Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental

Detalhes bibliográficos
Ano de defesa: 2025
Autor(a) principal: Gomes , Etiele Maldonado lattes
Orientador(a): Mestieri , Maria Ligia de Arruda lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal do Pampa
Programa de Pós-Graduação: Doutorado em Ciência Animal
Departamento: Campus Uruguaiana
País: Brasil
Palavras-chave em Português:
Cartilagem
Doença articular degenerativa
Articular degenerative disease
Nanotecnologia;
Ultrasound
Cartilage;
Ultrassom
Nanotechnology
Área do conhecimento CNPq:
CIENCIAS AGRARIAS
Link de acesso: https://repositorio.unipampa.edu.br/handle/123456789/11249
Resumo: The present study aimed to evaluate the effects of curcumin and meloxicam, in different formulations, on osteoarthritis, with an emphasis on their potential anti-inflammatory, antioxidant, and chondroprotective properties. Fifty-four male Wistar rats, approximately 70 days old, were used. Of these, six animals participated in a pilot study for the standardization of techniques, while post-traumatic osteoarthritis (PTOA) was induced in the remaining 48. The animals were distributed into eight treatment groups: (1) free vehicle; (2) nanoencapsulated vehicle; (3) free curcumin; (4) nanoencapsulated curcumin; (5) free meloxicam; (6) nanoencapsulated meloxicam; (7) free curcumin + meloxicam; (8) nanoencapsulated curcumin + meloxicam. Treatments were administered orally every 24 hours for 30 days. Efficacy was assessed through clinical parameters (body weight, food consumption, and measurement of joint edema), joint functionality (open field tests, grip strength, and rotarod tests), imaging examinations (radiography and ultrasonography), biochemical analysis (serum levels of reactive oxygen species, antioxidants, and pro-inflammatory cytokines), and histological analysis. The results highlighted the use of ultrasonography as an auxiliary tool in monitoring the progression of osteoarthritis. Furthermore, the combination of curcumin and meloxicam for the treatment of PTOA demonstrated potential synergism, especially when nanoencapsulated.
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spelling Mestieri , Maria Ligia de Arrudahttp://lattes.cnpq.br/1689306155948159http://lattes.cnpq.br/1450036913425522Gomes , Etiele Maldonado2026-09-17T18:08:15Z20262025GOMES, Etiele Maldonado. Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental. 2025. 90 p. Tese (Doutorado em Ciência Animal) - Universidade Federal do Pampa, Uruguaiana, 2025.https://repositorio.unipampa.edu.br/handle/123456789/11249The present study aimed to evaluate the effects of curcumin and meloxicam, in different formulations, on osteoarthritis, with an emphasis on their potential anti-inflammatory, antioxidant, and chondroprotective properties. Fifty-four male Wistar rats, approximately 70 days old, were used. Of these, six animals participated in a pilot study for the standardization of techniques, while post-traumatic osteoarthritis (PTOA) was induced in the remaining 48. The animals were distributed into eight treatment groups: (1) free vehicle; (2) nanoencapsulated vehicle; (3) free curcumin; (4) nanoencapsulated curcumin; (5) free meloxicam; (6) nanoencapsulated meloxicam; (7) free curcumin + meloxicam; (8) nanoencapsulated curcumin + meloxicam. Treatments were administered orally every 24 hours for 30 days. Efficacy was assessed through clinical parameters (body weight, food consumption, and measurement of joint edema), joint functionality (open field tests, grip strength, and rotarod tests), imaging examinations (radiography and ultrasonography), biochemical analysis (serum levels of reactive oxygen species, antioxidants, and pro-inflammatory cytokines), and histological analysis. The results highlighted the use of ultrasonography as an auxiliary tool in monitoring the progression of osteoarthritis. Furthermore, the combination of curcumin and meloxicam for the treatment of PTOA demonstrated potential synergism, especially when nanoencapsulated.O presente estudo teve como objetivo avaliar os efeitos da curcumina e do meloxicam, em diferentes formulações, sobre a osteoartrite, com ênfase nos potenciais efeitos anti-inflamatórios, antioxidantes e condroprotetores. Foram utilizados 48 ratos machos da linhagem Wistar, com aproximadamente 70 dias de idade, distribuídos em oito grupos de tratamento: (1) veículo livre; (2) veículo nanoencapsulado; (3) curcumina livre; (4) curcumina nanoencapsulada; (5) meloxicam livre; (6) meloxicam nanoencapsulado; (7) curcumina + meloxicam livres; (8) curcumina + meloxicam nanoencapsulados. Os tratamentos foram administrados por via oral, a cada 24 horas, durante 30 dias. A eficácia foi avaliada por meio de parâmetros clínicos (peso corporal, consumo alimentar e mensuração da espessura articular), funcionalidade articular (testes de open field, força de preensão e rotarod), exames de imagem (radiografia e ultrassonografia), análise bioquímica (níveis séricos de espécies reativas de oxigênio, antioxidantes e citocinas pró-inflamatórias) e análise histológica. Os resultados indicam que a ultrassonografia é uma ferramenta eficaz no monitoramento da progressão da osteoartrite. Além disso, a associação da curcumina e do meloxicam para o tratamento da PTOA demonstrou potencial sinergismo, especialmente na formulação nanoencapsulada. Esses achados sugerem novas abordagens terapêuticas para o manejo da osteoartrite e destacam a necessidade de estudos adicionais para avaliar sua aplicabilidade clínica.Agência 1porUniversidade Federal do PampaDoutorado em Ciência AnimalUNIPAMPABrasilCampus UruguaianaCIENCIAS AGRARIASCartilagemDoença articular degenerativaArticular degenerative diseaseNanotecnologia;UltrasoundCartilage;UltrassomNanotechnologyUso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimentalUse