade por Design Analítico (AQbD) aplicado ao desenvolvimento de métodos por cromatografia gasosa na matéria-prima de Cloridrato de Duloxetina. 2021. 114 f. Dissertação (Mestrado em Química) - Universidade Estadual do Oeste do Paraná, Toledo, 2021. |
url |
http://tede.unioeste.br/handle/tede/5715 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
1435648362225100898 |
dc.relation.confidence.fl_str_mv |
600 600 600 |
dc.relation.department.fl_str_mv |
-7734402124082146922 |
dc.relation.cnpq.fl_str_mv |
1571700325303117195 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual do Oeste do Paraná Toledo |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Química |
dc.publisher.initials.fl_str_mv |
UNIOESTE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Centro de Engenharias e Ciências Exatas |
publisher.none.fl_str_mv |
Universidade Estadual do Oeste do Paraná Toledo |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações do UNIOESTE instname:Universidade Estadual do Oeste do Paraná (UNIOESTE) instacron:UNIOESTE |
instname_str |
Universidade Estadual do Oeste do Paraná (UNIOESTE) |
instacron_str |
UNIOESTE |
institution |
UNIOESTE |
reponame_str |
Biblioteca Digital de Teses e Dissertações do UNIOESTE |
collection |
Biblioteca Digital de Teses e Dissertações do UNIOESTE |
bitstream.url.fl_str_mv |
http://tede.unioeste.br:8080/tede/bitstream/tede/5715/2/Leonardo_Oliveira_2021.pdf http://tede.unioeste.br:8080/tede/bitstream/tede/5715/1/license.txt |
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3f620ca5a4c4cf4f17b114a6e888ae00 bd3efa91386c1718a7f26a329fdcb468 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações do UNIOESTE - Universidade Estadual do Oeste do Paraná (UNIOESTE) |
repository.mail.fl_str_mv |
biblioteca.repositorio@unioeste.br |
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1798040118651518976 |