Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression

Detalhes bibliográficos
Ano de defesa: 2013
Autor(a) principal: Fernandez Garcia, Geysson Javier [UNESP]
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Estadual Paulista (Unesp)
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Atrofia muscular
Sistema musculoesquelético
Síndrome metabólica
Caquexia
Metabolic syndrome
Link de acesso: http://hdl.handle.net/11449/108576
Resumo: The skeletal muscle atrophy is a common phenomenon in many chronic systemic diseases such a sepsis, chronic heart failure, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, AIDS and cancer. These diseases may be accompanied by a complex metabolic syndrome characterized by muscle wasting, denominated cachexia. The molecular pathways responsible for cachexia are not completely understood, however, evidence suggest that pro-inflammatory cytokines like Tumor Necrosis Factor (TNF)-α and Interferon (INF)-γ have a key role in molecular pathways related to loss of function and muscle mass. The complexity of mechanisms controlling gene expression in this process suggests the involvement of additional regulatory molecules, such as microRNAs; these RNA molecules encoded by the genome regulate the function of skeletal muscle during development and various muscle diseases. MicroRNAs orchestrate common pathways or biological function, this unique feature gives rise as an effective tool for determining the pathways involved in specific diseases or biological processes. The hypothesis of this work is that the muscle atrophy induced by TNF-α and INF-γ has a microRNAs expression profile that allow the identification of regulatory networks and molecular pathways
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spelling Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expressionAtrofia muscularSistema musculoesqueléticoSíndrome metabólicaCaquexiaMetabolic syndromeThe skeletal muscle atrophy is a common phenomenon in many chronic systemic diseases such a sepsis, chronic heart failure, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, AIDS and cancer. These diseases may be accompanied by a complex metabolic syndrome characterized by muscle wasting, denominated cachexia. The molecular pathways responsible for cachexia are not completely understood, however, evidence suggest that pro-inflammatory cytokines like Tumor Necrosis Factor (TNF)-α and Interferon (INF)-γ have a key role in molecular pathways related to loss of function and muscle mass. The complexity of mechanisms controlling gene expression in this process suggests the involvement of additional regulatory molecules, such as microRNAs; these RNA molecules encoded by the genome regulate the function of skeletal muscle during development and various muscle diseases. MicroRNAs orchestrate common pathways or biological function, this unique feature gives rise as an effective tool for determining the pathways involved in specific diseases or biological processes. The hypothesis of this work is that the muscle atrophy induced by TNF-α and INF-γ has a microRNAs expression profile that allow the identification of regulatory networks and molecular pathwaysUniversidade Estadual Paulista (Unesp)Pai, Maeli Dal [UNESP]Carvalho, Robson Francisco [UNESP]Universidade Estadual Paulista (Unesp)Fernandez Garcia, Geysson Javier [UNESP]2014-08-13T14:50:45Z2014-08-13T14:50:45Z2013-09-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis93 f.application/pdfFERNANDEZ GARCIA, Geysson Javier. Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression. 2013. 93 f. Dissertação (mestrado) - Universidade Estadual Paulista Julio de Mesquita Filho, Instituto de Biociências de Botucatu, 2013.http://hdl.handle.net/11449/108576000755543000755543.pdf33004064026P954065187991284856171323341671821Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2025-10-23T13:02:51Zoai:repositorio.unesp.br:11449/108576Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-10-23T13:02:51Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression
title Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression
spellingShingle Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression
Fernandez Garcia, Geysson Javier [UNESP]
Atrofia muscular
Sistema musculoesquelético
Síndrome metabólica
Caquexia
Metabolic syndrome
title_short Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression
title_full Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression
title_fullStr Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression
title_full_unstemmed Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression
title_sort Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression
author Fernandez Garcia, Geysson Javier [UNESP]
author_facet Fernandez Garcia, Geysson Javier [UNESP]
author_role author
dc.contributor.none.fl_str_mv Pai, Maeli Dal [UNESP]
Carvalho, Robson Francisco [UNESP]
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Fernandez Garcia, Geysson Javier [UNESP]
dc.subject.por.fl_str_mv Atrofia muscular
Sistema musculoesquelético
Síndrome metabólica
Caquexia
Metabolic syndrome
topic Atrofia muscular
Sistema musculoesquelético
Síndrome metabólica
Caquexia
Metabolic syndrome
description The skeletal muscle atrophy is a common phenomenon in many chronic systemic diseases such a sepsis, chronic heart failure, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, AIDS and cancer. These diseases may be accompanied by a complex metabolic syndrome characterized by muscle wasting, denominated cachexia. The molecular pathways responsible for cachexia are not completely understood, however, evidence suggest that pro-inflammatory cytokines like Tumor Necrosis Factor (TNF)-α and Interferon (INF)-γ have a key role in molecular pathways related to loss of function and muscle mass. The complexity of mechanisms controlling gene expression in this process suggests the involvement of additional regulatory molecules, such as microRNAs; these RNA molecules encoded by the genome regulate the function of skeletal muscle during development and various muscle diseases. MicroRNAs orchestrate common pathways or biological function, this unique feature gives rise as an effective tool for determining the pathways involved in specific diseases or biological processes. The hypothesis of this work is that the muscle atrophy induced by TNF-α and INF-γ has a microRNAs expression profile that allow the identification of regulatory networks and molecular pathways
publishDate 2013
dc.date.none.fl_str_mv 2013-09-26
2014-08-13T14:50:45Z
2014-08-13T14:50:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv FERNANDEZ GARCIA, Geysson Javier. Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression. 2013. 93 f. Dissertação (mestrado) - Universidade Estadual Paulista Julio de Mesquita Filho, Instituto de Biociências de Botucatu, 2013.
http://hdl.handle.net/11449/108576
000755543
000755543.pdf
33004064026P9
5406518799128485
6171323341671821
identifier_str_mv FERNANDEZ GARCIA, Geysson Javier. Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression. 2013. 93 f. Dissertação (mestrado) - Universidade Estadual Paulista Julio de Mesquita Filho, Instituto de Biociências de Botucatu, 2013.
000755543
000755543.pdf
33004064026P9
5406518799128485
6171323341671821
url http://hdl.handle.net/11449/108576
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 93 f.
application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.source.none.fl_str_mv Aleph
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1854955046055182336

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