of curcumin and Meloxicam co-nanoencapsulated for the treatment of osteoarthritis in an experimental modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIPAMPAinstname:Universidade Federal do Pampa (UNIPAMPA)instacron:UNIPAMPALICENSElicense.txtWritten by org.dspace.content.LicenseUtilstext/plain; charset=utf-81670https://repositorio.unipampa.edu.br/bitstreams/4da8f2e4-0fe8-4d95-850a-9c010ac80562/download0d1676a7f543432696ddf2f1676dffe0MD51falseAnonymousREADORIGINALETIELE MALDONADO GOMES ate MAIO 2030.pdfETIELE MALDONADO GOMES ate MAIO 2030.pdfEmbargo conforme termo de autorização.application/pdf3896588https://repositorio.unipampa.edu.br/bitstreams/d0652287-a0f6-4870-96a6-5ca4901fbeb0/download231d73b20a8468cf57944fd54ca9e6caMD52trueAnonymousREAD2030-12-31123456789/112492026-09-17 15:08:15.329embargo2030-12-31oai:repositorio.unipampa.edu.br:123456789/11249https://repositorio.unipampa.edu.brRepositório InstitucionalPUBhttp://dspace.unipampa.edu.br:8080/oai/requestsisbi@unipampa.edu.bropendoar:2026-09-17T18:08:15Repositório Institucional da UNIPAMPA - Universidade Federal do Pampa (UNIPAMPA)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
dc.title.none.fl_str_mv Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental
dc.title.alternative.none.fl_str_mv Use of curcumin and Meloxicam co-nanoencapsulated for the treatment of osteoarthritis in an experimental model
title Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental
spellingShingle Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental
Gomes , Etiele Maldonado
CIENCIAS AGRARIAS
Cartilagem
Doença articular degenerativa
Articular degenerative disease
Nanotecnologia;
Ultrasound
Cartilage;
Ultrassom
Nanotechnology
title_short Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental
title_full Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental
title_fullStr Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental
title_full_unstemmed Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental
title_sort Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental
author Gomes , Etiele Maldonado
author_facet Gomes , Etiele Maldonado
author_role author
dc.contributor.advisor1.fl_str_mv Mestieri , Maria Ligia de Arruda
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1689306155948159
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1450036913425522
dc.contributor.author.fl_str_mv Gomes , Etiele Maldonado
contributor_str_mv Mestieri , Maria Ligia de Arruda
dc.subject.cnpq.fl_str_mv CIENCIAS AGRARIAS
topic CIENCIAS AGRARIAS
Cartilagem
Doença articular degenerativa
Articular degenerative disease
Nanotecnologia;
Ultrasound
Cartilage;
Ultrassom
Nanotechnology
dc.subject.por.fl_str_mv Cartilagem
Doença articular degenerativa
Articular degenerative disease
Nanotecnologia;
Ultrasound
Cartilage;
Ultrassom
Nanotechnology
description The present study aimed to evaluate the effects of curcumin and meloxicam, in different formulations, on osteoarthritis, with an emphasis on their potential anti-inflammatory, antioxidant, and chondroprotective properties. Fifty-four male Wistar rats, approximately 70 days old, were used. Of these, six animals participated in a pilot study for the standardization of techniques, while post-traumatic osteoarthritis (PTOA) was induced in the remaining 48. The animals were distributed into eight treatment groups: (1) free vehicle; (2) nanoencapsulated vehicle; (3) free curcumin; (4) nanoencapsulated curcumin; (5) free meloxicam; (6) nanoencapsulated meloxicam; (7) free curcumin + meloxicam; (8) nanoencapsulated curcumin + meloxicam. Treatments were administered orally every 24 hours for 30 days. Efficacy was assessed through clinical parameters (body weight, food consumption, and measurement of joint edema), joint functionality (open field tests, grip strength, and rotarod tests), imaging examinations (radiography and ultrasonography), biochemical analysis (serum levels of reactive oxygen species, antioxidants, and pro-inflammatory cytokines), and histological analysis. The results highlighted the use of ultrasonography as an auxiliary tool in monitoring the progression of osteoarthritis. Furthermore, the combination of curcumin and meloxicam for the treatment of PTOA demonstrated potential synergism, especially when nanoencapsulated.
publishDate 2025
dc.date.issued.fl_str_mv 2025
dc.date.accessioned.fl_str_mv 2026-09-17T18:08:15Z
dc.date.available.fl_str_mv 2026
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Etiele Maldonado. Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental. 2025. 90 p. Tese (Doutorado em Ciência Animal) - Universidade Federal do Pampa, Uruguaiana, 2025.
dc.identifier.uri.fl_str_mv https://repositorio.unipampa.edu.br/handle/123456789/11249
identifier_str_mv GOMES, Etiele Maldonado. Uso da curcumina e Meloxicam conanoencapsulados no tratamento da osteoartrite em modelo experimental. 2025. 90 p. Tese (Doutorado em Ciência Animal) - Universidade Federal do Pampa, Uruguaiana, 2025.
url https://repositorio.unipampa.edu.br/handle/123456789/11249
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal do Pampa
dc.publisher.program.fl_str_mv Doutorado em Ciência Animal
dc.publisher.initials.fl_str_mv UNIPAMPA
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Campus Uruguaiana
publisher.none.fl_str_mv Universidade Federal do Pampa
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIPAMPA
instname:Universidade Federal do Pampa (UNIPAMPA)
instacron:UNIPAMPA
instname_str Universidade Federal do Pampa (UNIPAMPA)
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institution UNIPAMPA
reponame_str Repositório Institucional da UNIPAMPA
collection Repositório Institucional da UNIPAMPA
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